WO2000012760A3 - Toxicological response markers - Google Patents

Toxicological response markers Download PDF

Info

Publication number
WO2000012760A3
WO2000012760A3 PCT/US1999/019768 US9919768W WO0012760A3 WO 2000012760 A3 WO2000012760 A3 WO 2000012760A3 US 9919768 W US9919768 W US 9919768W WO 0012760 A3 WO0012760 A3 WO 0012760A3
Authority
WO
WIPO (PCT)
Prior art keywords
response markers
toxicological response
composition
relates
present
Prior art date
Application number
PCT/US1999/019768
Other languages
French (fr)
Other versions
WO2000012760A2 (en
Inventor
Mary Jane Cunningham
Gary B Zweiger
Scott R Panzer
Jeffrey J Seilhamer
Original Assignee
Incyte Pharma Inc
Mary Jane Cunningham
Gary B Zweiger
Scott R Panzer
Jeffrey J Seilhamer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/141,825 external-priority patent/US6403778B1/en
Priority claimed from US09/172,108 external-priority patent/US6160104A/en
Priority claimed from US09/172,711 external-priority patent/US6160105A/en
Application filed by Incyte Pharma Inc, Mary Jane Cunningham, Gary B Zweiger, Scott R Panzer, Jeffrey J Seilhamer filed Critical Incyte Pharma Inc
Priority to CA002340589A priority Critical patent/CA2340589A1/en
Priority to JP2000567743A priority patent/JP2002523112A/en
Priority to AU60222/99A priority patent/AU6022299A/en
Priority to EP99968250A priority patent/EP1108067A2/en
Publication of WO2000012760A2 publication Critical patent/WO2000012760A2/en
Publication of WO2000012760A3 publication Critical patent/WO2000012760A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a composition comprising a plurality of nucleic acid molecules. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound.
PCT/US1999/019768 1998-08-28 1999-08-27 Toxicological response markers WO2000012760A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002340589A CA2340589A1 (en) 1998-08-28 1999-08-27 Toxicological response markers
JP2000567743A JP2002523112A (en) 1998-08-28 1999-08-27 Toxicological markers
AU60222/99A AU6022299A (en) 1998-08-28 1999-08-27 Toxicological response markers
EP99968250A EP1108067A2 (en) 1998-08-28 1999-08-27 Toxicological response markers

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/141,825 US6403778B1 (en) 1998-05-04 1998-08-28 Toxicological response markers
US09/141,825 1998-08-28
US09/172,711 1998-10-13
US09/172,108 US6160104A (en) 1998-10-13 1998-10-13 Markers for peroxisomal proliferators
US09/172,108 1998-10-13
US09/172,711 US6160105A (en) 1998-10-13 1998-10-13 Monitoring toxicological responses

Publications (2)

Publication Number Publication Date
WO2000012760A2 WO2000012760A2 (en) 2000-03-09
WO2000012760A3 true WO2000012760A3 (en) 2000-08-03

Family

ID=27385714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019768 WO2000012760A2 (en) 1998-08-28 1999-08-27 Toxicological response markers

Country Status (5)

Country Link
EP (1) EP1108067A2 (en)
JP (1) JP2002523112A (en)
AU (1) AU6022299A (en)
CA (1) CA2340589A1 (en)
WO (1) WO2000012760A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881571B1 (en) 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
FR2798392B1 (en) * 1999-09-13 2005-07-15 Exonhit Therapeutics Sa GENETIC MARKERS OF TOXICITY, PREPARATION AND USES
WO2002008453A2 (en) * 2000-07-21 2002-01-31 Phase-1 Molecular Toxicology Canine toxicity genes
AU2001280889A1 (en) * 2000-07-31 2002-02-13 Gene Logic, Inc. Molecular toxicology modeling
US7590493B2 (en) 2000-07-31 2009-09-15 Ocimum Biosolutions, Inc. Methods for determining hepatotoxins
EP1368499A2 (en) * 2001-01-29 2003-12-10 Phase-1 Molecular Toxicology Inc. Rat toxicologically relevant genes and uses thereof
US7415358B2 (en) 2001-05-22 2008-08-19 Ocimum Biosolutions, Inc. Molecular toxicology modeling
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
US20040241690A1 (en) * 2001-08-03 2004-12-02 Takayuki Souka Method of evaluating biocompatibility
JP4836403B2 (en) * 2001-08-24 2011-12-14 独立行政法人産業技術総合研究所 Method for detecting toxic substances
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
EP1344834A3 (en) * 2002-03-14 2004-06-02 F. Hoffmann-La Roche Ag Methods for the toxicity prediction of a compound
GB0215509D0 (en) * 2002-07-04 2002-08-14 Novartis Ag Marker genes
WO2004058957A2 (en) * 2002-12-31 2004-07-15 Pharmacia & Upjohn Company Llc Canine cyp1a2 sequences

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020681A1 (en) * 1994-01-27 1995-08-03 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020681A1 (en) * 1994-01-27 1995-08-03 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL embl heidelberg; 30 September 1995 (1995-09-30), LEE H.N. ET AL.,: "EST108960 rat PC-12 cells", XP002130308 *
LEE N.H. ET AL.,: "Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment", PROC. NATL. ACAD. SCI. USA, vol. 92, - August 1995 (1995-08-01), pages 8303 - 8307, XP002047703 *
SCHENA M ET AL: "PARALLEL HUMAN GENOME ANALYSIS: MICROARRAY-BASED EXPRESSION MONITORING OF 1000 GENES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 93, no. 20, 1 October 1996 (1996-10-01), pages 10614 - 10619, XP002912238, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1108067A2 (en) 2001-06-20
AU6022299A (en) 2000-03-21
JP2002523112A (en) 2002-07-30
CA2340589A1 (en) 2000-03-09
WO2000012760A2 (en) 2000-03-09

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