WO2000033913A3 - System and method for stimulation and/or enhancement of myocardial angiogenesis - Google Patents

System and method for stimulation and/or enhancement of myocardial angiogenesis Download PDF

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Publication number
WO2000033913A3
WO2000033913A3 PCT/US1999/029037 US9929037W WO0033913A3 WO 2000033913 A3 WO2000033913 A3 WO 2000033913A3 US 9929037 W US9929037 W US 9929037W WO 0033913 A3 WO0033913 A3 WO 0033913A3
Authority
WO
WIPO (PCT)
Prior art keywords
shock
fluid
wave
waves
balloon
Prior art date
Application number
PCT/US1999/029037
Other languages
French (fr)
Other versions
WO2000033913A2 (en
Inventor
Stephen M Fry
Original Assignee
Strategic Business Dev Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Strategic Business Dev Inc filed Critical Strategic Business Dev Inc
Priority to AU20455/00A priority Critical patent/AU2045500A/en
Publication of WO2000033913A2 publication Critical patent/WO2000033913A2/en
Publication of WO2000033913A3 publication Critical patent/WO2000033913A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/26—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00392—Transmyocardial revascularisation

Abstract

Shock-waves are applied using a combination lithotripsy probe/balloon system, comprising a needle and cannular balloon which can be inserted through the skin at a point between the ribs into the cavity beneath the chest wall and overlying the heart. Alternatively, the shock-wave can be administered extracorporally or via a catheter. A fluid injector is connected to the balloon, allowing it to be inflated with saline or other appropriate fluid to fill the space (for transmission of shock waves and/or to displace tissue - such as lung) and contact the surface of the heart. A shock-wave (acoustic) generator is used to generate shock-waves through the lithotripsy probe, through the fluid and into the myocardial tissue. The fluid provides a uniform medium for transmission of the acoustic energy, allowing precise focus and direction of the shock-wave to induce repeatable cavitation events, producing small fissures which are created by the cavitation bubbles. In this case, channels would not be 'drilled' into the heart muscle, minimizing trauma to the tissue while still creating conditions that will stimulate increased expression of angiogenic growth factors.
PCT/US1999/029037 1998-12-08 1999-12-08 System and method for stimulation and/or enhancement of myocardial angiogenesis WO2000033913A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20455/00A AU2045500A (en) 1998-12-08 1999-12-08 System and method for stimulation and/or enhancement of myocardial angiogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11134798P 1998-12-08 1998-12-08
US60/111,347 1998-12-08

Publications (2)

Publication Number Publication Date
WO2000033913A2 WO2000033913A2 (en) 2000-06-15
WO2000033913A3 true WO2000033913A3 (en) 2003-05-08

Family

ID=22337999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/029037 WO2000033913A2 (en) 1998-12-08 1999-12-08 System and method for stimulation and/or enhancement of myocardial angiogenesis

Country Status (2)

Country Link
AU (1) AU2045500A (en)
WO (1) WO2000033913A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511444B2 (en) * 1998-02-17 2003-01-28 Brigham And Women's Hospital Transmyocardial revascularization using ultrasound
ATE326183T1 (en) * 2002-01-08 2006-06-15 Bio Scan Ltd ULTRASONIC TRANSDUCER PROBE
US8657811B2 (en) 2003-05-01 2014-02-25 Keio University Intravascular diagnostic or therapeutic apparatus using high-intensity pulsed light
EP1541091A1 (en) 2003-12-10 2005-06-15 EL.EN. S.p.A. Device for treating tumors by laser thermotherapy
CA2638012A1 (en) * 2006-02-02 2007-08-09 Releaf Medical Ltd. Shock-wave generating device, such as for the treatment of calcific aortic stenosis
AT503787B1 (en) 2006-11-30 2008-01-15 Mohl Werner Ddr Method for intermittent occlusion of coronary sinus in heart of patient, involves releasing occlusion of coronary sinus as function of one characteristic value derived from pressure values in occluded coronary sinus
US9855049B2 (en) 2013-12-11 2018-01-02 Miracor Medical Systems Gmbh System and method for treating heart tissue

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009762A1 (en) * 1989-02-22 1990-09-07 Physical Sciences Inc. Acoustic impact delivery catheter with end cap
WO1997039691A1 (en) * 1996-04-24 1997-10-30 The Regents Of The University Of California Opto-acoustic transducer for medical applications
EP0834287A1 (en) * 1996-10-03 1998-04-08 Interventional Technologies Inc Neovascularization catheter
WO1998016157A1 (en) * 1996-10-17 1998-04-23 Ethicon Endo-Surgery, Inc. Methods and devices for improving blood flow to the heart of a patient
US5827203A (en) * 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
WO1998051224A2 (en) * 1997-05-16 1998-11-19 Henry Nita Therapeutic ultrasound system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223676A (en) 1977-12-19 1980-09-23 Cavitron Corporation Ultrasonic aspirator
EP0355175A1 (en) 1988-08-17 1990-02-28 Siemens Aktiengesellschaft Apparatus for the contactless disintegration of concrements in the body of a living being
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US5524620A (en) 1991-11-12 1996-06-11 November Technologies Ltd. Ablation of blood thrombi by means of acoustic energy

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009762A1 (en) * 1989-02-22 1990-09-07 Physical Sciences Inc. Acoustic impact delivery catheter with end cap
WO1997039691A1 (en) * 1996-04-24 1997-10-30 The Regents Of The University Of California Opto-acoustic transducer for medical applications
EP0834287A1 (en) * 1996-10-03 1998-04-08 Interventional Technologies Inc Neovascularization catheter
WO1998016157A1 (en) * 1996-10-17 1998-04-23 Ethicon Endo-Surgery, Inc. Methods and devices for improving blood flow to the heart of a patient
US5827203A (en) * 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
WO1998051224A2 (en) * 1997-05-16 1998-11-19 Henry Nita Therapeutic ultrasound system

Also Published As

Publication number Publication date
WO2000033913A2 (en) 2000-06-15
AU2045500A (en) 2000-06-26

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