WO2000020441A3 - Cyclic peptides as antifungal agents - Google Patents

Cyclic peptides as antifungal agents Download PDF

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Publication number
WO2000020441A3
WO2000020441A3 PCT/US1999/022844 US9922844W WO0020441A3 WO 2000020441 A3 WO2000020441 A3 WO 2000020441A3 US 9922844 W US9922844 W US 9922844W WO 0020441 A3 WO0020441 A3 WO 0020441A3
Authority
WO
WIPO (PCT)
Prior art keywords
antifungal agents
cyclic peptides
antifungal
antipneumocystic
treating
Prior art date
Application number
PCT/US1999/022844
Other languages
French (fr)
Other versions
WO2000020441A2 (en
Inventor
Wei-Bo Wang
Qun Li
Lisa A Hasvold
Hui-Ju Chen
Leping Li
Paul A Lartey
Akiyo Claiborne
Beth A Steiner
Youssef Bennani
Daniel Dickman
Hong Ding
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to AU64084/99A priority Critical patent/AU6408499A/en
Publication of WO2000020441A2 publication Critical patent/WO2000020441A2/en
Publication of WO2000020441A3 publication Critical patent/WO2000020441A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a novel cyclic hexapeptide having antifungal and antipneumocystic activity as well as pharmaceutical compositions comprising, methods of treating using, and a process for preparing the claimed compounds.
PCT/US1999/022844 1998-10-05 1999-10-01 Cyclic peptides as antifungal agents WO2000020441A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64084/99A AU6408499A (en) 1998-10-05 1999-10-01 Cyclic peptides as antifungal agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16630798A 1998-10-05 1998-10-05
US09/166,307 1998-10-05

Publications (2)

Publication Number Publication Date
WO2000020441A2 WO2000020441A2 (en) 2000-04-13
WO2000020441A3 true WO2000020441A3 (en) 2000-11-23

Family

ID=22602704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022844 WO2000020441A2 (en) 1998-10-05 1999-10-01 Cyclic peptides as antifungal agents

Country Status (2)

Country Link
AU (1) AU6408499A (en)
WO (1) WO2000020441A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210130411A1 (en) 2018-04-25 2021-05-06 Stella PEÑA BARÓN Cyclic hexapeptides compounds with anti-malarial activity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541160A (en) * 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5569646A (en) * 1993-05-17 1996-10-29 Fujisawa Pharmaceutical Co., Ltd. Polypeptide compound and a process for preparation thereof
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569646A (en) * 1993-05-17 1996-10-29 Fujisawa Pharmaceutical Co., Ltd. Polypeptide compound and a process for preparation thereof
US5541160A (en) * 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents

Also Published As

Publication number Publication date
AU6408499A (en) 2000-04-26
WO2000020441A2 (en) 2000-04-13

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