WO2000034329A3 - Differentiation signal - Google Patents

Differentiation signal Download PDF

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Publication number
WO2000034329A3
WO2000034329A3 PCT/NL1999/000752 NL9900752W WO0034329A3 WO 2000034329 A3 WO2000034329 A3 WO 2000034329A3 NL 9900752 W NL9900752 W NL 9900752W WO 0034329 A3 WO0034329 A3 WO 0034329A3
Authority
WO
WIPO (PCT)
Prior art keywords
differentiation
erythroid
cells
proliferation
differentiation signal
Prior art date
Application number
PCT/NL1999/000752
Other languages
French (fr)
Other versions
WO2000034329A2 (en
Inventor
Franklin Gerardus Grosveld
David John Whyatt
Jacobus Nicolaas Joz Philipsen
Fokke Albert Lindeboom
Original Assignee
Univ Erasmus
Franklin Gerardus Grosveld
David John Whyatt
Jacobus Nicolaas Joz Philipsen
Fokke Albert Lindeboom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus, Franklin Gerardus Grosveld, David John Whyatt, Jacobus Nicolaas Joz Philipsen, Fokke Albert Lindeboom filed Critical Univ Erasmus
Priority to EP99960025A priority Critical patent/EP1137756A2/en
Priority to AU16972/00A priority patent/AU1697200A/en
Publication of WO2000034329A2 publication Critical patent/WO2000034329A2/en
Publication of WO2000034329A3 publication Critical patent/WO2000034329A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to the field of haematopoietic disorders, in particular to the regulation or proliferation and/or differentiation of specific cell-lineages of cells of haematopoietic origin. The invention relates specifically to the proliferation and/or differentiation of erythroid cells. The invention provides a method for stimulating erythroid differentiation of erythroid cells of which said differentiation is impaired or hampered, comprising contacting said cells with erythroid cells capable of erythroid differentiation or with at least one substance secreted by said cells capable of erythroid differentiation.
PCT/NL1999/000752 1998-12-08 1999-12-08 Differentiation signal WO2000034329A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99960025A EP1137756A2 (en) 1998-12-08 1999-12-08 Differentiation signal
AU16972/00A AU1697200A (en) 1998-12-08 1999-12-08 Differentiation signal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204157 1998-12-08
EP98204157.6 1998-12-08

Publications (2)

Publication Number Publication Date
WO2000034329A2 WO2000034329A2 (en) 2000-06-15
WO2000034329A3 true WO2000034329A3 (en) 2000-09-08

Family

ID=8234444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1999/000752 WO2000034329A2 (en) 1998-12-08 1999-12-08 Differentiation signal

Country Status (3)

Country Link
EP (1) EP1137756A2 (en)
AU (1) AU1697200A (en)
WO (1) WO2000034329A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024903A1 (en) * 1996-12-05 1998-06-11 Km Biotech, Inc. Isolation and use of erythroid differentiation and denucleation factors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024903A1 (en) * 1996-12-05 1998-06-11 Km Biotech, Inc. Isolation and use of erythroid differentiation and denucleation factors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLOBEL G A ET AL: "CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1998 MAR 3) 95 (5) 2061-6, XP002105083 *
BRIEGEL K ET AL: "Regulation and function of transcription factor GATA-1 during red blood cell differentiation.", DEVELOPMENT, (1996 DEC) 122 (12) 3839-50, XP002105085 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; February 1997 (1997-02-01), WHYATT DAVID J ET AL: "The level of the tissue-specific factor GATA-I affects the cell-cycle machinery.", XP002138404, Database accession no. PREV199800118123 *
ELEFANTY A G ET AL: "GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.", EMBO JOURNAL, (1996 JAN 15) 15 (2) 319-33, XP002105084 *
GENES AND FUNCTION FEB., 1997, vol. 1, no. 1, February 1997 (1997-02-01), pages 11 - 24, ISSN: 1360-7413 *

Also Published As

Publication number Publication date
EP1137756A2 (en) 2001-10-04
AU1697200A (en) 2000-06-26
WO2000034329A2 (en) 2000-06-15

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