WO2000027873A3 - Interleukin-2 binding protein from arthropods - Google Patents

Interleukin-2 binding protein from arthropods Download PDF

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Publication number
WO2000027873A3
WO2000027873A3 PCT/US1999/026197 US9926197W WO0027873A3 WO 2000027873 A3 WO2000027873 A3 WO 2000027873A3 US 9926197 W US9926197 W US 9926197W WO 0027873 A3 WO0027873 A3 WO 0027873A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
arthropods
interleukin
present
binding protein
Prior art date
Application number
PCT/US1999/026197
Other languages
French (fr)
Other versions
WO2000027873A2 (en
WO2000027873A9 (en
Inventor
Richard G Titus
R Dean Gillespie
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Publication of WO2000027873A2 publication Critical patent/WO2000027873A2/en
Publication of WO2000027873A3 publication Critical patent/WO2000027873A3/en
Publication of WO2000027873A9 publication Critical patent/WO2000027873A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43527—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from ticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides arthropod interleukin-2 binding proteins, antibodies raised against such proteins and agonists and antagonists of such proteins. Methods of puryfying such IL-2 binding proteins are also provided. The present invention further provides pharmaceutical compositions containing such proteins, antibodies, agonists or antagonists, as well as the use of such pharmaceutical compositions in protecting animals, including humans, from arthropod infestation and/or the transmission of infectious organisms by arthropods. The therapeutic compositions of the present invention can also be used to modulate the activity of the immune system of animals, including humans.
PCT/US1999/026197 1998-11-06 1999-11-05 Interleukin-2 binding protein from arthropods WO2000027873A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10744198P 1998-11-06 1998-11-06
US60/107,441 1998-11-06

Publications (3)

Publication Number Publication Date
WO2000027873A2 WO2000027873A2 (en) 2000-05-18
WO2000027873A3 true WO2000027873A3 (en) 2000-09-08
WO2000027873A9 WO2000027873A9 (en) 2000-10-26

Family

ID=22316651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026197 WO2000027873A2 (en) 1998-11-06 1999-11-05 Interleukin-2 binding protein from arthropods

Country Status (1)

Country Link
WO (1) WO2000027873A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1254168A2 (en) * 2000-02-11 2002-11-06 Evolutec Limited Cytokine inhibittory molecules from tick salivary glands
DE602004022191D1 (en) * 2003-12-24 2009-09-03 Merck Serono Sa Coinsins CC CHEMOKIN BINDING TICK PROTEINS
ATE537184T1 (en) 2005-10-31 2011-12-15 Merck Serono Sa NEW CXC CHEMOKINE ANTAGONISTS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238971A2 (en) * 1986-03-17 1987-09-30 F. Hoffmann-La Roche Ag Antibodies directed to a lymphokine
EP0621338A2 (en) * 1993-04-21 1994-10-26 Ajinomoto Co., Inc. Immunosuppressant able to block the interleukin - 2 response
WO1998049303A2 (en) * 1997-04-29 1998-11-05 Yale University Compositions and methods for conferring tick immunity and preventing tick borne diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238971A2 (en) * 1986-03-17 1987-09-30 F. Hoffmann-La Roche Ag Antibodies directed to a lymphokine
EP0621338A2 (en) * 1993-04-21 1994-10-26 Ajinomoto Co., Inc. Immunosuppressant able to block the interleukin - 2 response
WO1998049303A2 (en) * 1997-04-29 1998-11-05 Yale University Compositions and methods for conferring tick immunity and preventing tick borne diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERGMAN, D.K., ET AL.: "Characterization of an Immunosuppressant Protein from Dermacentor andersoni (Acari: Ixodidae) Salivary Glands", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 35, no. 4, July 1998 (1998-07-01), pages 505 - 509, XP000881825 *
BERGMAN, D.K., ET AL.: "Dermacentor andersoni: Salivary Gland Proteins Suppressing T-Lymphocyte Responses to Concavalin A in vitro", EXPERIMENTAL PARASITOLOGY, vol. 81, 1995, pages 262 - 271, XP000881684 *
TITUS, R.G.; GILLESPIE, R.D.: "Characterization of an IL-2 binding protein from Ixodes scapularis (tick) saliva", FASEB JOURNAL, vol. 13, 15 March 1999 (1999-03-15), pages A954, XP000881956 *
URIOSTE, SANDY ET AL: "Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E-2-dependent mechanism.", JOURNAL OF EXPERIMENTAL MEDICINE, (1994) VOL. 180, NO. 3, PP. 1077-1085., XP000881637 *
WIKEL, S.K., ET AL.: "Tick-induced modulation of the host immune response", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 24, no. 1, 1994, pages 59 - 66, XP000881654 *

Also Published As

Publication number Publication date
WO2000027873A2 (en) 2000-05-18
WO2000027873A9 (en) 2000-10-26

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