WO2000012048A3 - Carbapenem antibacterial compositions and methods of treatment - Google Patents

Carbapenem antibacterial compositions and methods of treatment Download PDF

Info

Publication number
WO2000012048A3
WO2000012048A3 PCT/US1999/020052 US9920052W WO0012048A3 WO 2000012048 A3 WO2000012048 A3 WO 2000012048A3 US 9920052 W US9920052 W US 9920052W WO 0012048 A3 WO0012048 A3 WO 0012048A3
Authority
WO
WIPO (PCT)
Prior art keywords
methicillin resistant
combination
antibacterial compositions
treating
useful
Prior art date
Application number
PCT/US1999/020052
Other languages
French (fr)
Other versions
WO2000012048A2 (en
Inventor
Karen L Dorso
Charles J Gill
Jesse J Jackson
Joyce Kohler
Lynn L Silver
Original Assignee
Merck & Co Inc
Karen L Dorso
Charles J Gill
Jesse J Jackson
Joyce Kohler
Lynn L Silver
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Karen L Dorso, Charles J Gill, Jesse J Jackson, Joyce Kohler, Lynn L Silver filed Critical Merck & Co Inc
Priority to AU61335/99A priority Critical patent/AU6133599A/en
Priority to EP99948094A priority patent/EP1115419A2/en
Priority to JP2000571020A priority patent/JP2002525275A/en
Priority to CA002341650A priority patent/CA2341650A1/en
Publication of WO2000012048A2 publication Critical patent/WO2000012048A2/en
Publication of WO2000012048A3 publication Critical patent/WO2000012048A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other β-lactams, which are useful in treating and preventing enterococcal infections. The combinations have anti-PBP5 activity as well as activity against the critical PBPs of sensitive isolates. The antibacterial compositions of the present invention thus comprise an important contribution to therapy for treating infections caused by these difficult to control pathogens. This combination is also useful against gram positive microorganisms, especially methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).
PCT/US1999/020052 1998-09-01 1999-08-31 Carbapenem antibacterial compositions and methods of treatment WO2000012048A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU61335/99A AU6133599A (en) 1998-09-01 1999-08-31 Carbapenem antibacterial compositions and methods of treatment
EP99948094A EP1115419A2 (en) 1998-09-01 1999-08-31 Carbapenem antibacterial compositions and methods of treatment
JP2000571020A JP2002525275A (en) 1998-09-01 1999-08-31 Carbapenem antimicrobial compositions and methods of treatment
CA002341650A CA2341650A1 (en) 1998-09-01 1999-08-31 Carbapenem antibacterial compositions and methods of treatment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9873898P 1998-09-01 1998-09-01
US60/098,738 1998-09-01

Publications (2)

Publication Number Publication Date
WO2000012048A2 WO2000012048A2 (en) 2000-03-09
WO2000012048A3 true WO2000012048A3 (en) 2000-06-22

Family

ID=22270688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020052 WO2000012048A2 (en) 1998-09-01 1999-08-31 Carbapenem antibacterial compositions and methods of treatment

Country Status (5)

Country Link
EP (1) EP1115419A2 (en)
JP (1) JP2002525275A (en)
AU (1) AU6133599A (en)
CA (1) CA2341650A1 (en)
WO (1) WO2000012048A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070061895A (en) * 2004-10-08 2007-06-14 다이닛본 스미토모 세이야꾸 가부시끼가이샤 Novel antimicrobial medicine
WO2008085913A1 (en) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Methods for treating, preventing, or reducing the risk of opthalmic, otic, and nasal infections
US8916542B2 (en) * 2008-11-12 2014-12-23 Synedgen, Inc. Chitosan derivatives, compositions and related methods of use
WO2014031897A1 (en) * 2012-08-22 2014-02-27 Xenoport, Inc. Oral dosage forms having a high loading of (n,n- diethylcarbamoyl)methyl methyl|(2e)but-2-ene-1,4-dioate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494666A (en) * 1994-03-11 1996-02-27 Hoffmann-La Roche Inc. β-lactam compounds
US5637579A (en) * 1993-08-24 1997-06-10 Hoffmann-La Roche Inc. Penam derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637579A (en) * 1993-08-24 1997-06-10 Hoffmann-La Roche Inc. Penam derivatives
US5494666A (en) * 1994-03-11 1996-02-27 Hoffmann-La Roche Inc. β-lactam compounds

Also Published As

Publication number Publication date
CA2341650A1 (en) 2000-03-09
WO2000012048A2 (en) 2000-03-09
AU6133599A (en) 2000-03-21
JP2002525275A (en) 2002-08-13
EP1115419A2 (en) 2001-07-18

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