WO2000002550A3 - Acetylpiperazines for modulating sexual activity - Google Patents

Acetylpiperazines for modulating sexual activity Download PDF

Info

Publication number
WO2000002550A3
WO2000002550A3 PCT/US1999/015571 US9915571W WO0002550A3 WO 2000002550 A3 WO2000002550 A3 WO 2000002550A3 US 9915571 W US9915571 W US 9915571W WO 0002550 A3 WO0002550 A3 WO 0002550A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetylpiperazines
sexual activity
modulating
modulating sexual
sexual
Prior art date
Application number
PCT/US1999/015571
Other languages
French (fr)
Other versions
WO2000002550A2 (en
Inventor
Gregory N Beatch
Lewis S L P D Choi
Eric S Hayes
Alexander B Zolotoy
Original Assignee
Nortran Pharmaceuticals Inc
Gregory N Beatch
Lewis S L P D Choi
Eric S Hayes
Alexander B Zolotoy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nortran Pharmaceuticals Inc, Gregory N Beatch, Lewis S L P D Choi, Eric S Hayes, Alexander B Zolotoy filed Critical Nortran Pharmaceuticals Inc
Priority to AU49811/99A priority Critical patent/AU4981199A/en
Publication of WO2000002550A2 publication Critical patent/WO2000002550A2/en
Publication of WO2000002550A3 publication Critical patent/WO2000002550A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention discloses that substituted acetic acid derivatives containing a piperazine moiety are useful as pro-libido agents for males and females, and may be used for the treatment of sexual dysfonction including erectile dysfunction and impotence and to enhance sexual performance.
PCT/US1999/015571 1998-07-08 1999-07-08 Acetylpiperazines for modulating sexual activity WO2000002550A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49811/99A AU4981199A (en) 1998-07-08 1999-07-08 Compositions and methods for modulating sexual activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9209798P 1998-07-08 1998-07-08
US60/092,097 1998-07-08

Publications (2)

Publication Number Publication Date
WO2000002550A2 WO2000002550A2 (en) 2000-01-20
WO2000002550A3 true WO2000002550A3 (en) 2000-06-15

Family

ID=22231535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015571 WO2000002550A2 (en) 1998-07-08 1999-07-08 Acetylpiperazines for modulating sexual activity

Country Status (2)

Country Link
AU (1) AU4981199A (en)
WO (1) WO2000002550A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
WO2000028993A1 (en) * 1998-11-19 2000-05-25 Nortran Pharmaceuticals, Inc. Serotonin ligands as pro-erectile compounds
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
US7291640B2 (en) 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
WO2006100557A1 (en) 2005-03-21 2006-09-28 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (en) 2013-03-15 2017-01-18 ファイザー・インク Indazole compounds that activate AMPK
SI3860998T1 (en) 2018-10-05 2024-06-28 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008544A1 (en) * 1993-09-24 1995-03-30 The University Of British Columbia Aminocyclohexylesters and uses thereof
WO1999002159A1 (en) * 1997-07-09 1999-01-21 Nortran Pharmaceuticals Inc. Aroylpiperazines for modulating sexual activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008544A1 (en) * 1993-09-24 1995-03-30 The University Of British Columbia Aminocyclohexylesters and uses thereof
US5637583A (en) * 1993-09-24 1997-06-10 University Of British Columbia Aminocyclohexylesters and uses thereof
WO1999002159A1 (en) * 1997-07-09 1999-01-21 Nortran Pharmaceuticals Inc. Aroylpiperazines for modulating sexual activity

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
"The pro-erectile project", NORTRAN PHARMACEUTICALS INTERNET SITE, XP002132463, Retrieved from the Internet <URL:http://www.nortran,com/projects/PE.html> [retrieved on 20000209] *
CECCARELLI, STEFANO ET AL: "Synthesis of novel 2-substituted-5-oxycoumarans via a direct route to 2,3-dihydro-5-hydroxy-2-benzofuranacetic acids", J. HETEROCYCL. CHEM. (1993), 30(3), 679-90, 1993, XP002132466 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BINIECKI, STANISLAW ET AL: "Synthesis of 3-indolylacetylpiperazines and reduction of compounds obtained with lithium aluminum hydride", XP002132467, retrieved from STN Database accession no. 84:59381 CA *
DE COSTA, BRIAN R. ET AL: "Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamines at.sigma. receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds", J. MED. CHEM. (1993), 36(16), 2311-20, 1993, XP002132464 *
E.S. HAYES ET AL.: "RSD 992 enhances erection and copulation in rats and erection in primates", INT. J. IMPOT. RES., vol. 8, no. 3, 1996, pages 189, XP000879354 *
E.S. HAYES ET AL.: "The effects of 5HT agonists on central peripheral and local erectile pathways", INT. J. IMPOT. RES., vol. 9, no. suppl., 1997, pages s34, XP000878783 *
HAYES E S ET AL: "ACTIONS OF ARYLPIPERAZINES ON CORPUS CAVERNOSUM SMOOTH MUSCLE IN VITRO", ASIA PACIFIC J. PHARMACOL., vol. 12, no. 3-4, 1997, pages 97 - 103, XP000874585 *
ROCZ. CHEM. (1975), 49(9), 1585-8, 1975 *
SAUTER, FRITZ ET AL: "N-Substituted benzo[b]thiophene-3-acetamide and 3-(.beta.- aminoethyl)benzo[b]thiophene", MONATSH. CHEM. (1967), 98(5), 2089-96, 1967, XP002132465 *

Also Published As

Publication number Publication date
WO2000002550A2 (en) 2000-01-20
AU4981199A (en) 2000-02-01

Similar Documents

Publication Publication Date Title
BR9810554A (en) Aroil piperazines to regulate sexual activity
ATE245650T1 (en) PYRAZOLOPYIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCY
TR200200706T2 (en) The use of retigabine for the treatment of neuropathic pain.
CA2296373A1 (en) Composition and method for treating penile erectile dysfunction
WO1997044063A3 (en) Dha-pharmaceutical agent conjugates
GC0000096A (en) Treatment of female sexual dysfunction.
WO2001079458A3 (en) Polypeptides having haloperoxidase activity
YU23599A (en) Stabilized antihistamine syrup
BRPI0113670B8 (en) pharmaceutical composition and method to treat hypogonadism
WO2001066564A3 (en) Gamma-secretase inhibitors
WO2000002550A3 (en) Acetylpiperazines for modulating sexual activity
ATE303804T1 (en) TREATMENT OF SEXUAL DYSFUNCTION WITH BOMBESIN RECEPTOR ANTAGONISTS
EP1475386A3 (en) Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction
ZA200007019B (en) Use of prostaglandin agonists to treat erectile dysfunction or impotence.
DE69819515D1 (en) HYDROXY PROSTAGLAND DERIVATIVES FOR TREATING ERECTILE DYSFUNCTION
BG105664A (en) Use of apomophines for the treatment of organic erectile dysfunction in males
AU4314199A (en) Compounds, compositions and methods for treating erectile dysfunction
BR0109163A (en) Use of pyrido [3,2-e] -pyrazinones as phosphodietherase 5 inhibitors for erectile dysfunction therapy
EP1900802A3 (en) Toilet bar having a latent acidifier
MXPA00012647A (en) N-substituted derivatives of 5-oxyiminobarbituric acid.
WO2002005642A3 (en) Synergistic biocidal compositions
MXPA03004303A (en) Substituted derivatives of aminofuran-2-yl-acetic acid and aminothien-2-yl-acetic acid and the use thereof for treating migraines and pain.
AU9157698A (en) Piperazine derivatives active on the lower urinary tract
AU2641199A (en) Remedies for erectile dysfunction
TR199900189A2 (en) Elimination of the urgency of olive oil

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 09743298

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
WWE Wipo information: entry into national phase

Ref document number: 10052001

Country of ref document: US