WO1999059643A3 - Complexe d'apport par liposomes - Google Patents

Complexe d'apport par liposomes Download PDF

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Publication number
WO1999059643A3
WO1999059643A3 PCT/US1999/011177 US9911177W WO9959643A3 WO 1999059643 A3 WO1999059643 A3 WO 1999059643A3 US 9911177 W US9911177 W US 9911177W WO 9959643 A3 WO9959643 A3 WO 9959643A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery complex
liposomal delivery
antibody
liposome
connecting moiety
Prior art date
Application number
PCT/US1999/011177
Other languages
English (en)
Other versions
WO1999059643A2 (fr
Inventor
John R Lau
Original Assignee
Sdg Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sdg Inc filed Critical Sdg Inc
Priority to AU40902/99A priority Critical patent/AU4090299A/en
Publication of WO1999059643A2 publication Critical patent/WO1999059643A2/fr
Publication of WO1999059643A3 publication Critical patent/WO1999059643A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

On décrit un complexe d'apport par liposome qui permet de transporter à un site spécifique sur la surface d'une cellule un agent pharmacologique avec une meilleure efficacité de ciblage. Le complexe d'apport par liposome comprend de manière générale un liposome, un anticorps, et une fraction de connexion qui se lie à la région Fc de l'anticorps pour lier le liposome à l'anticorps. Dans une forme de réalisation préférée, la fraction de connexion est une protéine G'.
PCT/US1999/011177 1998-05-20 1999-05-19 Complexe d'apport par liposomes WO1999059643A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40902/99A AU4090299A (en) 1998-05-20 1999-05-19 Liposomal delivery complex

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8634798P 1998-05-20 1998-05-20
US60/086,347 1998-05-20

Publications (2)

Publication Number Publication Date
WO1999059643A2 WO1999059643A2 (fr) 1999-11-25
WO1999059643A3 true WO1999059643A3 (fr) 2000-03-16

Family

ID=22197991

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011177 WO1999059643A2 (fr) 1998-05-20 1999-05-19 Complexe d'apport par liposomes

Country Status (2)

Country Link
AU (1) AU4090299A (fr)
WO (1) WO1999059643A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
ATE511543T1 (de) 1999-02-22 2011-06-15 Univ Georgetown Immunoliposome mit einem targeting- antikörperfragment zur systemischen genverabreichung
AU2002307035A1 (en) * 2001-04-02 2002-10-15 Georgetown University A simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
DK2298347T3 (en) 2003-05-06 2016-01-11 Biogen Hemophilia Inc COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER
CA2652222A1 (fr) 2006-05-15 2007-12-13 Georgetown University Preparation d'immunoliposomes cibles sur un anticorps ou un fragment d'anticorps pour l'administration systemique d'agents therapeutiques ou diagnostiques et utilisations connexes
WO2008033253A2 (fr) * 2006-09-11 2008-03-20 Medtronic, Inc. Complexes liposomiques contenant des agents pharmaceutiques et procédés
EP2100597A3 (fr) * 2008-03-11 2009-12-30 Medtronic, Inc. Complexes de liposomes
JP6199746B2 (ja) 2011-02-15 2017-09-20 バキシオン セラピューティクス，リミテッド ライアビリティ カンパニー 抗体およびＦｃ含有標的化分子に基づく生理活性分子の標的送達のための細菌ミニ細胞による治療用組成物および方法
KR102485491B1 (ko) 2012-10-02 2023-01-04 벡션 테라퓨틱스 엘엘씨 면역 조절성 미니세포 및 사용 방법
GB2552473A (en) 2016-07-21 2018-01-31 Evox Therapeutics Ltd Surface decoration of extracellular vesicles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010585A1 (fr) * 1994-09-30 1996-04-11 Inex Pharmaceuticals Corp. Conjugues de proteines glycosylees/liposomes et leurs procedes de preparation
US5567432A (en) * 1991-08-02 1996-10-22 Lau; John R. Masking of liposomes from RES recognition
WO1997039735A1 (fr) * 1996-04-24 1997-10-30 Sdg, Inc. Procede ameliore permettant de masquer les liposomes pour eviter leur reconnaissance par le systeme reticuloendothelial
WO1999001110A1 (fr) * 1997-07-02 1999-01-14 Sdg, Inc. Produit de recombinaison liposomique cible et son utilisation a des fins diagnostiques et therapeutiques
WO1999059545A1 (fr) * 1998-05-19 1999-11-25 Sdg, Inc. Systeme de liberation ciblee de medicament encapsule dans des liposomes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567432A (en) * 1991-08-02 1996-10-22 Lau; John R. Masking of liposomes from RES recognition
WO1996010585A1 (fr) * 1994-09-30 1996-04-11 Inex Pharmaceuticals Corp. Conjugues de proteines glycosylees/liposomes et leurs procedes de preparation
WO1997039735A1 (fr) * 1996-04-24 1997-10-30 Sdg, Inc. Procede ameliore permettant de masquer les liposomes pour eviter leur reconnaissance par le systeme reticuloendothelial
WO1999001110A1 (fr) * 1997-07-02 1999-01-14 Sdg, Inc. Produit de recombinaison liposomique cible et son utilisation a des fins diagnostiques et therapeutiques
WO1999059545A1 (fr) * 1998-05-19 1999-11-25 Sdg, Inc. Systeme de liberation ciblee de medicament encapsule dans des liposomes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. J. (1990), 267(1), 171-7 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GOWARD, CHRISTOPHER R. ET AL: "Expression and purification of a truncated recombinant streptococcal Protein G", XP002126486, retrieved from STN Database accession no. 113:146593 *
ELIASSON, MARGARETA ET AL: "Chimeric IgG-binding receptors engineered from staphylococcal protein A and streptococcal protein G", J. BIOL. CHEM. (1988), 263(9), 4323-7, XP002126485 *

Also Published As

Publication number Publication date
WO1999059643A2 (fr) 1999-11-25
AU4090299A (en) 1999-12-06

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