WO2000021577A3 - Compositions - Google Patents

Compositions Download PDF

Info

Publication number
WO2000021577A3
WO2000021577A3 PCT/GB1999/003344 GB9903344W WO0021577A3 WO 2000021577 A3 WO2000021577 A3 WO 2000021577A3 GB 9903344 W GB9903344 W GB 9903344W WO 0021577 A3 WO0021577 A3 WO 0021577A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agents
particulate compositions
compositions
vesicles
enhance
Prior art date
Application number
PCT/GB1999/003344
Other languages
French (fr)
Other versions
WO2000021577A2 (en
Inventor
Gregory Lynn Mcintire
Edward Richard Bacon
Original Assignee
Nycomed Imaging As
Cockbain Julian
Gregory Lynn Mcintire
Edward Richard Bacon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Cockbain Julian, Gregory Lynn Mcintire, Edward Richard Bacon filed Critical Nycomed Imaging As
Priority to AU62171/99A priority Critical patent/AU6217199A/en
Priority to GB0016470A priority patent/GB2349335A/en
Publication of WO2000021577A2 publication Critical patent/WO2000021577A2/en
Publication of WO2000021577A3 publication Critical patent/WO2000021577A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Water-soluble iodinated X-ray contrast agents can stabilise certain particulate compositions comprising vesicles or liquid droplets for thermal sterilisation. Such contrast agents also enhance the physical stability of particulate compositions to settling during storage.
PCT/GB1999/003344 1998-10-09 1999-10-08 Compositions WO2000021577A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU62171/99A AU6217199A (en) 1998-10-09 1999-10-08 Compositions
GB0016470A GB2349335A (en) 1998-10-09 1999-10-08 Compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9822158.3A GB9822158D0 (en) 1998-10-09 1998-10-09 Compositions
GB9822158.3 1998-10-09

Publications (2)

Publication Number Publication Date
WO2000021577A2 WO2000021577A2 (en) 2000-04-20
WO2000021577A3 true WO2000021577A3 (en) 2000-07-27

Family

ID=10840358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/003344 WO2000021577A2 (en) 1998-10-09 1999-10-08 Compositions

Country Status (3)

Country Link
AU (1) AU6217199A (en)
GB (2) GB9822158D0 (en)
WO (1) WO2000021577A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004529161A (en) 2001-05-04 2004-09-24 トゥラリック インコーポレイテッド Fused heterocyclic compounds
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
CN1335182A (en) * 2001-08-08 2002-02-13 华中科技大学 Insulin spray for oral cavity and its prepn process
US20040067221A1 (en) * 2002-05-22 2004-04-08 Medtronic, Inc. Cell delivery fluid for prevention of cell settling in delivery system
US20050287125A1 (en) * 2002-05-22 2005-12-29 Medtronic, Inc. Cell delivery fluid for prevention of cell settling in delivery system
CN101134757A (en) 2002-11-06 2008-03-05 安姆根有限公司 Fused heterocyclic compounds

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2613172A (en) * 1949-08-10 1952-10-07 American Cystoscope Makers Inc X-ray contrast compositions
WO1980001244A1 (en) * 1978-12-19 1980-06-26 Bykgulden Lomberg Chem Fab X-ray contrast media solutions
EP0128578A1 (en) * 1983-06-14 1984-12-19 Byk Gulden Lomberg Chemische Fabrik GmbH Ethanolic suspensions of contrast agents
EP0602691A2 (en) * 1992-12-15 1994-06-22 NanoSystems L.L.C. Controlled precipitation of particulate diagnostic imaging contrast agents
WO1996007434A1 (en) * 1994-09-06 1996-03-14 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1997006132A1 (en) * 1995-08-10 1997-02-20 Nanosystems L.L.C. Triiodoalkylphenyl esters as novel x-ray contrast agents
WO1997036576A1 (en) * 1996-04-01 1997-10-09 Korea Institute Of Science And Technology Preparation method of emulsion for chemoembolization
WO1998041239A1 (en) * 1997-03-14 1998-09-24 Nycomed Imaging As Compositions comprising flexible particles, non-ionic surfactant and non-ionic cloud-point modifier
WO1998048847A1 (en) * 1997-04-25 1998-11-05 Nycomed Imaging As Nanoparticle composition containing iodinated x-ray contrast agent as stabilizer for thermal sterilization

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2613172A (en) * 1949-08-10 1952-10-07 American Cystoscope Makers Inc X-ray contrast compositions
WO1980001244A1 (en) * 1978-12-19 1980-06-26 Bykgulden Lomberg Chem Fab X-ray contrast media solutions
EP0128578A1 (en) * 1983-06-14 1984-12-19 Byk Gulden Lomberg Chemische Fabrik GmbH Ethanolic suspensions of contrast agents
EP0602691A2 (en) * 1992-12-15 1994-06-22 NanoSystems L.L.C. Controlled precipitation of particulate diagnostic imaging contrast agents
WO1996007434A1 (en) * 1994-09-06 1996-03-14 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1997006132A1 (en) * 1995-08-10 1997-02-20 Nanosystems L.L.C. Triiodoalkylphenyl esters as novel x-ray contrast agents
WO1997036576A1 (en) * 1996-04-01 1997-10-09 Korea Institute Of Science And Technology Preparation method of emulsion for chemoembolization
WO1998041239A1 (en) * 1997-03-14 1998-09-24 Nycomed Imaging As Compositions comprising flexible particles, non-ionic surfactant and non-ionic cloud-point modifier
WO1998048847A1 (en) * 1997-04-25 1998-11-05 Nycomed Imaging As Nanoparticle composition containing iodinated x-ray contrast agent as stabilizer for thermal sterilization

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOHLE FLORIAN ET AL: "New iodinated contrast agents: The physicochemical and biological properties of asymmetric dimers.", INVESTIGATIVE RADIOLOGY 1994, vol. 29, no. SUPPL. 2, 1994, pages S264 - S266, XP000906758, ISSN: 0020-9996 *
DICK ARMIN ET AL: "Computed tomography of experimental liver abscesses using a new liposomal contrast agent.", INVESTIGATIVE RADIOLOGY 1996, vol. 31, no. 4, 1996, pages 194 - 203, XP000906757, ISSN: 0020-9996 *
HORI S ET AL: "NEW CONTRAST MATERIAL FOR CT OF THE LIVER AND SPLEEN USING IODINATED OIL EMULSIFIED BY A NON-IONIC CONTRAST MATERIAL", NIPPON ACTA RADIOLOGICA 1988, vol. 48, no. 12, 1988, pages 1503 - 1510, XP000906834, ISSN: 0048-0428 *
KANEMATSU MASAYUKI: "Transcatheter arterial chemoembolization therapy with epirubicin hydrochloride, mitomycin C-iohexol-lipiodol emulsion (EMILE) for hepatocellular carcinoma.", JOURNAL OF GASTROENTEROLOGY 1995, vol. 30, no. 2, 1995, pages 215 - 223, XP000906736 *

Also Published As

Publication number Publication date
WO2000021577A2 (en) 2000-04-20
GB0016470D0 (en) 2000-08-23
GB2349335A (en) 2000-11-01
GB9822158D0 (en) 1998-12-02
AU6217199A (en) 2000-05-01

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