WO2000027873A3 - Interleukin-2 binding protein from arthropods - Google Patents

Interleukin-2 binding protein from arthropods Download PDF

Info

Publication number
WO2000027873A3
WO2000027873A3 PCT/US1999/026197 US9926197W WO0027873A3 WO 2000027873 A3 WO2000027873 A3 WO 2000027873A3 US 9926197 W US9926197 W US 9926197W WO 0027873 A3 WO0027873 A3 WO 0027873A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
arthropods
interleukin
present
binding protein
Prior art date
Application number
PCT/US1999/026197
Other languages
French (fr)
Other versions
WO2000027873A9 (en
WO2000027873A2 (en
Inventor
Richard G Titus
R Dean Gillespie
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Publication of WO2000027873A2 publication Critical patent/WO2000027873A2/en
Publication of WO2000027873A3 publication Critical patent/WO2000027873A3/en
Publication of WO2000027873A9 publication Critical patent/WO2000027873A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43527—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from ticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides arthropod interleukin-2 binding proteins, antibodies raised against such proteins and agonists and antagonists of such proteins. Methods of puryfying such IL-2 binding proteins are also provided. The present invention further provides pharmaceutical compositions containing such proteins, antibodies, agonists or antagonists, as well as the use of such pharmaceutical compositions in protecting animals, including humans, from arthropod infestation and/or the transmission of infectious organisms by arthropods. The therapeutic compositions of the present invention can also be used to modulate the activity of the immune system of animals, including humans.
PCT/US1999/026197 1998-11-06 1999-11-05 Interleukin-2 binding protein from arthropods WO2000027873A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10744198P 1998-11-06 1998-11-06
US60/107,441 1998-11-06

Publications (3)

Publication Number Publication Date
WO2000027873A2 WO2000027873A2 (en) 2000-05-18
WO2000027873A3 true WO2000027873A3 (en) 2000-09-08
WO2000027873A9 WO2000027873A9 (en) 2000-10-26

Family

ID=22316651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026197 WO2000027873A2 (en) 1998-11-06 1999-11-05 Interleukin-2 binding protein from arthropods

Country Status (1)

Country Link
WO (1) WO2000027873A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058941A1 (en) 2000-02-11 2001-08-16 Evolutec Limited Cytokine activity regulator molecules from tick salivary glands
AU2004309111B2 (en) * 2003-12-24 2011-02-24 Merck Serono Sa CC-chemokine-binding tick proteins
ES2379192T3 (en) * 2005-10-31 2012-04-23 Merck Serono Sa New CXC chemokine antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238971A2 (en) * 1986-03-17 1987-09-30 F. Hoffmann-La Roche Ag Antibodies directed to a lymphokine
EP0621338A2 (en) * 1993-04-21 1994-10-26 Ajinomoto Co., Inc. Immunosuppressant able to block the interleukin - 2 response
WO1998049303A2 (en) * 1997-04-29 1998-11-05 Yale University Compositions and methods for conferring tick immunity and preventing tick borne diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238971A2 (en) * 1986-03-17 1987-09-30 F. Hoffmann-La Roche Ag Antibodies directed to a lymphokine
EP0621338A2 (en) * 1993-04-21 1994-10-26 Ajinomoto Co., Inc. Immunosuppressant able to block the interleukin - 2 response
WO1998049303A2 (en) * 1997-04-29 1998-11-05 Yale University Compositions and methods for conferring tick immunity and preventing tick borne diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERGMAN, D.K., ET AL.: "Characterization of an Immunosuppressant Protein from Dermacentor andersoni (Acari: Ixodidae) Salivary Glands", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 35, no. 4, July 1998 (1998-07-01), pages 505 - 509, XP000881825 *
BERGMAN, D.K., ET AL.: "Dermacentor andersoni: Salivary Gland Proteins Suppressing T-Lymphocyte Responses to Concavalin A in vitro", EXPERIMENTAL PARASITOLOGY, vol. 81, 1995, pages 262 - 271, XP000881684 *
TITUS, R.G.; GILLESPIE, R.D.: "Characterization of an IL-2 binding protein from Ixodes scapularis (tick) saliva", FASEB JOURNAL, vol. 13, 15 March 1999 (1999-03-15), pages A954, XP000881956 *
URIOSTE, SANDY ET AL: "Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E-2-dependent mechanism.", JOURNAL OF EXPERIMENTAL MEDICINE, (1994) VOL. 180, NO. 3, PP. 1077-1085., XP000881637 *
WIKEL, S.K., ET AL.: "Tick-induced modulation of the host immune response", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 24, no. 1, 1994, pages 59 - 66, XP000881654 *

Also Published As

Publication number Publication date
WO2000027873A9 (en) 2000-10-26
WO2000027873A2 (en) 2000-05-18

Similar Documents

Publication Publication Date Title
CS782986A2 (en) Insecticide and method of its active component preparation
WO2004003147A3 (en) Cngh0004 polypeptides, antibodies, compositions, methods and uses
AU1790101A (en) Products comprising an isothiocyanate preservative system and methods of their use
WO2004039956A3 (en) Compositions and methods for the treatment of immune related diseases
AU2002305450A1 (en) Proteomimetic compounds and methods
WO1996034107A3 (en) Antiviral proteins, dna coding sequences therefor, and uses thereof
WO2003018771A3 (en) A system for antibody expression and assembly
WO2003035847A3 (en) Il-13 mutein proteins, antibodies, compositions, methods and uses
EP0695171A1 (en) Lyospheres comprising gonadotropin
AU600688B2 (en) Insecticidal pyrazolines
AUPO427596A0 (en) Anti-microbial protein
MY119916A (en) Pesticidal 1-aryl-3-iminopyrazoles
EP1412388A4 (en) Humanized antibodies derived from dd-3b6/22, specific for the d-dimer fragment of fibrin
AU3025795A (en) Compositions which are suitable for employment as antidotes to blood anticoagulants, and their use
WO1999061618A3 (en) Canine and feline immunoregulatory proteins, nucleic acid molecules, and uses thereof
WO2001040313A3 (en) Feline immunoregulatory proteins, nucleic acid molecules, and uses thereof
WO2004024072A3 (en) Novel compositions and methods for the treatment of immune related diseases
WO1999047558A3 (en) T cell costimulatory proteins, sequences and uses thereof
WO2000027873A3 (en) Interleukin-2 binding protein from arthropods
WO2003057821A3 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
EP0816504A3 (en) Platelet activating factor acetylhdrolase, and gene thereof
AU3711597A (en) A novel galanin receptor
WO1990007321A3 (en) Lymphocyte receptor homing sequences and their uses
WO2003057719A3 (en) Methods of modulating localization and physiological function of ip3 receptors
AU4609693A (en) An interferon-alpha/beta binding protein its preparation and pharmaceutical compositions containing it

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: C2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

COP Corrected version of pamphlet

Free format text: PAGES 1/13-13/13, DRAWINGS, REPLACED BY NEW PAGES 1/13-13/13; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

122 Ep: pct application non-entry in european phase