WO2000005347A3 - Hepatitis b culture system - Google Patents

Hepatitis b culture system Download PDF

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Publication number
WO2000005347A3
WO2000005347A3 PCT/GB1999/002214 GB9902214W WO0005347A3 WO 2000005347 A3 WO2000005347 A3 WO 2000005347A3 GB 9902214 W GB9902214 W GB 9902214W WO 0005347 A3 WO0005347 A3 WO 0005347A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
culture system
same
virus
human hepatitis
Prior art date
Application number
PCT/GB1999/002214
Other languages
French (fr)
Other versions
WO2000005347A2 (en
Inventor
Joseph Lih Chyn Lu
Steven Myint
Original Assignee
Univ Leicester
Joseph Lih Chyn Lu
Steven Myint
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leicester, Joseph Lih Chyn Lu, Steven Myint filed Critical Univ Leicester
Priority to AU50482/99A priority Critical patent/AU5048299A/en
Publication of WO2000005347A2 publication Critical patent/WO2000005347A2/en
Publication of WO2000005347A3 publication Critical patent/WO2000005347A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10151—Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention concerns a system for the in vitro culture of human hepatitis B virus (HBV), a novel human hepatitis B virus, its use in same, hepatitis B cultures in same, and a kit of parts for same.
PCT/GB1999/002214 1998-07-23 1999-07-23 Hepatitis b culture system WO2000005347A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50482/99A AU5048299A (en) 1998-07-23 1999-07-23 Hepatitis b culture system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9815939.5 1998-07-23
GB9815939A GB9815939D0 (en) 1998-07-23 1998-07-23 Hepatitis B culture system

Publications (2)

Publication Number Publication Date
WO2000005347A2 WO2000005347A2 (en) 2000-02-03
WO2000005347A3 true WO2000005347A3 (en) 2000-04-20

Family

ID=10835953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002214 WO2000005347A2 (en) 1998-07-23 1999-07-23 Hepatitis b culture system

Country Status (3)

Country Link
AU (1) AU5048299A (en)
GB (1) GB9815939D0 (en)
WO (1) WO2000005347A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028987A2 (en) * 1979-11-13 1981-05-20 Merck & Co. Inc. Process for the in vitro culture of hepatitis B virus
WO1994025064A1 (en) * 1993-05-04 1994-11-10 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMANSERVIC ES Hepatitis c virus cell propagation and related methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028987A2 (en) * 1979-11-13 1981-05-20 Merck & Co. Inc. Process for the in vitro culture of hepatitis B virus
WO1994025064A1 (en) * 1993-05-04 1994-11-10 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMANSERVIC ES Hepatitis c virus cell propagation and related methods

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 18 April 1997 (1997-04-18), ASAHINA, Y.: "Complete nucleotide sequences of hepatitis B virus genomes associated with epidemic fulminant hepatitis, Journal of Medical Virology, 48, 1996, pages 171-178.", XP002129620 *
GANNE-CARRIÉ, N. ET AL.: "Effects of ethanol on hepatitis B virus Pre-S/S gene expression in the human hepatocellular carcinoma derived HEP G2 hepatitis B DNA positive cell line", JOURNAL OF HEPATOLOGY, vol. 23, no. 2, August 1995 (1995-08-01), pages 153-159, XP000872041 *
GRIPON, P. ET AL.: "Regulation of dimethylsulfoxide, insulin and corticosteroids of hepatitis B virus replication in a transfected human hepatoma cell line", JOURNAL OF MEDICAL VIROLOGY, vol. 28, July 1989 (1989-07-01), pages 193-199, XP000872077 *
NI, F. ET AL.: "A new immune escape mutant of hepatitis B virus with an Asp to Ala substitution in aa144 of the envelope major protein", RES. VIROL., vol. 146, 1995, pages 397 - 407, XP000872067 *
PULT, I.: "A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B", HEPATOLOGY, vol. 25, no. 6, June 1997 (1997-06-01), pages 1507 - 1515, XP000872066 *
SELLS, M.A. ET AL.: "Replicative intermediates of Hepatitis B virus in HepG2 cells that produce infectious virions", JOURNAL OF VIROLOGY, vol. 62, no. 8, August 1988 (1988-08-01), pages 2836 - 2844, XP000872074 *

Also Published As

Publication number Publication date
AU5048299A (en) 2000-02-14
WO2000005347A2 (en) 2000-02-03
GB9815939D0 (en) 1998-09-23

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