WO2000028953A1 - Compositions et procedes de blanchiment des dents - Google Patents

Compositions et procedes de blanchiment des dents Download PDF

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Publication number
WO2000028953A1
WO2000028953A1 PCT/US1999/026355 US9926355W WO0028953A1 WO 2000028953 A1 WO2000028953 A1 WO 2000028953A1 US 9926355 W US9926355 W US 9926355W WO 0028953 A1 WO0028953 A1 WO 0028953A1
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WO
WIPO (PCT)
Prior art keywords
teeth
whitening composition
tooth whitening
dental
composition
Prior art date
Application number
PCT/US1999/026355
Other languages
English (en)
Inventor
Steven D. Jensen
Dan E. Fischer
Original Assignee
Ultradent Products, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/190,709 external-priority patent/US6309625B1/en
Priority claimed from US09/191,854 external-priority patent/US6306370B1/en
Application filed by Ultradent Products, Inc. filed Critical Ultradent Products, Inc.
Priority to AU16121/00A priority Critical patent/AU1612100A/en
Publication of WO2000028953A1 publication Critical patent/WO2000028953A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to compositions and methods for whitening and desensitizing teeth.
  • the present invention relates to compositions that may be applied directly to a person's teeth for shorter periods of time, and those specifically formulated for use with flexible, thin-walled dental trays in order to provide prolonged treatment of a patient's teeth over longer periods of time.
  • a tooth is comprised of an inner dentin layer and an outer hard enamel layer that is slightly porous.
  • the outer layer is the protective layer of the tooth.
  • the natural color of the tooth is opaque to translucent white or slightly off-white.
  • Some dental compositions like dentrifices, toothpastes, gels, and powders contain active oxygen or hydrogen peroxide liberating bleaching agents.
  • bleaching agents include peroxides, percarbonates and perborates of the alkali and alkaline earth metals or complex compounds containing hydrogen peroxide.
  • peroxide salts of the alkali or alkaline earth metals are known to be useful in whitening teeth.
  • carbamide peroxide CO(NH 2 ) 2 ⁇ 2 0 2
  • urea hydrogen peroxide hydrogen peroxide carbamide
  • perhydrol-urea carbamide peroxide
  • Carbamide peroxide has been used by dental clinicians for several decades as an oral antiseptic. Tooth bleaching was an observed side effect of extended contact time.
  • Over-the-counter compositions of 10% carbamide peroxide are available as GLY- OXIDE® by Marion Laboratories and PROXIGEL® by Reed and Carnrick.
  • a bleaching gel which is able to hold a comfortable-fitting dental tray in position for an extended time period is available under the trademark OPALESCENCE® from Ultradent Products, Inc. in South Jordan, Utah.
  • OH OH
  • sodium perborate are also known in the medical, dental and cosmetic arts. Patients who have desired to have their teeth whitened have typically done so by applying a bleaching composition to the teeth by means of a dental tray for repeated treatments, or they have had to submit to conventional in-office bleaching techniques that required from 4 to 10 visits to the dental office before clinically significant results were achieved. Clinically significant results are quantifiable such as by measuring gray scale,
  • Brushing teeth with toothpaste does not address the problem of excessively translucent teeth.
  • Brushing teeth with toothpastes or polishes is also less effective for whitening teeth compared to the application of bleaching treatments. Tooth brushing is less effective for whitening teeth as brushing teeth only cleans the external surface of the teeth while bleaching addresses internal stains in the teeth.
  • compositions and methods for opacifying and decreasing the transparency of teeth are compositions and methods for opacifying and decreasing the transparency of teeth.
  • compositions and methods which are able to bleach teeth while concurrently offsetting the tendency of bleaching agents to cause teeth to become overly sensitive.
  • the present invention generally relates to dental whitening compositions and methods for treating excessively translucent teeth.
  • the present invention relates to bleaching compositions that result in reduced sensitivity.
  • the present invention utilizes potassium nitrate (KNO 3 ) dispersed within a carrier as an opacifying agent to reduce the tendency of some teeth to appear grey or translucent.
  • Potassium nitrate can act as an opacifying agent either alone or in combination with a bleaching agent. Because potassium nitrate also has desensitizing or anesthetic properties, it can desensitize and/or opacity when used in conjunction with a bleaching agent, or it can be applied separately to desensitize teeth after bleaching has occurred.
  • the whitening compositions will include a bleaching agent, such as carbamide peroxide, which can also act as a disinfectant.
  • the whitening compositions may include one or more other dental agents, such as anticariogenic agents for reinforcing teeth against tooth decay or antimicrobial agents for treating gum diseases.
  • the most commonly used anticariogenic agents include fluoride salts, such as stannous or sodium fluoride, which can also impart antidemineralization or even remineralization properties to the tooth whitening compositions.
  • Examples of preferred antimicrobial agents include chlorhexidine, tetracycline, cetyl pyridinium chloride, benzalkonium chloride, cetyl pyridinium bromide, methyl benzoate, and propyl benzoate.
  • compositions are preferably substantially free of abrasives, as the compositions are typically not scrubbed onto teeth.
  • abrasive toothpastes people typically brush for less than 60 seconds, which is not enough time for the active ingredients to perform their intended activity.
  • scrubbing teeth with an abrasive material for an extended period of time can be harmful in some cases. Therefore, in order to allow for extended application, the inventive compositions will preferably not include substantial quantities of an abrasive.
  • the compositions are preferably used with a dental tray that is thin-walled, flexible and lightweight. Such trays can be held by the dental composition in position adjacent to the person' s tooth surfaces to be treated.
  • the preferred dental tray should be adapted for maximum comfort and will exert little if any significant mechanical pressure onto the person's teeth or gums.
  • the dental whitening compositions will preferably be sufficiently sticky, viscous and resistant to dilution by saliva such that they can act as a glue and reliably adhere and retain the dental tray over the person' s teeth for varying time durations. Nevertheless, although such dental trays are preferred, any conventional dental trays may also be utilized.
  • the inventive dental compositions can be applied directly to a person's teeth without a tray.
  • the carrier will include a sticky matrix material formed by combining a sufficient quantity of a tackifying agent, such as carboxypolymethylene, with a solvent, such as glycerin, polyethylene glycol, or water.
  • a tackifying agent such as carboxypolymethylene
  • a solvent such as glycerin, polyethylene glycol, or water.
  • the carrier is preferably formed by combining a tackifying agent and a solvent, the carrier may comprise a solvent without a tackifying agent in some embodiments.
  • Preferred compositions are relatively sticky and glue-like to enable a preferred dental tray to be held and retained against a person's teeth.
  • Preferred carriers are preferably safe for oral use, do not readily dissolve in saliva, and do not react with the tooth opacifying agent.
  • examples of other suitable tackifying agents, or thickening agents that can assist other tackifying agents include xanthan gum, talha gum, tragacanth gum, carboxymethylcellulose, locust bean gum, guar gum, Irish moss gum, ghatti gum, furcelleran gum, carrageenan gum, arabic gum, alginic acid gum, agar gum, alginate gum, PEMULEN®, a proprietary compound of B.F. Goodrich,
  • POLYOX® a mixture of polyethylene oxides having a molecular weight of 100,000- 8,000,000 and available from Union Carbide, or any compositional or chemical equivalents of the foregoing.
  • PEMULEN® is a propriety formula that includes a significant quantity of a polyacrylic copolymer that has a slightly hydrophobic end and a strongly hydrophilic end.
  • polyols may serve as suitable solvents.
  • the solvent may also be water alone or in combination with a polyol.
  • Glycerin is a preferred solvent as it works well in forming a sticky gel with carboxypolymethylene.
  • Glycerin also provides some flavor enhancement.
  • a few possible substitutes for glycerin include propylene glycols, polypropylene glycol, polyethylene glycols, erythritol, sorbitol, mannitol, other polyols, and the like.
  • polyols such as glycerin, polyethylene glycols, polypropylene glycol, propylene glycol, and sorbitol may also be used without a tackifying agent.
  • one currently preferred sticky matrix material includes a mixture of carboxypolymethylene together and other suitable admixtures.
  • carboxypolymethylene is used to denote a broad category of polymers, particularly copolymers of acrylic acid and polyallyl sucrose. Because carboxypolymethylene that has not been completely neutralized includes carboxylic acid groups or moieties, carboxypolymethylene can be classified as a weak acid. When dispersed in water, carboxypolymethylene can have a pH as low as about 2.5. Because highly acidic compositions can etch teeth, it is generally preferable to adjust the pH of dental compositions that include carboxypolymethylene or other acids to make them less acidic.
  • compositions that include carboxypolymethylene it is preferable to adjust the pH of compositions that include carboxypolymethylene to within a range from about 4 to about 9, more preferably to within a range from about 5 to about 7. Because it is contemplated that the carboxypolymethylene used in the matrix material and the compositions of the present invention will be mixed with a base to raise the pH of the resulting dental composition, the term "carboxypolymethylene” shall include carboxypolymethylene polymers within compositions at any pH.
  • the matrix material can include other optional components in addition to the carboxypolymethylene in order to provide bulk and also to yield a matrix material having the desired level of stickiness.
  • One such admixture is glycerin, which is easily mixed with carboxypolymethylene.
  • Another optional component is water, as set forth above.
  • a base in order to adjust the pH of the matrix material.
  • Preferred bases can include inorganic bases such as sodium hydroxide or ammonium hydroxide.
  • the base may include an organic base such as triethanolamine or other organic amines.
  • potassium nitrate can simultaneously provide both opacification and desensitization.
  • Other desensitizing agents can also be used to desensitize teeth, including citric acid, citric acid salts, strontium chloride, and the like. Since the present invention allows for prolonged contact via the use of an appropriate tray and/or a sticky composition, desensitizing agents in the composition are able to penetrate through the enamel.
  • the opacifying dental compositions within the scope of the present invention will be sufficiently sticky and generally viscous such that positive pressure is needed to dispense them from the container; gravity is not sufficient.
  • preferred whitening compositions according to the present invention will be packaged within a syringe, squeezable tube, or other similar positive pressure dispensing device.
  • An improved dental tray that is thin-walled, flexible and lightweight for holding the dental composition adjacent to a person's teeth is preferably used in combination with sticky and viscous dental whitening compositions of the present invention.
  • the general process for preparing such dental trays is as follows. First, an alginate impression which registers all teeth surfaces plus the gingival margin is made and a stone cast is made of the impression. Optional reservoirs can be prepared by building a layer of rigid material on the stone cast on specific teeth surfaces to be treated. A dental tray is then vacuum formed from the modified cast using a thin, flexible plastic sheet material. Once formed, the tray is preferably trimmed barely shy of the gingival margin on both the buccal and lingual surfaces of the person's teeth.
  • the resulting tray provides a comfortable fit of the person's teeth with optional reservoirs or spaces located where the rigid material was placed on the stone cast.
  • the trays can optionally overlap the gums if desired to provide contact between the dental compositions and a person's gums.
  • the trays of the present invention have greatly increased comfort and exert little or no significant mechanical pressure on a person's teeth or gums. Instead, sticky dental compositions within the scope of the invention can act like a glue to hold the improved trays in place.
  • the amount of tooth whitening obtained through the use of the inventive compositions and methods is dependent primarily upon (1) the length of time each day the tray is worn; and (2) the number of days the tray is worn.
  • the treatment schedule may be tailored to each person's lifestyle or response to the treatment and can be performed as often as a person desires to provide effective relief from excessively translucent teeth. It has been found that treatment during sleep is a good treatment period since there is less mouth activity which causes less whitening composition to be pumped from the tray.
  • the present invention provides compositions and methods for treating excessively translucent teeth.
  • compositions for treating excessively translucent teeth which can optionally include other dental agents, such as bleaching agents, antimicrobial agents or anticariogenic agents.
  • compositions for bleaching teach that include a desensitizing agent for offsetting the tendency of peroxide bleaching agents to make teeth more sensitive.
  • compositions for treating excessively translucent teeth that are sufficiently sticky and resistant to dilution by saliva such that they have the ability to adhere and retain a flexible, thin-walled dental tray against a person's teeth, wherein the dental tray does not exert significant mechanical pressures onto the person's teeth or gums.
  • Figure 1 is a perspective view of a stone cast of a patient's teeth with a coating being applied to selected teeth surfaces.
  • Figure 2 is a perspective view of the stone cast of Figure 1 with a dental tray formed from the cast and trimmed below the gingival margin.
  • Figure 3 is a cross-sectional view taken along line 3-3 of Figure 2.
  • Figure 3A is an enlarged close-up view taken within the section line 3A-3A of
  • Figure 4 is a cross- sectional view taken along line 4-4 of Figure 2.
  • Figure 5 is a perspective view of the opacifying composition being delivered from a syringe into a thin-walled, flexible dental tray.
  • Figure 6 is a perspective view of a thin-walled, flexible dental tray filled with the opacifying composition just before being positioned on a patient's upper arch.
  • Figure 7 is a perspective view of a thin-walled, flexible dental tray filled with the opacifying composition positioned on a patient's upper arch.
  • the present invention generally relates to dental whitening compositions and methods for treating excessively translucent teeth.
  • the inventive compositions will include potassium nitrate, which can act as either an opacifying agent, a desensitizing agent, or both.
  • the potassium nitrate is delivered to the teeth by means of a carrier, which includes any component other than the active dental agent(s).
  • the inventive compositions may include a bleaching agent, such as carbamide peroxide, hydrogen peroxide, and the like, in order to further whiten a person's teeth.
  • the desensitizing properties of the potassium nitrate can assist in reducing sensitivity that may be caused in some people by the bleaching agent.
  • the compositions may also include an anticariogenic agent or antimicrobial agent.
  • the compositions are preferably abrasiveless as the compositions are not typically scrubbed onto a person' s teeth for 60 seconds or less like typical toothpastes.
  • the dental whitening compositions will be used in conjunction with a thin, flexible, comfortable-fitting dental tray in order to hold the compositions against the person's teeth.
  • Preferred dental trays will conform to the size and shape of a person's teeth and will exert little or no significant mechanical pressure onto the person's teeth and/or gums. This makes them more comfortable and pleasant to use compared to conventional dental trays.
  • the inventive tooth whitening compositions may certainly be used with conventional dental trays, or with no tray at all.
  • the potassium nitrate and optional dental agents will preferably be dispersed in a carrier containing a matrix material capable of exerting a glue-like action such that the whitening composition adheres and retains the tray to a person's teeth.
  • the potassium nitrate may alternatively be placed directly onto the person's teeth without a tray, or by means of conventional dental trays that are held in place by mechanical fit.
  • the amount of potassium nitrate that is included within the whitening compositions of the present invention may vary depending on whether it is desired to desensitize, opacify or both. In general, it is possible to both desensitize and opacify at concentrations between about 0.1% to about 10%> by weight of the dental composition. Nevertheless, concentrations up to 50% can be used in some cases in order maximize the speed and effects of the potassium nitrate, although good results are certainly possible at lower concentrations.
  • inventive compositions may preferably include potassium nitrate in a wide range from about 0.1 % to about 50% by weight of the whitening composition, more preferably in a range from about 1% to about 25% by weight of the whitening composition, and most preferably in a range from about 3% to about 10% by weight of the whitening composition.
  • the potassium nitrate can act to decrease the sensitivity of teeth.
  • the ability to decrease the sensitizing of teeth is particularly beneficial when the dental whitening composition also contains a bleaching agent such as carbamide peroxide, which has reportedly caused some people to experience increased sensitivity.
  • a bleaching agent such as carbamide peroxide
  • the carrier will include a tackifying agent and a solvent, which together yield a sticky matrix material, although a solvent may be used alone in some embodiments.
  • the preferred matrix material will be sufficiently sticky to enable a preferred dental tray to be held and retained against a person's teeth.
  • tackifying agents will be described hereinbelow.
  • Suitable sticky matrix materials are preferably safe for oral use and do not inactivate the potassium nitrate. They are preferably viscous and do not readily dissolve in saliva.
  • One currently preferred tackifying agent used to form a sticky and viscous matrix material comprises carboxypolymethylene.
  • Carboxypolymethylene can be used to form a glue-like dental whitening composition that itself can act as an adhesive in holding a comfortable, non-self-retaining dental tray against a person's teeth.
  • carboxypolymethylene eliminates the need to use dental trays that are self-retaining (/. e. , typically trays that are rigid and which mechanically interlock over a person's teeth or gums and which are intended for use with less sticky compositions).
  • Carboxypolymethylene is a broad term that refers to vinyl polymers having active carboxyl groups. Suitable carboxypolymethylene compositions may be obtained from B. F. Goodrich Company under the tradename CARBOPOL®. Another tradename for carboxypolymethylene is CARBOMER®. In a commonly-sold form, carboxypoly- methylene can have a pH as low as 2.5. As discussed below, the pH of compositions made with carboxypolymethylene can be raised to yield compositions that are less acidic. The amount of carboxypolymethylene within the inventive dental whitening compositions can vary depending on the desired level of stickiness and also the identities and amounts of the other components within the dental composition.
  • the dental whitening compositions of the present invention will preferably include carboxypolymethylene in a concentration in a range from about 0.5%> to about 25%> by weight of the dental whitening composition, more preferably in a range from about 2% to about 12%) and most preferably in a range from about 3%> to about 10%>.
  • carboxypolymethylene in a concentration in a range from about 0.5%> to about 25%> by weight of the dental whitening composition, more preferably in a range from about 2% to about 12%) and most preferably in a range from about 3%> to about 10%>.
  • carboxypolymethylene may be adjusted to achieve a desired level of any or all of these properties. Increased stickiness assists in retaining the preferred dental trays against a person's teeth.
  • compositions can be made less adhesive and tacky if desired, particularly is applied directly without a dental tray.
  • the actual amount of carboxypolymethylene is not critical for obtaining a sticky, viscous dental composition.
  • the sticky matrix material may include other tackifying components that in combination with, or in lieu of some or all of, the carboxypolymethylene will yield a dental whitening composition having the desired level of stickiness needed to hold a preferred, comfortable-fitting dental tray in place over a person's teeth.
  • Other synthetic polymers and/or natural gums, proteins, or other gel-forming admixtures can be used so long as they yield a sticky dental whitening composition.
  • CARBOPOL 934P is a high purity pharmaceutical grade of CARBOPOL 934, having an approximate molecular weight of about 3,000,000. In addition to thickening and suspending, CARBOPOL 934P has been used in dry tablets to impart sustained release properties. Extensive toxicity studies have been conducted on CARBOPOL 934P, and a master file has been established with the Food and Drug Administration. It is listed as CARBOMER 934P in the National Formulary. A more recently preferred carboxypolymethylene is CARBOPOL 974P NF, which has more recently surpassed CARBOPOL 934P as the carboxypolymethylene of choice. Although CARBOPOL 974P NF is similar or identical in molecular weight compared to CARBOPOL 934P, it is purified in a way that makes it more pharmaceutically acceptable material.
  • CARBOPOL 940 may be substituted for CARBOPOL 934P or CARBOPOL 974P NF.
  • CARBOPOL 934P and CARBOPOL 974P NF are currently preferred because they are obtainable in a pharmaceutical grade.
  • carboxypolymethylene be mixed with a suitable solvent before attempting to add other components that are less compatible with carboxypolymethylene, such as water.
  • suitable solvents for use with carboxypolymethylene include glycerin, other polyhydric alcohols, polyalkylene glycols and other polyols, and the like. Glycerin appears to enable larger quantities of carboxypolymethylene to be dispersed in water.
  • the concentration of glycerin, polyol, or like substance utilized as a solvent in the dental whitening compositions be added in a range from about 15%> to about 85%o by weight of the dental whitening compositions, more preferably in a range from about 25%> to about 75% by weight, and most preferably in a range from about 30% to about 65% by weight.
  • Glycerin, other polyols, and the like are inexpensive solvents that work well in forming a sticky gel with carboxypolymethylene.
  • the glycerin also provides some flavor enhancement such that a bland, sweet flavor is perceived.
  • a few possible substitutes for glycerin include propylene glycols, polypropylene glycol, polyethylene glycols, other polyols, sorbitol, mannitol, erythritol, other polyhydric alcohols, stearyl alcohol and other alcohols, and the like. Ethylene glycol would also work but is disfavored since it is toxic.
  • hydrophilic solvents such as glycerin, polyethylene glycols, polypropylene glycol, propylene glycol, and sorbitol may also be used as a suitable carrier without a tackifying agent.
  • Water may also be included as a solvent within the compositions of the present invention, although more carboxypolymethylene must generally be added as water is added to maintain the same level of stickiness.
  • the amount of water included within the dental whitening compositions of the present invention is preferably in a range from about 0% to about 50%) by weight of the dental whitening composition, more preferably in a range from about 1%> to about 45%> by weight and most preferably in a range from about 2%> to about 40% by weight . It will be appreciated that the total quantity of water in the dental whitening composition may come from different sources. For instance, some constituents such as dental agents and bases discussed below may come as aqueous solutions.
  • carboxypolymethylene is a polycarboxylic acid, it tends to lower the pH of the resulting dental whitening compositions significantly, down to a pH of about 2.5 in some cases. It appears, based upon clinical and in vitro testing, that dental whitening compositions with a pH below about 5 are able to etch enamel. To avoid etching enamel, it is preferable to add a neutralizing agent, or more specifically, a base in order to raise the pH of the inventive dental whitening compositions to within a pH range of about 4 to about 9. When such a composition is used having a pH at the lower or upper extremes of such a range, the exposure period is preferably relatively brief.
  • the pH is preferably adjusted to within a range from about 5 to about 8 and most preferably from about 6 to about 7.
  • Inorganic and organic bases may be used, with the use of concentrated aqueous sodium hydroxide (50% NaOH in water) being one currently preferred embodiment.
  • inorganic bases may be used such as potassium hydroxide and ammonium hydroxide.
  • suitable organic bases include alkyl amines such as triethanolamine, di-isopropanol amine and other similar amines.
  • the amount of neutralizing agent or base to be included will generally depend on the desired pH and the amount of carboxypolymethylene in the dental whitening composition.
  • neutralizing agents or bases are preferably included in a range from about 1%> to about 12%> by weight of the dental whitening composition, more preferably in a range from about 2%> to about 8% by weight and most preferably in a range from about 3% to about 7%> by weight.
  • carboxypolymethylene shall be understood to include carboxypolymethylene resins regardless of the pH of the overall dental composition.
  • the term “carboxypolymethylene” broadly includes resins that have been mixed with a base to raise the pH of the compositions.
  • he term “carboxypolymethylene” shall broadly include carboxypolymethylene resins that have reacted with, formed complexes with, or otherwise been altered in any way by other components within the dental whitening compositions of the present invention so long as the carboxypolymethylene is able to impart the desired level of stickiness and viscosity to the final dental whitening composition in combination with the other components within the dental whitening composition.
  • tackifying and thickening agents include gums such as xanthan gum, talha gum, tragacanth gum, locust bean gum, guar gum, Irish moss gum, ghatti gum, furcelleran gum, carrageenan gum, arabic gum, alginic acid gum, agar gum, alginate gum.
  • Another suitable tackifying agent is sold as PEMULEN®, a proprietary compound from B.F. Goodrich, or a compositional or chemical equivalent thereof.
  • PEMULEN® includes a significant quantity of a polyacrylic copolymer that has a slightly hydrophobic end and a strongly hydrophilic end.
  • suitable tackifying agents include polyethylene oxides such as POLYOX® sold by Union Carbide. These tackifying agents may be present in the same ranges as discussed above in relation to carboxypolymethylene.
  • a bleaching agent to enable the whitening composition to simultaneously bleach and opacify the teeth.
  • suitable bleaching agents include hydrogen peroxide, carbamide peroxide, benzoyl peroxide, glyceryl peroxide and sodium perborate.
  • the bleaching agents are preferably included in a range from about 0.5%> to about 50%> by weight of the dental whitening composition, more preferably in a range from about 1% to about 30% by weight and most preferably in a range from about 3% to about 20%> by weight.
  • an ion scavenger such as EDTA and salts of EDTA such as edetate disodium, oxine EDTN calcium disodium EDTN and others.
  • ion scavengers such as citric acid, succinic acid, adipic acid, nitrates and phosphates of tin and any other commonly-used chelating agents may be used.
  • Ion scavengers are preferably included in an amount in a range from about 0% to about 1% by weight of the dental whitening composition, more preferably in a range from about 0.03%> to about 0.5% by weight and most preferably in a range from about 0.05%o to about 0.2% by weight.
  • anticariogenic and antidemineralizing agents include fluoride salts, more particularly sodium monofluorophosphate, sodium fluoride, and stannous fluoride.
  • fluoride salts more particularly sodium monofluorophosphate, sodium fluoride, and stannous fluoride.
  • the fluoride will be included in a range from about 0%> to about 1% by weight of the dental whitening composition, more preferably in a range from about 0.1% to about 0.5%> by weight.
  • Antimicrobial agents e.g., for fighting gum disease, may be included in conjunction with the potassium nitrate or other opacifying agent.
  • useful antimicrobial agents include chlorhexidine, tetracycline, cetyl pyridinium chloride, benzalkonium chloride, cetyl pyridinium bromide, methyl benzoate, and propyl benzoate.
  • the antimicrobial agents are preferably included in an amount in a range from about 0% to about 15%) with the dental whitening composition, more preferably in a range from about 1%) to about 5% by weight.
  • the dental whitening compositions of the present invention preferably do not include an abrasive.
  • Abrasives only externally treat a tooth; however, it is believed that opacification of a tooth is achieved by the action of the potassium nitrate internally within a tooth. Not only are abrasives unnecessary but inclusion of abrasives in the composition may be undesirable in preferred embodiments where it is desired for the whitening composition to remain on the teeth for an extended period of time (i.e., greater than about 3 minutes). It is common experience that toothpastes become quickly diluted by saliva and will not persist in a paste-like form for more than a short period of time (i.e., for more than about a minute).
  • Suitable tooth desensitizing agents that may be used in addition to potassium nitrate according to the present invention include citric acid, citric acid salts, strontium chloride, and the like, as well as other desensitizing agents known in the art.
  • the amount of desensitizing agent included within the dental whitening compositions of the present invention may vary according to the concentration of the potassium nitrates, the desired strength and intended treatment times. Accordingly, if included at all, the other desensitizing agents will preferably be included in an amount in a range from about 0.1%> to about 10%) by weight of the dental desensitizing composition, more preferably in a range from about 1 to about 7% by weight.
  • One currently preferred method of dispensing sticky and viscous dental whitening compositions within the scope of the present invention is by means of a syringe.
  • Squeezable tubes and other similar dispensing devices may also be used to dispense the compositions.
  • the dental whitening compositions are sufficiently viscous that they do not easily settle or spread once dispensed, but will generally remain as a single extruded strand or bead of dental whitening composition.
  • bottles, tubes or other dispensing means known in the art may be used, particularly where the whitening composition has lower viscosity, low stickiness, and does not include a thickening agent.
  • dental whitening compositions in a syringe or similar dispensing device.
  • the person can load the precise amount of dental whitening composition onto the dental tray for each treatment period.
  • the dentist is also able to monitor how many doses the person has received and used.
  • sticky and viscous dental whitening compositions of the present invention are preferably used to treat a person's teeth in conjunction with dental trays that exert little or no significant mechanical pressure onto a person' s teeth and gums.
  • the whitening compositions can be applied directly to the person' s teeth without a dental tray, or a less viscous and sticky whitening composition according to the invention may be used in conjunction with self-retaining trays known in the art.
  • an alginate impression is made which registers all teeth surfaces plus the gingival margin. Thereafter, a stone cast is made of the impression. Excess stone can be trimmed away for easy manipulation and forming the dental tray.
  • one or more reservoirs can be formed in the resultant dental tray by applying a thin coating 10 of a rigid material to the stone cast 12 corresponding to teeth where it is desired to provide more of the dental whitening composition.
  • the coating 10 may be applied using a brush tipped applicator 14.
  • the coating may also be light curable for convenience.
  • the coating material will preferably be applied in a manner that is kept at a distance greater than about 1 mm from the gingival line 16, more preferably in a range from about 1.25 to about 1.5 mm from the gingival line 16.
  • the finished coating will have a thickness corresponding to the desired reservoir depth, which will commonly be about 0.5 mm. It is generally preferred that the rigid coating material not be applied over the stone cast corresponding to the incisal edges 18 and occlusal edges 20 of the person's teeth. This because it is preferable for the incisal edges and occlusal edges of the person's actual teeth to contact the finished tray in order to prevent or reduce vertical movement of the tray during use, which movement could act as a pump that could express the dental whitening composition from the tray and result in the intake of saliva within the dental tray. A dental tray 22 is then vacuum formed from the stone cast using conventional techniques.
  • the dental tray 22 is preferably constructed of a soft transparent vinyl material preferably having a preformed thickness in a range from about 0.2 mm to about 1.5 mm, more preferably in a range from about 0.25 mm to about 1 mm. Soft materials yield dental trays that are more comfortable for the patient to wear. It will be appreciated that the final tray thickness may vary depending on the technique used to prepare the tray, as well as the size and shape of the person's teeth. Patients suspected of being breuxers or hard biters may require either a thicker or a harder material. Of course, patients should be counselled not to eat with trays in place or to bite firmly into them.
  • the dental tray 22 is preferably trimmed barely shy of the gingival margin 16 of the person's teeth on both the buccal and lingual surfaces for maximum comfort. Enough tray material should be left to assure that the teeth will be covered to within about 1/4 mm to about 1/3 mm of the gingival border upon finishing and beveling of the tray periphery. It is also generally preferred to scallop up and around the interdental papilla so that the finished tray does not cover them. The tray edges are preferably smoothed so that the lip and tongue will not feel an edge prominence. Slight adjustments to the tray may be made by carefully heating and stretching the tray material.
  • Figure 5 depicts the dental whitening composition 40 being deposited into a dental tray 50 from a syringe 60.
  • Figure 6 depicts dental tray 50 being inserted onto an arch 70 in a patient's mouth.
  • Figure 7 depicts dental tray 50 in position on the teeth of arch 70.
  • the dental composition may be deposited throughout the dental tray to contact the entire arch or may be deposited within a portion of the tray to only contact a portion of the arch. Additionally, the dental tray may be configured to only contact a portion of an arch or only a single tooth. While depositing the dental whitening composition into dental tray 50 as shown in Figure 5 is the preferred method, the dental whitening composition may also alternatively be deposited directly onto the teeth and then tray 50 may be positioned on the teeth of arch 70.
  • the aforementioned thin, flexible dental trays are preferred when treating a person' s teeth, it may be preferable in some cases to allow the dental tray to overlap the person's gums in the case where dental agents are included to fight gum diseases.
  • the dental trays can always be constructed to overlap the gums.
  • the dental tray of the present invention preferably will not exert significant mechanical pressure onto the person's gums.
  • the dental whitening compositions described herein can be made to exert little or no mechanical pressure onto a person's teeth and gums, it will be important in such cases for the inventive dental whitening compositions to be able to act like a glue to reliably adhere and retain the dental tray over a person's teeth for the desired length of treatment. Accordingly, the dental whitening compositions will preferably have a stickiness such that they can reliably adhere and retain a dental tray over a person' s teeth for at least about one hour without significant mechanical pressure from the dental tray, more preferably for at least about two hours, and most preferably for at least about four hours.
  • the dental whitening compositions of the present invention may be used at any time and for any duration by a person that desires to make his or her teeth less translucent and more white.
  • the dental whitening compositions of the present invention facilitate the use of flexible, thin-walled dental trays that are more comfortable to use compared to prior dental trays, the insertion of any dental tray within a person's mouth will cause some alteration of behavior and diminution of the freedom to use one's mouth. Therefore, in order to maximize treatment time and reduce the inconvenience of having a dental tray lodged within a person's mouth, it is recommended to use the dental trays at night during a person's sleep.
  • the treatment regime may alternatively entail exposure for a period of time such as an hour without further exposure until the subsequent day.
  • the whitening compositions be applied for about 1 to 3 hours.
  • the length of the treatment period during night use may vary with the sleep pattern of the particular person and may accordingly be between about 5 to 9 hours.
  • the dental whitening compositions of the present invention may be applied and allowed to contact teeth for several hours, much shorter periods of time, even as brief as 3 minutes, result in some degree of opacification.
  • the rate of opacification will usually be much slower than when the exposure time is an hour or several hours.
  • dental trays are preferred as extended contact between the composition and the teeth is enabled through the support and protection of the tray.
  • inventive dental whitening composition are also within the scope of the invention in addition to the use of the dental whitening composition with a dental tray.
  • the dental whitening composition can be merely deposited onto a tooth or several teeth during one or more dental office visits.
  • the dental whitening composition is sufficiently sticky and viscous to stay in contact with the tooth or teeth to be whitened for a period of time of at least about three minutes without significant agitation of the composition against the tooth or teeth.
  • the dental whitening composition may be used with rubber dams and resin barriers, particularly when the composition includes bleaching agents.
  • the dental whitening composition may be used in combination with rubber dams and resin barriers when the method involves high concentrations of bleaching agents or rapid whitening which involves directing heat or light to the bleaching composition.
  • rubber dams and resin barriers are disclosed in U. S. Patent Application Serial No.
  • a whitening composition within the scope of the present invention was prepared by combining the following ingredients in the following proportions, measured as percentage by weight of the whitening composition:
  • the CARBOPOL 974P NF was obtained from B.F. Goodrich Company in Cleveland, Ohio.
  • the CARBOPOL 974P NF was first combined with the glycerin and polyethylene glycol 300 then mixed with the water. Mixing glycerin and polyethylene glycol 300 within the CARBOPOL 974P NF enabled it to be more easily mixed with the water.
  • the KNO 3 , carbamide peroxide and disodium EDTA were added to the mixture, after which the sodium hydroxide was blended into the homogeneous composition in order to raise the pH to an acceptable level.
  • the sodium fluoride was then added.
  • the resulting dental whitening composition had opacifying, bleaching, desensitizing and anticariogenic properties, and was sufficiently sticky that it could reliably hold and maintain a dental tray against a person's teeth without significant mechanical pressure being exerted by the tray onto a person's teeth and gums.
  • EXAMPLE 2 A sticky opacifying dental whitening composition within the scope of the present invention was made according to the procedure of Example 1, except that more KNO 3 was included and slightly less glycerin was added such that the remaining components were combined in the following amounts as a percentage by weight of the composition: CARBOPOL 974P NF 6.8%
  • the foregoing procedure resulted in a dental whitening composition.
  • the resulting dental whitening composition had more opacifying and desensitizing capability than the composition of Example 1.
  • the composition was sufficiently sticky that it could reliably hold and maintain a dental tray against a person's teeth without significant mechanical pressure on the patient's teeth and gums as in Example 1.
  • EXAMPLE 3 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent:
  • EXAMPLE 4 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the glycerin is replaced by propylene glycol. The ingredients are combined in the following concentrations by weight percent: CARBOPOL 974P NF 6.8%
  • EXAMPLE 5 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentration by weight percent: CARBOPOL 974P NF 6.8%
  • a dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent:
  • the foregoing procedure results in a sticky dental whitening composition having a lower viscosity compared with the composition in Example 1.
  • the composition has a similar level of opacifying capability and slightly more effective bleaching capability than the composition of Example 1.
  • EXAMPLE 7 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent: CARBOPOL 974P NF 6.8%
  • a dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent:
  • a dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent:
  • Disodium EDTA 0.2% The foregoing procedure results in a dental whitening composition having similar opacifying and desensitizing capabilities compared to the composition of Example 1.
  • the composition is less sticky than the composition of Example 1 and has greater bleaching capability.
  • EXAMPLE 10 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1 , except that the ingredients are combined in the following concentrations by weight percent:
  • Carbamide peroxide 15.0%> The foregoing procedure results in a dental whitening composition having similar opacifying and desensitizing capabilities compared to the composition of Example 1. However, the composition is less sticky than the composition of Example 1 and has greater bleaching capability.
  • EXAMPLE 11 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent:
  • EXAMPLE 12 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent.
  • the foregoing procedure results in a dental whitening composition that is less sticky and has a lower viscosity than the composition of Example 1.
  • the composition is able to impart a higher degree of opacification, desensitization, and bleaching compared to the composition of Example 1.
  • EXAMPLE 13 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent: Glycerin 30.0%
  • the foregoing procedure results in a dental whitening composition that is less sticky and has a lower viscosity than the composition of Example 1.
  • the composition is able to impart a higher degree of opacification, desensitization, and bleaching compared to the composition of Example 1.
  • EXAMPLE 14 A dental whitening composition within the scope of the present invention is made according to the procedure of Example 1, except that the ingredients are combined in the following concentrations by weight percent:
  • the foregoing procedure results in a dental whitening composition that is less sticky and has a lower viscosity than the composition of Example 1.
  • the composition has about the same opacifying and desensitizing capability but greater bleaching capability compared to the composition of Example 1.
  • EXAMPLE 15 To any of the foregoing dental whitening compositions is added one or more of the following antimicrobial agents for treatment of a patient's gums: chlorhexidine, tetracycline, cetyl pyridinium chloride, benzalkonium chloride, cetyl pyridinium bromide, methyl benzoate, and propyl benzoate. These compositions are preferably used in conjunction with a thin walled, flexible dental tray that overlaps the person's gums in order for the dental whitening compositions to contact the gums being treated.
  • EXAMPLE 16 To any of the foregoing dental whitening compositions which include a bleaching agent and do not include a bleaching agent stabilizer, one of the following chelating agents may be added: EDTN monosodium EDTN citric acid, succinic acid, and adipic acid.
  • the present invention provides compositions and methods for treating excessively translucent teeth to opacify and thereby whiten the teeth.
  • the present invention also provides dental whitening compositions for treating excessively translucent teeth which optionally include other dental agents for treating teeth and/or gums, such as bleaching, antimicrobial or anticariogenic agents.
  • the present invention also provides dental whitening compositions for bleaching teeth while relieving excessive sensitivity of a person's teeth.
  • the present invention provides compositions for treating excessively translucent teeth that can be sufficiently sticky and resistant to dilution by saliva such that they have the ability to adhere and retain a flexible, thin-walled dental tray against a person's teeth, wherein the dental tray does not exert significant mechanical pressures onto the person's teeth or gums.
  • the present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore, indicated by the appended claims rather than by the foregoing description. All changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Abstract

L'invention porte sur des compositions et procédés utilisant du nitrate de potassium pour réduire la sensibilité des dents et un agent de blanchiment tel que par exemple du peroxyde d'hydrogène ou du peroxyde de carbamide. Lesdites compositions (10) peuvent s'appliquer sur les dents (18) directement ou après avoir été déposées sur un tampon dentaire (22) souple, mince et d'un port agréable, qui se place contre les dents (18). Dans de dernier cas, les compositions (10) comprendront un agent gluant, par exemple du carboxypolyméthylène, aidant la composition (10) à maintenir en place le tampon (22) sur les dents (18) du fait de ses propriétés adhésives plutôt que de l'adaptation mécanique du tampon aux dents. Les compositions peuvent en outre contenir des agents anticariogènes et antimicrobiens.
PCT/US1999/026355 1998-11-12 1999-11-08 Compositions et procedes de blanchiment des dents WO2000028953A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16121/00A AU1612100A (en) 1998-11-12 1999-11-08 Compositions and methods for whitening teeth

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19073898A 1998-11-12 1998-11-12
US09/191,854 1998-11-12
US09/190,709 US6309625B1 (en) 1998-11-12 1998-11-12 One-part dental compositions and methods for bleaching and desensitizing teeth
US09/190,738 1998-11-12
US09/190,709 1998-11-12
US09/191,854 US6306370B1 (en) 1997-05-30 1998-11-12 Compositions and methods for whitening and desensitizing teeth

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1251793A1 (fr) * 2000-01-31 2002-10-30 Ultradent Products, Inc. Compositions et methodes permettant de blanchir et de desensibiliser les dents
GB2409976A (en) * 2004-01-19 2005-07-20 Glaxo Group Ltd Tooth whitening composition
GB2409975A (en) * 2004-01-19 2005-07-20 Glaxo Group Ltd Tooth whitening composition
US6986883B2 (en) 1999-09-09 2006-01-17 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
US7060256B2 (en) 1999-09-09 2006-06-13 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
US7086862B2 (en) 2002-11-15 2006-08-08 Discus Dental, Inc. Tooth bleaching process
US8562954B2 (en) 2004-07-02 2013-10-22 Discus Dental, Llc Dental compositions with sensitivity relief
US8936778B2 (en) 1998-11-12 2015-01-20 Ultradent Products, Inc. Methods for bleaching and desensitizing teeth
EP1691893B1 (fr) 2003-08-15 2015-05-06 Colgate-Palmolive Company Systeme hydrophobe de blanchiment des dents et procedes d'utilisation associes
CN109820748A (zh) * 2019-03-25 2019-05-31 昆明蓝橙口腔医院有限责任公司 一种用于口腔产品的无水分基质及其应用

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US3863006A (en) * 1973-01-29 1975-01-28 Milton Hodosh Method for desensitizing teeth
US5505933A (en) * 1994-06-27 1996-04-09 Colgate Palmolive Company Desensitizing anti-tartar dentifrice

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Publication number Priority date Publication date Assignee Title
US3863006A (en) * 1973-01-29 1975-01-28 Milton Hodosh Method for desensitizing teeth
US3863006B1 (fr) * 1973-01-29 1983-06-21
US5505933A (en) * 1994-06-27 1996-04-09 Colgate Palmolive Company Desensitizing anti-tartar dentifrice

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8936778B2 (en) 1998-11-12 2015-01-20 Ultradent Products, Inc. Methods for bleaching and desensitizing teeth
US6986883B2 (en) 1999-09-09 2006-01-17 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
US7060256B2 (en) 1999-09-09 2006-06-13 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
EP1251793A4 (fr) * 2000-01-31 2004-06-30 Ultradent Products Inc Compositions et methodes permettant de blanchir et de desensibiliser les dents
EP1251793A1 (fr) * 2000-01-31 2002-10-30 Ultradent Products, Inc. Compositions et methodes permettant de blanchir et de desensibiliser les dents
US7086862B2 (en) 2002-11-15 2006-08-08 Discus Dental, Inc. Tooth bleaching process
US7581864B2 (en) 2002-11-15 2009-09-01 Discus Dental, Llc Tooth bleaching process
EP1691893B2 (fr) † 2003-08-15 2018-03-21 Colgate-Palmolive Company Systeme hydrophobe de blanchiment des dents et procedes d'utilisation associes
EP1691893B1 (fr) 2003-08-15 2015-05-06 Colgate-Palmolive Company Systeme hydrophobe de blanchiment des dents et procedes d'utilisation associes
GB2409975A (en) * 2004-01-19 2005-07-20 Glaxo Group Ltd Tooth whitening composition
GB2409976A (en) * 2004-01-19 2005-07-20 Glaxo Group Ltd Tooth whitening composition
US8652445B2 (en) 2004-07-02 2014-02-18 Discus Dental, Llc Dental compositions with sensitivity relief
US8562954B2 (en) 2004-07-02 2013-10-22 Discus Dental, Llc Dental compositions with sensitivity relief
CN109820748A (zh) * 2019-03-25 2019-05-31 昆明蓝橙口腔医院有限责任公司 一种用于口腔产品的无水分基质及其应用
CN109820748B (zh) * 2019-03-25 2021-10-22 昆明蓝橙口腔医院有限责任公司 一种用于口腔产品的无水分基质及其应用

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