WO2000003746A3 - Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization - Google Patents
Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization Download PDFInfo
- Publication number
- WO2000003746A3 WO2000003746A3 PCT/US1999/015827 US9915827W WO0003746A3 WO 2000003746 A3 WO2000003746 A3 WO 2000003746A3 US 9915827 W US9915827 W US 9915827W WO 0003746 A3 WO0003746 A3 WO 0003746A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- agents
- nitric oxide
- cytoskeletal organization
- endothelial cell
- actin cytoskeletal
- Prior art date
Links
- 102000007469 Actins Human genes 0.000 title abstract 4
- 108010085238 Actins Proteins 0.000 title abstract 4
- 230000003436 cytoskeletal effect Effects 0.000 title abstract 4
- 230000008520 organization Effects 0.000 title abstract 4
- 102000008299 Nitric Oxide Synthase Human genes 0.000 title abstract 3
- 108010021487 Nitric Oxide Synthase Proteins 0.000 title abstract 3
- 210000002889 endothelial cell Anatomy 0.000 title abstract 3
- 230000003827 upregulation Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 208000032382 Ischaemic stroke Diseases 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000000260 hypercholesteremic effect Effects 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 230000004899 motility Effects 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU49905/99A AU4990599A (en) | 1998-07-14 | 1999-07-14 | Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/115,387 | 1998-07-14 | ||
US09/115,387 US6423751B1 (en) | 1998-07-14 | 1998-07-14 | Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
US27322499A | 1999-03-19 | 1999-03-19 | |
US09/273,224 | 1999-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000003746A2 WO2000003746A2 (en) | 2000-01-27 |
WO2000003746A3 true WO2000003746A3 (en) | 2000-04-20 |
Family
ID=26813141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/015827 WO2000003746A2 (en) | 1998-07-14 | 1999-07-14 | Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4990599A (en) |
WO (1) | WO2000003746A2 (en) |
Cited By (1)
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US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
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US6147109A (en) * | 1997-10-14 | 2000-11-14 | The General Hospital Corporation | Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors |
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Citations (13)
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EP0187371A2 (en) * | 1984-12-27 | 1986-07-16 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
JPS6287581A (en) * | 1985-10-11 | 1987-04-22 | Hokuriku Seiyaku Co Ltd | Naphthalenesulfonamide derivative |
JPS6317870A (en) * | 1986-07-09 | 1988-01-25 | Hokuriku Seiyaku Co Ltd | Naphthalenesulfonamide derivative |
WO1991006293A2 (en) * | 1989-11-01 | 1991-05-16 | University Of Vermont And State Agricultural College | Composition containing 2,3-butanedione monoxime and method for reversibly arresting muscle activity |
EP0457295A2 (en) * | 1990-05-16 | 1991-11-21 | The Rockefeller University | Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with Alzheimer's disease |
EP0654266A1 (en) * | 1992-08-10 | 1995-05-24 | Asahi Kasei Kogyo Kabushiki Kaisha | Cardiac protective |
WO1995014465A2 (en) * | 1993-11-22 | 1995-06-01 | The Johns Hopkins University | Methods for amelioration of immunodeficiency virus induced neurodegeneration by covering nitric oxide or superoxide concentration |
US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
WO1997041857A1 (en) * | 1996-05-03 | 1997-11-13 | Children's Hospital Medical Center | Composition comprising a katp channel inhibitor for use in the treatment of hemorrhagic shock |
WO1998034615A1 (en) * | 1997-02-07 | 1998-08-13 | Synapse Pharmaceuticals International, Inc. | Pharmaceutical composition for treatment of synaptic dysfunction comprising an oxime |
US5830910A (en) * | 1995-10-23 | 1998-11-03 | University Of Kentucky Research Foundation | Cytochalasins useful in providing protection against nerve cell injury associated with neurodegenerative disorders |
WO1999000117A2 (en) * | 1997-06-27 | 1999-01-07 | Ontogeny, Inc. | Neuroprotective methods and reagents |
WO1999047153A2 (en) * | 1998-03-19 | 1999-09-23 | Brigham & Women's Hospital, Inc. | UPREGULATION OF TYPE III ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE BY rho GTPase FUNCTION INHIBITORS |
-
1999
- 1999-07-14 AU AU49905/99A patent/AU4990599A/en not_active Abandoned
- 1999-07-14 WO PCT/US1999/015827 patent/WO2000003746A2/en active Application Filing
Patent Citations (13)
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EP0187371A2 (en) * | 1984-12-27 | 1986-07-16 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
JPS6287581A (en) * | 1985-10-11 | 1987-04-22 | Hokuriku Seiyaku Co Ltd | Naphthalenesulfonamide derivative |
JPS6317870A (en) * | 1986-07-09 | 1988-01-25 | Hokuriku Seiyaku Co Ltd | Naphthalenesulfonamide derivative |
WO1991006293A2 (en) * | 1989-11-01 | 1991-05-16 | University Of Vermont And State Agricultural College | Composition containing 2,3-butanedione monoxime and method for reversibly arresting muscle activity |
EP0457295A2 (en) * | 1990-05-16 | 1991-11-21 | The Rockefeller University | Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with Alzheimer's disease |
EP0654266A1 (en) * | 1992-08-10 | 1995-05-24 | Asahi Kasei Kogyo Kabushiki Kaisha | Cardiac protective |
US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
WO1995014465A2 (en) * | 1993-11-22 | 1995-06-01 | The Johns Hopkins University | Methods for amelioration of immunodeficiency virus induced neurodegeneration by covering nitric oxide or superoxide concentration |
US5830910A (en) * | 1995-10-23 | 1998-11-03 | University Of Kentucky Research Foundation | Cytochalasins useful in providing protection against nerve cell injury associated with neurodegenerative disorders |
WO1997041857A1 (en) * | 1996-05-03 | 1997-11-13 | Children's Hospital Medical Center | Composition comprising a katp channel inhibitor for use in the treatment of hemorrhagic shock |
WO1998034615A1 (en) * | 1997-02-07 | 1998-08-13 | Synapse Pharmaceuticals International, Inc. | Pharmaceutical composition for treatment of synaptic dysfunction comprising an oxime |
WO1999000117A2 (en) * | 1997-06-27 | 1999-01-07 | Ontogeny, Inc. | Neuroprotective methods and reagents |
WO1999047153A2 (en) * | 1998-03-19 | 1999-09-23 | Brigham & Women's Hospital, Inc. | UPREGULATION OF TYPE III ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE BY rho GTPase FUNCTION INHIBITORS |
Non-Patent Citations (6)
Title |
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DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HIDAKA, HIROYOSHI ET AL: "Preparation of naphthalenesulfonylhomopiperazine and -piperizine derivatives as cardiovascular agents", XP002128508, retrieved from STN Database accession no. 107:154355 CA * |
FUJITA, SATOSHI ET AL: "Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts", CARDIOVASC. RES. (1998), 38(3), 655-667, XP000870320 * |
LAUFS U ET AL: "Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.", CIRCULATION, (1998 MAR 31) 97 (12) 1129-35., XP000870148 * |
LAUFS, ULRICH ET AL: "Cytoskeletal regulation of endothelial nitric oxide synthase.", CIRCULATION, (OCT. 27, 1998) VOL. 98, NO. 17 SUPPL., PP. I405-I406. MEETING INFO.: 71ST SCIENTIFIC SESSIONS OF THE AMERICAN HEART ASSOCIATION DALLAS, TEXAS, USA NOVEMBER 8-11, 1998 THE AMERICAN HEART ASSOCIATION., XP000870318 * |
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VOIGTLANDER, J. ET AL: "Effects of 2,3-butanedione monoxime (BDM) during cardioplegia versus initial BDM reperfusion on myocardial and vascular function in isolated hearts", WORLD CONGR. MICROCIRC., 6TH (1996), 457-460. EDITOR(S): MESSMER, KONRAD;KUEBLER, WOLFGANG M. PUBLISHER: MONDUZZI EDITORE, BOLOGNA, ITALY., 1996, XP000874142 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
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AU4990599A (en) | 2000-02-07 |
WO2000003746A2 (en) | 2000-01-27 |
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