WO2000001413A1 - Intracellular sensitizers for sonodynamic therapy - Google Patents
Intracellular sensitizers for sonodynamic therapy Download PDFInfo
- Publication number
- WO2000001413A1 WO2000001413A1 PCT/US1999/015154 US9915154W WO0001413A1 WO 2000001413 A1 WO2000001413 A1 WO 2000001413A1 US 9915154 W US9915154 W US 9915154W WO 0001413 A1 WO0001413 A1 WO 0001413A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- texaphyrin
- cells
- sonodynamic
- intracellular
- ultrasound
- Prior art date
Links
- 230000003834 intracellular effect Effects 0.000 title claims abstract description 28
- 238000009214 sonodynamic therapy Methods 0.000 title claims abstract description 21
- 238000002604 ultrasonography Methods 0.000 claims abstract description 61
- 238000000034 method Methods 0.000 claims abstract description 42
- 241000124008 Mammalia Species 0.000 claims abstract description 12
- 210000004027 cell Anatomy 0.000 claims description 62
- 210000001519 tissue Anatomy 0.000 claims description 26
- 206010028980 Neoplasm Diseases 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 13
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 12
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 12
- 210000002744 extracellular matrix Anatomy 0.000 claims description 12
- WIQKYZYFTAEWBF-UHFFFAOYSA-L motexafin lutetium hydrate Chemical compound O.[Lu+3].CC([O-])=O.CC([O-])=O.C1=C([N-]2)C(CC)=C(CC)C2=CC(C(=C2C)CCCO)=NC2=CN=C2C=C(OCCOCCOCCOC)C(OCCOCCOCCOC)=CC2=NC=C2C(C)=C(CCCO)C1=N2 WIQKYZYFTAEWBF-UHFFFAOYSA-L 0.000 claims description 10
- AARXZCZYLAFQQU-UHFFFAOYSA-N motexafin gadolinium Chemical compound [Gd].CC(O)=O.CC(O)=O.C1=C([N-]2)C(CC)=C(CC)C2=CC(C(=C2C)CCCO)=NC2=CN=C2C=C(OCCOCCOCCOC)C(OCCOCCOCCOC)=CC2=NC=C2C(C)=C(CCCO)C1=N2 AARXZCZYLAFQQU-UHFFFAOYSA-N 0.000 claims description 8
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 230000001613 neoplastic effect Effects 0.000 claims description 6
- 230000035508 accumulation Effects 0.000 claims description 5
- 238000009825 accumulation Methods 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 206010018691 Granuloma Diseases 0.000 claims description 4
- 206010070834 Sensitisation Diseases 0.000 claims description 4
- 208000027866 inflammatory disease Diseases 0.000 claims description 4
- 230000008313 sensitization Effects 0.000 claims description 4
- 206010052779 Transplant rejections Diseases 0.000 claims description 3
- 238000003745 diagnosis Methods 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 238000010348 incorporation Methods 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 23
- 238000011282 treatment Methods 0.000 description 18
- 210000003734 kidney Anatomy 0.000 description 15
- 150000004032 porphyrins Chemical class 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 229910052751 metal Inorganic materials 0.000 description 10
- 239000002184 metal Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 241001529936 Murinae Species 0.000 description 7
- 150000001768 cations Chemical class 0.000 description 7
- 230000003013 cytotoxicity Effects 0.000 description 7
- 231100000135 cytotoxicity Toxicity 0.000 description 7
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 208000007093 Leukemia L1210 Diseases 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000030833 cell death Effects 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000035899 viability Effects 0.000 description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
- 229930195725 Mannitol Natural products 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 239000000594 mannitol Substances 0.000 description 4
- 235000010355 mannitol Nutrition 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000001235 sensitizing effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 206010003210 Arteriosclerosis Diseases 0.000 description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 239000002612 dispersion medium Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 239000007951 isotonicity adjuster Substances 0.000 description 3
- 238000002428 photodynamic therapy Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 238000011260 co-administration Methods 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000007306 functionalization reaction Methods 0.000 description 2
- 230000002962 histologic effect Effects 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010002412 Angiocentric lymphomas Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 208000011200 Kawasaki disease Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 239000002616 MRI contrast agent Substances 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 201000011152 Pemphigus Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 239000003070 absorption delaying agent Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 229940125683 antiemetic agent Drugs 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 230000003034 chemosensitisation Effects 0.000 description 1
- 239000006114 chemosensitizer Substances 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- -1 coatings Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 238000009650 gentamicin protection assay Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000006116 lymphomatoid granulomatosis Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 1
- 239000004084 narcotic analgesic agent Substances 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 230000002020 noncytotoxic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 201000001976 pemphigus vulgaris Diseases 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000035924 thermogenesis Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 231100000747 viability assay Toxicity 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
- A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Oncology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU48596/99A AU4859699A (en) | 1998-07-06 | 1999-07-02 | Intracellular sensitizers for sonodynamic therapy |
CA002335808A CA2335808A1 (en) | 1998-07-06 | 1999-07-02 | Intracellular sensitizers for sonodynamic therapy |
EP99932244A EP1096956A1 (en) | 1998-07-06 | 1999-07-02 | Intracellular sensitizers for sonodynamic therapy |
US09/755,824 US20010002251A1 (en) | 1998-07-06 | 2001-01-05 | Intracellular sensitizers for sonodynamic therapy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11114898A | 1998-07-06 | 1998-07-06 | |
US09/111,148 | 1998-07-06 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/755,824 Continuation US20010002251A1 (en) | 1998-07-06 | 2001-01-05 | Intracellular sensitizers for sonodynamic therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000001413A1 true WO2000001413A1 (en) | 2000-01-13 |
Family
ID=22336858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/015154 WO2000001413A1 (en) | 1998-07-06 | 1999-07-02 | Intracellular sensitizers for sonodynamic therapy |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1096956A1 (en) |
AU (1) | AU4859699A (en) |
CA (1) | CA2335808A1 (en) |
WO (1) | WO2000001413A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002060483A2 (en) * | 2001-01-30 | 2002-08-08 | Governors Of The University Of Alberta | Perylenequinones for use as photosensitizers and sonosensitizers |
WO2003063901A1 (en) * | 2002-01-29 | 2003-08-07 | Altachem Pharma, Ltd. | Amino-substituted hypocrellins for use as sonosensitizers |
US6638924B2 (en) | 2000-08-30 | 2003-10-28 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
EP1449541A1 (en) * | 2001-11-22 | 2004-08-25 | Anges MG, Inc. | Compositions inhibiting rejection in organ transplantation and method of using the same |
CN100340302C (en) * | 2002-11-04 | 2007-10-03 | 亚什兰许可和知识产权有限公司 | Device and process for treating a liquid medium using ultrasound in preventing the growth of hyperproliferative or infected cells |
US7449454B2 (en) | 2000-08-30 | 2008-11-11 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
US8410263B2 (en) | 2005-09-26 | 2013-04-02 | Pharmacyclics, Inc. | High-purity texaphyrin metal complexes |
CN114886869A (en) * | 2022-05-12 | 2022-08-12 | 江苏大学 | Macrophage-based ultrasonic delivery system and construction method and application thereof |
US11793983B2 (en) | 2017-09-05 | 2023-10-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Sonodynamic therapy using microbubbles and pulsed wave ultrasound methods and systems |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996023524A1 (en) * | 1995-02-02 | 1996-08-08 | Nycomed Imaging A/S | Contrast media for in vivo imaging based on light transmission on reflection |
US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
WO1998048845A1 (en) * | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Method of demarcating tissue |
WO1998052609A1 (en) * | 1997-05-19 | 1998-11-26 | Nycomed Imaging As | Sonodynamic therapy using an ultrasound sensitizer compound |
WO1998052610A1 (en) * | 1997-05-22 | 1998-11-26 | Technion Research And Development Foundation Ltd. | Photodynamic and sonodynamic therapy and agents and system for use therefor |
-
1999
- 1999-07-02 CA CA002335808A patent/CA2335808A1/en not_active Abandoned
- 1999-07-02 EP EP99932244A patent/EP1096956A1/en not_active Withdrawn
- 1999-07-02 WO PCT/US1999/015154 patent/WO2000001413A1/en not_active Application Discontinuation
- 1999-07-02 AU AU48596/99A patent/AU4859699A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
WO1996023524A1 (en) * | 1995-02-02 | 1996-08-08 | Nycomed Imaging A/S | Contrast media for in vivo imaging based on light transmission on reflection |
WO1998048845A1 (en) * | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Method of demarcating tissue |
WO1998052609A1 (en) * | 1997-05-19 | 1998-11-26 | Nycomed Imaging As | Sonodynamic therapy using an ultrasound sensitizer compound |
WO1998052610A1 (en) * | 1997-05-22 | 1998-11-26 | Technion Research And Development Foundation Ltd. | Photodynamic and sonodynamic therapy and agents and system for use therefor |
Non-Patent Citations (3)
Title |
---|
JIN, ZHAO-HUI ET AL: "Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice", PHOTOMED. PHOTOBIOL. (1997), 19, 65-68, XP002117019 * |
JIN, ZHAO-HUI ET AL: "Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice", PROC. SPIE-INT. SOC. OPT. ENG. (1998), 3344(LASER MEDICINE AND SURGERY), 301-307, XP002117018 * |
SUZUKI, TOSHIO ET AL: "A study on sonodynamic therapy-antitumor effect of novel sonodynamic compounds under ultrasound", HETEROCYCLES (1994), 38(6), 1209-11, XP002117017 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638924B2 (en) | 2000-08-30 | 2003-10-28 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
US7449454B2 (en) | 2000-08-30 | 2008-11-11 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
WO2002060483A2 (en) * | 2001-01-30 | 2002-08-08 | Governors Of The University Of Alberta | Perylenequinones for use as photosensitizers and sonosensitizers |
WO2002060483A3 (en) * | 2001-01-30 | 2003-12-24 | Univ Alberta | Perylenequinones for use as photosensitizers and sonosensitizers |
EP1449541A1 (en) * | 2001-11-22 | 2004-08-25 | Anges MG, Inc. | Compositions inhibiting rejection in organ transplantation and method of using the same |
EP1449541A4 (en) * | 2001-11-22 | 2006-05-31 | Anges Mg Inc | Compositions inhibiting rejection in organ transplantation and method of using the same |
WO2003063901A1 (en) * | 2002-01-29 | 2003-08-07 | Altachem Pharma, Ltd. | Amino-substituted hypocrellins for use as sonosensitizers |
CN100340302C (en) * | 2002-11-04 | 2007-10-03 | 亚什兰许可和知识产权有限公司 | Device and process for treating a liquid medium using ultrasound in preventing the growth of hyperproliferative or infected cells |
US8410263B2 (en) | 2005-09-26 | 2013-04-02 | Pharmacyclics, Inc. | High-purity texaphyrin metal complexes |
US11793983B2 (en) | 2017-09-05 | 2023-10-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Sonodynamic therapy using microbubbles and pulsed wave ultrasound methods and systems |
CN114886869A (en) * | 2022-05-12 | 2022-08-12 | 江苏大学 | Macrophage-based ultrasonic delivery system and construction method and application thereof |
CN114886869B (en) * | 2022-05-12 | 2023-12-15 | 江苏大学 | Macrophage-based ultrasonic delivery system and construction method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
EP1096956A1 (en) | 2001-05-09 |
CA2335808A1 (en) | 2000-01-13 |
AU4859699A (en) | 2000-01-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Lafond et al. | Sonodynamic therapy: advances and challenges in clinical translation | |
Fan et al. | Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery | |
Miller et al. | In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer | |
Sadanala et al. | Sono-photodynamic combination therapy: a review on sensitizers | |
Kochneva et al. | Photosensitizer Radachlorin®: Skin cancer PDT phase II clinical trials | |
KR101702227B1 (en) | Sonosensitizer composition containing titanium oxide nanoparticle as active ingredient, composition for preventing or treating cancer comprising the same, and the preparation thereof | |
Wu et al. | ROS‐responsive blended nanoparticles: Cascade‐amplifying synergistic effects of sonochemotherapy with on‐demand boosted drug release during SDT process | |
US20050159401A1 (en) | Texaphyrin coordination compounds and uses thereof | |
JPH01146829A (en) | Physiological action-enhancing agent for tumor treatment by ultrasonic wave | |
JP5207247B2 (en) | Radiation or anticancer chemotherapy sensitizer | |
Chatlani et al. | Selective necrosis in hamster pancreatic tumours using photodynamic therapy with phthalocyanine photosensitization | |
Dai et al. | Sonodynamic therapy (SDT): A novel treatment of cancer based on sonosensitizer liposome as a new drug carrier | |
Prada et al. | Fluorescein-mediated sonodynamic therapy in a rat glioma model | |
KR20140110757A (en) | Use of Photosensitizer In Preparation of Virus-Inactivating Medicaments For Treating Diseases | |
US20010002251A1 (en) | Intracellular sensitizers for sonodynamic therapy | |
Yumita et al. | Sonodynamic antitumour effect of chloroaluminum phthalocyanine tetrasulfonate on murine solid tumour | |
EP1096956A1 (en) | Intracellular sensitizers for sonodynamic therapy | |
Zhao et al. | Self‐Delivery Nanomedicine for Glutamine‐Starvation Enhanced Photodynamic Tumor Therapy | |
Wang et al. | Nanoscale Hf-hematoporphyrin frameworks for synergetic sonodynamic/radiation therapy of deep-seated tumors | |
Walther | The role of photodynamic therapy in the treatment of recurrent superficial bladder cancer | |
Schaffer et al. | Porphyrins as radiosensitizing agents for solid neoplasms | |
Sasaki et al. | Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga‐porphyrin complex | |
Yumita et al. | Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104 | |
JP2002519390A (en) | Use of texaphyrin in macrophage-mediated diseases | |
US20020115649A1 (en) | Use of texaphyrins in macrophage-mediated disease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase |
Ref document number: 2335808 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09755824 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1999932244 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1999932244 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1999932244 Country of ref document: EP |