WO1999065474A3 - Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds - Google Patents

Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds Download PDF

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Publication number
WO1999065474A3
WO1999065474A3 PCT/JP1999/003154 JP9903154W WO9965474A3 WO 1999065474 A3 WO1999065474 A3 WO 1999065474A3 JP 9903154 W JP9903154 W JP 9903154W WO 9965474 A3 WO9965474 A3 WO 9965474A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
cartilage disease
containing heterocyclic
heterocyclic compounds
treating cartilage
Prior art date
Application number
PCT/JP1999/003154
Other languages
French (fr)
Other versions
WO1999065474A2 (en
Inventor
Haruhiko Makino
Takashi Sohda
Kohei Notoya
Original Assignee
Takeda Chemical Industries Ltd
Haruhiko Makino
Takashi Sohda
Kohei Notoya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Haruhiko Makino, Takashi Sohda, Kohei Notoya filed Critical Takeda Chemical Industries Ltd
Priority to EP99925310A priority Critical patent/EP1087774A2/en
Priority to AU41656/99A priority patent/AU4165699A/en
Priority to CA002334815A priority patent/CA2334815A1/en
Publication of WO1999065474A2 publication Critical patent/WO1999065474A2/en
Publication of WO1999065474A3 publication Critical patent/WO1999065474A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention provides a pharmaceutical composition comprising a compound of formula (I) wherein ring A is an optionally substituted benzene ring; R is a hydrogen atom or an optionally substituted hydrocarbon group; B is an optionally esterified or amidated carboxyl group; X is -CH(OH)- or -CO-; k is 0 or 1; and k' is 0, 1 or 2, or its salt, which can be advantageously used as an agent for prevention and/or treatment of a cartilage disease.
PCT/JP1999/003154 1998-06-15 1999-06-14 Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds WO1999065474A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99925310A EP1087774A2 (en) 1998-06-15 1999-06-14 Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds
AU41656/99A AU4165699A (en) 1998-06-15 1999-06-14 Composition for treating cartilage disease
CA002334815A CA2334815A1 (en) 1998-06-15 1999-06-14 Composition for treating cartilage disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10/167507 1998-06-15
JP16750798 1998-06-15

Publications (2)

Publication Number Publication Date
WO1999065474A2 WO1999065474A2 (en) 1999-12-23
WO1999065474A3 true WO1999065474A3 (en) 2000-04-06

Family

ID=15850970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/003154 WO1999065474A2 (en) 1998-06-15 1999-06-14 Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds

Country Status (5)

Country Link
EP (1) EP1087774A2 (en)
AR (1) AR019664A1 (en)
AU (1) AU4165699A (en)
CA (1) CA2334815A1 (en)
WO (1) WO1999065474A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000008018A1 (en) 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
WO2001066142A1 (en) * 2000-03-10 2001-09-13 Chugai Seiyaku Kabushiki Kaisha Preparations for chondrogenesis
AU5880801A (en) * 2000-05-23 2001-12-03 Takeda Chemical Industries Ltd. Medicinal compositions containing thiophene derivatives
FI129515B (en) 2020-11-06 2022-03-31 Salarusta Oy Hica for use in prophylaxis and/or treatment of a disease or condition involving degradation of cartilage and/or disruption of cartilage homeostasis and/or integrity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376197A1 (en) * 1988-12-28 1990-07-04 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0460488A1 (en) * 1990-05-30 1991-12-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0719782A1 (en) * 1994-12-28 1996-07-03 Takeda Chemical Industries, Ltd. Optically active benzothiepin derivative, its preparation and use
WO1996039134A1 (en) * 1995-06-05 1996-12-12 Takeda Chemical Industries, Ltd. Osteogenetic promoting pharmaceutical composition
WO1998008517A2 (en) * 1996-08-26 1998-03-05 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376197A1 (en) * 1988-12-28 1990-07-04 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0460488A1 (en) * 1990-05-30 1991-12-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0719782A1 (en) * 1994-12-28 1996-07-03 Takeda Chemical Industries, Ltd. Optically active benzothiepin derivative, its preparation and use
WO1996039134A1 (en) * 1995-06-05 1996-12-12 Takeda Chemical Industries, Ltd. Osteogenetic promoting pharmaceutical composition
WO1998008517A2 (en) * 1996-08-26 1998-03-05 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
H. AKIYAMA: "TAK-778, a novel synthetic 3-benzothiepin derivative, promotes chondrogenesis in-vivo and in-vitro", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 261, no. 1, July 1999 (1999-07-01), pages 131 - 138, XP000867478 *

Also Published As

Publication number Publication date
CA2334815A1 (en) 1999-12-23
WO1999065474A2 (en) 1999-12-23
EP1087774A2 (en) 2001-04-04
AU4165699A (en) 2000-01-05
AR019664A1 (en) 2002-03-13

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