WO2000033812A3 - Transdermal patch for delivering volatile liquid drugs - Google Patents

Transdermal patch for delivering volatile liquid drugs Download PDF

Info

Publication number
WO2000033812A3
WO2000033812A3 PCT/US1999/028697 US9928697W WO0033812A3 WO 2000033812 A3 WO2000033812 A3 WO 2000033812A3 US 9928697 W US9928697 W US 9928697W WO 0033812 A3 WO0033812 A3 WO 0033812A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
transdermal patch
volatile liquid
liquid drugs
layer
Prior art date
Application number
PCT/US1999/028697
Other languages
French (fr)
Other versions
WO2000033812A2 (en
WO2000033812A9 (en
Inventor
J Miranda
C J Ii Betlach
Original Assignee
Elan Corp Plc
J Miranda
C J Ii Betlach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22337613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000033812(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Elan Corp Plc, J Miranda, C J Ii Betlach filed Critical Elan Corp Plc
Priority to AU25877/00A priority Critical patent/AU778992B2/en
Priority to CA002380391A priority patent/CA2380391A1/en
Priority to NZ512788A priority patent/NZ512788A/en
Priority to EP99968461A priority patent/EP1137406B2/en
Priority to AT99968461T priority patent/ATE264098T1/en
Priority to DE69916492T priority patent/DE69916492T3/en
Priority to JP2000586306A priority patent/JP2002531488A/en
Publication of WO2000033812A2 publication Critical patent/WO2000033812A2/en
Publication of WO2000033812A3 publication Critical patent/WO2000033812A3/en
Publication of WO2000033812A9 publication Critical patent/WO2000033812A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A transdermal patch for administering a volatile liquid drug, such as nicotine, transdermally to a patient comprising a four-layer laminated composite of: a top drug impermeable backing layer; a pressure sensitive silicone adhesive layer containing the drug; a pressure sensitive acrylic adhesive layer also containing the drug; and a removable siliconized release liner layer. Also disclosed is a method for treating a person for nicotine dependence and particularly for treating a woman for nicotine dependence.
PCT/US1999/028697 1998-12-07 1999-12-07 Transdermal patch for delivering volatile liquid drugs WO2000033812A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU25877/00A AU778992B2 (en) 1998-12-07 1999-12-07 Transdermal patch for delivering volatile liquid drugs
CA002380391A CA2380391A1 (en) 1998-12-07 1999-12-07 Transdermal patch for delivering volatile liquid drugs
NZ512788A NZ512788A (en) 1998-12-07 1999-12-07 Transdermal patch for delivering volatile liquid drugs
EP99968461A EP1137406B2 (en) 1998-12-07 1999-12-07 Transdermal patch for delivering volatile liquid drugs
AT99968461T ATE264098T1 (en) 1998-12-07 1999-12-07 PATCH FOR TRANSDERMAL APPLICATION OF VOLATILE, LIQUID ACTIVE INGREDIENTS
DE69916492T DE69916492T3 (en) 1998-12-07 1999-12-07 PLASTER FOR THE TRANSDERMAL APPLICATION OF VOLATILE, LIQUID ACTIVE SUBSTANCES
JP2000586306A JP2002531488A (en) 1998-12-07 1999-12-07 Transdermal patches for delivering volatile liquid drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11128598P 1998-12-07 1998-12-07
US60/111,285 1998-12-07

Publications (3)

Publication Number Publication Date
WO2000033812A2 WO2000033812A2 (en) 2000-06-15
WO2000033812A3 true WO2000033812A3 (en) 2000-11-23
WO2000033812A9 WO2000033812A9 (en) 2002-04-25

Family

ID=22337613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028697 WO2000033812A2 (en) 1998-12-07 1999-12-07 Transdermal patch for delivering volatile liquid drugs

Country Status (9)

Country Link
EP (1) EP1137406B2 (en)
JP (1) JP2002531488A (en)
KR (1) KR100885235B1 (en)
AT (1) ATE264098T1 (en)
AU (1) AU778992B2 (en)
CA (1) CA2380391A1 (en)
DE (1) DE69916492T3 (en)
NZ (2) NZ512788A (en)
WO (1) WO2000033812A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
CA2331264C (en) 1999-01-14 2008-09-23 Noven Pharmaceuticals, Inc. Compositions and methods for drug delivery
US20030170195A1 (en) 2000-01-10 2003-09-11 Noven Pharmaceuticals, Inc. Compositions and methods for drug delivery
DE10110391A1 (en) 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Highly flexible nicotine transdermal therapeutic system with nicotine as active ingredient
JP2004525921A (en) * 2001-03-19 2004-08-26 イオマイ コーポレイシヨン Transdermal immunization patch
US7099713B2 (en) 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
PT1603544E (en) * 2003-03-14 2008-01-22 Agi Therapeutics Res Ltd De
US20070224284A1 (en) 2004-03-12 2007-09-27 John Devane Methods and compositions comprising at least one alpha3 beta4 nAChR antagonist or pharmaceutically acceptable salt thereof
US8784874B2 (en) 2003-09-10 2014-07-22 Noven Pharmaceuticals, Inc. Multi-layer transdermal drug delivery device
EP1682061B1 (en) 2003-10-28 2017-03-15 Noven Pharmaceuticals, Inc. Transdermal drug delivery device
ITMI20041697A1 (en) * 2004-09-03 2004-12-03 Bouty S P A THERAPEUTIC SYSTEM WITH CONTROLLED RELEASE FOR TOPICAL USE IN THE FORM OF A MULTI-LAYER PATCH
WO2006041911A2 (en) 2004-10-08 2006-04-20 Noven Pharmaceuticals, Inc. Device transdermal administration of drugs including acrylic polymers
WO2006041907A2 (en) 2004-10-08 2006-04-20 Noven Pharmaceuticals, Inc. Transdermal delivery of estradiol
IL177071A0 (en) 2005-08-01 2006-12-10 Nitto Denko Corp Method of preparing a nicotine transdermal preparation
ES2499067T3 (en) 2005-10-13 2014-09-26 Nitto Denko Corporation Transdermal preparation of nicotine and its production method
DE102006054733A1 (en) 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with high drug utilization rate and dosing accuracy
US20100080842A1 (en) * 2008-09-30 2010-04-01 Jianye Wen Transdermal extended-delivery donepezil compositions and methods for using the same
EP2298277A1 (en) * 2009-09-09 2011-03-23 Labtec GmbH Transdermal patch formulation
JP5820469B2 (en) * 2010-04-30 2015-11-24 テイコク ファーマ ユーエスエー インコーポレーテッド Transdermal composition of propynylaminoindane
CN103476404B (en) 2011-03-24 2017-09-29 帝国制药美国公司 Transdermal composition comprising active agent layer and activating agent conversion coating
US9913812B2 (en) 2011-11-09 2018-03-13 Teikoku Pharma Usa, Inc. Methods for the treatment of skin neoplasms
CA2887705C (en) 2012-11-02 2018-07-24 Teikoku Pharma Usa, Inc. Propynylaminoindan transdermal compositions
DE102013013397A1 (en) 2013-08-13 2015-03-12 Epinamics Gmbh Aerosol dispenser for transdermal pharmaceutical compositions
DE102013020633A1 (en) 2013-12-16 2015-06-18 Epinamics Gmbh Dermal and / or transdermal pharmaceutical composition containing a terpenoid compound
DE102020112143B4 (en) 2020-05-05 2022-03-17 Lts Lohmann Therapie-Systeme Ag Nicotine - Corona

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717568A (en) * 1985-08-09 1988-01-05 Alza Corporation Laminar arrangement for increasing delivery of beneficial agent from dispenser
US5176915A (en) * 1989-03-14 1993-01-05 Lts Lohmann Plaster used as therapeutic system for the administration of active substances to the skin which exhibits a graduated active substance release, process for the production of the plaster and the use thereof
WO1993000058A1 (en) * 1991-06-27 1993-01-07 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5230898A (en) * 1989-04-01 1993-07-27 Lts Lohmann Therapie-Systeme Gmbh & Co. K.G. Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof
US5316759A (en) * 1986-03-17 1994-05-31 Robert J. Schaap Agonist-antagonist combination to reduce the use of nicotine and other drugs
WO1996040085A2 (en) * 1995-06-07 1996-12-19 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
US5691365A (en) * 1995-07-18 1997-11-25 University Of Kentucky Research Foundation Nicotinic receptor antagonists in the treatment of neuropharmacological disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629304A1 (en) † 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg TRANSDERMAL THERAPEUTIC SYSTEM, ITS USE AND METHOD FOR THE PRODUCTION THEREOF
CH674618A5 (en) * 1987-04-02 1990-06-29 Ciba Geigy Ag
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
GB8807504D0 (en) † 1988-03-29 1988-05-05 Sandoz Ltd Improvements in/relating to organic compounds
DE69422925T2 (en) † 1993-07-09 2000-08-17 Cygnus, Inc. METHOD AND DEVICE FOR THE TRANSDERMAL OR TRANSBUCCAL THERAPEUTIC ADMINISTRATION OF NICOTINE SUBSTITUTES
DE4332094C2 (en) † 1993-09-22 1995-09-07 Lohmann Therapie Syst Lts Active substance plaster which can be produced without solvent and process for its preparation
EP0743842B1 (en) * 1994-03-07 2003-08-13 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
JPH09301853A (en) * 1996-05-14 1997-11-25 Nitto Denko Corp Plaster and plaster preparation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717568A (en) * 1985-08-09 1988-01-05 Alza Corporation Laminar arrangement for increasing delivery of beneficial agent from dispenser
US5316759A (en) * 1986-03-17 1994-05-31 Robert J. Schaap Agonist-antagonist combination to reduce the use of nicotine and other drugs
US5176915A (en) * 1989-03-14 1993-01-05 Lts Lohmann Plaster used as therapeutic system for the administration of active substances to the skin which exhibits a graduated active substance release, process for the production of the plaster and the use thereof
US5230898A (en) * 1989-04-01 1993-07-27 Lts Lohmann Therapie-Systeme Gmbh & Co. K.G. Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof
WO1993000058A1 (en) * 1991-06-27 1993-01-07 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
WO1996040085A2 (en) * 1995-06-07 1996-12-19 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
US5691365A (en) * 1995-07-18 1997-11-25 University Of Kentucky Research Foundation Nicotinic receptor antagonists in the treatment of neuropharmacological disorders

Also Published As

Publication number Publication date
WO2000033812A2 (en) 2000-06-15
NZ512788A (en) 2003-07-25
EP1137406A2 (en) 2001-10-04
DE69916492D1 (en) 2004-05-19
AU778992B2 (en) 2004-12-23
EP1137406B2 (en) 2008-01-23
KR20010101147A (en) 2001-11-14
DE69916492T3 (en) 2008-08-14
CA2380391A1 (en) 2000-06-15
NZ525878A (en) 2004-12-24
EP1137406B1 (en) 2004-04-14
ATE264098T1 (en) 2004-04-15
JP2002531488A (en) 2002-09-24
DE69916492T2 (en) 2005-05-12
KR100885235B1 (en) 2009-02-24
AU2587700A (en) 2000-06-26

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