WO2000013701A2 - Angiogenically effective unit dose of fgf-2 and method of use - Google Patents
Angiogenically effective unit dose of fgf-2 and method of use Download PDFInfo
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- WO2000013701A2 WO2000013701A2 PCT/US1999/019770 US9919770W WO0013701A2 WO 2000013701 A2 WO2000013701 A2 WO 2000013701A2 US 9919770 W US9919770 W US 9919770W WO 0013701 A2 WO0013701 A2 WO 0013701A2
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- WIPO (PCT)
- Prior art keywords
- unit dose
- fgf
- mutein
- rfgf
- active fragment
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims
Priority Applications (5)
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AU60223/99A AU6022399A (en) | 1998-09-03 | 1999-08-27 | Angiogenically effective unit dose of fgf-2 and method of use |
DE69921348T DE69921348T2 (en) | 1998-09-03 | 1999-08-27 | FGF-2 ANGIOGENIC EFFECTIVE UNIT DOSE AND ITS USE |
EP99968630A EP1121142B1 (en) | 1998-09-03 | 1999-08-27 | Angiogenically effective unit dose of fgf-2 and use thereof |
JP2000568509A JP5329729B2 (en) | 1998-09-03 | 1999-08-27 | Unit dose FGF-2 effective for angiogenesis and methods of use |
AT99968630T ATE279937T1 (en) | 1998-09-03 | 1999-08-27 | FGF-2 ANGIOGENIC EFFECTIVE UNIT DOSE AND ITS USE |
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WO2000013701A2 true WO2000013701A2 (en) | 2000-03-16 |
WO2000013701A3 WO2000013701A3 (en) | 2000-08-03 |
WO2000013701A9 WO2000013701A9 (en) | 2000-10-05 |
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PCT/US1999/019770 WO2000013701A2 (en) | 1998-09-03 | 1999-08-27 | Angiogenically effective unit dose of fgf-2 and method of use |
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EP (2) | EP1121142B1 (en) |
JP (2) | JP5329729B2 (en) |
AT (2) | ATE434440T1 (en) |
AU (1) | AU6022399A (en) |
DE (2) | DE69941034D1 (en) |
ES (2) | ES2233101T3 (en) |
HK (1) | HK1075409A1 (en) |
WO (1) | WO2000013701A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001013031A2 (en) * | 1999-08-13 | 2001-02-22 | Chiron Corporation | Dose of an angiogenic factor and method of administering to improve myocardial blood flow |
WO2001068125A2 (en) * | 2000-03-10 | 2001-09-20 | Chiron Corporation | Methods and compositions for the treatment and prevention of erectile dysfunction |
WO2001098346A2 (en) * | 2000-06-22 | 2001-12-27 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
WO2002058720A2 (en) * | 2001-01-26 | 2002-08-01 | Chiron Corporation | Angiogenically effective unit dose of fgf-2 and method of use |
EP1894570A2 (en) * | 2000-06-22 | 2008-03-05 | Novartis Vaccines and Diagnostics, Inc. | Methods and compositions for the treatment of peripheral artery disease |
US7511019B2 (en) | 1998-10-13 | 2009-03-31 | Novartis Vaccines And Diagnostics, Inc. | Method of treating coronary artery disease by administering FGF-4 |
US8618052B2 (en) | 1998-10-13 | 2013-12-31 | Novartis Vaccines And Diagnostics, Inc. | Method of treating coronary artery disease by administering FGF-5 |
EP3615560A4 (en) * | 2017-04-26 | 2020-12-23 | University of Cincinnati | Compositions of fibroblast growth factor ligands and methods of treating patients unergoing ischemia-reperfusion therapy |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2622562T3 (en) | 2008-12-09 | 2017-07-06 | Pfizer Vaccines Llc | IgE CH3 peptide vaccine |
Family Cites Families (6)
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US4956455A (en) | 1984-03-05 | 1990-09-11 | The Salk Institute For Biological Studies | Bovine fibroblast growth factor |
US5155214A (en) | 1984-03-05 | 1992-10-13 | The Salk Institute For Biological Studies | Basic fibroblast growth factor |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US5439818A (en) | 1985-09-12 | 1995-08-08 | Scios Nova Inc. | DNA encoding human recombinant basic fibroblast growth factor |
DE3689845T3 (en) * | 1985-09-12 | 2001-11-15 | Scios Inc | RECOMBINANT FIBROBLAST GROWTH FACTOR. |
US5852177A (en) * | 1987-02-24 | 1998-12-22 | Takeda Chemical Industries, Ltd. | Basic fibroblast growth factor (bFGF) muteins |
-
1999
- 1999-08-27 ES ES99968630T patent/ES2233101T3/en not_active Expired - Lifetime
- 1999-08-27 AT AT04018831T patent/ATE434440T1/en not_active IP Right Cessation
- 1999-08-27 WO PCT/US1999/019770 patent/WO2000013701A2/en active IP Right Grant
- 1999-08-27 ES ES04018831T patent/ES2327839T3/en not_active Expired - Lifetime
- 1999-08-27 DE DE69941034T patent/DE69941034D1/en not_active Expired - Lifetime
- 1999-08-27 AU AU60223/99A patent/AU6022399A/en not_active Abandoned
- 1999-08-27 JP JP2000568509A patent/JP5329729B2/en not_active Expired - Lifetime
- 1999-08-27 DE DE69921348T patent/DE69921348T2/en not_active Expired - Lifetime
- 1999-08-27 EP EP99968630A patent/EP1121142B1/en not_active Expired - Lifetime
- 1999-08-27 AT AT99968630T patent/ATE279937T1/en not_active IP Right Cessation
- 1999-08-27 EP EP09161208.5A patent/EP2123292B1/en not_active Expired - Lifetime
-
2005
- 2005-10-27 HK HK05109562.4A patent/HK1075409A1/en not_active IP Right Cessation
-
2010
- 2010-04-08 JP JP2010089915A patent/JP2010163457A/en active Pending
Non-Patent Citations (3)
Title |
---|
SCHUMACHER B. ET AL: "Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease." CIRCULATION, (24 FEB 1998) 97/7 (645-650). , XP000891969 * |
SELLKE FRANK W ET AL: "Therapeutic angiogenesis with basic fibroblast growth factor: Technique and early results." ANNALS OF THORACIC SURGERY JUNE, 1998, vol. 65, no. 6, June 1998 (1998-06), pages 1540-1544, XP000891950 ISSN: 0003-4975 * |
UCHIDA YASUMI ET AL: "Angiogenic therapy of acute myocardial infarction by intrapericardial injection of basic fibroblast growth factor and heparin sulfate: An experimental study." AMERICAN HEART JOURNAL 1995, vol. 130, no. 6, 1995, pages 1182-1188, XP000891915 ISSN: 0002-8703 * |
Cited By (22)
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US9149507B2 (en) | 1998-10-13 | 2015-10-06 | Novartis Vaccines and Dignostics, Inc. | Method of treating coronary artery disease by administering FGF-9 |
US8618052B2 (en) | 1998-10-13 | 2013-12-31 | Novartis Vaccines And Diagnostics, Inc. | Method of treating coronary artery disease by administering FGF-5 |
US7858584B2 (en) | 1998-10-13 | 2010-12-28 | Novartis Vaccines And Diagnostics, Inc. | Angiogenically effective unit dose of FGF and method of administering |
US7112560B2 (en) | 1998-10-13 | 2006-09-26 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
US7541333B2 (en) | 1998-10-13 | 2009-06-02 | Novartis Vaccines And Diagnostics, Inc. | Angiogenically effective unit dose of FGF-2 and method of use |
US7511019B2 (en) | 1998-10-13 | 2009-03-31 | Novartis Vaccines And Diagnostics, Inc. | Method of treating coronary artery disease by administering FGF-4 |
US7531511B2 (en) | 1999-08-13 | 2009-05-12 | Novartis Vaccines And Diagnostics, Inc. | Method for inducing angiogenesis or vascular perfusion in the myocardium comprising administering FGF-2 |
WO2001013031A3 (en) * | 1999-08-13 | 2001-08-30 | Chiron Corp | Dose of an angiogenic factor and method of administering to improve myocardial blood flow |
US8178493B2 (en) | 1999-08-13 | 2012-05-15 | Novartis Vaccines And Diagnostics, Inc. | Method for inducing angiogenesis in a heart of a patient |
WO2001013031A2 (en) * | 1999-08-13 | 2001-02-22 | Chiron Corporation | Dose of an angiogenic factor and method of administering to improve myocardial blood flow |
WO2001068125A2 (en) * | 2000-03-10 | 2001-09-20 | Chiron Corporation | Methods and compositions for the treatment and prevention of erectile dysfunction |
WO2001068125A3 (en) * | 2000-03-10 | 2002-03-21 | Chiron Corp | Methods and compositions for the treatment and prevention of erectile dysfunction |
EP1894570A3 (en) * | 2000-06-22 | 2009-11-11 | Novartis Vaccines and Diagnostics, Inc. | Methods and compositions for the treatment of peripheral artery disease |
EP1894570A2 (en) * | 2000-06-22 | 2008-03-05 | Novartis Vaccines and Diagnostics, Inc. | Methods and compositions for the treatment of peripheral artery disease |
US7541337B2 (en) | 2000-06-22 | 2009-06-02 | Novartis Vaccines And Diagnostics, Inc. | Methods and compositions for the treatment of peripheral artery disease |
WO2001098346A3 (en) * | 2000-06-22 | 2003-05-01 | Chiron Corp | Methods and compositions for the treatment of peripheral artery disease |
WO2001098346A2 (en) * | 2000-06-22 | 2001-12-27 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
JP2004533411A (en) * | 2001-01-26 | 2004-11-04 | カイロン コーポレイション | Unit doses of angiogenically effective FGF-2 and methods of use |
JP2010053144A (en) * | 2001-01-26 | 2010-03-11 | Novartis Vaccines & Diagnostics Inc | Angiogenically effective unit dose of fgf-2 and method of use |
WO2002058720A3 (en) * | 2001-01-26 | 2003-05-15 | Chiron Corp | Angiogenically effective unit dose of fgf-2 and method of use |
WO2002058720A2 (en) * | 2001-01-26 | 2002-08-01 | Chiron Corporation | Angiogenically effective unit dose of fgf-2 and method of use |
EP3615560A4 (en) * | 2017-04-26 | 2020-12-23 | University of Cincinnati | Compositions of fibroblast growth factor ligands and methods of treating patients unergoing ischemia-reperfusion therapy |
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Publication number | Publication date |
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ES2327839T3 (en) | 2009-11-04 |
JP2010163457A (en) | 2010-07-29 |
JP2002524420A (en) | 2002-08-06 |
EP2123292A1 (en) | 2009-11-25 |
EP2123292B1 (en) | 2016-05-04 |
DE69921348D1 (en) | 2004-11-25 |
DE69941034D1 (en) | 2009-08-06 |
ATE279937T1 (en) | 2004-11-15 |
WO2000013701A3 (en) | 2000-08-03 |
ATE434440T1 (en) | 2009-07-15 |
JP5329729B2 (en) | 2013-10-30 |
HK1075409A1 (en) | 2005-12-16 |
EP1121142A2 (en) | 2001-08-08 |
AU6022399A (en) | 2000-03-27 |
WO2000013701A9 (en) | 2000-10-05 |
DE69921348T2 (en) | 2006-02-09 |
ES2233101T3 (en) | 2005-06-01 |
EP1121142B1 (en) | 2004-10-20 |
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