WO1999063116A3 - Use of prothymosin in the diagnosis and treatment of endometriosis - Google Patents

Use of prothymosin in the diagnosis and treatment of endometriosis Download PDF

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Publication number
WO1999063116A3
WO1999063116A3 PCT/US1999/012336 US9912336W WO9963116A3 WO 1999063116 A3 WO1999063116 A3 WO 1999063116A3 US 9912336 W US9912336 W US 9912336W WO 9963116 A3 WO9963116 A3 WO 9963116A3
Authority
WO
WIPO (PCT)
Prior art keywords
prothymosin
endometriosis
diagnosis
treatment
expression
Prior art date
Application number
PCT/US1999/012336
Other languages
French (fr)
Other versions
WO1999063116A2 (en
Inventor
Patrick A Schneider
Cynthia K French
Karen K Yamamoto
Original Assignee
Reprogen Inc
Patrick A Schneider
Cynthia K French
Karen K Yamamoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reprogen Inc, Patrick A Schneider, Cynthia K French, Karen K Yamamoto filed Critical Reprogen Inc
Priority to AU42305/99A priority Critical patent/AU760613B2/en
Priority to US09/485,193 priority patent/US6753138B1/en
Priority to CA002299436A priority patent/CA2299436A1/en
Priority to JP2000552308A priority patent/JP2002517209A/en
Priority to EP99926150A priority patent/EP1002136A2/en
Publication of WO1999063116A2 publication Critical patent/WO1999063116A2/en
Publication of WO1999063116A3 publication Critical patent/WO1999063116A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/364—Endometriosis, i.e. non-malignant disorder in which functioning endometrial tissue is present outside the uterine cavity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Prothymosin expression is up-regulated in endometriotic tissue. This invention provides methods of diagnosing endometriosis by detecting up-regulation of a prothymosin gene product, and methods of treating endometriosis by down-regulating expression of prothymosin in ectopic or eutopic endometriotic tissue.
PCT/US1999/012336 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis WO1999063116A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU42305/99A AU760613B2 (en) 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis
US09/485,193 US6753138B1 (en) 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis
CA002299436A CA2299436A1 (en) 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis
JP2000552308A JP2002517209A (en) 1998-06-04 1999-06-03 Use of prothymosin in diagnosis and treatment of endometriosis
EP99926150A EP1002136A2 (en) 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8801698P 1998-06-04 1998-06-04
US60/088,016 1998-06-04

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/485,193 A-371-Of-International US6753138B1 (en) 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis
US10/654,592 Division US20040096884A1 (en) 1998-06-04 2003-09-02 Use of prothymosin in the diagnosis and treatment of endometriosis

Publications (2)

Publication Number Publication Date
WO1999063116A2 WO1999063116A2 (en) 1999-12-09
WO1999063116A3 true WO1999063116A3 (en) 2000-03-02

Family

ID=22208698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012336 WO1999063116A2 (en) 1998-06-04 1999-06-03 Use of prothymosin in the diagnosis and treatment of endometriosis

Country Status (5)

Country Link
EP (1) EP1002136A2 (en)
JP (1) JP2002517209A (en)
AU (1) AU760613B2 (en)
CA (1) CA2299436A1 (en)
WO (1) WO1999063116A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023572A2 (en) * 1999-09-30 2001-04-05 Curagen Corporation Polynucleotides and polypeptides encoded thereby
EP1801236B1 (en) * 2000-02-25 2009-11-18 Siemens Healthcare Diagnostics Inc. Endometriosis related markers and uses thereof
US6777182B2 (en) * 2000-02-25 2004-08-17 Metriogene Biosciences Inc. Methods for determining the likelihood of endometriosis in a female subject
EP1321768A1 (en) * 2001-12-18 2003-06-25 Roche Diagnostics GmbH Diagnosis of endometriosis from menstrual blood
CA2489568A1 (en) * 2002-05-14 2004-07-22 The Board Of Trustees Of The Leland Stanford Junior University Endometrial genes in endometrial disorders
US7268117B2 (en) 2003-07-11 2007-09-11 Praecis Pharmaceuticals Incorporated Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis
AU2004303448A1 (en) * 2003-12-23 2005-07-07 Mount Sinai Hospital Methods for detecting markers associated with endometrial disease or phase
US20060008876A1 (en) 2004-07-07 2006-01-12 Shami A S E ME-5, ME-2, and EPP2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis
EP1931993A2 (en) * 2005-09-14 2008-06-18 Medizinische Universität Wien Means and methods for diagnosing endometriosis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696915A (en) * 1984-05-25 1987-09-29 Hoffmann-La Roche Inc. Parathymosin alpha
US5248591A (en) * 1991-05-02 1993-09-28 Puente Fernando D Diagnosis of cancer and other proliferative disorders by analysis of prothymosin alpha expression
WO1995032708A1 (en) * 1994-05-26 1995-12-07 Metris Therapeutics Limited Use of anti-vegf agents in the treatment of endometriosis
WO1998012324A1 (en) * 1996-09-18 1998-03-26 Center For Blood Research, Inc. Monocyte chemotactic protein 5 (mcp-5) molecules and uses therefor
WO1998042185A1 (en) * 1997-03-26 1998-10-01 Reprogen, Inc. Endometriosis mouse model

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696915A (en) * 1984-05-25 1987-09-29 Hoffmann-La Roche Inc. Parathymosin alpha
US5248591A (en) * 1991-05-02 1993-09-28 Puente Fernando D Diagnosis of cancer and other proliferative disorders by analysis of prothymosin alpha expression
WO1995032708A1 (en) * 1994-05-26 1995-12-07 Metris Therapeutics Limited Use of anti-vegf agents in the treatment of endometriosis
WO1998012324A1 (en) * 1996-09-18 1998-03-26 Center For Blood Research, Inc. Monocyte chemotactic protein 5 (mcp-5) molecules and uses therefor
WO1998042185A1 (en) * 1997-03-26 1998-10-01 Reprogen, Inc. Endometriosis mouse model

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAXEVANIS ET AL.: "PROTHYMOSIN ALPHA ENHANCES HUMAN AND MURINE MHC CLASS II SURFACE ANTIGEN EXPRESSION AND MESSENGER RNA ACCUMULATION", J.IMMUNOL., vol. 148, no. 7, 1992, pages 1979 - 1984, XP002125674 *
DATABASE MEDLINE July 1998 (1998-07-01), OTA ET AL.: "IS ADENOMYOSIS AN IMMUNE DISEASE", XP002123261 *
HILL: "IMMUNOLOGY AND ENDOMETRIOSIS", OBSTET GYNECOL CLIN NORTH AM, vol. 24, no. 2, 1997, pages 291 - 306, XP000857031 *
OIKAWA ET AL.: "EXPRESSION OF GONADOTROPIN-RELEASING HORMONE AND PROTHYMOSIN-ALPHA MESSENGER RIBONUCLEIC ACID IN THE OVARY", ENDOCRINOLOGY, vol. 127, no. 5, 1990, XP000857700 *
OTA AND IGARASHI: "EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II ANTIGEN IN ENDOMETRIC TISSUE IN PATIENTS WITH ENDOMETRIOSIS AND ADENOMYOSIS", FERTIL STERIL, vol. 60, no. 5, 1993, pages 834 - 838, XP000857027 *
SHARPE-TIMMS: "BASIC RESEARCH IN ENDOMETRIOIS", OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, vol. 24, no. 2, June 1997 (1997-06-01), pages 269 - 290, XP000853792 *

Also Published As

Publication number Publication date
WO1999063116A2 (en) 1999-12-09
CA2299436A1 (en) 1999-12-09
JP2002517209A (en) 2002-06-18
EP1002136A2 (en) 2000-05-24
AU760613B2 (en) 2003-05-22
AU4230599A (en) 1999-12-20

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