WO2000012543A3 - Compositions cristallines de farnesyl proteine transferase et procedes d'utilisation - Google Patents

Compositions cristallines de farnesyl proteine transferase et procedes d'utilisation Download PDF

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Publication number
WO2000012543A3
WO2000012543A3 PCT/US1999/018819 US9918819W WO0012543A3 WO 2000012543 A3 WO2000012543 A3 WO 2000012543A3 US 9918819 W US9918819 W US 9918819W WO 0012543 A3 WO0012543 A3 WO 0012543A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
crystalline
protein transferase
farnesyl protein
methods
Prior art date
Application number
PCT/US1999/018819
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English (en)
Other versions
WO2000012543A2 (fr
Inventor
Corey Strickland
Patricia C Weber
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU56787/99A priority Critical patent/AU5678799A/en
Publication of WO2000012543A2 publication Critical patent/WO2000012543A2/fr
Publication of WO2000012543A3 publication Critical patent/WO2000012543A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des compositions cristallines comprenant des polypeptides de type farnésyl protéine transférase en complexe avec des substrats et inhibiteurs. L'invention concerne également des conditions de cristallisation pour ces compositions et leur utilisation pour la détermination structurale de complexes FPT:FPP/analogues de FPP:peptide/inhibiteur.
PCT/US1999/018819 1998-08-28 1999-08-26 Compositions cristallines de farnesyl proteine transferase et procedes d'utilisation WO2000012543A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56787/99A AU5678799A (en) 1998-08-28 1999-08-26 Crystalline farnesyl protein transferase compositions and methods for use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14165198A 1998-08-28 1998-08-28
US09/141,651 1998-08-28

Publications (2)

Publication Number Publication Date
WO2000012543A2 WO2000012543A2 (fr) 2000-03-09
WO2000012543A3 true WO2000012543A3 (fr) 2000-06-15

Family

ID=22496594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018819 WO2000012543A2 (fr) 1998-08-28 1999-08-26 Compositions cristallines de farnesyl proteine transferase et procedes d'utilisation

Country Status (2)

Country Link
AU (1) AU5678799A (fr)
WO (1) WO2000012543A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525479A (en) * 1992-06-17 1996-06-11 Merck & Co., Inc. Fluorescence assay of Ras farnesyl protein transferase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525479A (en) * 1992-06-17 1996-06-11 Merck & Co., Inc. Fluorescence assay of Ras farnesyl protein transferase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DUNTEN P ET AL: "Protein farnesyltransferase: structure and implications for substrate binding.", BIOCHEMISTRY, (1998 JUN 2) 37 (22) 7907-12., XP000872369 *
LONG S B ET AL: "Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.", BIOCHEMISTRY, (1998 JUL 7) 37 (27) 9612-8., XP000872368 *
PARK H W ET AL: "Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution [see comments] [published erratum appears in Science 1997 Apr 4;276(5309):21].", SCIENCE, (1997 MAR 21) 275 (5307) 1800-4., XP000872421 *
PARK H W ET AL: "Protein farnesyltransferase.", CURRENT OPINION IN STRUCTURAL BIOLOGY, (1997 DEC) 7 (6) 873-80. REF: 65, XP000872382 *
STRICKLAND C L ET AL: "Crystal structure of farnesyl protein transferase complexed wit a CaaX peptide and farnesyl diphosphate analogue.", BIOCHEMISTRY, (1998 NOV 24) 37 (47) 16601-11., XP000872402 *
WU Z ET AL: "Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies.", BIOCHEMISTRY, (1999 AUG 31) 38 (35) 11239-49., XP000872405 *

Also Published As

Publication number Publication date
AU5678799A (en) 2000-03-21
WO2000012543A2 (fr) 2000-03-09

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