WO1999064092A1 - A dose setting device for medical injectors - Google Patents

A dose setting device for medical injectors Download PDF

Info

Publication number
WO1999064092A1
WO1999064092A1 PCT/GB1999/001861 GB9901861W WO9964092A1 WO 1999064092 A1 WO1999064092 A1 WO 1999064092A1 GB 9901861 W GB9901861 W GB 9901861W WO 9964092 A1 WO9964092 A1 WO 9964092A1
Authority
WO
WIPO (PCT)
Prior art keywords
knob
dose
dose setting
barrel
scale
Prior art date
Application number
PCT/GB1999/001861
Other languages
French (fr)
Inventor
Jeremy Marshall
Paul Edward Jansen
Original Assignee
Owen Mumford Limited
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owen Mumford Limited, Eli Lilly And Company filed Critical Owen Mumford Limited
Priority to DK99955438T priority Critical patent/DK1034008T3/en
Priority to EP99955438A priority patent/EP1034008B1/en
Priority to US09/485,493 priority patent/US6666849B1/en
Priority to JP2000553159A priority patent/JP2002517289A/en
Priority to DE69910969T priority patent/DE69910969T2/en
Priority to CA002298674A priority patent/CA2298674C/en
Publication of WO1999064092A1 publication Critical patent/WO1999064092A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose

Definitions

  • This invention concerns a dose setting device for self- use medical injectors of the kind having a knob at the rear end which is rotated, before use, by an amount that determines the dose that is to be dispensed.
  • a knob is knurled or ribbed for a good grip and when rotated it clicks round over a ratchet mechanism.
  • a sequence of numbers around its periphery indexes past a datum mark en the barrel of the injector, the user ceasing to rotate the knob when the number representing the required dose registers with that mark.
  • the mark is often a raised stud, of arrowhead form for example.
  • the injector is fired, the knob is released and is returned to its initial position with zero opposite the mark.
  • Such an injector is sold under the Registered Trade Mark AUTOPEN.
  • a dose setting device for medical injectors of the kind having a rotary dose setting knob at the rear end of a barrel that can be indexed around from a zeroed position to bring an indicator opposite a mark on a scale, the device comprising an annular member adapted to fit retentively over the dose setting knob in any of a plurality of relative rotational positions each corresponding to a selected dose, and having an abutment which can co-operate with a raised stud on the barrel, rotation of the knob for dose setting being arrested by the abutment meeting the stud with the indicator opposite the selected dose mark.
  • the annular member prefferably be adapted for the scale being on the barrel, the stud being at the zero point thereof, and the indicator being on the knob.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Many self-use medical injectors have a knob at the rear end of a barrel which is rotated from a zeroed position to set the dose and which rotates back again, to the zeroed position, when the injector is fired. A scale is provided on the knob (2) or barrel (1) and a datum mark or indicator on the barrel or knob co-operates with the scale. Often there is a raised stud (3, 11, 12, 16) providing the indicator or the zero mark of the scale. An annular member (4, 10, 14, 17) fitted over the knob if the stud is on the barrel or over the barrel if the stud is on the knob has a projection (9, 12, 15, 18) which is registered with a mark on the scale corresponding to the required dose. This projection abuts the stud when the knob is rotated and thus sets the knob for the correct dose.

Description

"A Dose Setting Device for Medical Injectors."
This invention concerns a dose setting device for self- use medical injectors of the kind having a knob at the rear end which is rotated, before use, by an amount that determines the dose that is to be dispensed. Generally, such a knob is knurled or ribbed for a good grip and when rotated it clicks round over a ratchet mechanism. A sequence of numbers around its periphery indexes past a datum mark en the barrel of the injector, the user ceasing to rotate the knob when the number representing the required dose registers with that mark. The mark is often a raised stud, of arrowhead form for example. When the injector is fired, the knob is released and is returned to its initial position with zero opposite the mark. Such an injector is sold under the Registered Trade Mark AUTOPEN.
While it is commercially sensible to have an injector capable of being set to dispense a wide range of doses, each individual user is likely to be prescribed a set dose, and therefore the knob of his injector is always rotated the same amount before each injection. It is the aim of this invention to make the pre- setting operation easy and almost automatic every time.
According to one aspect of the present invention there is provided a dose setting device for medical injectors of the kind having a rotary dose setting knob at the rear end of a barrel that can be indexed around from a zeroed position to bring an indicator opposite a mark on a scale, the device comprising an annular member adapted to fit retentively over the dose setting knob in any of a plurality of relative rotational positions each corresponding to a selected dose, and having an abutment which can co-operate with a raised stud on the barrel, rotation of the knob for dose setting being arrested by the abutment meeting the stud with the indicator opposite the selected dose mark.
In the preferred form the annular member is the mouth- portion of a cup that press fits over and covers the knob. Conveniently the scale is on the knob and the annular member is adapted to leave at least part of the scale visible .
However, it is possible for the annular member to be adapted for the scale being on the barrel, the stud being at the zero point thereof, and the indicator being on the knob.
According to another aspect of the present invention there is provided a dose setting device for medical injectors of the kind having a rotary dose setting knob at the rear end of a barrel that can be indexed around from a zeroed position to bring an indicator opposite a mark on a scale, the device comprising an annular member adapted to fit retentively over the rear end of the barrel in any of a plurality of relative rotational positions each corresponding to a selected dose, and having an abutment which can co-operate with a raised stud on the knob, rotation of the knob for dose setting being arrested by the stud meeting the abutment with the indicator opposite the selected dose mark. The annular member is adapted for the scale being on the knob, the stud being at the zero point thereof, and the indicator being on the barrel .
Alternatively, the scale may be on the barrel, in which case the annular member will preferably be adapted to leave at least part of the scale visible.
When the annular member is so adapted, whether it is on the knob or the barrel, it may be opaque, except for a window through which the selected dose mark may be seen. Alternatively, the annular member could be a unitary moulding of transparent plastics material, with a short section thickened into a magnifying lens for placement over the selected dose number.
In either case the indicator is conveniently provided by the stud and the abutment projects from the annular member immediately adjacent the window or lens.
For a better understanding of the invention some embodiments will now be described, by way of example, with reference to the accompanying drawing, in which: Figure 1 is a perspective view of a dose setting device in conjunction with the rear end of a self-use medical injector,
Figure 2 is a perspective view of another dose setting device in conjunction with a different injector, Figure 3 is a perspective view of a further dose setting device fitted to a third injector, and
Figure 4 is a perspective view of yet another dose setting device fitted to a fourth injector. The injector of Figure 1 has a barrel 1 at the rear end of which there is a ribbed knob 2 of generally frusto- conical form. Its base is adjacent the barrel, and around it is printed a sequence of numbers or a scale representing the dose to be dispensed. Pre-use, from a position in which the zero mark of the scale is in registry with an arrowhead stud 3 on the barrel 1, the knob is clicked round until a selected number comes opposite the stud 3.
A cup-like adaptor 4 is press fits over the knob 2 with the letter zeroed. It is a unitary moulding of transparent plastics, and a short section 5 of its skirt 6 is thickened and shaped to form a magnifying lens across the centre of which, in an axial direction, runs a fine rib 7 forming a "hairline". The lens is clear, but the rest of the adaptor 4, and in particular the skirt 6, may be frosted or opaque. When placed over the knob 2, therefore, the number below the lens 5 is clear and magnified while the other numbers are relatively obscure or invisible. Alternatively, there could just be an open window instead of the lens. The adaptor 4 is formed with external ribs 8 for a good grip, and a trapezoidal lug 9 projects axially from the base of the skirt 6, one sloping side terminating at the skirt 6 directly in line with the rib 7.
The adaptor 4 is fitted so that the lens 5 is over the number representing the required dose. It is not usually possible to print every number (they would be too small if this were done) and so the user may have to interpolate, bringing the rib 7 to a position between two numbers, the lens 5 being circumferentially long enough to show two. The knob 2 is then rotated, through the intermediary of the adaptor 4, until the lug 9 abuts the side of the stud 3, bringing the rotation to a halt. The required dose number or mark is then directly opposite the stud 3 and the injector is correctly set.
When fired, the knob is rotated back again, bringing its zero mark opposite the stud 3. For subsequent injections the procedure is repeated, the same dose being set each time by virtue of the adaptor 4.
Some injectors have the dose numbers or scale on the barrel and a datum mark or indicator on the knob. Figure 2 shows an adaptor 10 suitable for such an injector, with a raised arrowhead stud 11 at the zero position of the scale. The adaptor has a projection 12 on its skirt similar to the lug 9, and it is fitted with this projection registering with a selected number on the barrel. However, that number does not represent the required dose: with a 360° scale, the required dose number is subtracted from the highest number on the scale and the result is the number against which the projection is aligned. There need be no magnifying lens on the main part of the adaptor, but the skirt will preferably be transparent so that the datum mark or indicator can be seen whatever the positioning of the adaptor on the knob. The projection 12 can be formed as a magnifying lens to enhance the number on the barrel over which it lies.
In a third embodiment, as shown in Figure 3, the dose scale is again on the knob but the knob has a raised arrowhead stud 13 at the zero position and the barrel just has a datum mark or indicator. The adaptor 14 takes the form of an annular ring which fits over the mark on the barrel and with a projection 15 extending rearwardly over the base of the knob. The ring will preferably be transparent so that the datum mark or indicator can be seen whatever the position of the ring on the barrel. The projection 15 can be formed as a magnifying lens to enhance the number over which it lies. But as with Figure 2, a subtraction has to be done to calculate where the projection 15 should be so that, when the knob is rotated to bring the stud 13 up against the projection 15, the correct dose has been set .
A further arrangement is shown in Figure 4 where the dose scale is on the barrel and the knob has a raised arrowhead stud 16 that serves as the indicator. The adaptor 17 is again an annular ring which fits over the dose scale on the barrel and with a projection 18 extending rearwardly over the base of the knob. Conveniently the ring has a window 19 or is formed with a lens similar to that of Figure 1 so that the relevant part of the scale can be seen; in this embodiment the projection 18 will be positioned adjacent the actual dose number or mark required and no calculation will be necessary.

Claims

1. A dose setting device for medical injectors of the kind having a rotary dose setting knob at the rear end of a barrel that can be indexed around from a zeroed position to bring an indicator opposite a mark on a scale, the device comprising an annular member adapted to fit retentively over the dose-setting knob in any of a plurality of relative rotational positions each corresponding to a selected dose, and having an abutment which can co-operate with a raised stud on the barrel, rotation of the knob for dose setting being arrested by the abutment meeting the stud with the indicator opposite the selected dose mark.
2. A dose setting device as claimed in Claim 1, wherein the annular member is the mouth portion of a cup that press fits over and covers the knob.
3. A dose setting device as claimed in Claim 1 or 2 , wherein the scale is on the knob and the annular member is adapted to leave at least part of the scale visible.
4. A dose setting devices as claimed in Claim 1 or 2 , wherein the annular member is adapted for the scale being on the barrel, the stud being at the zero point thereof, and the indicator being on the knob.
5. A dose setting device for medical injectors of the kind having a rotary dose setting knob at the rear end of a barrel that can be indexed around from a zeroed position to bring an indicator opposite a mark on a scale, the device comprising an annular member adapted to fit retentively over the rear end of the barrel in any of a plurality of relative rotational positions each corresponding to a selected dose, and having an abutment which can co-operate with a raised stud on the knob, rotation of the knob for dose setting being arrested by the stud meeting the abutment with the indicator opposite the selected dose mark.
6. A dose setting device as claimed in Claim 4, wherein the annular member is adapted for the scale being on the knob, the stud being at the zero point thereof, and the indicator being on the barrel.
7. A dose setting device as claimed in Claim 6, wherein the scale is on the barrel and the annular member is adapted to leave at least part of the scale visible.
8. A dose setting device as claimed in Claim 3 or 7 , wherein the annular member is opaque, except for a window through which the selected dose mark may be seen.
9. A dose setting device as claimed in Claim 3 or 7 , wherein the annular member is a unitary moulding of transparent plastics material, with a short section thickened into a magnifying lens for placement over the selected dose number.
10. A dose setting device as claimed in Claim 8 or 9 , wherein the indicator is provided by the stud and the abutment projects from the annular member immediately adjacent the window or lens.
PCT/GB1999/001861 1998-06-11 1999-06-11 A dose setting device for medical injectors WO1999064092A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DK99955438T DK1034008T3 (en) 1998-06-11 1999-06-11 Dose adjusting device for medical injectors
EP99955438A EP1034008B1 (en) 1998-06-11 1999-06-11 A dose setting device for medical injectors
US09/485,493 US6666849B1 (en) 1998-06-11 1999-06-11 Dose setting device for medical injectors
JP2000553159A JP2002517289A (en) 1998-06-11 1999-06-11 Dose setting device for medical injection device
DE69910969T DE69910969T2 (en) 1998-06-11 1999-06-11 ADJUSTMENT DEVICE FOR DOSING MEDICAL SYRINGES
CA002298674A CA2298674C (en) 1998-06-11 1999-06-11 A dose setting device for medical injectors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9812472.0 1998-06-11
GBGB9812472.0A GB9812472D0 (en) 1998-06-11 1998-06-11 A dose setting device for medical injectors

Publications (1)

Publication Number Publication Date
WO1999064092A1 true WO1999064092A1 (en) 1999-12-16

Family

ID=10833505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001861 WO1999064092A1 (en) 1998-06-11 1999-06-11 A dose setting device for medical injectors

Country Status (9)

Country Link
US (1) US6666849B1 (en)
EP (1) EP1034008B1 (en)
JP (1) JP2002517289A (en)
CA (1) CA2298674C (en)
DE (1) DE69910969T2 (en)
DK (1) DK1034008T3 (en)
ES (1) ES2207303T3 (en)
GB (1) GB9812472D0 (en)
WO (1) WO1999064092A1 (en)

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CN103998077B (en) 2011-12-29 2017-05-31 诺沃—诺迪斯克有限公司 With dialing up/stir quantitative mechanism downwards automatic injector pen is rolled tightly based on torque spring
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GB2375965A (en) * 2000-01-28 2002-12-04 Novo Nordisk As A dose setting limiter
US6524280B2 (en) 2000-01-28 2003-02-25 Noro Nordisk A/S Dose setting limiter
GB2375965B (en) * 2000-01-28 2004-09-01 Novo Nordisk As A dose setting limiter
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WO2002064199A1 (en) * 2001-02-12 2002-08-22 Disetronic Licensing Ag Adjustment lock for a device for administration of an adjustable dose of an injectable product
WO2002064198A1 (en) * 2001-02-12 2002-08-22 Disetronic Licensing Ag Reading aid for a device for administering an adjustable dose of an injectable product
DE10106367A1 (en) * 2001-02-12 2002-08-22 Disetronic Licensing Ag Reading aid for a device for administering an adjustable dose of an injectable product
DE10106368A1 (en) * 2001-02-12 2002-09-05 Disetronic Licensing Ag Adjustment lock for a device for administering an adjustable dose of an injectable product
DE10106368B4 (en) * 2001-02-12 2006-02-02 Tecpharma Licensing Ag An adjustment barrier for a device for administering an adjustable dose of an injectable product
US7377913B2 (en) 2001-02-12 2008-05-27 Tecpharma Licensing Ag Adjustment block for a device for administering a settable dosage of an injectable product
US7407492B2 (en) 2001-02-12 2008-08-05 Tecpharma Licensing, Ag Reading aid for a device for administering a settable dosage of an injectable product
US9387293B2 (en) 2005-02-28 2016-07-12 Novo Nordisk A/S Dose setting mechanism for an injection device capable of presetting a maximum dose
US9101722B2 (en) 2005-02-28 2015-08-11 Novo Nordisk A/S Dose setting mechanism for an injection device capable of presetting a maximum dose
US9669168B2 (en) 2005-02-28 2017-06-06 Novo Nordisk A/S Dose setting mechanism for an injection device and having a preset feature
EP1855743B2 (en) † 2005-02-28 2020-04-22 Novo Nordisk A/S Dose setting mechanism for an injection device capable of presetting a maximum dose
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US10449299B2 (en) 2007-04-18 2019-10-22 Sanofi-Aventis Deutschland Gmbh Injection device for dispensing a medicament
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US10004851B2 (en) 2012-04-13 2018-06-26 Becton, Dickinson And Company Self-injection device with indicator for indicating proper connection of components
WO2014096396A1 (en) 2012-12-21 2014-06-26 Novo Nordisk A/S State changing appliance for a drug delivery device
CN105025960A (en) * 2012-12-21 2015-11-04 诺和诺德股份有限公司 State changing appliance for a drug delivery device
US10117996B2 (en) 2012-12-21 2018-11-06 Novo Nordisk A/S State changing appliance for a drug delivery device

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DE69910969D1 (en) 2003-10-09
EP1034008B1 (en) 2003-09-03
CA2298674C (en) 2007-04-17
DE69910969T2 (en) 2004-07-22
GB9812472D0 (en) 1998-08-05
US6666849B1 (en) 2003-12-23
EP1034008A1 (en) 2000-09-13
JP2002517289A (en) 2002-06-18
DK1034008T3 (en) 2003-12-22
CA2298674A1 (en) 1999-12-16
ES2207303T3 (en) 2004-05-16

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