WO2000035922A1 - 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists - Google Patents
2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists Download PDFInfo
- Publication number
- WO2000035922A1 WO2000035922A1 PCT/US1999/029894 US9929894W WO0035922A1 WO 2000035922 A1 WO2000035922 A1 WO 2000035922A1 US 9929894 W US9929894 W US 9929894W WO 0035922 A1 WO0035922 A1 WO 0035922A1
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- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
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- 0 **(CC1)CC2N1c1c(*)c(*)c(*)c(*)c1N(*)*2 Chemical compound **(CC1)CC2N1c1c(*)c(*)c(*)c(*)c1N(*)*2 0.000 description 6
- OIRAUPNNUFUFAP-UHFFFAOYSA-N OC(C(C1)NCCN1OC(c1ccccc1)=O)=O Chemical compound OC(C(C1)NCCN1OC(c1ccccc1)=O)=O OIRAUPNNUFUFAP-UHFFFAOYSA-N 0.000 description 2
- OIRAUPNNUFUFAP-SNVBAGLBSA-N OC([C@@H](C1)NCCN1OC(c1ccccc1)=O)=O Chemical compound OC([C@@H](C1)NCCN1OC(c1ccccc1)=O)=O OIRAUPNNUFUFAP-SNVBAGLBSA-N 0.000 description 1
- JSSXHAMIXJGYCS-SCSAIBSYSA-N OC([C@@H]1NCCNC1)=O Chemical compound OC([C@@H]1NCCNC1)=O JSSXHAMIXJGYCS-SCSAIBSYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL14332399A IL143323A0 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists |
PL99348815A PL348815A1 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists |
HU0104773A HUP0104773A3 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them |
NZ512765A NZ512765A (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4A-tetrahydro-1H-pyrazino(1,2-A)quinoxalin- 5(6H)one derivatives being 5HT2C agonists |
SK819-2001A SK8192001A3 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivatives being 5ht2c agonists |
KR1020017007583A KR20010108025A (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-Tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)one derivatives being 5HT2C agonists |
BR9916326-8A BR9916326A (en) | 1998-12-17 | 1999-12-16 | Derivatives of 2,3,4,4a-tetrahydro-1h-pyrazine (1,2-a) quinoxalin-5- (6h) one being 5ht2c agonists |
JP2000588181A JP2002532504A (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4A-Tetrahydro-1H-pyrazino (1,2-A) quinoxalin-5 (6H) -one derivative which is a 5-HT2C agonist |
EP99965285A EP1140940A1 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)qinoxalin-5(6h)one derivates being 5ht2c agonists |
CA002351385A CA2351385A1 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists |
AU31234/00A AU3123400A (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists |
EA200100671A EA200100671A1 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-TETRAHYDRO-1H-PIRAZINO [1,2a] CHINOXALIN-5 (6H) -OH DERIVATIVES, AHONIST 5HT2C AGONISTS |
NO20013001A NO20013001D0 (en) | 1998-12-17 | 2001-06-15 | 2,3,4,4A-tetrahydro-1H-pyrazino (1,2-A) quinoxaline-5 (6H) one derivatives which are 5HT2C agonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21347198A | 1998-12-17 | 1998-12-17 | |
US09/213,471 | 1998-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000035922A1 true WO2000035922A1 (en) | 2000-06-22 |
Family
ID=22795247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/029894 WO2000035922A1 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1140940A1 (en) |
JP (1) | JP2002532504A (en) |
KR (1) | KR20010108025A (en) |
CN (1) | CN1240701C (en) |
AR (1) | AR022687A1 (en) |
AU (1) | AU3123400A (en) |
BR (1) | BR9916326A (en) |
CA (1) | CA2351385A1 (en) |
CZ (1) | CZ20012193A3 (en) |
EA (1) | EA200100671A1 (en) |
HU (1) | HUP0104773A3 (en) |
IL (1) | IL143323A0 (en) |
NO (1) | NO20013001D0 (en) |
NZ (1) | NZ512765A (en) |
PL (1) | PL348815A1 (en) |
SK (1) | SK8192001A3 (en) |
WO (1) | WO2000035922A1 (en) |
ZA (1) | ZA200104598B (en) |
Cited By (52)
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---|---|---|---|---|
WO2002010169A1 (en) * | 2000-07-31 | 2002-02-07 | F. Hoffmann-La Roche Ag | Piperazine derivatives |
WO2002040457A1 (en) | 2000-11-20 | 2002-05-23 | Biovitrum Ab | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
WO2002042304A2 (en) * | 2000-11-03 | 2002-05-30 | Wyeth | Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists |
WO2002051844A1 (en) * | 2000-12-27 | 2002-07-04 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
WO2002059127A2 (en) * | 2000-12-20 | 2002-08-01 | Bristol-Myers Squibb Pharma Company | Pyrazinoquinoxaline derivatives as serotonin agonists and antagonists |
WO2002074746A1 (en) * | 2001-03-16 | 2002-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Benzazepine derivatives |
US6593330B2 (en) | 2000-11-20 | 2003-07-15 | Biovitrum | Compounds and their use |
WO2004000830A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
US6759405B2 (en) | 2000-11-03 | 2004-07-06 | Wyeth | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6777407B2 (en) | 2000-11-03 | 2004-08-17 | Wyeth | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6784172B2 (en) | 2000-11-03 | 2004-08-31 | Wyeth | Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
US6858604B2 (en) | 2000-11-03 | 2005-02-22 | Wyeth | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
WO2005016902A1 (en) * | 2003-06-20 | 2005-02-24 | Arena Pharmaceuticals, Inc. | N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
US6881749B2 (en) | 2001-06-01 | 2005-04-19 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
US6916922B2 (en) | 2000-11-03 | 2005-07-12 | Wyeth | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives |
US6956036B1 (en) | 2000-03-17 | 2005-10-18 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
US6960608B2 (en) | 2001-06-01 | 2005-11-01 | Alcon, Inc. | Fused indazoles and indoles and their use for the treatment of glaucoma |
US6989445B2 (en) | 2003-12-15 | 2006-01-24 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
US7012089B2 (en) | 2002-04-25 | 2006-03-14 | Wyeth | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents |
US7022707B2 (en) | 2000-12-15 | 2006-04-04 | Hoffman-La Roche Inc. | Piperazine derivatives |
WO2006037481A1 (en) * | 2004-09-30 | 2006-04-13 | F.Hoffmann-La Roche Ag | Benzoxazine and quinoxaline derivatives and uses |
US7060704B2 (en) | 1998-05-19 | 2006-06-13 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
US7071225B2 (en) | 2001-06-01 | 2006-07-04 | Alcon, Inc. | Arylaminopropane analogues and their use for the treatment of glaucoma |
US7071185B2 (en) | 2002-04-25 | 2006-07-04 | Wyeth | 1,2,3,4,7,8-hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
US7109339B2 (en) | 2002-12-19 | 2006-09-19 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
US7129237B2 (en) | 2002-04-25 | 2006-10-31 | Wyeth | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
US7141563B2 (en) | 2000-11-03 | 2006-11-28 | Wyeth | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives |
US7208512B2 (en) | 2001-12-20 | 2007-04-24 | Alcon, Inc. | Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
US7208494B2 (en) | 2003-06-26 | 2007-04-24 | Hoffmann-La Roche Inc. | 5HT2c receptor agonists |
WO2007132841A1 (en) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
US7396856B2 (en) | 2002-12-13 | 2008-07-08 | Alcon, Inc. | Benzopyran analogs and their use for the treatment of glaucoma |
US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
US7476687B2 (en) | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
WO2009063992A1 (en) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | Condensed pyridine derivative and use thereof |
EP2108649A1 (en) | 2008-04-10 | 2009-10-14 | Korea Research Institute of Chemical Technology | Novel indol carboxylic acid bispyridyl carboxamide derivatives as 5-HT2c receptor antagonists |
US7671196B2 (en) | 2005-07-26 | 2010-03-02 | Wyeth Llc | Diazepinoquinolines, synthesis thereof, and intermediates thereto |
US7781427B2 (en) | 2004-11-05 | 2010-08-24 | Wyeth Llc | Process for preparing quinoline compounds and products obtained therefrom |
EP2248524A2 (en) | 2004-08-25 | 2010-11-10 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
EP2277513A2 (en) | 2003-04-25 | 2011-01-26 | Pfizer Inc. | Treatment of incontinence with 5htc2 agonists |
WO2011071136A1 (en) | 2009-12-11 | 2011-06-16 | アステラス製薬株式会社 | Therapeutic agent for fibromyalgia |
WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
KR101110199B1 (en) | 2009-05-18 | 2012-03-14 | 한국화학연구원 | Piperazine-quinoline derivatives, pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for prevention or treatment of central nervous system diseases containing the same as an active ingredient |
US8492591B2 (en) | 2010-02-04 | 2013-07-23 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-HT(2C) receptor agonists that show anti-psychotic effects with antagonist activity at the 5-HT(2B) receptor |
US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
US9067949B2 (en) | 2011-01-19 | 2015-06-30 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
WO2016123164A1 (en) | 2015-01-29 | 2016-08-04 | The Board Of Trustees Of The University Of Illinois | Cyclopropylmethanamines as selective 5-ht(2c) receptor agonists |
WO2019131902A1 (en) | 2017-12-27 | 2019-07-04 | 武田薬品工業株式会社 | Therapeutic agent for stress urinary incontinence and fecal incontinence |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032639A (en) * | 1976-03-22 | 1977-06-28 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension |
US4089958A (en) * | 1976-12-20 | 1978-05-16 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof |
US4203987A (en) * | 1979-05-21 | 1980-05-20 | American Home Products Corporation | 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones |
EP0410535A2 (en) * | 1989-07-28 | 1991-01-30 | Merck Sharp & Dohme Ltd. | Octahydrobenzisoquinoline derivatives as antipsychotic agents |
EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
WO1996023789A1 (en) * | 1995-02-03 | 1996-08-08 | Sankyo Company, Limited | Hexahydropyrazinoquinoline derivatives |
-
1999
- 1999-12-16 EA EA200100671A patent/EA200100671A1/en unknown
- 1999-12-16 WO PCT/US1999/029894 patent/WO2000035922A1/en not_active Application Discontinuation
- 1999-12-16 HU HU0104773A patent/HUP0104773A3/en unknown
- 1999-12-16 BR BR9916326-8A patent/BR9916326A/en not_active IP Right Cessation
- 1999-12-16 KR KR1020017007583A patent/KR20010108025A/en not_active Application Discontinuation
- 1999-12-16 PL PL99348815A patent/PL348815A1/en not_active Application Discontinuation
- 1999-12-16 CZ CZ20012193A patent/CZ20012193A3/en unknown
- 1999-12-16 IL IL14332399A patent/IL143323A0/en unknown
- 1999-12-16 SK SK819-2001A patent/SK8192001A3/en unknown
- 1999-12-16 CN CNB998144169A patent/CN1240701C/en not_active Expired - Fee Related
- 1999-12-16 AU AU31234/00A patent/AU3123400A/en not_active Abandoned
- 1999-12-16 NZ NZ512765A patent/NZ512765A/en unknown
- 1999-12-16 AR ARP990106455A patent/AR022687A1/en not_active Application Discontinuation
- 1999-12-16 EP EP99965285A patent/EP1140940A1/en not_active Withdrawn
- 1999-12-16 CA CA002351385A patent/CA2351385A1/en not_active Abandoned
- 1999-12-16 JP JP2000588181A patent/JP2002532504A/en not_active Withdrawn
-
2001
- 2001-06-05 ZA ZA200104598A patent/ZA200104598B/en unknown
- 2001-06-15 NO NO20013001A patent/NO20013001D0/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US4032639A (en) * | 1976-03-22 | 1977-06-28 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension |
US4089958A (en) * | 1976-12-20 | 1978-05-16 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof |
US4203987A (en) * | 1979-05-21 | 1980-05-20 | American Home Products Corporation | 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones |
EP0410535A2 (en) * | 1989-07-28 | 1991-01-30 | Merck Sharp & Dohme Ltd. | Octahydrobenzisoquinoline derivatives as antipsychotic agents |
EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
WO1996023789A1 (en) * | 1995-02-03 | 1996-08-08 | Sankyo Company, Limited | Hexahydropyrazinoquinoline derivatives |
Non-Patent Citations (5)
Title |
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GUPTA,Y.K. ET AL.: "Therapeutic Potentials of 5HT Receptor Modulators", INDIAN J.PHARMACOL., vol. 26, 1994, pages 94 - 107, XP000571272 * |
HUFF,J.R. ET AL.: "Bioactive Conformation of 1-Aryl-piperazines at Central Serotonin Receptors", J.MED.CHEM., vol. 28, no. 7, July 1985 (1985-07-01), WASHINGTON, pages 945 - 948, XP000885743 * |
KUMAR,N. ET AL.: "Agents acting on CNS : XXVII. Synthesis of 3-substituted 2,3,4,4a,5,6-hexahydro-1H-pyrazino-[1,2-a]quinoxalines", INDIAN J.CHEM., vol. 17B, 1979, pages 244 - 245, XP000885997 * |
MOKROSZ,J.L. ET AL.: "SAR studies of CNS agents. III. On the Bioactive Conformations of 1-Aryl-piperazines at 5-HT1A Receptor", POL.J.PHARMACOL.PHARM., vol. 44, 1992, pages 87 - 97, XP000885854 * |
SLEIGHT,A.P. ET AL.: "Identification of 5-hydroxytryptamine1A receptor agents using a composite pharmacophor analysis and chemical database screening", NAUNYN-SCHMIEDEBERG'S ARCH.PHARMACOL., vol. 343, 1991, HEIDELBERG, pages 109 - 116, XP000650292 * |
Cited By (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CA2351385A1 (en) | 2000-06-22 |
ZA200104598B (en) | 2002-09-05 |
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CZ20012193A3 (en) | 2001-12-12 |
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AU3123400A (en) | 2000-07-03 |
JP2002532504A (en) | 2002-10-02 |
HUP0104773A2 (en) | 2002-04-29 |
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BR9916326A (en) | 2001-10-02 |
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