WO2000025829A3 - Radiodense compositions - Google Patents

Radiodense compositions Download PDF

Info

Publication number
WO2000025829A3
WO2000025829A3 PCT/US1999/025529 US9925529W WO0025829A3 WO 2000025829 A3 WO2000025829 A3 WO 2000025829A3 US 9925529 W US9925529 W US 9925529W WO 0025829 A3 WO0025829 A3 WO 0025829A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiodense
compositions
tumors
particulate
hour
Prior art date
Application number
PCT/US1999/025529
Other languages
French (fr)
Other versions
WO2000025829A2 (en
Inventor
Gregory L Mcintire
Edward R Bacon
Kathleen J Illig
Gerald L Wolf
Original Assignee
Gen Hospital Corp
Nycomed Imaging As
Gregory L Mcintire
Edward R Bacon
Kathleen J Illig
Gerald L Wolf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9909799.0A external-priority patent/GB9909799D0/en
Application filed by Gen Hospital Corp, Nycomed Imaging As, Gregory L Mcintire, Edward R Bacon, Kathleen J Illig, Gerald L Wolf filed Critical Gen Hospital Corp
Priority to EP99958715A priority Critical patent/EP1126884A2/en
Priority to AU16017/00A priority patent/AU1601700A/en
Priority to JP2000579267A priority patent/JP2002528521A/en
Priority to CA002348536A priority patent/CA2348536A1/en
Publication of WO2000025829A2 publication Critical patent/WO2000025829A2/en
Publication of WO2000025829A3 publication Critical patent/WO2000025829A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1091—Kilovoltage or orthovoltage range photons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Abstract

The invention relates to radiodense compositions for use in methods of radiation treatment of target tissues, such as tumors, the radiodense compositions include a particulate or polymeric contrast agent that has a dwell time within the target tissue of at least one hour.
PCT/US1999/025529 1998-10-29 1999-10-29 Radiodense compositions WO2000025829A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99958715A EP1126884A2 (en) 1998-10-29 1999-10-29 Radiodense compositions
AU16017/00A AU1601700A (en) 1998-10-29 1999-10-29 Radiodense compositions
JP2000579267A JP2002528521A (en) 1998-10-29 1999-10-29 Radiation-dense composition
CA002348536A CA2348536A1 (en) 1998-10-29 1999-10-29 Radiodense compositions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US18316698A 1998-10-29 1998-10-29
US09/183,166 1998-10-29
US13141899P 1999-04-28 1999-04-28
GBGB9909799.0A GB9909799D0 (en) 1999-04-28 1999-04-28 Method
US60/131,418 1999-04-28
GB9909799.0 1999-04-28

Publications (2)

Publication Number Publication Date
WO2000025829A2 WO2000025829A2 (en) 2000-05-11
WO2000025829A3 true WO2000025829A3 (en) 2000-11-30

Family

ID=27269711

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1999/025558 WO2000025819A1 (en) 1998-10-29 1999-10-29 Enhanced radiation therapy
PCT/US1999/025529 WO2000025829A2 (en) 1998-10-29 1999-10-29 Radiodense compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025558 WO2000025819A1 (en) 1998-10-29 1999-10-29 Enhanced radiation therapy

Country Status (5)

Country Link
EP (2) EP1124580A1 (en)
JP (2) JP2003520192A (en)
AU (2) AU1601700A (en)
CA (2) CA2348536A1 (en)
WO (2) WO2000025819A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US7390668B2 (en) 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US6493570B1 (en) 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
CA2348536A1 (en) * 1998-10-29 2000-05-11 The General Hospital Corporation Radiodense compositions
US6986740B2 (en) 1998-11-02 2006-01-17 Xantech Pharmaceuticals, Inc. Ultrasound contrast using halogenated xanthenes
US8470296B2 (en) 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
DE102008034020A1 (en) 2008-07-16 2010-01-21 Bayer Schering Pharma Aktiengesellschaft Contrast agent enhanced radiotherapy with high performance tubes
DE102010052613A1 (en) * 2010-11-29 2012-05-31 Stefan Brühl Heavy atoms containing substance, useful in a medical procedure, which is radiation therapy, preferably X-rays, for the treatment of tumors and to increase the biological effect of radiation, preferably X-rays
WO2015134845A1 (en) * 2014-03-07 2015-09-11 Stc.Unm Quantitatively describing biophysical markers

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008907A (en) * 1989-05-31 1991-04-16 The Regents Of The University Of California Therapy x-ray scanner
WO1994027644A1 (en) * 1993-06-02 1994-12-08 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
US5665330A (en) * 1995-02-08 1997-09-09 Nano Systems Llc Dual purposed diagnostic/therapeutic agent having a tri-iodinated benzoyl group linked to a coumarin
WO1998047532A1 (en) * 1997-04-24 1998-10-29 Nycomed Imaging As Embolus therapy using insoluble microparticles or vesicles containing contrast agents
WO2000025819A1 (en) * 1998-10-29 2000-05-11 The General Hospital Corporation Enhanced radiation therapy
WO2000043045A1 (en) * 1999-01-25 2000-07-27 Photogen, Inc. Method for improved radiation therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627309C2 (en) * 1996-06-27 1999-07-29 Schering Ag Aqueous injectable formulations usable as contrast agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008907A (en) * 1989-05-31 1991-04-16 The Regents Of The University Of California Therapy x-ray scanner
WO1994027644A1 (en) * 1993-06-02 1994-12-08 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
US5665330A (en) * 1995-02-08 1997-09-09 Nano Systems Llc Dual purposed diagnostic/therapeutic agent having a tri-iodinated benzoyl group linked to a coumarin
WO1998047532A1 (en) * 1997-04-24 1998-10-29 Nycomed Imaging As Embolus therapy using insoluble microparticles or vesicles containing contrast agents
WO2000025819A1 (en) * 1998-10-29 2000-05-11 The General Hospital Corporation Enhanced radiation therapy
WO2000043045A1 (en) * 1999-01-25 2000-07-27 Photogen, Inc. Method for improved radiation therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SANTOS MELLO R ET AL: "Radiation dose enhancement in tumors with iodine.", XP002134800, retrieved from STN Database accession no. 83191891 *
MEDICAL PHYSICS, (1983 JAN-FEB) 10 (1) 75-8. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease

Also Published As

Publication number Publication date
WO2000025819A9 (en) 2000-09-21
AU1601700A (en) 2000-05-22
AU1710600A (en) 2000-05-22
WO2000025819A1 (en) 2000-05-11
EP1124580A1 (en) 2001-08-22
WO2000025829A2 (en) 2000-05-11
EP1126884A2 (en) 2001-08-29
JP2002528521A (en) 2002-09-03
CA2347915A1 (en) 2000-05-11
CA2348536A1 (en) 2000-05-11
JP2003520192A (en) 2003-07-02

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