WO1999067416A3 - METHOD FOR DETERMINING ANTIBIOTICS WITH β-LACTAM CORE IN A BIOLOGICAL FLUID - Google Patents

METHOD FOR DETERMINING ANTIBIOTICS WITH β-LACTAM CORE IN A BIOLOGICAL FLUID Download PDF

Info

Publication number
WO1999067416A3
WO1999067416A3 PCT/EP1999/002166 EP9902166W WO9967416A3 WO 1999067416 A3 WO1999067416 A3 WO 1999067416A3 EP 9902166 W EP9902166 W EP 9902166W WO 9967416 A3 WO9967416 A3 WO 9967416A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological fluid
antibiotics
identifying agent
lactam core
amount
Prior art date
Application number
PCT/EP1999/002166
Other languages
French (fr)
Other versions
WO1999067416A2 (en
Inventor
Jacques Degelaen
Benoit Granier
Jean-Marie Frere
Bernard Joris
Original Assignee
Ucb Bioproducts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3891319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999067416(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ508965A priority Critical patent/NZ508965A/en
Priority to AU37032/99A priority patent/AU737906B2/en
Priority to IL14025899A priority patent/IL140258A/en
Priority to CA002335734A priority patent/CA2335734C/en
Priority to PL99345396A priority patent/PL195495B1/en
Application filed by Ucb Bioproducts filed Critical Ucb Bioproducts
Priority to BRPI9911500-0A priority patent/BR9911500B1/en
Priority to DE69932161T priority patent/DE69932161T2/en
Priority to EP99919158A priority patent/EP1082451B1/en
Priority to JP2000556056A priority patent/JP4426103B2/en
Publication of WO1999067416A2 publication Critical patent/WO1999067416A2/en
Publication of WO1999067416A3 publication Critical patent/WO1999067416A3/en
Priority to NO20006574A priority patent/NO20006574L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Abstract

The invention concerns a method for detecting antibiotics with β-lactam core in a biological fluid comprising the following steps: a) contacting a specific volume of said biological fluid with an amount of identifying agent and incubating the resulting mixture in conditions for forming a complex of the antibiotics possibly present in said biological fluid with the identifying agent; b) contacting the mixture resulting from step a) with at least a reference antibiotic immobilised on a support, in conditions for forming a complex of the reference antibiotic with the amount of identifying agent which has not reacted in step a); and c) determining the amount of identifying agent fixed on the support. The invention is characterised in that the identifying agent comprises a receptor sensitive to antibiotics with β-lactam core obtained from Bacillus licheniformis.
PCT/EP1999/002166 1998-06-25 1999-03-30 METHOD FOR DETERMINING ANTIBIOTICS WITH β-LACTAM CORE IN A BIOLOGICAL FLUID WO1999067416A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2000556056A JP4426103B2 (en) 1998-06-25 1999-03-30 Method for measuring antibiotics containing a β-lactam ring in biological fluids
AU37032/99A AU737906B2 (en) 1998-06-25 1999-03-30 Process for determining antibiotics containing a beta-lactam ring in a biological fluid
IL14025899A IL140258A (en) 1998-06-25 1999-03-30 Method for determining antibiotics with beta-lactam core in a biological fluid
CA002335734A CA2335734C (en) 1998-06-25 1999-03-30 Method for determining antibiotics with .beta.-lactam core in a biological liquid
PL99345396A PL195495B1 (en) 1998-06-25 1999-03-30 Method for determining antibiotics with beta-lactam core in a biological fluid
NZ508965A NZ508965A (en) 1998-06-25 1999-03-30 Method for determining antibiotics containing a beta-lactam ring in a biological fluid
BRPI9911500-0A BR9911500B1 (en) 1998-06-25 1999-03-30 A method for the detection of antibiotics containing a beta-lactam ring in a biological fluid and a test kit for the detection of antibiotics in a biological fluid.
DE69932161T DE69932161T2 (en) 1998-06-25 1999-03-30 METHOD FOR DETERMINING THE ANTIBIOTICS CONTAINING BETA-LACTAM NUCLEUS
EP99919158A EP1082451B1 (en) 1998-06-25 1999-03-30 Method for determining antibiotics with beta-lactam core in a biological fluid
NO20006574A NO20006574L (en) 1998-06-25 2000-12-21 Method of Determining Antibiotics with <beta> -lactam core in a biological fluid as well as test kit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9800485 1998-06-25
BE9800485A BE1012049A6 (en) 1998-06-25 1998-06-25 Method for determining core antibiotics beta-lactam in a biological liquid.

Publications (2)

Publication Number Publication Date
WO1999067416A2 WO1999067416A2 (en) 1999-12-29
WO1999067416A3 true WO1999067416A3 (en) 2000-04-27

Family

ID=3891319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002166 WO1999067416A2 (en) 1998-06-25 1999-03-30 METHOD FOR DETERMINING ANTIBIOTICS WITH β-LACTAM CORE IN A BIOLOGICAL FLUID

Country Status (23)

Country Link
US (2) US6524804B2 (en)
EP (1) EP1082451B1 (en)
JP (1) JP4426103B2 (en)
KR (1) KR100577700B1 (en)
CN (1) CN1145029C (en)
AR (1) AR018821A1 (en)
AT (1) ATE331808T1 (en)
AU (1) AU737906B2 (en)
BE (1) BE1012049A6 (en)
BR (1) BR9911500B1 (en)
CA (1) CA2335734C (en)
CZ (1) CZ298192B6 (en)
DE (1) DE69932161T2 (en)
DK (1) DK1082451T3 (en)
ES (1) ES2268860T3 (en)
IL (1) IL140258A (en)
NO (1) NO20006574L (en)
NZ (1) NZ508965A (en)
PL (1) PL195495B1 (en)
PT (1) PT1082451E (en)
RU (1) RU2213973C2 (en)
TR (1) TR200003833T2 (en)
WO (1) WO1999067416A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481334B1 (en) 2001-11-06 2013-07-09 Charm Sciences, Inc. Method of attaching a ligand to a solid support
EP1712914A1 (en) 2005-04-14 2006-10-18 Unisensor S.A. In vitro process and kit for the simultaneous detection and identification of antibiotics belonging to different classes.
PL385415A1 (en) * 2008-06-11 2009-12-21 Marek Ciesielski Method of bacterial resistance detection, diagnostic kit and application of the determination of presencea of the drug and/or products of its decomposition
CA2730197A1 (en) * 2008-07-10 2010-01-14 Tacount Exact Ltd. Method, kit and system for culturable cell count
GB0914001D0 (en) * 2009-08-11 2009-09-16 Benson Jennifer M Biodegradable pregnancy test
RU2524624C2 (en) * 2010-01-29 2014-07-27 Тарту Юликоол (Юниверсити Оф Тарту) Real-time system, method of calibrating system and simultaneous detection of residues of antibiotics and their concentration in milk
CN102192980B (en) * 2010-03-08 2014-04-09 苏州浩欧博生物医药有限公司 Nonmetallic colloidal particle immune analysis reagent and method
WO2013037888A1 (en) * 2011-09-16 2013-03-21 Dsm Ip Assets B.V. Immunoassay for detecting antibiotics
WO2013037886A1 (en) * 2011-09-16 2013-03-21 Dsm Ip Assets B.V. Immunoassay for detecting antibiotics
PL2756306T3 (en) * 2011-09-16 2020-03-31 Dsm Ip Assets B.V. Immunoassay for detecting antibiotics
WO2013053953A1 (en) * 2011-10-14 2013-04-18 Université de Liège Method for measuring beta-lactam antibiotics
MX2018006231A (en) * 2015-11-20 2018-11-09 Dsm Sinochem Pharm Nl Bv Assay for determining antibiotics in waste.
US10837914B2 (en) 2016-12-28 2020-11-17 Neogen Corporation Implement analyzing device and method for utilizing the same
USD834721S1 (en) 2017-03-03 2018-11-27 Neogen Corporation Assay cartridge
JP6987593B2 (en) * 2017-10-16 2022-01-05 株式会社ニップン Mutant receptor protein
JP7206645B2 (en) * 2018-06-08 2023-01-18 株式会社島津製作所 Fluidic device manufacturing method and fluidic device
CN111830015B (en) * 2019-04-18 2022-12-09 中国农业科学院农产品加工研究所 Method for quantitatively detecting antibiotics
CN110241056A (en) * 2019-07-19 2019-09-17 石河子大学 A kind of bacillus utilizes the bacillus to carry out the method and its application of antibiotics leftover detection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762782A (en) * 1985-05-16 1988-08-09 Micromol Corporation Assay for Beta-lactam antibiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239852A (en) * 1978-06-12 1980-12-16 Penicillin Assays, Inc. Antibiotic detection method
US5028535A (en) * 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5434053A (en) * 1992-10-06 1995-07-18 Gist-Brocades N.V. Detection of antibiotics
US5985675A (en) 1997-12-31 1999-11-16 Charm Sciences, Inc. Test device for detection of an analyte
EP0998676B1 (en) 1997-07-16 2007-04-11 Charm Sciences Inc. A test device and method for detecting the presence of a residue analyte in a sample
WO1999018439A1 (en) * 1997-10-07 1999-04-15 Ucb Bioproducts, S.A. Testing device for determining analytes in a liquid dairy product

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762782A (en) * 1985-05-16 1988-08-09 Micromol Corporation Assay for Beta-lactam antibiotics

Also Published As

Publication number Publication date
DE69932161D1 (en) 2006-08-10
DK1082451T3 (en) 2006-10-09
PL195495B1 (en) 2007-09-28
BR9911500A (en) 2001-03-20
PT1082451E (en) 2006-09-29
AU737906B2 (en) 2001-09-06
CN1145029C (en) 2004-04-07
AR018821A1 (en) 2001-12-12
CN1311857A (en) 2001-09-05
RU2213973C2 (en) 2003-10-10
ES2268860T3 (en) 2007-03-16
DE69932161T2 (en) 2007-05-16
NZ508965A (en) 2002-10-25
KR20010034916A (en) 2001-04-25
EP1082451B1 (en) 2006-06-28
IL140258A0 (en) 2002-02-10
KR100577700B1 (en) 2006-05-10
PL345396A1 (en) 2001-12-17
CZ298192B6 (en) 2007-07-18
US6524804B2 (en) 2003-02-25
NO20006574D0 (en) 2000-12-21
JP4426103B2 (en) 2010-03-03
CZ20004790A3 (en) 2001-07-11
CA2335734A1 (en) 1999-12-29
ATE331808T1 (en) 2006-07-15
BE1012049A6 (en) 2000-04-04
NO20006574L (en) 2001-02-15
IL140258A (en) 2005-05-17
EP1082451A2 (en) 2001-03-14
TR200003833T2 (en) 2001-06-21
WO1999067416A2 (en) 1999-12-29
US8106155B2 (en) 2012-01-31
US20020192715A1 (en) 2002-12-19
BR9911500B1 (en) 2013-04-30
AU3703299A (en) 2000-01-10
US20020164639A1 (en) 2002-11-07
JP2002518062A (en) 2002-06-25
CA2335734C (en) 2005-10-04

Similar Documents

Publication Publication Date Title
WO1999067416A3 (en) METHOD FOR DETERMINING ANTIBIOTICS WITH β-LACTAM CORE IN A BIOLOGICAL FLUID
CA2192744A1 (en) Stable coupling dye for photometric determination of analytes
CA2199490A1 (en) Dye couple for spectrophotometric determination of analytes
WO1995018377A1 (en) Binding assay
CA2448713A1 (en) Analytical instruments, biosensors and methods thereof
IL117021A0 (en) Assay device for detecting the presence of an analyte
AU2044795A (en) Reagents for specific binding assays
AU6383396A (en) Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition
EP1086376A4 (en) Inflammatory bowel disease first step assay system
AU5570498A (en) Biochemical and immunochemical assay device
EP1443690A3 (en) Minimizing dispersion in optical-fiber transmission lines
AU8354198A (en) Fluorescent polymeric sensor for the detection of urea
CA2305774A1 (en) Testing device for determining analytes in a liquid dairy product
AU6234196A (en) Method for quantitative measurement of an enzyme linked immunosorbent assay
WO2001042788A3 (en) Analyte assay device with preabsorbing zone
EP0653637A3 (en) Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase labeled reagents.
WO1997007235A3 (en) All-in-one nucleic acid amplification assay
EP0902286A3 (en) Immunoassay utilizing two incubations with labelled antigen
WO2000075363A3 (en) Enzymatic measurement of mycophenolic acid
CA2204305A1 (en) Apparatus and method for determination of urine color
WO2002014830A3 (en) Method of identification and quantification of biological molecules and apparatus therefore
AU2707597A (en) Method of assay
EP0822992A4 (en) Detection of biomolecules
WO2000017636A8 (en) Alcohol concentration test system
AU3437700A (en) Method for detecting superantigen activity in a biological sample

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99809405.6

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 140258

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 1999919158

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: PA/a/2000/012583

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2335734

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 508965

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: PV2000-4790

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 37032/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2000/03833

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 1020007014639

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1999919158

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020007014639

Country of ref document: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2000-4790

Country of ref document: CZ

WWG Wipo information: grant in national office

Ref document number: 37032/99

Country of ref document: AU

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 1020007014639

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 1999919158

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: PV2000-4790

Country of ref document: CZ