WO2000014113A3 - Method of stimulating prosaposin receptor activity - Google Patents

Method of stimulating prosaposin receptor activity Download PDF

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Publication number
WO2000014113A3
WO2000014113A3 PCT/US1999/020829 US9920829W WO0014113A3 WO 2000014113 A3 WO2000014113 A3 WO 2000014113A3 US 9920829 W US9920829 W US 9920829W WO 0014113 A3 WO0014113 A3 WO 0014113A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor activity
prosaposin receptor
stimulating
cells
prosaposin
Prior art date
Application number
PCT/US1999/020829
Other languages
French (fr)
Other versions
WO2000014113A2 (en
Inventor
John S O'brien
D Elliot Parks
Original Assignee
Myelos Corp
Brien John S O
D Elliot Parks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020017003018A priority Critical patent/KR20010079770A/en
Priority to IL14186599A priority patent/IL141865A0/en
Priority to EP99948186A priority patent/EP1112090A2/en
Priority to BR9913870-0A priority patent/BR9913870A/en
Priority to HU0103994A priority patent/HUP0103994A3/en
Priority to AU61415/99A priority patent/AU6141599A/en
Priority to JP2000568870A priority patent/JP2002524468A/en
Priority to CA002341325A priority patent/CA2341325A1/en
Application filed by Myelos Corp, Brien John S O, D Elliot Parks filed Critical Myelos Corp
Priority to PCT/US1999/020829 priority patent/WO2000014113A2/en
Publication of WO2000014113A2 publication Critical patent/WO2000014113A2/en
Publication of WO2000014113A3 publication Critical patent/WO2000014113A3/en
Priority to US09/802,617 priority patent/US20020028783A1/en
Priority to HK02100071.0A priority patent/HK1039744A1/en
Priority to US10/293,819 priority patent/US20030096786A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for stimulating prosaposin receptor activity in a cell by transfecting the cell with a DNA or RNA molecule encoding prosaposin or a prosaposin receptor agonist. The DNA or RNA molecule is administered either in vivo or used to transfect neural cells or neural stem cells ex vivo followed by reintroduction of the cells into an individual.
PCT/US1999/020829 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity WO2000014113A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2000568870A JP2002524468A (en) 1998-09-09 1999-09-09 Methods of stimulating prosaposin receptor activity
EP99948186A EP1112090A2 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
BR9913870-0A BR9913870A (en) 1998-09-09 1999-09-09 Method of stimulation of prosaposine receptor activity
HU0103994A HUP0103994A3 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
AU61415/99A AU6141599A (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
KR1020017003018A KR20010079770A (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
CA002341325A CA2341325A1 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
IL14186599A IL141865A0 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
PCT/US1999/020829 WO2000014113A2 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity
US09/802,617 US20020028783A1 (en) 1999-09-09 2001-03-09 Method of stimulating prosaposin receptor activity
HK02100071.0A HK1039744A1 (en) 1998-09-09 2002-01-04 Method of stimulating prosaposin receptor activity
US10/293,819 US20030096786A1 (en) 1998-09-09 2002-11-13 Methods of treating neurodegenerative or myelination disorders using prosaposin-derived peptides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14997798A 1998-09-09 1998-09-09
US09/149,977 1998-09-09
PCT/US1999/020829 WO2000014113A2 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US14997798A Continuation 1998-09-09 1998-09-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/802,617 Continuation US20020028783A1 (en) 1998-09-09 2001-03-09 Method of stimulating prosaposin receptor activity

Publications (2)

Publication Number Publication Date
WO2000014113A2 WO2000014113A2 (en) 2000-03-16
WO2000014113A3 true WO2000014113A3 (en) 2000-11-16

Family

ID=26795763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020829 WO2000014113A2 (en) 1998-09-09 1999-09-09 Method of stimulating prosaposin receptor activity

Country Status (9)

Country Link
EP (1) EP1112090A2 (en)
JP (1) JP2002524468A (en)
KR (1) KR20010079770A (en)
AU (1) AU6141599A (en)
BR (1) BR9913870A (en)
CA (1) CA2341325A1 (en)
HK (1) HK1039744A1 (en)
HU (1) HUP0103994A3 (en)
WO (1) WO2000014113A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571787A (en) 1993-07-30 1996-11-05 Myelos Corporation Prosaposin as a neurotrophic factor
BR112020006671A2 (en) 2017-10-03 2020-12-01 Prevail Therapeutics, Inc. genetic therapies for lysosomal disorders
CA3078464A1 (en) * 2017-10-03 2019-04-11 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003821A1 (en) * 1993-07-30 1995-02-09 The Regents Of The University Of California Prosaposin and cytokine-derived peptides as therapeutic agents
WO1995005452A2 (en) * 1993-08-12 1995-02-23 Cytotherapeutics, Inc. Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
WO1999012559A1 (en) * 1997-09-09 1999-03-18 The Regents Of The University Of California Inhibition of apoptotis using prosaposin receptor agonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003821A1 (en) * 1993-07-30 1995-02-09 The Regents Of The University Of California Prosaposin and cytokine-derived peptides as therapeutic agents
WO1995005452A2 (en) * 1993-08-12 1995-02-23 Cytotherapeutics, Inc. Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
WO1999012559A1 (en) * 1997-09-09 1999-03-18 The Regents Of The University Of California Inhibition of apoptotis using prosaposin receptor agonists

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
AEBISCHER ET AL: "INTRATHECAL DELIVERY OF CNTF USING ENCAPSULATED GENETICALLY MODIFIED XENOGENEIC CELLS IN AMYOTROPHIC LALTERAL SCLEOSIS PATIENTS", NATURE MEDICINE, vol. 2, 1996, pages 696 - 699, XP002135052 *
AMERICAN JOURNAL OF HUMAN GENETICS, (1992 JUN) 50 (6) 1252-8. *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; RAFI M A ET AL: "Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured cells from a patient with SAP-1 deficiency.", XP002135053, retrieved from STN Database accession no. 92286276 *
HIRAIWA ET AL: "CELL DEATH PREVENTION, MITOGEN-ACTIVATED PROTEIN KINASE STIMULATION, AND INCREASED SULFATIDE CONCENTRATIONS IN SCHWANN CELLS AND OLIGODENDROCYTES BY PROSAPOSIN AND PROSAPTIDES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SICENCES, USA, vol. 94, 1997, pages 4778 - 4781, XP002135051 *
KOTANI E A: "A hydrophilic peptide comprising 18 amino acid residues of the prosaposin sequence has neurotrophic activity in vitro and in vivo", JOURNAL OF NEUROCHEMISTRY,US,NEW YORK, NY, vol. 5, no. 66, 1 January 1996 (1996-01-01), pages 2197 - 2200, XP002077621, ISSN: 0022-3042 *
MILLER N ET AL: "TARGETED VECTORS FOR GENE THERAPY", FASEB JOURNAL,US,FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, vol. 9, no. 2, 1 February 1995 (1995-02-01), pages 190 - 199, XP000616414, ISSN: 0892-6638 *
WALTHER W ET AL: "EMPLOYMENT OF THE MDR1 PROMOTER FOR THE CHEMOTHERAPY-INDUCIBLE EXPRESSION OF THERAPEUTIC GENES IN CANCER GENE THERAPY", GENE THERAPY,GB,MACMILLAN PRESS LTD., BASINGSTOKE, vol. 4, no. 6, 1 June 1997 (1997-06-01), pages 544 - 552, XP002052739, ISSN: 0969-7128 *
WILKINSON G W G ET AL: "CONSTITUTIVE AND ENHANCED EXPRESSION FROM THE CMV MAJOR IE PROMOTERIN A DEFECTIVE ADENOVIRUS VECTOR", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 20, no. 9, 11 May 1992 (1992-05-11), pages 2233 - 2239, XP002007821, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
BR9913870A (en) 2001-07-24
WO2000014113A2 (en) 2000-03-16
HK1039744A1 (en) 2002-05-10
KR20010079770A (en) 2001-08-22
EP1112090A2 (en) 2001-07-04
HUP0103994A2 (en) 2002-02-28
AU6141599A (en) 2000-03-27
JP2002524468A (en) 2002-08-06
CA2341325A1 (en) 2000-03-16
HUP0103994A3 (en) 2004-03-01

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