WO2000006197A8 - Combined vaccine for immunoprophylaxis against viral hepatitis b and d, tetanus and diphtheria - Google Patents

Combined vaccine for immunoprophylaxis against viral hepatitis b and d, tetanus and diphtheria

Info

Publication number
WO2000006197A8
WO2000006197A8 PCT/RU1999/000266 RU9900266W WO0006197A8 WO 2000006197 A8 WO2000006197 A8 WO 2000006197A8 RU 9900266 W RU9900266 W RU 9900266W WO 0006197 A8 WO0006197 A8 WO 0006197A8
Authority
WO
WIPO (PCT)
Prior art keywords
amount
tetanus
diphtheria
viral hepatitis
immunoprophylaxis against
Prior art date
Application number
PCT/RU1999/000266
Other languages
French (fr)
Russian (ru)
Other versions
WO2000006197A1 (en
Inventor
Vera Nikolaevna Borisova
Vladimir Alexeevich Melnikov
Mikhail Valentinovich Budanov
Irina Michailovna Jakovleva
Veniamin Filippovich Petrov
Nina Pavlovna Efimova
Alevtina Maximovna Nikolaeva
Elena Valentinovna Pushkareva
Diana Vasilievna Gryaznova
Original Assignee
Aktsionernoe Obschestvo Zakryt
Perm N Proizv Ob Biomed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktsionernoe Obschestvo Zakryt, Perm N Proizv Ob Biomed filed Critical Aktsionernoe Obschestvo Zakryt
Publication of WO2000006197A1 publication Critical patent/WO2000006197A1/en
Publication of WO2000006197A8 publication Critical patent/WO2000006197A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention pertains to the field of medicine, more precisely to that of clinical immunology, and essentially relates to the production as well as to the use of a new complex preparation for immunoprophylaxis against various types of infections simultaneously. This invention essentially relates to the use of preparations for immunoprophylaxis against viral hepatitis B and D, tetanus and diphtheria. This invention also relates to a combined vaccine for immunoprophylaxis against viral hepatitis B ad D, tetanus and diphtheria, wherein said vaccine contains the antigens thereof as well as a builder. This vaccine is characterised in that it also contains the following members as antigens for an amount of 1 ml: an antigen of the hepatitis B virus (HBsAg) obtained by cultivating transformed cells from the strain S. cerevisiae VKPM Y-2203 in an amount of 5 to 10 νg; a purified and concentrated diphtheric anatoxin in an amount of 5 to 30 Lf; a purified and concentrated tetanic anatoxin in an amount of 5 to 10 EC; merthiolate in an amount of 0.01 ? 0.002 %; a hydroxide aluminium gel in an amount of 0.6 to 1.2 mg as converted into aluminium; and up to 1.0 ml of a pharmaceutically acceptable solvent. These preparations have a high seroconversion rate due to the mutual promoting action of the components used therein.
PCT/RU1999/000266 1998-07-31 1999-07-30 Combined vaccine for immunoprophylaxis against viral hepatitis b and d, tetanus and diphtheria WO2000006197A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU98114005/14A RU2130779C1 (en) 1998-07-31 1998-07-31 Mixed vaccine for immune prophylaxis of viral hepatitis b, tetanus and diphtheria
RU98114005 1998-07-31

Publications (2)

Publication Number Publication Date
WO2000006197A1 WO2000006197A1 (en) 2000-02-10
WO2000006197A8 true WO2000006197A8 (en) 2000-08-10

Family

ID=20208735

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU1999/000266 WO2000006197A1 (en) 1998-07-31 1999-07-30 Combined vaccine for immunoprophylaxis against viral hepatitis b and d, tetanus and diphtheria

Country Status (2)

Country Link
RU (1) RU2130779C1 (en)
WO (1) WO2000006197A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1187753B (en) * 1985-07-05 1987-12-23 Sclavo Spa GLYCOPROTEIC CONJUGATES WITH TRIVALENT IMMUNOGENIC ACTIVITY
ATE168271T1 (en) * 1992-05-23 1998-08-15 Smithkline Beecham Biolog COMBINED VACCINES CONTAINING HEPATITIS B SURFACE ANTIGEN AND OTHER ANTIGENS
RU2116086C1 (en) * 1997-08-19 1998-07-27 Акционерное общество закрытого типа НПК "Комбиотех Лтд" Method of vaccination against viral hepatitis b

Also Published As

Publication number Publication date
WO2000006197A1 (en) 2000-02-10
RU2130779C1 (en) 1999-05-27

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