WO2000025777A1 - SUBSTITUTED PHENETHYLSULFONES AND METHOD OF REDUCING TNFαLEVELS - Google Patents
SUBSTITUTED PHENETHYLSULFONES AND METHOD OF REDUCING TNFαLEVELS Download PDFInfo
- Publication number
- WO2000025777A1 WO2000025777A1 PCT/US1999/024376 US9924376W WO0025777A1 WO 2000025777 A1 WO2000025777 A1 WO 2000025777A1 US 9924376 W US9924376 W US 9924376W WO 0025777 A1 WO0025777 A1 WO 0025777A1
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- WO
- WIPO (PCT)
- Prior art keywords
- ethoxy
- hydrogen
- methoxyphenyl
- compound
- methyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatment Of Water By Oxidation Or Reduction (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69934708T DE69934708T2 (en) | 1998-10-30 | 1999-10-19 | SUBSTITUTED PHENETHYLSULPHONES AND METHOD FOR REDUCING THE TNF-ALPHA MIRROR AND PDE-IV MIRROR |
EP99971317A EP1126839B1 (en) | 1998-10-30 | 1999-10-19 | Substituted phenethylsulfones and method of reducing tnf-alpha and pde-iv levels |
BR9915201-0A BR9915201A (en) | 1998-10-30 | 1999-10-19 | Substituted phenethyl sulfones and method of reducing tnf levels "alpha" |
DK99971317T DK1126839T3 (en) | 1998-10-30 | 1999-10-19 | Substituted phenethylsulfones and process for reducing the levels of TNF-alpha and PDE-IV |
NZ511253A NZ511253A (en) | 1998-10-30 | 1999-10-19 | Substituted phenethylsulfones useful for reducing TNF-alpha levels |
CA002348993A CA2348993C (en) | 1998-10-30 | 1999-10-19 | Substituted phenethylsulfones and method of reducing tnf.alpha. levels |
AU14472/00A AU756308B2 (en) | 1998-10-30 | 1999-10-19 | Substituted phenethylsulfones and method of reducing TNF alpha levels |
JP2000579218A JP4530543B2 (en) | 1998-10-30 | 1999-10-19 | Substituted phenethyl sulfones and methods for reducing TNFα levels |
BRPI9915201 BRPI9915201B8 (en) | 1998-10-30 | 1999-10-19 | substituted phenethylsulfones and method of reducing "alpha" tnf levels. |
NO20012021A NO319790B1 (en) | 1998-10-30 | 2001-04-24 | Substituted Phenylethyl Sulfones and Methods for Reduction of TNF <alfa> Levels |
HK02100185.3A HK1038696B (en) | 1998-10-30 | 2002-01-10 | Substituted phenethylsulfones and method of reducing tnf-alpha and pde-iv levels |
AU2003203681A AU2003203681B2 (en) | 1998-10-30 | 2003-04-09 | Substituted phenethylsulfones and methods of reducing TNF-alpha-levels |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/183,049 | 1998-10-30 | ||
US09/183,049 US6020358A (en) | 1998-10-30 | 1998-10-30 | Substituted phenethylsulfones and method of reducing TNFα levels |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000025777A1 true WO2000025777A1 (en) | 2000-05-11 |
Family
ID=22671217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/024376 WO2000025777A1 (en) | 1998-10-30 | 1999-10-19 | SUBSTITUTED PHENETHYLSULFONES AND METHOD OF REDUCING TNFαLEVELS |
Country Status (16)
Country | Link |
---|---|
US (2) | US6020358A (en) |
EP (3) | EP2305248B1 (en) |
JP (1) | JP4530543B2 (en) |
AT (2) | ATE350033T1 (en) |
AU (1) | AU756308B2 (en) |
BR (2) | BRPI9915201B8 (en) |
CA (1) | CA2348993C (en) |
CY (3) | CY1107499T1 (en) |
DE (2) | DE69942532D1 (en) |
DK (3) | DK1752148T3 (en) |
ES (3) | ES2343744T3 (en) |
HK (2) | HK1038696B (en) |
NO (1) | NO319790B1 (en) |
NZ (1) | NZ511253A (en) |
PT (3) | PT2305248E (en) |
WO (1) | WO2000025777A1 (en) |
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EP1228071A1 (en) * | 1999-11-12 | 2002-08-07 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
WO2004080423A3 (en) * | 2003-03-12 | 2004-11-04 | Celgene Corp | 7-amino- isoindolyl compounds amd their pharmaceutical uses |
JP2005525386A (en) * | 2002-03-20 | 2005-08-25 | セルジーン・コーポレーション | (+)-2- [1- (3-Ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl] -4-acetylaminoisoindoline-1,3-dione, methods of use and compositions thereof |
WO2006025991A2 (en) * | 2004-07-28 | 2006-03-09 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
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US7893102B2 (en) | 2002-12-30 | 2011-02-22 | Celgene Corporation | Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses |
WO2012083153A1 (en) * | 2010-12-16 | 2012-06-21 | Nektar Therapeutics | Oligomer-containing apremilast moiety compounds |
CN103402980A (en) * | 2011-01-10 | 2013-11-20 | 细胞基因公司 | Phenethylsulfone isoindoline derivatives as inhibitors of PDE 4 and/or cytokines |
EP2730278A1 (en) | 2012-11-08 | 2014-05-14 | Ratiopharm GmbH | Composition melt |
US8883843B2 (en) | 2009-06-18 | 2014-11-11 | Concert Pharmaceuticals, Inc. | Substituted isoindoline-1,3-dione derivatives |
CN104496886A (en) * | 2014-12-11 | 2015-04-08 | 杭州新博思生物医药有限公司 | Preparation method of high-purity apremilast B crystal form |
US9018243B2 (en) | 2002-03-20 | 2015-04-28 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
CN104945306A (en) * | 2015-05-25 | 2015-09-30 | 山东铭康医药技术有限公司 | Method for preparing optically pure apremilast |
EP2949645A1 (en) | 2014-05-28 | 2015-12-02 | LEK Pharmaceuticals d.d. | Processes for the preparation of ß-aminosulfone compounds |
CN105294533A (en) * | 2015-12-02 | 2016-02-03 | 宋彤云 | Pharmaceutical composition for treating bone diseases |
CN105461610A (en) * | 2014-09-10 | 2016-04-06 | 杭州普晒医药科技有限公司 | Apremilast crystal form, and preparation method, pharmaceutical composition and application thereof |
WO2016161996A1 (en) | 2015-04-09 | 2016-10-13 | Zentiva, K.S. | A method of chiral resolution of the key intermediate of the synthesis of apremilast and its use for the preparation of pure apremilast |
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EP3691682A1 (en) | 2017-09-14 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
AU2018357775B2 (en) | 2017-10-23 | 2024-02-15 | Boehringer Ingelheim International Gmbh | New combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (PF-ILD) |
BR112020022190A2 (en) | 2018-05-02 | 2021-02-02 | Tianjin Hemay Pharmaceutical Co., Ltd. | crystal form of thiophene derivative |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556673A (en) * | 1980-06-06 | 1985-12-03 | Andersen Lars H | Use of phthalyltaurine sulfonamide derivatives in treating epilepsy and arrythmia |
US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US5658940A (en) * | 1995-10-06 | 1997-08-19 | Celgene Corporation | Succinimide and maleimide cytokine inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4173652A (en) * | 1976-12-18 | 1979-11-06 | Akzona Incorporated | Pharmaceutical hydroxamic acid compositions and uses thereof |
US4820828A (en) * | 1987-03-04 | 1989-04-11 | Ortho Pharmaceutical Corporation | Cinnamohydroxamic acids |
US5698579A (en) * | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
US5703098A (en) * | 1994-12-30 | 1997-12-30 | Celgene Corporation | Immunotherapeutic imides/amides |
US6225351B1 (en) * | 1995-07-26 | 2001-05-01 | Pfizer Inc. | N-(aroyl) glycine hydroxamic acid derivatives and related compounds |
US5728845A (en) * | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic nitriles |
US5728844A (en) * | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic agents |
DK0871439T3 (en) * | 1996-01-02 | 2004-08-02 | Aventis Pharma Inc | Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds |
-
1998
- 1998-10-30 US US09/183,049 patent/US6020358A/en not_active Expired - Lifetime
-
1999
- 1999-06-29 US US09/340,617 patent/US6011050A/en not_active Expired - Lifetime
- 1999-10-19 AT AT99971317T patent/ATE350033T1/en active
- 1999-10-19 PT PT101668556T patent/PT2305248E/en unknown
- 1999-10-19 NZ NZ511253A patent/NZ511253A/en not_active IP Right Cessation
- 1999-10-19 BR BRPI9915201 patent/BRPI9915201B8/en unknown
- 1999-10-19 WO PCT/US1999/024376 patent/WO2000025777A1/en active IP Right Grant
- 1999-10-19 DK DK06023050.5T patent/DK1752148T3/en active
- 1999-10-19 AU AU14472/00A patent/AU756308B2/en not_active Expired
- 1999-10-19 EP EP10166855.6A patent/EP2305248B1/en not_active Expired - Lifetime
- 1999-10-19 PT PT99971317T patent/PT1126839E/en unknown
- 1999-10-19 CA CA002348993A patent/CA2348993C/en not_active Expired - Fee Related
- 1999-10-19 ES ES06023050T patent/ES2343744T3/en not_active Expired - Lifetime
- 1999-10-19 ES ES10166855T patent/ES2421153T3/en not_active Expired - Lifetime
- 1999-10-19 ES ES99971317T patent/ES2278467T3/en not_active Expired - Lifetime
- 1999-10-19 DK DK99971317T patent/DK1126839T3/en active
- 1999-10-19 DE DE69942532T patent/DE69942532D1/en not_active Expired - Lifetime
- 1999-10-19 BR BR9915201-0A patent/BR9915201A/en not_active IP Right Cessation
- 1999-10-19 EP EP99971317A patent/EP1126839B1/en not_active Expired - Lifetime
- 1999-10-19 AT AT06023050T patent/ATE471718T1/en active
- 1999-10-19 PT PT06023050T patent/PT1752148E/en unknown
- 1999-10-19 EP EP06023050A patent/EP1752148B1/en not_active Expired - Lifetime
- 1999-10-19 JP JP2000579218A patent/JP4530543B2/en not_active Expired - Lifetime
- 1999-10-19 DE DE69934708T patent/DE69934708T2/en not_active Expired - Lifetime
- 1999-10-19 DK DK10166855.6T patent/DK2305248T3/en active
-
2001
- 2001-04-24 NO NO20012021A patent/NO319790B1/en not_active IP Right Cessation
-
2002
- 2002-01-10 HK HK02100185.3A patent/HK1038696B/en not_active IP Right Cessation
-
2007
- 2007-01-15 CY CY20071100051T patent/CY1107499T1/en unknown
- 2007-08-13 HK HK07108775.7A patent/HK1103224A1/en not_active IP Right Cessation
-
2010
- 2010-08-30 CY CY20101100791T patent/CY1110752T1/en unknown
-
2013
- 2013-07-16 CY CY20131100599T patent/CY1114304T1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556673A (en) * | 1980-06-06 | 1985-12-03 | Andersen Lars H | Use of phthalyltaurine sulfonamide derivatives in treating epilepsy and arrythmia |
US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US5658940A (en) * | 1995-10-06 | 1997-08-19 | Celgene Corporation | Succinimide and maleimide cytokine inhibitors |
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AU782409B2 (en) * | 1999-11-12 | 2005-07-28 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
EP2263669A1 (en) * | 1999-11-12 | 2010-12-22 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
EP2255801A1 (en) * | 1999-11-12 | 2010-12-01 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
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US10385062B2 (en) | 2009-05-14 | 2019-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Thiophene derivatives |
AU2010246749B2 (en) * | 2009-05-14 | 2013-09-05 | Ganzhou Hemay Pharmaceutical Co., Ltd | Thiophene derivatives |
US9630975B2 (en) | 2009-05-14 | 2017-04-25 | Tianjin Hemay Bio-Tech Co., Ltd. | Thiophene derivatives |
US10611775B2 (en) | 2009-05-14 | 2020-04-07 | Tianjin Hemay Pharmaceutical Co., Ltd. | Thiophene derivatives |
US8952178B2 (en) | 2009-05-14 | 2015-02-10 | Tianjin Hemay Bio-Tech Co., Ltd. | Thiophene derivatives |
WO2010130224A1 (en) * | 2009-05-14 | 2010-11-18 | 天津和美生物技术有限公司 | Thiophene derivatives |
AU2010246749A8 (en) * | 2009-05-14 | 2014-03-20 | Ganzhou Hemay Pharmaceutical Co., Ltd | Thiophene derivatives |
CN101885731A (en) * | 2009-05-14 | 2010-11-17 | 天津和美生物技术有限公司 | Thiophene derivative |
CN107501290A (en) * | 2009-05-14 | 2017-12-22 | 天津合美医药科技有限公司 | Thiophene derivant |
AU2010246749B8 (en) * | 2009-05-14 | 2014-03-20 | Ganzhou Hemay Pharmaceutical Co., Ltd | Thiophene derivatives |
US9296689B2 (en) | 2009-06-18 | 2016-03-29 | Concert Pharmaceuticals, Inc. | Substituted isoindoline-1,3-dione derivatives |
US8883843B2 (en) | 2009-06-18 | 2014-11-11 | Concert Pharmaceuticals, Inc. | Substituted isoindoline-1,3-dione derivatives |
WO2012083153A1 (en) * | 2010-12-16 | 2012-06-21 | Nektar Therapeutics | Oligomer-containing apremilast moiety compounds |
CN103402980B (en) * | 2011-01-10 | 2016-06-29 | 细胞基因公司 | Phenethyl sulfone isoindoline derivative as PDE4 and/or cytokine inhibitor |
CN103402980A (en) * | 2011-01-10 | 2013-11-20 | 细胞基因公司 | Phenethylsulfone isoindoline derivatives as inhibitors of PDE 4 and/or cytokines |
EP2797581B1 (en) | 2011-12-27 | 2020-05-06 | Amgen (Europe) GmbH | Formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione |
EP2730278A1 (en) | 2012-11-08 | 2014-05-14 | Ratiopharm GmbH | Composition melt |
US9994522B2 (en) | 2014-05-11 | 2018-06-12 | Mapi Pharma Ltd. | Amorphous form of apremilast |
EP2949645A1 (en) | 2014-05-28 | 2015-12-02 | LEK Pharmaceuticals d.d. | Processes for the preparation of ß-aminosulfone compounds |
US9944599B2 (en) | 2014-05-28 | 2018-04-17 | Lek Pharmaceuticals D.D. | Processes for the preparation of beta-aminosulfone compounds |
WO2015181249A1 (en) | 2014-05-28 | 2015-12-03 | Lek Pharmaceuticals D.D. | PROCESSES FOR THE PREPARATION OF β-AMINOSULFONE COMPOUNDS |
CN106536479B (en) * | 2014-05-28 | 2018-10-19 | 斯洛文尼亚莱柯制药股份有限公司 | The method for being used to prepare beta-amino sulphones |
US10300042B2 (en) | 2014-06-23 | 2019-05-28 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
CN105461610A (en) * | 2014-09-10 | 2016-04-06 | 杭州普晒医药科技有限公司 | Apremilast crystal form, and preparation method, pharmaceutical composition and application thereof |
CN104496886A (en) * | 2014-12-11 | 2015-04-08 | 杭州新博思生物医药有限公司 | Preparation method of high-purity apremilast B crystal form |
WO2016161996A1 (en) | 2015-04-09 | 2016-10-13 | Zentiva, K.S. | A method of chiral resolution of the key intermediate of the synthesis of apremilast and its use for the preparation of pure apremilast |
WO2016169533A1 (en) | 2015-04-24 | 2016-10-27 | Zentiva, K.S. | A solid form of apremilast and a process for preparing the same |
US10370329B2 (en) * | 2015-04-27 | 2019-08-06 | Mylan Laboratories Limited | Process for the enantiomeric resolution of apremilast intermediates |
CN104945306B (en) * | 2015-05-25 | 2017-07-21 | 山东铭康医药技术有限公司 | The method for preparing optical voidness Apremilast |
CN104945306A (en) * | 2015-05-25 | 2015-09-30 | 山东铭康医药技术有限公司 | Method for preparing optically pure apremilast |
WO2016192694A1 (en) | 2015-06-05 | 2016-12-08 | Zentiva, K.S. | A process for preparing the key intermediate of apremilast, using enzymatic resolution of the racemic amines |
WO2016202806A1 (en) | 2015-06-15 | 2016-12-22 | Lek Pharmaceuticals D.D. | A novel synthetic pathway towards apremilast |
EP3106457A1 (en) | 2015-06-15 | 2016-12-21 | LEK Pharmaceuticals d.d. | A novel synthetic pathway towards apremilast |
EP3144393A1 (en) | 2015-09-18 | 2017-03-22 | LEK Pharmaceuticals d.d. | A synthetic pathway towards apremilast |
CN105294533A (en) * | 2015-12-02 | 2016-02-03 | 宋彤云 | Pharmaceutical composition for treating bone diseases |
US11337964B2 (en) | 2017-02-28 | 2022-05-24 | Kangpu Biopharmaceuticals, Ltd. | Isoindoline derivative, pharmaceutical composition and use thereof |
WO2018157779A1 (en) * | 2017-02-28 | 2018-09-07 | 康朴生物医药技术(上海)有限公司 | Novel isoindoline derivative, and pharmaceutical composition and application thereof |
CN110291065B (en) * | 2017-02-28 | 2022-08-19 | 康朴生物医药技术(上海)有限公司 | Novel isoindoline derivative, pharmaceutical composition and application thereof |
CN110291065A (en) * | 2017-02-28 | 2019-09-27 | 康朴生物医药技术(上海)有限公司 | A kind of new isoindoline derivative, its pharmaceutical composition and application |
US11628161B2 (en) | 2017-02-28 | 2023-04-18 | Kangpu Biopharmaceuticals, Ltd. | Isoindoline derivative, pharmaceutical composition and use thereof |
RU2728829C1 (en) * | 2017-02-28 | 2020-07-31 | Канпу Биофармасьютикалз, Лтд. | New isoindoline derivative, pharmaceutical composition including thereof and use thereof |
US10689332B2 (en) | 2017-04-04 | 2020-06-23 | Quimica Sintetica, S.A. | Racemic beta-aminosulfone compounds |
WO2018184936A1 (en) | 2017-04-04 | 2018-10-11 | Quimica Sintetica, S. A. | Resolution of racemic beta-aminosulfone compounds |
WO2018184933A1 (en) | 2017-04-04 | 2018-10-11 | Quimica Sintetica, S. A. | Racemic beta-aminosulfone compounds |
US11149003B2 (en) | 2017-04-04 | 2021-10-19 | Quimica Sintetica, S.A. | Resolution of racemic beta-aminosulfone compounds |
CN109422671A (en) * | 2017-08-31 | 2019-03-05 | 重庆医药工业研究院有限责任公司 | A kind of preparation method of Apremilast intermediate |
CN109422671B (en) * | 2017-08-31 | 2022-06-07 | 重庆医药工业研究院有限责任公司 | Preparation method of apremilast intermediate |
WO2019142124A1 (en) | 2018-01-17 | 2019-07-25 | Cadila Healthcare Limited | Pharmaceutical compositions for treatment of vitiligo |
WO2020020101A1 (en) * | 2018-07-22 | 2020-01-30 | 上海星叶医药科技有限公司 | Benzisoselenazolidone amine compound, and preparation method therefor and use thereof |
CN110423213B (en) * | 2019-08-22 | 2021-06-04 | 上海英诺富成生物科技有限公司 | Apremilast derivative and preparation method and application thereof |
CN110423213A (en) * | 2019-08-22 | 2019-11-08 | 上海英诺富成生物科技有限公司 | A kind of Apremilast derivative and the preparation method and application thereof |
WO2021259860A1 (en) | 2020-06-22 | 2021-12-30 | Biohorm, S.L. | Anti-inflammatory compounds and methods for their manufacture |
EP3929179A1 (en) | 2020-06-22 | 2021-12-29 | Biohorm, S.L. | Anti-inflammatory compounds and methods for their manufacture |
WO2023015944A1 (en) | 2021-08-13 | 2023-02-16 | 苏州璞正医药有限公司 | Substituted isoindolin-1,3-dione pde4 inhibitor and pharmaceutical use thereof |
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