WO2000027446A1 - Use of implantable pumps - Google Patents
Use of implantable pumps Download PDFInfo
- Publication number
- WO2000027446A1 WO2000027446A1 PCT/GB1999/003693 GB9903693W WO0027446A1 WO 2000027446 A1 WO2000027446 A1 WO 2000027446A1 GB 9903693 W GB9903693 W GB 9903693W WO 0027446 A1 WO0027446 A1 WO 0027446A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- patient
- pump
- impeller
- drive
- power supply
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0057—Pumps therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
- A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
- A61M60/416—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted directly by the motor rotor drive shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/585—User interfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1025—Respiratory system
- A61M2210/1032—Trachea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1089—Urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Mechanical Engineering (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Human Computer Interaction (AREA)
- External Artificial Organs (AREA)
- Prostheses (AREA)
Abstract
The use of an implantable pump in the treatment of a condition characterised by inadequate fluid flow, in vivo, in or through a vessel, channel or conduit, is disclosed. This comprises inserting said implantable pump into said vessel, channel or conduit and causing it to operate when required. Control is preferably by telemetric means. Conditions susceptible to treatment in this way include urinary incontinence, pulmonary hypertension and inadequate pulmonary ventilation.
Description
Use of Implantable Pumps
This invention relates to the use of implantable pumps and to the treatment of medical conditions; and to apparatus for use therein. A variety of conditions are susceptible to treatment in accordance with this invention, as will be apparent from the examples given hereinafter. In these methods, implantable homeostatic pumps may be used.
According to one aspect of the present invention, there is provided the use of an implantable pump in the treatment of a condition characterised by inadequate fluid flow, in vivo , in or through a vessel, channel or conduit, which comprises inserting said implantable pump into said vessel, channel or conduit and causing it to operate when required.
Operation of the implantable pump is preferably controlled by telemetry. The pump may, in addition, be constructed and arranged to operate as a valve.
The vessel, channel or conduit may be the urethra of a patient; or a blood vessel, for example a pulmonary artery or a peripheral blood vessel. It may also be a tracheotomy tube inserted into the trachea of a patient.
According to a second aspect of the present invention, there is provided a method for the treatment of urinary incontinence, which method comprises:
(a) surgically inserting into the urethra of the patient a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged
so as, in use, to drive fluid in a direction away from the bladder;
( 2 ) means for supplying power to drive the impeller; and
(3) a sensor responsive to signals applied externally of the patient ' s body to activate the power supplying means and thus to drive the impeller, thereby permitting the controllable expulsion of urine from the patient;
and (b) supplying control signals from outside the body of the patient to actuate the pump.
Preferably, the means for supplying power to the motor is a device for generating electrical energy from electromagnetic waves which are directed through the patient ' s body towards the motor from an external source. The electromagnetic waves may be, for example, microwaves or radio waves . Such a power supply arrangement dispenses with the need for a replaceable power source such as a conventional battery.
The pump may, if desired, act as a valve - i.e. it may demonstrate three operative conditions, namely: (a) valve closed - no flow, no pumping action; (b) valve open - flow, but no pumping action; and (c) valve open, pumping activated - giving enhanced flow. In some patients, simple valve control will suffice to control their incontinence; in others, e.g. men with prostatic interference of the urethra, a positive pumping action may be required to expel urine.
Telemetric control of the pump is advantageous in that it allows the patient considerable freedom,
thereby liberating him/her from many of the problems associated with urinary incontinence.
According to another aspect of the present invention, there is provided a method for the treatment of pulmonary hypertension, which method comprises:
(a) surgically inserting into a pulmonary artery of the patient a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged so as, in use, to drive blood in a direction away from the heart towards the lungs;
(2) power supply means for supplying power to drive the impeller; and
( 3 ) a device for regenerating the power supply means in response to signals applied externally of the patient's body;
(b) operating said miniature pump to drive blood from the heart through said pulmonary artery to the lungs; and
(c) regularly supplying control signals from outside the body of the patient to regenerate said power supply means .
Preferably, the device for regenerating said power supply means comprises a device for generating electrical energy from electromagnetic waves which are directed through the patient ' s body towards the motor from an external source. The electromagnetic waves may be, for example, microwaves or radio waves. Such an arrangement dispenses with the need for a replaceable
power source such as a conventional battery.
According to a third aspect of the present invention, there is provided a method of treating peripheral vascular ' disease, which comprises:
(a) surgically inserting into a peripheral blood vessel of the patient a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged so as, in use, to assist blood circulation;
( 2 ) power supply means for supplying power to drive the impeller; and
( 3 ) a device for regenerating the power supply means in response to signals applied externally of the patient's body;
(b) operating said miniature pump to drive blood in the circulatory direction through the peripheral blood vessel; and
(c) regularly supplying control signals from outside the body of the patient to regenerate said power supply means .
According to a fourth aspect of the present invention, there is provided a method of pulmonary ventilation, which comprises:
(a) performing a tracheostomy and inserting a tracheotomy tube into the opening formed in the trachea to provide an artificial airway into the patient ' s lungs;
(b) inserting into the tracheostomy tube a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged so as, in use, to drive air into the lungs in one mode of action and to assist in expelling air from the lungs in a second mode of action;
( 2 ) means for supplying power to drive the impeller; and
( 3 ) a device for regenerating the power supply means in response to signals applied externally of the patient's body;
(b) operating said miniature pump cyclically to drive air into the lungs and to expel air from the lungs; and
(c) regularly supplying control signals from outside the body of the patient to regenerate said power supply means .
In this embodiment, the pump is preferably arranged to maintain a positive pressure of about 5cm Hg in order to prevent alveolar collapse.
If desired, the pump may be provided with a cooling system; this may, for example, be in the form of a water jacket surrounding that part of the tracheostomy tube within which the pump is located.
In all of the embodiments described above, the pump preferably comprises a hollow stator within which is mounted an impeller in the form of a shaft carrying at least one helical ridge or vane. It is also preferred, with each of the embodiments, to incorporate
sensors, e.g. pressure sensors and flow sensors, at the two extremities of the pump ( input/output ends ) . These sensors are preferably arranged so that data they obtain can be transmitted externally of the patient by telemetric means.
Claims
1. The use of an implantable pump in the treatment of a condition characterised by inadequate fluid flow, in vivo , in or through a vessel, channel or conduit, which comprises inserting said implantable pump into said vessel, channel or conduit and causing it to operate when required.
2. Use as claimed in claim 1, wherein operation of said implantable pump is controlled by telemetry.
3. Use as claimed in claim 1 or 2, wherein said pump is, in addition, constructed and arranged to operate as a valve.
4. Use as claimed in claim 1, 2 or 3, wherein said vessel, channel or conduit is the urethra of a patient .
5. Use as claimed in claim 1, 2 or 3, wherein said vessel, channel or conduit is a blood vessel.
6. Use as claimed in claim 5, wherein said blood vessel is a pulmonary artery.
7. Use as claimed claim 5, wherein said blood vessel is a peripheral blood vessel.
8. Use as claimed in claim 1, 2 or 3, wherein said vessel, channel or conduit is a tracheotomy tube inserted into the trachea of a patient.
9. A method for the treatment of urinary incontinence, which method comprises: (a) surgically inserting into the urethra of the patient a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged so as, in use, to drive fluid in a direction away from the bladder;
( 2 ) means for supplying power to drive the impeller; and
(3) a sensor responsive to signals applied externally of the patient ' s body to activate the power supplying means and thus to drive the impeller, thereby permitting the controllable expulsion of urine from the patient;
and (b) supplying control signals from outside the body of the patient to actuate the pump.
10. A method for the treatment of pulmonary hypertension, which method comprises:
(a) surgically inserting into a pulmonary artery of the patient a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged so as, in use, to drive blood in a direction away from the heart towards the lungs;
( 2 ) power supply means for supplying power to drive the impeller; and
( 3 ) a device for regenerating the power supply means in response to signals applied externally of the patient's body; (b) operating said miniature pump to drive blood from the heart through said pulmonary artery to the lungs; and
(c) regularly supplying control signals from outside the body of the patient to regenerate said power supply means .
11. A method of treating peripheral vascular disease, which comprises:
( a ) surgically inserting into a peripheral blood vessel of the patient a miniature pump, said pump comprising:
(1) a motor having an impeller which is arranged so as, in use, to assist blood circulation;
( 2 ) power supply means for supplying power to drive the impeller; and
( 3 ) a device for regenerating the power supply means in response to signals applied externally of the patient's body;
(b) operating said miniature pump to drive blood in the circulatory direction through the peripheral blood vessel; and
(c) regularly supplying control signals from outside the body of the patient to regenerate said power supply means .
12. A method of pulmonary ventilation, which comprises:
( a ) performing a tracheostomy and inserting a tracheotomy tube into the opening formed in the trachea to provide an artificial airway into the patient ' s lungs;
(b) inserting into the tracheostomy tube a miniature pump, said pump comprising:
( 1 ) a motor having an impeller which is arranged so as, in use, to drive air into the lungs in one mode of action and to assist in expelling air from the lungs in a second mode of action;
( 2 ) means for supplying power to drive the impeller; and
(3) a device for regenerating the power supply means in response to signals applied externally of the patient ' s body;
(b) operating said miniature pump cyclically to drive air into the lungs and to expel air from the lungs; and
(c) regularly supplying control signals from outside the body of the patient to regenerate said power supply means.
13. A method according to claim 12, wherein said pump is arranged to maintain a positive pressure of the order of 5cm Hg in order to prevent alveolar collapse.
14. A method according to claim 9, 10, 11 or 12, wherein said means for supplying power to the motor is a device for generating electrical energy from electromagnetic waves which are directed through the patient's body towards said motor from an external source.
15. A method according to claim 14, wherein said electromagnetic waves are microwaves or radio waves .
16. Use or a method as claimed in any preceding claim, wherein said pump comprises a hollow stator within which is mounted an impeller in the form of a shaft carrying at least one helical ridge or vane.
17. Use or a method as claimed in any preceding claim, wherein said pump is provided with pressure sensors and/or flow sensors at its input and output ends.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9824436.1A GB9824436D0 (en) | 1998-11-06 | 1998-11-06 | Methods of treatment |
GB9824436.1 | 1998-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000027446A1 true WO2000027446A1 (en) | 2000-05-18 |
Family
ID=10842034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/003693 WO2000027446A1 (en) | 1998-11-06 | 1999-11-08 | Use of implantable pumps |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB9824436D0 (en) |
WO (1) | WO2000027446A1 (en) |
Cited By (33)
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---|---|---|---|---|
US8900060B2 (en) | 2009-04-29 | 2014-12-02 | Ecp Entwicklungsgesellschaft Mbh | Shaft arrangement having a shaft which extends within a fluid-filled casing |
US8926492B2 (en) | 2011-10-11 | 2015-01-06 | Ecp Entwicklungsgesellschaft Mbh | Housing for a functional element |
US8932141B2 (en) | 2009-10-23 | 2015-01-13 | Ecp Entwicklungsgesellschaft Mbh | Flexible shaft arrangement |
US8944748B2 (en) | 2009-05-05 | 2015-02-03 | Ecp Entwicklungsgesellschaft Mbh | Fluid pump changeable in diameter, in particular for medical application |
US8979493B2 (en) | 2009-03-18 | 2015-03-17 | ECP Entwicklungsgesellscaft mbH | Fluid pump |
US8998792B2 (en) | 2008-12-05 | 2015-04-07 | Ecp Entwicklungsgesellschaft Mbh | Fluid pump with a rotor |
US9028216B2 (en) | 2009-09-22 | 2015-05-12 | Ecp Entwicklungsgesellschaft Mbh | Rotor for an axial flow pump for conveying a fluid |
US9067006B2 (en) | 2009-06-25 | 2015-06-30 | Ecp Entwicklungsgesellschaft Mbh | Compressible and expandable blade for a fluid pump |
US9089670B2 (en) | 2009-02-04 | 2015-07-28 | Ecp Entwicklungsgesellschaft Mbh | Catheter device having a catheter and an actuation device |
US9217442B2 (en) | 2010-03-05 | 2015-12-22 | Ecp Entwicklungsgesellschaft Mbh | Pump or rotary cutter for operation in a fluid |
US9314558B2 (en) | 2009-12-23 | 2016-04-19 | Ecp Entwicklungsgesellschaft Mbh | Conveying blades for a compressible rotor |
US9328741B2 (en) | 2010-05-17 | 2016-05-03 | Ecp Entwicklungsgesellschaft Mbh | Pump arrangement |
US9339596B2 (en) | 2009-12-23 | 2016-05-17 | Ecp Entwicklungsgesellschaft Mbh | Radially compressible and expandable rotor for a fluid pump |
US9358330B2 (en) | 2009-12-23 | 2016-06-07 | Ecp Entwicklungsgesellschaft Mbh | Pump device having a detection device |
US9416783B2 (en) | 2009-09-22 | 2016-08-16 | Ecp Entwicklungsgellschaft Mbh | Compressible rotor for a fluid pump |
US9416791B2 (en) | 2010-01-25 | 2016-08-16 | Ecp Entwicklungsgesellschaft Mbh | Fluid pump having a radially compressible rotor |
US9603983B2 (en) | 2009-10-23 | 2017-03-28 | Ecp Entwicklungsgesellschaft Mbh | Catheter pump arrangement and flexible shaft arrangement having a core |
US9611743B2 (en) | 2010-07-15 | 2017-04-04 | Ecp Entwicklungsgesellschaft Mbh | Radially compressible and expandable rotor for a pump having an impeller blade |
US9771801B2 (en) | 2010-07-15 | 2017-09-26 | Ecp Entwicklungsgesellschaft Mbh | Rotor for a pump, produced with a first elastic material |
US9867916B2 (en) | 2010-08-27 | 2018-01-16 | Berlin Heart Gmbh | Implantable blood conveying device, manipulating device and coupling device |
US9895475B2 (en) | 2010-07-15 | 2018-02-20 | Ecp Entwicklungsgesellschaft Mbh | Blood pump for the invasive application within a body of a patient |
US9974893B2 (en) | 2010-06-25 | 2018-05-22 | Ecp Entwicklungsgesellschaft Mbh | System for introducing a pump |
US10107299B2 (en) | 2009-09-22 | 2018-10-23 | Ecp Entwicklungsgesellschaft Mbh | Functional element, in particular fluid pump, having a housing and a conveying element |
US10172985B2 (en) | 2009-08-06 | 2019-01-08 | Ecp Entwicklungsgesellschaft Mbh | Catheter device having a coupling device for a drive device |
US10391278B2 (en) | 2011-03-10 | 2019-08-27 | Ecp Entwicklungsgesellschaft Mbh | Push device for the axial insertion of an elongate, flexible body |
US10561773B2 (en) | 2011-09-05 | 2020-02-18 | Ecp Entwicklungsgesellschaft Mbh | Medical product comprising a functional element for the invasive use in a patient's body |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
US11969560B2 (en) | 2009-02-04 | 2024-04-30 | Ecp Entwicklungsgesellschaft Mbh | Catheter device having a catheter and an actuation device |
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WO1997037696A1 (en) * | 1996-04-04 | 1997-10-16 | Rau Guenter | Intravascular blood pump |
US5702430A (en) * | 1992-08-06 | 1997-12-30 | Electric Boat Corporation | Surgically implantable power supply |
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1999
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US5290227A (en) * | 1992-08-06 | 1994-03-01 | Pasque Michael K | Method of implanting blood pump in ascending aorta or main pulmonary artery |
US5702430A (en) * | 1992-08-06 | 1997-12-30 | Electric Boat Corporation | Surgically implantable power supply |
US5762599A (en) * | 1994-05-02 | 1998-06-09 | Influence Medical Technologies, Ltd. | Magnetically-coupled implantable medical devices |
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US10495101B2 (en) | 2008-12-05 | 2019-12-03 | Ecp Entwicklungsgesellschaft Mbh | Fluid pump with a rotor |
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US9067006B2 (en) | 2009-06-25 | 2015-06-30 | Ecp Entwicklungsgesellschaft Mbh | Compressible and expandable blade for a fluid pump |
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US10330101B2 (en) | 2009-06-25 | 2019-06-25 | Ecp Entwicklungsgesellschaft Mbh | Compressible and expandable blade for a fluid pump |
US10172985B2 (en) | 2009-08-06 | 2019-01-08 | Ecp Entwicklungsgesellschaft Mbh | Catheter device having a coupling device for a drive device |
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