WO2000034438A3 - Method for constructing libraries of phenotypic profiles - Google Patents

Method for constructing libraries of phenotypic profiles Download PDF

Info

Publication number
WO2000034438A3
WO2000034438A3 PCT/EP1999/009710 EP9909710W WO0034438A3 WO 2000034438 A3 WO2000034438 A3 WO 2000034438A3 EP 9909710 W EP9909710 W EP 9909710W WO 0034438 A3 WO0034438 A3 WO 0034438A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
constructing libraries
phenotypic profiles
worm
phenotypic
Prior art date
Application number
PCT/EP1999/009710
Other languages
French (fr)
Other versions
WO2000034438A2 (en
Inventor
Titus Kaletta
Richard Feichtinger
Poucke Jonas Van
Geel Anton Van
Saskia Appelmans
Criekinge Wim Van
Thierry Bogaert
Original Assignee
Devgen Nv
Titus Kaletta
Richard Feichtinger
Poucke Jonas Van
Geel Anton Van
Saskia Appelmans
Criekinge Wim Van
Thierry Bogaert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen Nv, Titus Kaletta, Richard Feichtinger, Poucke Jonas Van, Geel Anton Van, Saskia Appelmans, Criekinge Wim Van, Thierry Bogaert filed Critical Devgen Nv
Priority to AU19750/00A priority Critical patent/AU1975000A/en
Priority to EP99963460A priority patent/EP1137754A2/en
Priority to JP2000586872A priority patent/JP2002531115A/en
Publication of WO2000034438A2 publication Critical patent/WO2000034438A2/en
Publication of WO2000034438A3 publication Critical patent/WO2000034438A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C07K14/43545—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host

Abstract

Methods are provided for use in constructing libraries of phenotypic profiles in a nematode worm such as C. elegans. The methods require measurement of identifiable characteristics of the worm and systematic scoring of these characteristics. Also provided are methods of identifying compounds with potential pharmacological activity, for determining the mode of action of a given compound and for assigning genes to particular biochemical pathways.
PCT/EP1999/009710 1998-12-07 1999-12-07 Method for constructing libraries of phenotypic profiles WO2000034438A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU19750/00A AU1975000A (en) 1998-12-07 1999-12-07 Method for constructing libraries of phenotypic profiles
EP99963460A EP1137754A2 (en) 1998-12-07 1999-12-07 Method for constructing libraries of phenotypic profiles
JP2000586872A JP2002531115A (en) 1998-12-07 1999-12-07 How to Build a Library of Phenotype Profiles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9826890.7 1998-12-07
GBGB9826890.7A GB9826890D0 (en) 1998-12-07 1998-12-07 Method for screening compounds

Publications (2)

Publication Number Publication Date
WO2000034438A2 WO2000034438A2 (en) 2000-06-15
WO2000034438A3 true WO2000034438A3 (en) 2000-11-09

Family

ID=10843778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/009710 WO2000034438A2 (en) 1998-12-07 1999-12-07 Method for constructing libraries of phenotypic profiles

Country Status (5)

Country Link
EP (1) EP1137754A2 (en)
JP (1) JP2002531115A (en)
AU (1) AU1975000A (en)
GB (1) GB9826890D0 (en)
WO (1) WO2000034438A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9908676D0 (en) * 1999-04-15 1999-06-09 Devgen Nv Method for screening compounds
GB9908677D0 (en) * 1999-04-15 1999-06-09 Devgen Nv Compound assay
GB2351151B (en) * 1999-04-15 2001-07-25 Devgen Nv Compound Screening Method in Nematode Worms
US6787125B1 (en) 1999-04-15 2004-09-07 Devgen Nv Compound screening method
DE19924929C2 (en) 1999-05-31 2001-05-31 Elegene Gmbh New method to investigate the suitability of a material as a pharmaceutical
US7083947B2 (en) 2000-05-19 2006-08-01 Devgen Nv Assay techniques using nematode worms
WO2002033405A1 (en) * 2000-10-18 2002-04-25 Devgen Nv Methods for identifying pesticidal compounds
EP1732379B1 (en) 2004-04-09 2013-11-06 Monsanto Technology LLC Compositions and methods for control of insect infestations in plants
JP7045680B2 (en) * 2017-02-16 2022-04-01 国立大学法人東北大学 Biological activity evaluation method for substances using nematodes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009096A2 (en) * 1989-02-03 1990-08-23 Cambridge Neuroscience Research, Inc. Method of screening and classifying compounds
WO1996038555A2 (en) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009096A2 (en) * 1989-02-03 1990-08-23 Cambridge Neuroscience Research, Inc. Method of screening and classifying compounds
WO1996038555A2 (en) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AHRINGER ET AL.: "Turn to the worm!", CURRENT OPINION IN GENETICS AND DEVELOPMENT, vol. 7, 1997, pages 410 - 415, XP000886904 *
BOGAERT, T. ET AL: "Determination of the toxicity of four heavy metal compounds and three carcinogens using two marine nematode species, Monhystera microphthalma and Diplolaimelloides bruciei. ECOTOXICOLOGICAL TESTING FOR THE MARINE ENVIRONMENT. VOL. 2.", MAR. TOX., (1984) PP. 21-30. MEETING INFO.: INTERNATIONAL SYMPOSIUM ON ECOTOXICOLOGICAL TESTING FOR THE MARINE ENVIRONMENT. GHENT (BELGIUM). 12-14 SEP 1983. ISSN: 90-9000814-4;,90-9000813-6., Lab. Mol. Biol., Med. Res. Counc. Cent., University Med. Sch., Hills Rd., Cambridge CB2 2QH, UK, XP000886948 *
KATSURA ET AL.: "Isolation, characterization and epistasis of fluoride-resistant mutants of Caenorhabditis elegans", GENETICS, vol. 136, 1994, pages 145 - 154, XP000886900 *
SAMOILOFF, M.R. ET AL: "The use of nematodes in marine ecotoxicology. ECOTOXICOLOGICAL TESTING FOR THE MARINE ENVIRONMENT. VOL. 1.", MAR. TOX., (1984) PP. 407-426. MEETING INFO.: INTERNATIONAL SYMPOSIUM ON ECOTOXICOLOGICAL TESTING FOR THE MARINE ENVIRONMENT. GHENT (BELGIUM). 12-14 SEP 1983. ISSN: 90-9000814-4;,90-9000812-8., Dep. Zool., Univ. Manitoba, Winnipeg, Man. R3T 2N2, Canada, XP000886947 *
VAN SWINDEREN ET AL.: "Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans", PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 8232 - 8237, XP002137784 *

Also Published As

Publication number Publication date
WO2000034438A2 (en) 2000-06-15
EP1137754A2 (en) 2001-10-04
GB9826890D0 (en) 1999-01-27
AU1975000A (en) 2000-06-26
JP2002531115A (en) 2002-09-24

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