WO2000027340A3 - USE OF t-RNA AND FRAGMENTS FOR INHIBITING ANGIOGENESIS AND COMPOSITIONS THEREOF - Google Patents

USE OF t-RNA AND FRAGMENTS FOR INHIBITING ANGIOGENESIS AND COMPOSITIONS THEREOF Download PDF

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Publication number
WO2000027340A3
WO2000027340A3 PCT/US1999/026696 US9926696W WO0027340A3 WO 2000027340 A3 WO2000027340 A3 WO 2000027340A3 US 9926696 W US9926696 W US 9926696W WO 0027340 A3 WO0027340 A3 WO 0027340A3
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WO
WIPO (PCT)
Prior art keywords
rna
fragments
compositions
inhibiting angiogenesis
angiogenesis
Prior art date
Application number
PCT/US1999/026696
Other languages
French (fr)
Other versions
WO2000027340A9 (en
WO2000027340A2 (en
Inventor
Yuen Shing
Hui Zhao
Krzystof Bojanowski
M Judah Folkman
Original Assignee
Childrens Medical Center
Yuen Shing
Hui Zhao
Krzystof Bojanowski
M Judah Folkman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Yuen Shing, Hui Zhao, Krzystof Bojanowski, M Judah Folkman filed Critical Childrens Medical Center
Priority to AU20234/00A priority Critical patent/AU2023400A/en
Publication of WO2000027340A2 publication Critical patent/WO2000027340A2/en
Publication of WO2000027340A3 publication Critical patent/WO2000027340A3/en
Publication of WO2000027340A9 publication Critical patent/WO2000027340A9/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A therapeutic composition comprising an angiogenesis-inhibiting amount of a transfer ribonucleic acid (tRNA) or a fragment of tRNA and a pharmaceutically acceptable excipient are provided. Methods of administering the composition to inhibit an angiogenesis-dependent disease, such as cancer, are also provided.
PCT/US1999/026696 1998-11-12 1999-11-12 USE OF t-RNA AND FRAGMENTS FOR INHIBITING ANGIOGENESIS AND COMPOSITIONS THEREOF WO2000027340A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20234/00A AU2023400A (en) 1998-11-12 1999-11-12 Compositions and methods for inhibiting angiogenesis using trna and fragments thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10803698P 1998-11-12 1998-11-12
US60/108,036 1998-11-12

Publications (3)

Publication Number Publication Date
WO2000027340A2 WO2000027340A2 (en) 2000-05-18
WO2000027340A3 true WO2000027340A3 (en) 2000-08-17
WO2000027340A9 WO2000027340A9 (en) 2000-11-30

Family

ID=22319903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026696 WO2000027340A2 (en) 1998-11-12 1999-11-12 USE OF t-RNA AND FRAGMENTS FOR INHIBITING ANGIOGENESIS AND COMPOSITIONS THEREOF

Country Status (2)

Country Link
AU (1) AU2023400A (en)
WO (1) WO2000027340A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101005299B1 (en) 2000-10-18 2011-01-04 파마셋 인코포레이티드 Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
LT2578685T (en) * 2005-08-23 2019-06-10 The Trustees Of The University Of Pennsylvania Rna containing modified nucleosides and methods of use thereof
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
HUE058896T2 (en) 2010-10-01 2022-09-28 Modernatx Inc Ribonucleic acids containing n1-methyl-pseudouracils and uses thereof
JP2014511687A (en) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド Engineered nucleic acid delivery and formulation
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (en) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Modified nucleosides, nucleotides and nucleic acids and their application
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
AU2013243951A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
US20160032316A1 (en) 2013-03-14 2016-02-04 The Trustees Of The University Of Pennsylvania Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (en) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. POLYNUCLEOTES ENCODING THE RECEPTOR OF LOW DENSITY LIPOPROTEINS
CA2940192C (en) 2014-02-04 2022-09-27 Thomas Jefferson University Specific expression of half-trna in cancers
WO2018119421A1 (en) * 2016-12-22 2018-06-28 Thomas Jefferson University Compositions and methods of using rna fragments

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE876739A (en) * 1978-06-03 1979-12-03 Boehringer Sohn Ingelheim PREPARATIONS BASED ON RIBONUCLEIC TRANSFER ACIDS, WITH ANTIVIRAL ACTIVITY

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE876739A (en) * 1978-06-03 1979-12-03 Boehringer Sohn Ingelheim PREPARATIONS BASED ON RIBONUCLEIC TRANSFER ACIDS, WITH ANTIVIRAL ACTIVITY

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HWANG J.-M. ET AL: "Optic neuropathy associated with mitochondrial tRNA (Leu(UUR)) A3243G mutation.", OPHTHALMIC GENETICS, (1997) 18/2 (101-105)., XP000901440 *
SMITH P R (REPRINT) ET AL: "Pigmentary retinal dystrophy and the syndrome of maternally inherited diabetes and deafness caused by the mitochondrial DNA 3243 tRNA (Leu) A to G mutation", OPHTHALMOLOGY, (JUN 1999) VOL. 106, NO. 6, PP. 1101-1108. PUBLISHER: LIPPINCOTT WILLIAMS & WILKINS, 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106. ISSN: 0161-6420., QUEEN ELIZABETH HOSP, DEPT MED, BIRMINGHAM B15 2TH, W MIDLANDS, ENGLAND (Reprint);UNIV BIRMINGHAM, DEPT MED, BIRMINGHAM, W MIDLANDS, ENGLAND; BIRMINGHAM & MIDLAND EYE HOSP, CITY HOSP NHS TRUST, BIRMIN, XP000901445 *
SUK, D. ET AL: "Toxicological and antiproliferative effects of N6-(.DELTA.2- isopentenyl)adenosine, a natural component of mammalian transfer RNA", CANCER RES. (1970), 30(5), 1429-36, XP000901623 *
ZHAO, HUI ET AL: "New role for tRNA and its fragment purified from human urinary bladder carcinoma conditioned medium: Inhibition of endothelial cell growth.", JOURNAL OF CELLULAR BIOCHEMISTRY, (NOV., 1999) VOL. 76, NO. 1, PP. 109-117., XP002135747 *

Also Published As

Publication number Publication date
AU2023400A (en) 2000-05-29
WO2000027340A9 (en) 2000-11-30
WO2000027340A2 (en) 2000-05-18

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