WO2000031264A3 - Testis-specific cystatin-like protein cystatin t - Google Patents

Testis-specific cystatin-like protein cystatin t Download PDF

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Publication number
WO2000031264A3
WO2000031264A3 PCT/US1999/025519 US9925519W WO0031264A3 WO 2000031264 A3 WO2000031264 A3 WO 2000031264A3 US 9925519 W US9925519 W US 9925519W WO 0031264 A3 WO0031264 A3 WO 0031264A3
Authority
WO
WIPO (PCT)
Prior art keywords
cystatin
specific
testis
polypeptides
protein
Prior art date
Application number
PCT/US1999/025519
Other languages
French (fr)
Other versions
WO2000031264A2 (en
Inventor
James L Holloway
Andrew L Feldhaus
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU14591/00A priority Critical patent/AU1459100A/en
Priority to CA002364669A priority patent/CA2364669A1/en
Publication of WO2000031264A2 publication Critical patent/WO2000031264A2/en
Publication of WO2000031264A3 publication Critical patent/WO2000031264A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to cystatin T (also known as zcys3) polypeptides and polynucleotides encoding the same. Cystatin T polypeptide is testis specific and homologous to cystatin-related epididymal specific gene (CRES) and type 2 cystatins. The polypeptides would be useful for modulating spermatogenesis and may be used to study or modulate that function in in vitro or in vivo systems. The present invention also includes antibodies to the cystatin T polypeptides.
PCT/US1999/025519 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t WO2000031264A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU14591/00A AU1459100A (en) 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t
CA002364669A CA2364669A1 (en) 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19719598A 1998-11-20 1998-11-20
US09/197,195 1998-11-20

Publications (2)

Publication Number Publication Date
WO2000031264A2 WO2000031264A2 (en) 2000-06-02
WO2000031264A3 true WO2000031264A3 (en) 2000-10-19

Family

ID=22728426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025519 WO2000031264A2 (en) 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t

Country Status (3)

Country Link
AU (1) AU1459100A (en)
CA (1) CA2364669A1 (en)
WO (1) WO2000031264A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001265286A1 (en) * 2000-06-05 2001-12-17 Zymogenetics Inc. Zcys6: a member of the cystatin superfamily
AU2001265301A1 (en) * 2000-06-06 2001-12-17 Zymogenetics Inc. Zcys7: a member of the cystatin superfamily
EP1343813A4 (en) * 2000-12-19 2004-11-17 Smithkline Beecham Corp Novel compounds
EP1513865A4 (en) 2002-05-28 2006-05-03 Univ Minnesota Crisp polypeptides as contraceptives and inhibitors of sperm capacitation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373771A2 (en) * 1988-11-18 1990-06-20 Taisho Pharmaceutical Co. Ltd New pharmaceutical uses for cystatins
US5212297A (en) * 1989-05-16 1993-05-18 University Of Kansas cDNA clones encoding chicken egg white cystatin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373771A2 (en) * 1988-11-18 1990-06-20 Taisho Pharmaceutical Co. Ltd New pharmaceutical uses for cystatins
US5212297A (en) * 1989-05-16 1993-05-18 University Of Kansas cDNA clones encoding chicken egg white cystatin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AFFARA ET AL: "The identification of novel gene sequences of the human adult testis", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 22, 1 January 1994 (1994-01-01), pages 205 - 210, XP002089680, ISSN: 0888-7543 *
CORNWALL, G.A. ET AL.: "The CRES gene: a unique testis-regulated gene related to the cystatin family is highly restricted in its expression to the proximal region of the mouse epididymis", MOLECULAR ENDOCRINOLOGY, vol. 6, no. 10, October 1992 (1992-10-01), pages 1653 - 1664, XP000886213 *
HUH C ET AL: "Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3)", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 152, no. 2, 23 January 1995 (1995-01-23), pages 221 - 226, XP004042680, ISSN: 0378-1119 *
SHOEMAKER, K. ET AL.: "Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T", GENE, NL, ELSEVIER BIOMEDICAL PRESS, vol. 245, no. 1, 7 March 2000 (2000-03-07), pages 103-108, XP002135806 *
THIESSE, M.: "The human type-2 cystatin family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20", DNA AND CELL BIOLOGY, vol. 13, no. 2, February 1994 (1994-02-01), pages 97 - 116, XP000886234 *
TOEHOENEN V ET AL: "TESTATIN: A CYSTATIN-RELATED GENE EXPRESSED DURING EARLY TESTIS DEVELOPMENT", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 95, November 1998 (1998-11-01), pages 14208 - 14213, XP000857715, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU1459100A (en) 2000-06-13
CA2364669A1 (en) 2000-06-02
WO2000031264A2 (en) 2000-06-02

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