WO2000024358A3 - Synthesis and uses of thiopentone enantiomers - Google Patents

Synthesis and uses of thiopentone enantiomers Download PDF

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Publication number
WO2000024358A3
WO2000024358A3 PCT/AU1999/000919 AU9900919W WO0024358A3 WO 2000024358 A3 WO2000024358 A3 WO 2000024358A3 AU 9900919 W AU9900919 W AU 9900919W WO 0024358 A3 WO0024358 A3 WO 0024358A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiopentone
synthesis
enantiomers
relates
present
Prior art date
Application number
PCT/AU1999/000919
Other languages
French (fr)
Other versions
WO2000024358A2 (en
Inventor
Laurence Edward Mather
Colin C Duke
Original Assignee
Univ Sydney
Laurence Edward Mather
Colin C Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sydney, Laurence Edward Mather, Colin C Duke filed Critical Univ Sydney
Priority to AU11416/00A priority Critical patent/AU1141600A/en
Publication of WO2000024358A2 publication Critical patent/WO2000024358A2/en
Publication of WO2000024358A3 publication Critical patent/WO2000024358A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to the synthesis of R- and S- thiopentone and to an improved anaesthetic agent including R-thiopentone.
PCT/AU1999/000919 1998-10-22 1999-10-22 Synthesis and uses of thiopentone enantiomers WO2000024358A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU11416/00A AU1141600A (en) 1998-10-22 1999-10-22 Synthesis and uses of thiopentone enantiomers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP6638A AUPP663898A0 (en) 1998-10-22 1998-10-22 Synthesis and uses of thiopentone enantiomers
AUPP6638 1998-10-22

Publications (2)

Publication Number Publication Date
WO2000024358A2 WO2000024358A2 (en) 2000-05-04
WO2000024358A3 true WO2000024358A3 (en) 2000-08-17

Family

ID=3810858

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1999/000919 WO2000024358A2 (en) 1998-10-22 1999-10-22 Synthesis and uses of thiopentone enantiomers

Country Status (2)

Country Link
AU (1) AUPP663898A0 (en)
WO (1) WO2000024358A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG150495A1 (en) * 2004-02-04 2009-03-30 Api Corp Method for producing alcohol and carboxylic acid having optical activity
WO2006039841A1 (en) * 2004-10-14 2006-04-20 Wuxi Pharma Tech Co., Ltd. A NOVEL PROCESS FOR THE PREPARATION OF NONRACEMIC LONG CHAIN α-AMINO ACIDS DERIVATIVES

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C.E. COOK AND C.R. TALENT.: "Synthesis of (R)-5-(2'pentyl)barbituric acid derivatives of high optical purity", JOURNAL OF HETEROCYCLIC CHEMISTRY,, vol. 6, 1969, pages 203 - 206 *
Excerpta Med. Int. Congr. Ser., 1977, 399 (Anaesthesiology) L.C. Mark et al., "Barbiturate Stereoisomers: Direction for the Future?", pages 143-146. *
F.I. CARROLL AND R. MECK.: "Syntheses and optical rotatory dispersion studies of (S)-5-(2'pentyl)-barbituricacid derivatives", JOURNAL OF ORGANIC CHEMISTRY,, vol. 34, 1969, pages 2676 - 2680 *
Martindale: The extrapharmacopoeia. Edition 29, 1989, ed. J.E.F. Reynold. thiopentone sodium, pages 1125-1126. *
T.J. HALEY AND J.T. GIDLEY.: "Pharmacological comparison of R(+),S(-) and racemic thiopentone in mice", EUROPEAN JOURNAL OF PHARMACOLOGY,, vol. 36, 1976, pages 211 - 214 *
The Merck Index, Edition 12, 1996, pages 1595, entry 9487, tiopental sodium. *

Also Published As

Publication number Publication date
AUPP663898A0 (en) 1998-11-12
WO2000024358A2 (en) 2000-05-04

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