WO2000024429A3 - Compound - Google Patents

Compound Download PDF

Info

Publication number
WO2000024429A3
WO2000024429A3 PCT/GB1999/003488 GB9903488W WO0024429A3 WO 2000024429 A3 WO2000024429 A3 WO 2000024429A3 GB 9903488 W GB9903488 W GB 9903488W WO 0024429 A3 WO0024429 A3 WO 0024429A3
Authority
WO
WIPO (PCT)
Prior art keywords
state
compound
contrast
oxidation
relaxivity
Prior art date
Application number
PCT/GB1999/003488
Other languages
French (fr)
Other versions
WO2000024429A2 (en
Inventor
Kenneth Kellar
Original Assignee
Nycomed Imaging As
Golding Louise
Kenneth Kellar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Golding Louise, Kenneth Kellar filed Critical Nycomed Imaging As
Priority to AU63535/99A priority Critical patent/AU6353599A/en
Priority to EP99950946A priority patent/EP1123116A2/en
Publication of WO2000024429A2 publication Critical patent/WO2000024429A2/en
Publication of WO2000024429A3 publication Critical patent/WO2000024429A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

The invention relates to the use as a contrast agent in MR imaging of a physiologically tolerable lanthanide compound or salt thereof having first and second oxidation states which differ in relaxivity by a factor of at least 5, and which is convertible in vivo from said first to said second oxidation state whereby contrast is enhanced in a body region in which conversion to said second state does or does not occur.
PCT/GB1999/003488 1998-10-22 1999-10-22 Compound WO2000024429A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU63535/99A AU6353599A (en) 1998-10-22 1999-10-22 Compound
EP99950946A EP1123116A2 (en) 1998-10-22 1999-10-22 Contrast agents with variable oxidation states

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9823175.6A GB9823175D0 (en) 1998-10-22 1998-10-22 Compound
GB9823175.6 1998-10-22
US10721298P 1998-11-05 1998-11-05

Publications (2)

Publication Number Publication Date
WO2000024429A2 WO2000024429A2 (en) 2000-05-04
WO2000024429A3 true WO2000024429A3 (en) 2000-10-19

Family

ID=10841125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/003488 WO2000024429A2 (en) 1998-10-22 1999-10-22 Compound

Country Status (4)

Country Link
EP (1) EP1123116A2 (en)
AU (1) AU6353599A (en)
GB (1) GB9823175D0 (en)
WO (1) WO2000024429A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8679453B2 (en) 2009-07-13 2014-03-25 Universidad De Guanajuato Contrast agents

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0450742A1 (en) * 1990-04-06 1991-10-09 Schering Aktiengesellschaft DTPA-Monoamids, pharmaceutical compositions containing them, their use and process for their preparation
WO1994027977A1 (en) * 1993-05-28 1994-12-08 Schering Aktiengesellschaft Use of macrocyclic metal complexes as temperature probes
DE19507822A1 (en) * 1995-02-21 1996-08-22 Schering Ag New di:ethylene-tri:amine penta:acetic acid amide derivs. and complexes
WO1996038184A2 (en) * 1995-06-02 1996-12-05 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
WO1998047539A1 (en) * 1997-04-22 1998-10-29 Nycomed Imaging As Nmr image compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0450742A1 (en) * 1990-04-06 1991-10-09 Schering Aktiengesellschaft DTPA-Monoamids, pharmaceutical compositions containing them, their use and process for their preparation
WO1994027977A1 (en) * 1993-05-28 1994-12-08 Schering Aktiengesellschaft Use of macrocyclic metal complexes as temperature probes
DE19507822A1 (en) * 1995-02-21 1996-08-22 Schering Ag New di:ethylene-tri:amine penta:acetic acid amide derivs. and complexes
WO1996038184A2 (en) * 1995-06-02 1996-12-05 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
WO1998047539A1 (en) * 1997-04-22 1998-10-29 Nycomed Imaging As Nmr image compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DESSER T S ET AL: "DYNAMICS OF TUMOR IMAGING WITH GD-DTPA-POLYETHYLENE GLYCOL POLYMERS: DEPENDENCE ON MOLECULAR WEIGHT", JOURNAL OF MAGNETIC RESONANCE IMAGING,US,OAK BROOK, IL, vol. 4, no. 3, 1 May 1994 (1994-05-01), pages 467 - 472, XP000576804 *
GUNNLAUGSSON, THORFINNUR ET AL: "Luminescent europium tetraazamacrocyclic complexes with wide range pH sensitivity", CHEM. COMMUN. (CAMBRIDGE) (1998), (4), 511-512, - February 1998 (1998-02-01), XP002136097 *

Also Published As

Publication number Publication date
WO2000024429A2 (en) 2000-05-04
EP1123116A2 (en) 2001-08-16
GB9823175D0 (en) 1998-12-16
AU6353599A (en) 2000-05-15

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