WO2000014537A3 - Immunoconjugate for diagnosis of multidrug resistance - Google Patents

Immunoconjugate for diagnosis of multidrug resistance Download PDF

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Publication number
WO2000014537A3
WO2000014537A3 PCT/US1999/020017 US9920017W WO0014537A3 WO 2000014537 A3 WO2000014537 A3 WO 2000014537A3 US 9920017 W US9920017 W US 9920017W WO 0014537 A3 WO0014537 A3 WO 0014537A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
multidrug resistant
immunoconjugate
diagnosis
multidrug
immunoconjugates
Prior art date
Application number
PCT/US1999/020017
Other languages
French (fr)
Other versions
WO2000014537A2 (en )
Inventor
David M Goldenberg
Original Assignee
Immunomedics Inc
David M Goldenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody conjugates with carriers being antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody

Abstract

Immunoconjugates of a diagnostic agent and an antibody component that binds an epitope of a multidrug transporter protein are disclosed. Thesse immunoconjugates are used in in vivo diagnostic methods to determine whether the failure of traditional chemotherapy is due to the presence of multidrug resistant tumor cells, multidrug resistant HIV-infected cells or multidrug resistant infectious agents.
PCT/US1999/020017 1998-09-04 1999-09-01 Immunoconjugate for diagnosis of multidrug resistance WO2000014537A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US9930498 true 1998-09-04 1998-09-04
US60/099,304 1998-09-04

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU5799199A AU5799199A (en) 1998-09-04 1999-09-01 Diagnosis of multidrug resistance in cancer and infectious lesions

Publications (2)

Publication Number Publication Date
WO2000014537A2 true WO2000014537A2 (en) 2000-03-16
WO2000014537A3 true true WO2000014537A3 (en) 2000-07-20

Family

ID=22274363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020017 WO2000014537A3 (en) 1998-09-04 1999-09-01 Immunoconjugate for diagnosis of multidrug resistance

Country Status (1)

Country Link
WO (1) WO2000014537A3 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008802A1 (en) * 1990-10-29 1992-05-29 Cetus Oncology Corporation Bispecific antibodies, method of production, and uses thereof
WO1993002105A1 (en) * 1991-07-19 1993-02-04 Hybritech Incorporated Trifunctional compounds having specificity for multi-drug resistant cells
WO1993019094A1 (en) * 1992-03-20 1993-09-30 Board Of Trustees Of The University Of Illinois A monoclonal antibody to a human mdr1 multidrug resistance gene product, and uses
WO1993025700A1 (en) * 1992-06-17 1993-12-23 Istituto Superiore Di Sanita' Monoclonal antibodies to glycoprotein p
WO1996004313A1 (en) * 1994-08-05 1996-02-15 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008802A1 (en) * 1990-10-29 1992-05-29 Cetus Oncology Corporation Bispecific antibodies, method of production, and uses thereof
WO1993002105A1 (en) * 1991-07-19 1993-02-04 Hybritech Incorporated Trifunctional compounds having specificity for multi-drug resistant cells
WO1993019094A1 (en) * 1992-03-20 1993-09-30 Board Of Trustees Of The University Of Illinois A monoclonal antibody to a human mdr1 multidrug resistance gene product, and uses
WO1993025700A1 (en) * 1992-06-17 1993-12-23 Istituto Superiore Di Sanita' Monoclonal antibodies to glycoprotein p
WO1996004313A1 (en) * 1994-08-05 1996-02-15 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KARTNER N. ET AL: "Detection of P-glycoprotein in multidrug resistant cell lines by monoclonal antibodies", NATURE, vol. 316, no. 29, August 1985 (1985-08-01), pages 820 - 823, XP000857277 *

Also Published As

Publication number Publication date Type
WO2000014537A2 (en) 2000-03-16 application

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