WO2000035418A3 - Chewable drug delivery system - Google Patents

Chewable drug delivery system Download PDF

Info

Publication number
WO2000035418A3
WO2000035418A3 PCT/US1999/030119 US9930119W WO0035418A3 WO 2000035418 A3 WO2000035418 A3 WO 2000035418A3 US 9930119 W US9930119 W US 9930119W WO 0035418 A3 WO0035418 A3 WO 0035418A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
drug delivery
oral cavity
chewable
chewable drug
Prior art date
Application number
PCT/US1999/030119
Other languages
French (fr)
Other versions
WO2000035418A2 (en
Inventor
Hassan Nached
David Goldman
John M Amatruda
Original Assignee
Bayer Ag
Hassan Nached
David Goldman
John M Amatruda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Hassan Nached, David Goldman, John M Amatruda filed Critical Bayer Ag
Priority to AU23679/00A priority Critical patent/AU2367900A/en
Publication of WO2000035418A2 publication Critical patent/WO2000035418A2/en
Publication of WO2000035418A3 publication Critical patent/WO2000035418A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to an organoleptic chewable drug delivery system for a pharmaceutically active composition targeting the oral cavity. This chewable drug delivery system is capable of rapidly releasing the active pharmaceutical agent and extending its retention in the oral cavity to improve the therapeutic activity. The drug delivery system comprises a bioadhesive component and an effervescent disintegrating component. The invention also comprises a method for preparing the pharmaceutically active chewable drug delivery system and a method for prolonging the contact of the pharmaceutical composition in the oral cavity.
PCT/US1999/030119 1998-12-18 1999-12-16 Chewable drug delivery system WO2000035418A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23679/00A AU2367900A (en) 1998-12-18 1999-12-16 Chewable drug delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21570798A 1998-12-18 1998-12-18
US09/215,707 1998-12-18

Publications (2)

Publication Number Publication Date
WO2000035418A2 WO2000035418A2 (en) 2000-06-22
WO2000035418A3 true WO2000035418A3 (en) 2000-12-21

Family

ID=22804049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030119 WO2000035418A2 (en) 1998-12-18 1999-12-16 Chewable drug delivery system

Country Status (2)

Country Link
AU (1) AU2367900A (en)
WO (1) WO2000035418A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200604B1 (en) * 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US6350470B1 (en) 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US20020119192A1 (en) * 2000-09-22 2002-08-29 Vishwanathan Narayanan Badri Controlled release formulations for oral administration
DE10107659B4 (en) * 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhesive disintegratable drug preparation for drug administration in veterinary and human medicine
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
US20030124196A1 (en) 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
WO2006044595A2 (en) * 2004-10-13 2006-04-27 Cadbury Adams Usa Llc Effervescent pressed gum tablet compositions
WO2009125432A2 (en) * 2008-04-11 2009-10-15 Lupin Limited Gas empowered expandable drug delivery systems
RU2493829C2 (en) * 2008-08-22 2013-09-27 РЕКИТТ БЕНКАЙЗЕР ХЕЛТКЭА (Ю Кей) ЛИМИТЕД Improvement of compositions or whatever is relevant to compositions
JP6526956B2 (en) * 2013-12-19 2019-06-05 花王株式会社 Solid composition
EP4208155A1 (en) * 2020-09-03 2023-07-12 Elanco Tiergesundheit AG Chewable formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424706A1 (en) * 1989-10-25 1991-05-02 Pharmatrans Sanaq Ag Chewable or suckable pharmaceutical form, process for its preparation and its use
DE19802700A1 (en) * 1998-01-24 1999-07-29 Bayer Ag Preparation of fast-dissolving tablets for controlling blood sugar levels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424706A1 (en) * 1989-10-25 1991-05-02 Pharmatrans Sanaq Ag Chewable or suckable pharmaceutical form, process for its preparation and its use
DE19802700A1 (en) * 1998-01-24 1999-07-29 Bayer Ag Preparation of fast-dissolving tablets for controlling blood sugar levels

Also Published As

Publication number Publication date
AU2367900A (en) 2000-07-03
WO2000035418A2 (en) 2000-06-22

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