WO2000006728A3 - Phosphorylation effectors - Google Patents

Phosphorylation effectors Download PDF

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Publication number
WO2000006728A3
WO2000006728A3 PCT/US1999/017132 US9917132W WO0006728A3 WO 2000006728 A3 WO2000006728 A3 WO 2000006728A3 US 9917132 W US9917132 W US 9917132W WO 0006728 A3 WO0006728 A3 WO 0006728A3
Authority
WO
WIPO (PCT)
Prior art keywords
effectors
phsp
phosphorylation
provides
expression
Prior art date
Application number
PCT/US1999/017132
Other languages
French (fr)
Other versions
WO2000006728A8 (en
WO2000006728A2 (en
Inventor
Jennifer L Hillman
Preeti Lal
Y Tom Tang
Neil C Corley
Karl J Guegler
Mariah R Baughn
Chandra Patterson
Olga Bandman
Janice Au-Young
Gina A Gorgone
Henry Yue
Yalda Azimzai
Roopa Reddy
Dyung Aina M Lu
Leo L Shih
Original Assignee
Incyte Pharma Inc
Jennifer L Hillman
Preeti Lal
Y Tom Tang
Neil C Corley
Karl J Guegler
Mariah R Baughn
Chandra Patterson
Olga Bandman
Au Young Janice
Gina A Gorgone
Henry Yue
Yalda Azimzai
Roopa Reddy
Dyung Aina M Lu
Leo L Shih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Jennifer L Hillman, Preeti Lal, Y Tom Tang, Neil C Corley, Karl J Guegler, Mariah R Baughn, Chandra Patterson, Olga Bandman, Au Young Janice, Gina A Gorgone, Henry Yue, Yalda Azimzai, Roopa Reddy, Dyung Aina M Lu, Leo L Shih filed Critical Incyte Pharma Inc
Priority to CA002335644A priority Critical patent/CA2335644A1/en
Priority to AU51349/99A priority patent/AU5134999A/en
Priority to EP99935987A priority patent/EP1100904A2/en
Priority to JP2000562510A priority patent/JP2002526035A/en
Publication of WO2000006728A2 publication Critical patent/WO2000006728A2/en
Publication of WO2000006728A3 publication Critical patent/WO2000006728A3/en
Publication of WO2000006728A8 publication Critical patent/WO2000006728A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides human phosphorylation effectors (PHSP) and polynucleotides which identify and encode PHSP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PHSP.
PCT/US1999/017132 1998-07-28 1999-07-28 Phosphorylation effectors WO2000006728A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002335644A CA2335644A1 (en) 1998-07-28 1999-07-28 Phosphorylation effectors
AU51349/99A AU5134999A (en) 1998-07-28 1999-07-28 Phosphorylation effectors
EP99935987A EP1100904A2 (en) 1998-07-28 1999-07-28 Phosphorylation effectors
JP2000562510A JP2002526035A (en) 1998-07-28 1999-07-28 Phosphorylation effectors

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US15521398P 1998-07-28 1998-07-28
US12349498A 1998-07-28 1998-07-28
US60/155,213 1998-07-28
US15519698P 1998-09-14 1998-09-14
US15281498A 1998-09-14 1998-09-14
US60/155,196 1998-09-14
US17348298A 1998-10-14 1998-10-14
US15523998P 1998-10-14 1998-10-14
US60/155,239 1998-10-14
US10688998P 1998-11-03 1998-11-03
US60/106,889 1998-11-03
US10909398P 1998-11-19 1998-11-19
US60/109,093 1998-11-19
US11379698P 1998-12-22 1998-12-22
US60/113,796 1998-12-22
US22900599A 1999-01-12 1999-01-12
US60/155,233 1999-01-12

Publications (3)

Publication Number Publication Date
WO2000006728A2 WO2000006728A2 (en) 2000-02-10
WO2000006728A3 true WO2000006728A3 (en) 2000-05-04
WO2000006728A8 WO2000006728A8 (en) 2001-07-05

Family

ID=27581006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017132 WO2000006728A2 (en) 1998-07-28 1999-07-28 Phosphorylation effectors

Country Status (1)

Country Link
WO (1) WO2000006728A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759223B2 (en) 1999-05-28 2004-07-06 Immunex Corporation Calcium/calmodulin-dependent kinase

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053486A1 (en) * 1999-03-08 2001-07-26 Genentech, Inc. Compositions and methods for the treatment of tumor
US6482933B1 (en) * 1998-02-06 2002-11-19 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6033855A (en) 1998-02-06 2000-03-07 Millennium Pharmaceuticals, Inc. Genes encoding caspase recruitment domain polypeptides
US6469140B1 (en) 1998-02-06 2002-10-22 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6680167B2 (en) 1998-02-06 2004-01-20 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6340576B1 (en) 1998-02-06 2002-01-22 Millennium Pharmaceuticals, Inc. Nucleic acid molecules related to card-4L and CARD-4S
US6869775B2 (en) 1998-02-06 2005-03-22 Millennium Pharmaceuticals, Inc. Card related protein and uses thereof
US20030028004A1 (en) * 2000-12-22 2003-02-06 Millennium Pharmaceuticals, Inc. 68730 and 69112, protein kinase molecules and uses therefor
AU4206700A (en) * 1999-04-07 2000-10-23 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
EP1171613A1 (en) * 1999-04-07 2002-01-16 Ceptyr, Inc. Dsp-7 dual-specificity map kinase phosphatase
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
US6756196B2 (en) 1999-06-28 2004-06-29 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6558903B1 (en) 1999-06-30 2003-05-06 Millennium Pharmaceuticals, Inc. Kinases and uses thereof
US6656698B1 (en) * 1999-06-30 2003-12-02 Millennium Pharmaceuticals, Inc. 12832, a novel human kinase-like molecule and uses thereof
US7078210B2 (en) 1999-07-02 2006-07-18 Ceptyr, Inc. DSP-3 dual-specificity phosphatase
AU4367600A (en) * 1999-07-02 2001-01-22 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
JP2003507016A (en) * 1999-08-13 2003-02-25 スージェン・インコーポレーテッド Diagnosis and treatment of novel protein phosphatases and phosphatase-related diseases
WO2001014552A1 (en) * 1999-08-19 2001-03-01 Kurokawa, Kiyoshi Meg-1 protein
US6900043B1 (en) 1999-09-21 2005-05-31 Amgen Inc. Phosphatases which activate map kinase pathways
DE60139113D1 (en) * 2000-02-11 2009-08-13 Millennium Pharm Inc 18477, A HUMAN PROTEIN KINASE AND ITS USE
WO2002024925A2 (en) * 2000-09-25 2002-03-28 Millennium Pharmaceuticals, Inc. 69109, a novel human tyrosine phosphatase and uses therefor
JP2004510442A (en) * 2000-10-03 2004-04-08 グラクソ　グループ　リミテッド Tumor markers and methods of use
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
AU2002319261A1 (en) * 2001-06-25 2003-01-08 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase nek3
DE60234713D1 (en) 2001-12-18 2010-01-21 Endocube Sas NEW PROTEINS ASSOCIATED WITH CELL-DATE FROM THE THAP FAMILY AND PAR4 RELATED SIGNALING PATHS INVOLVED IN THE CONTROL OF APOPTOSIS
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
EP1472540A4 (en) * 2001-12-19 2005-08-03 Millennium Pharm Inc Methods and compositions in treating pain and painful disorders using 1465,1587, 2146, 2207, 32838, 336 and 52908
US20050216961A1 (en) * 2002-03-28 2005-09-29 Delaney Allen D Cancer associated protein kinases and their uses
WO2004015076A2 (en) * 2002-08-07 2004-02-19 Curagen Corporation Novel proteins and nucleic acids encoding same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002347A1 (en) * 1995-06-30 1997-01-23 Incyte Pharmaceuticals, Inc. A human map kinase homolog
WO1997048802A1 (en) * 1996-06-21 1997-12-24 Incyte Pharmaceuticals, Inc. HUMAN cAMP-DEPENDENT PROTEIN KINASE INHIBITOR HOMOLOG
WO1998011234A2 (en) * 1996-09-12 1998-03-19 Incyte Pharmaceuticals, Inc. Human protein kinases
WO1999004265A2 (en) * 1997-07-17 1999-01-28 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002347A1 (en) * 1995-06-30 1997-01-23 Incyte Pharmaceuticals, Inc. A human map kinase homolog
WO1997048802A1 (en) * 1996-06-21 1997-12-24 Incyte Pharmaceuticals, Inc. HUMAN cAMP-DEPENDENT PROTEIN KINASE INHIBITOR HOMOLOG
WO1998011234A2 (en) * 1996-09-12 1998-03-19 Incyte Pharmaceuticals, Inc. Human protein kinases
WO1999004265A2 (en) * 1997-07-17 1999-01-28 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HILLIER, L., ET AL.: "the WashU-Merck EST project", EMBL SEQUENCE DATA LIBRARY, 25 March 1995 (1995-03-25), heidelberg, germany, XP002121151 *
HILLIER, L., ET AL.: "WashU-NCI human EST project", EMBL SEQUENCE DATA LIBRARY, 6 February 1998 (1998-02-06), heidelberg, germany, XP002121148 *
ISHIKAWA, K., ET AL.: "prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 5, no. 3, 30 June 1998 (1998-06-30), pages 169 - 176, XP002121149 *
NAGASE, T., ET AL.: "prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 5, 1998, pages 31 - 39, XP002121152 *
WALDEN, P.D. AND COWAN, N.J.: "a novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette", MOLECULAR AND CELLULAR BIOLOGY, vol. 13, 1993, pages 7625 - 7635, XP002121150 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759223B2 (en) 1999-05-28 2004-07-06 Immunex Corporation Calcium/calmodulin-dependent kinase

Also Published As

Publication number Publication date
WO2000006728A8 (en) 2001-07-05
WO2000006728A2 (en) 2000-02-10

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