WO2000030671A3 - Nf-at mediates cardiac hypertrophy, methods and reagents related thereto - Google Patents

Nf-at mediates cardiac hypertrophy, methods and reagents related thereto Download PDF

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Publication number
WO2000030671A3
WO2000030671A3 PCT/US1999/027862 US9927862W WO0030671A3 WO 2000030671 A3 WO2000030671 A3 WO 2000030671A3 US 9927862 W US9927862 W US 9927862W WO 0030671 A3 WO0030671 A3 WO 0030671A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cardiac hypertrophy
reagents related
mediates cardiac
mediates
Prior art date
Application number
PCT/US1999/027862
Other languages
French (fr)
Other versions
WO2000030671A2 (en
WO2000030671A9 (en
Inventor
Gerald R Crabtree
Jeffrey P Northrop
Steffan N Ho
Original Assignee
Univ Leland Stanford Junior
Gerald R Crabtree
Jeffrey P Northrop
Steffan N Ho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Gerald R Crabtree, Jeffrey P Northrop, Steffan N Ho filed Critical Univ Leland Stanford Junior
Priority to IL14329799A priority Critical patent/IL143297A0/en
Priority to JP2000583554A priority patent/JP2002530349A/en
Priority to CA002352599A priority patent/CA2352599A1/en
Priority to EP99967129A priority patent/EP1131086A2/en
Publication of WO2000030671A2 publication Critical patent/WO2000030671A2/en
Publication of WO2000030671A3 publication Critical patent/WO2000030671A3/en
Publication of WO2000030671A9 publication Critical patent/WO2000030671A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention is a method for treating cardiac hypertrophy, or other preventing other growth of cardiac and vascular tissue, through the use of NF-AT antagonists.
PCT/US1999/027862 1998-11-24 1999-11-23 Nf-at mediates cardiac hypertrophy, methods and reagents related thereto WO2000030671A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL14329799A IL143297A0 (en) 1998-11-24 1999-11-23 Nf-at mediates cardiac hypertrophy, methods and reagents related thereto
JP2000583554A JP2002530349A (en) 1998-11-24 1999-11-23 NF-AT mediated cardiac hypertrophy and related methods and reagents
CA002352599A CA2352599A1 (en) 1998-11-24 1999-11-23 Nf-at mediates cardiac hypertrophy, methods and reagents related thereto
EP99967129A EP1131086A2 (en) 1998-11-24 1999-11-23 Nf-at mediates cardiac hypertrophy, methods and reagents related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19897798A 1998-11-24 1998-11-24
US09/198,977 1998-11-24

Publications (3)

Publication Number Publication Date
WO2000030671A2 WO2000030671A2 (en) 2000-06-02
WO2000030671A3 true WO2000030671A3 (en) 2000-11-09
WO2000030671A9 WO2000030671A9 (en) 2001-05-17

Family

ID=22735695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027862 WO2000030671A2 (en) 1998-11-24 1999-11-23 Nf-at mediates cardiac hypertrophy, methods and reagents related thereto

Country Status (5)

Country Link
EP (1) EP1131086A2 (en)
JP (1) JP2002530349A (en)
CA (1) CA2352599A1 (en)
IL (1) IL143297A0 (en)
WO (1) WO2000030671A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6687428B2 (en) 2000-09-21 2004-02-03 Tera Op (Usa) Inc. Optical switch
US20130183686A1 (en) * 2008-11-11 2013-07-18 Donna Davidovich Method of evaluating immunosuppression

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004203A1 (en) * 1991-08-22 1993-03-04 The Board Of Trustees Of The Leland Stanford Jr. University Screening methods for immunosuppressive agents
WO1994015964A1 (en) * 1993-01-15 1994-07-21 Dana-Farber Cancer Institute, Inc. NF-ATp, A T LYMPHOCYTE DNA-BINDING PROTEIN
WO1995005389A1 (en) * 1993-08-18 1995-02-23 The Board Of Trustees Of The Leland Stanford Junior University Sequence-specific glycoconjugate transcriptional antagonists
WO1995008554A1 (en) * 1993-09-20 1995-03-30 The Board Of Trustees Of The Leland Stanford Junior University Nf-at polypeptides and polynucleotides
WO1996026959A1 (en) * 1995-03-02 1996-09-06 Tularik, Inc. Human transcription factors and binding assays
WO1999019471A1 (en) * 1997-10-16 1999-04-22 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with nf-at3 function
WO1999040930A1 (en) * 1998-02-12 1999-08-19 Center For Blood Research, Inc. Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004203A1 (en) * 1991-08-22 1993-03-04 The Board Of Trustees Of The Leland Stanford Jr. University Screening methods for immunosuppressive agents
WO1994015964A1 (en) * 1993-01-15 1994-07-21 Dana-Farber Cancer Institute, Inc. NF-ATp, A T LYMPHOCYTE DNA-BINDING PROTEIN
WO1995005389A1 (en) * 1993-08-18 1995-02-23 The Board Of Trustees Of The Leland Stanford Junior University Sequence-specific glycoconjugate transcriptional antagonists
WO1995008554A1 (en) * 1993-09-20 1995-03-30 The Board Of Trustees Of The Leland Stanford Junior University Nf-at polypeptides and polynucleotides
WO1996026959A1 (en) * 1995-03-02 1996-09-06 Tularik, Inc. Human transcription factors and binding assays
WO1999019471A1 (en) * 1997-10-16 1999-04-22 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with nf-at3 function
WO1999040930A1 (en) * 1998-02-12 1999-08-19 Center For Blood Research, Inc. Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEALS C R ET AL: "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.", SCIENCE, vol. 275, no. 5308, 28 March 1997 (1997-03-28), pages 1930 - 1933, XP002140286 *
DE LA POMPA JL ET AL: "Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.", NATURE, vol. 392, no. 6672, 12 March 1998 (1998-03-12), pages 182 - 186, XP002140287 *
SUSSMAN M A ET AL: "Prevention of cardiac hypertrophy in mice by calcineurin inhibition.", SCIENCE, vol. 281, no. 5383, 11 September 1998 (1998-09-11), pages 1690 - 1693, XP002140285 *

Also Published As

Publication number Publication date
EP1131086A2 (en) 2001-09-12
JP2002530349A (en) 2002-09-17
CA2352599A1 (en) 2000-06-02
WO2000030671A2 (en) 2000-06-02
WO2000030671A9 (en) 2001-05-17
IL143297A0 (en) 2002-04-21

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