WO1999061586A8 - Promotion of cell differentiation by initially passaged cells - Google Patents

Promotion of cell differentiation by initially passaged cells

Info

Publication number
WO1999061586A8
WO1999061586A8 PCT/US1999/011949 US9911949W WO9961586A8 WO 1999061586 A8 WO1999061586 A8 WO 1999061586A8 US 9911949 W US9911949 W US 9911949W WO 9961586 A8 WO9961586 A8 WO 9961586A8
Authority
WO
WIPO (PCT)
Prior art keywords
promotion
cells
cell differentiation
passaged cells
initially
Prior art date
Application number
PCT/US1999/011949
Other languages
French (fr)
Other versions
WO1999061586A9 (en
WO1999061586A1 (en
Inventor
Ivan T Todorov
Kelly I Scheyhing
Original Assignee
Desmos Inc
Ivan T Todorov
Kelly I Scheyhing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Desmos Inc, Ivan T Todorov, Kelly I Scheyhing filed Critical Desmos Inc
Priority to IL13988399A priority Critical patent/IL139883A0/en
Priority to AU45442/99A priority patent/AU4544299A/en
Priority to CA002333702A priority patent/CA2333702A1/en
Priority to EP99928354A priority patent/EP1080183A1/en
Publication of WO1999061586A1 publication Critical patent/WO1999061586A1/en
Publication of WO1999061586A8 publication Critical patent/WO1999061586A8/en
Publication of WO1999061586A9 publication Critical patent/WO1999061586A9/en
Priority to US09/726,696 priority patent/US20010000324A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/22—Coculture with; Conditioned medium produced by pancreatic cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method for inducing differentiation of less differentiated passaged cells by contacting the cells with initially passaged (P0), more differentiated cells of the same cell type. The method produces differentiated cell aggregates, such as pancreatic islet cell aggregates, which are useful for transplantation.
PCT/US1999/011949 1998-05-29 1999-05-28 Promotion of cell differentiation by initially passaged cells WO1999061586A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL13988399A IL139883A0 (en) 1998-05-29 1999-05-28 Promotion of cell differentiation by intially passaged cells
AU45442/99A AU4544299A (en) 1998-05-29 1999-05-28 Promotion of cell differentiation by initially passaged cells
CA002333702A CA2333702A1 (en) 1998-05-29 1999-05-28 Promotion of cell differentiation by initially passaged cells
EP99928354A EP1080183A1 (en) 1998-05-29 1999-05-28 Promotion of cell differentiation by initially passaged cells
US09/726,696 US20010000324A1 (en) 1998-05-29 2000-11-29 Promotion of cell differentiation by initially passaged cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8768598A 1998-05-29 1998-05-29
US09/087,685 1998-05-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/726,696 Continuation US20010000324A1 (en) 1998-05-29 2000-11-29 Promotion of cell differentiation by initially passaged cells

Publications (3)

Publication Number Publication Date
WO1999061586A1 WO1999061586A1 (en) 1999-12-02
WO1999061586A8 true WO1999061586A8 (en) 2000-03-09
WO1999061586A9 WO1999061586A9 (en) 2000-04-27

Family

ID=22206656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011949 WO1999061586A1 (en) 1998-05-29 1999-05-28 Promotion of cell differentiation by initially passaged cells

Country Status (5)

Country Link
EP (1) EP1080183A1 (en)
AU (1) AU4544299A (en)
CA (1) CA2333702A1 (en)
IL (1) IL139883A0 (en)
WO (1) WO1999061586A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759039B2 (en) 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
US7101546B2 (en) 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005931A1 (en) * 1986-04-03 1987-10-08 East Carolina University Extracellular matrix induction method to produce pancreatic islet tissue
US5510263A (en) * 1993-04-05 1996-04-23 Desmos, Inc. Growth of pancreatic islet-like cell clusters
AU706026B2 (en) * 1995-06-06 1999-06-10 Case Western Reserve University Myogenic differentiation of human mesenchymal stem cells
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells
AU7443996A (en) * 1995-10-30 1997-05-22 Vivorx, Inc. Method for ex vivo proliferation and differentiation of adult pancreatic islet cells, media useful therefor and uses thereof

Also Published As

Publication number Publication date
EP1080183A1 (en) 2001-03-07
WO1999061586A9 (en) 2000-04-27
WO1999061586A1 (en) 1999-12-02
CA2333702A1 (en) 1999-12-02
AU4544299A (en) 1999-12-13
IL139883A0 (en) 2002-02-10

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