WO1999059522A1 - Improved bag for infusions - Google Patents

Improved bag for infusions Download PDF

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Publication number
WO1999059522A1
WO1999059522A1 PCT/SE1999/000772 SE9900772W WO9959522A1 WO 1999059522 A1 WO1999059522 A1 WO 1999059522A1 SE 9900772 W SE9900772 W SE 9900772W WO 9959522 A1 WO9959522 A1 WO 9959522A1
Authority
WO
WIPO (PCT)
Prior art keywords
bag
infusion
outlet
inlet
membrane
Prior art date
Application number
PCT/SE1999/000772
Other languages
French (fr)
Inventor
Stefan LINDSTRÖM
Original Assignee
Pharmalink Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmalink Ab filed Critical Pharmalink Ab
Priority to EP19990927040 priority Critical patent/EP1077667A1/en
Priority to AU44034/99A priority patent/AU4403499A/en
Publication of WO1999059522A1 publication Critical patent/WO1999059522A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2037—Separating means having valve means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • the present invention concerns an improved bag for infusions and in particular a bag for infusion, said bag being suitable for the admixture of intravenously administered pharmaceuticals.
  • Bags for infusion containing a non-therapeutical liquid, for example saline (9 mg per ml NaCl) or glucose (50 mg per ml) are routinely used for the administration of pharmaceuticals.
  • a hospitalised patient is given a bag for infusion, connected via a cannula to suitable vein, mostly a vein on the back of the hand.
  • Pharmaceuticals to be administered intravenously to the patient can then be injected in the bag for infusion.
  • the pharmaceutical is prepared in the hospital pharmacy or at the ward by medical personnel, by injecting the pharmaceutical in the bag for infusion.
  • US-A-5,053,012 provides an example of this: in the general context of the document, which relates to an apparatus for pressurising infusion bags (and thus only indirectly with infusion bags as such), a conventional infusion bag 12 is shown in Fig 1, fitted with an outlet port 16 adapted to be punctured by a coupler 18 of a recipient set.
  • the bag 12 is furthermore fitted with an injection port 28 for the purpose of injecting a drug into the liquid in the bag to be administered.
  • DE-A-3, 244,151 discloses a medical storage bag made of a flexible plastic material which has at least one outlet nozzle sealed with a mem- brane.
  • the outlet nozzle has an adapter piece with an annular bead on the internal surface, which permits use of differently dimensioned connecting needles of infusion devices without having to use excessive force to penetrate the membrane.
  • a transfer adapter which includes a special two-way cannula or needle having a protective cylinder, said cylinder being of a diameter adapted to the cap of the vial.
  • soft bags are manufactured of poly vinyl chloride PVC
  • semi-rigid bags are manufactured of one or a mixture of the polymer materials polyacetate (PA), polypropylene (PP) and polyethylene (PE)
  • PA polyacetate
  • PP polypropylene
  • PE polyethylene
  • the rigid, almost bottle-like containers are manufactured of one of the above polymer materials PA, PP and PE.
  • FIG. 1 shows a bag for infusion according to the present invention
  • Fig. 2 is a side view of the bag in Fig. 1,
  • Fig. 3 is detailed cross-sectional view of the first inlet/outlet of the bag in Fig. 1
  • Fig. 4 is detailed cross-sectional view of the second inlet/outlet of the bag in Fig. 1
  • Fig. 5 shows, in perspective view, the different components; vial, transfer adapter and bag according to the present invention.
  • a normal bag for infusion comprises a liquid filled cavity of a certain, suitable volume. This volume is generally in the interval of one hundred to one thousand millilitres.
  • the bag further comprises means for suspension, for example a loop arranged in the bag material, above and outside the liquid filled area.
  • a bag for infusion comprises one or more inlets/outlets for the addition and/or withdrawal of liquid.
  • Said inlets/outlets comprise, according to the prior art, at least one membrane suitable to be penetrated with a cannula.
  • the other inlet/outlet if altogether present, can be a cou- pling such as a threaded coupling or a bayonet mount for the attachment of a syringe or tubing.
  • an infusion bag 10 has two inlets/outlets 20, 40 for the addition and/or withdrawal of liquid.
  • the first inlet/outlet 20, shown in more detail in Fig. 3, comprises a membrane 30, and the second inlet/outlet 40, shown in more detail in Fig. 4, comprises a mechanical valve 50.
  • the valve 50 opens when a syringe 100 is inserted, as illustrated in Fig. 5, and closes when said syringe 100 is removed, and the membrane 30 has a removable seal 60, adapted to be combined with both a needle and an infusion apparatus, and said membrane being enclosed in a casing 70, adapted to fit in a transfer adapter 90.
  • this first and second inlet/outlet 20, 40 are extended from the liquid filled part of the bag 10 for infusion in order to avoid hindering the normal use of a transfer adapter 90. Additionally, the first and second inlet/outlet 20, 40 are arranged at a distance from each other, said distance allowing convenient access to the inlets/outlets 20, 40.
  • one of these two inlets/outlets 20 comprises a penetrable membrane 30, preferably enclosed in a Tulip -type membrane holder or port, adapted for use with a so- called transfer adapter 90.
  • the other inlet/outlet 40 comprises, according to one embodiment of the invention, a coupling with an outer thread, preferably the male part of a so-called Luer ® -lock.
  • said inlet/outlet 40 comprising the coupling preferably comprises a valve 50 which, under mechanical influence, allows the transport of fluid in or out of the bag 10 for infusion.
  • a valve 50 which, under mechanical influence, allows the transport of fluid in or out of the bag 10 for infusion.
  • a valve 50 which, under mechanical influence, allows the transport of fluid in or out of the bag 10 for infusion.
  • One example of such valve is an elastic plug 80, arranged in narrowing of the inlet/outlet 40, reachable with the tip of a syringe 100 when said syringe is locked to the threaded coupling. The tip of the syringe 100 compresses the elastic plug 80 and thereby the inlet/outlet 40 is held open.
  • these two inlets/outlets 20, 40 are at a suitable distance from each other. Preferably they are placed at least 40 millimetres from the liquid filled part of the bag 10 for infusion. Further the centreline of each two inlets/outlets 20, 40 run parallel at the distance of at least 35 mm.

Abstract

Bag (10) for infusion having two inlets/outlets (20, 40), said inlets/outlets (20, 40) being arranged at a minimum distance from each other and from the liquid filled part of the bag for infusion. This makes possible safe and convenient handling. Preferably one of said inlets/outlets comprises a membrane, penetrable with a cannula, and the other inlet/outlet comprises a threaded coupling (50) and a mechanical valve.

Description

IMPROVED BAG FOR INFUSIONS
The present invention concerns an improved bag for infusions and in particular a bag for infusion, said bag being suitable for the admixture of intravenously administered pharmaceuticals.
The background of the invention Bags for infusion, containing a non-therapeutical liquid, for example saline (9 mg per ml NaCl) or glucose (50 mg per ml) are routinely used for the administration of pharmaceuticals. A hospitalised patient is given a bag for infusion, connected via a cannula to suitable vein, mostly a vein on the back of the hand. Pharmaceuticals to be administered intravenously to the patient can then be injected in the bag for infusion. In many cases the pharmaceutical is prepared in the hospital pharmacy or at the ward by medical personnel, by injecting the pharmaceutical in the bag for infusion.
US-A-5,053,012 provides an example of this: in the general context of the document, which relates to an apparatus for pressurising infusion bags (and thus only indirectly with infusion bags as such), a conventional infusion bag 12 is shown in Fig 1, fitted with an outlet port 16 adapted to be punctured by a coupler 18 of a recipient set. The bag 12 is furthermore fitted with an injection port 28 for the purpose of injecting a drug into the liquid in the bag to be administered.
Another example is provided in DE-A-3, 244,151: it discloses a medical storage bag made of a flexible plastic material which has at least one outlet nozzle sealed with a mem- brane. The outlet nozzle has an adapter piece with an annular bead on the internal surface, which permits use of differently dimensioned connecting needles of infusion devices without having to use excessive force to penetrate the membrane.
However, when handling very potent pharmaceuticals, such as cytostatic agents for the treatment of cancer, the preparation of the bag for infusion is performed under rigorous security precautions.
When preparing doses where the active substance is stored in freeze-dried form, part of the content is transferred from the bag for infusion to the pharmaceutical vial and returned to the bag. For the handling of such vials, a transfer adapter has been developed, which includes a special two-way cannula or needle having a protective cylinder, said cylinder being of a diameter adapted to the cap of the vial.
Commercially available bags for infusion can be divided in three main categories: soft bags, semi-rigid and rigid bags. Soft bags are manufactured of poly vinyl chloride PVC, semi-rigid bags are manufactured of one or a mixture of the polymer materials polyacetate (PA), polypropylene (PP) and polyethylene (PE) and the rigid, almost bottle-like containers are manufactured of one of the above polymer materials PA, PP and PE.
In accordance with the aim of eliminating the use of PVC-containing plastics, the use of semi-rigid bags is increasing. These also have other benefits, such as better barrier proper- ties and less transport of chemicals, for instance softeners, from the bag material to its contents. This is an important consideration, especially in long term treatment of chronically ill patients.
The use of semi-rigid bags has however some drawbacks: the commonly used transfer adapters can not be used, because they are blocked by the liquid containing part of the bag, which entail an increased risk for the medical personnel of coming in contact with potent and possibly toxic pharmaceuticals or being harmed by the sharp end of the cannula.
Consequently there exists a need for new infusion bag constructions, making possible a more safe and convenient handling.
Summary of the invention The new bag for infusion according to the attached claims eliminates the above drawbacks.
Short description of the drawings The invention will be described in closer detail below, with reference to the enclosed drawings, in which Fig. 1 shows a bag for infusion according to the present invention,
Fig. 2 is a side view of the bag in Fig. 1,
Fig. 3 is detailed cross-sectional view of the first inlet/outlet of the bag in Fig. 1, Fig. 4 is detailed cross-sectional view of the second inlet/outlet of the bag in Fig. 1, Fig. 5 shows, in perspective view, the different components; vial, transfer adapter and bag according to the present invention.
Description of the invention A normal bag for infusion comprises a liquid filled cavity of a certain, suitable volume. This volume is generally in the interval of one hundred to one thousand millilitres. The bag further comprises means for suspension, for example a loop arranged in the bag material, above and outside the liquid filled area. Finally, a bag for infusion comprises one or more inlets/outlets for the addition and/or withdrawal of liquid.
Said inlets/outlets comprise, according to the prior art, at least one membrane suitable to be penetrated with a cannula. The other inlet/outlet, if altogether present, can be a cou- pling such as a threaded coupling or a bayonet mount for the attachment of a syringe or tubing.
With reference to Fig. 1 and 2, an infusion bag 10 according to one embodiment of the present invention has two inlets/outlets 20, 40 for the addition and/or withdrawal of liquid. The first inlet/outlet 20, shown in more detail in Fig. 3, comprises a membrane 30, and the second inlet/outlet 40, shown in more detail in Fig. 4, comprises a mechanical valve 50. The valve 50 opens when a syringe 100 is inserted, as illustrated in Fig. 5, and closes when said syringe 100 is removed, and the membrane 30 has a removable seal 60, adapted to be combined with both a needle and an infusion apparatus, and said membrane being enclosed in a casing 70, adapted to fit in a transfer adapter 90.
Importantly, this first and second inlet/outlet 20, 40 are extended from the liquid filled part of the bag 10 for infusion in order to avoid hindering the normal use of a transfer adapter 90. Additionally, the first and second inlet/outlet 20, 40 are arranged at a distance from each other, said distance allowing convenient access to the inlets/outlets 20, 40. Preferably, one of these two inlets/outlets 20 comprises a penetrable membrane 30, preferably enclosed in a Tulip -type membrane holder or port, adapted for use with a so- called transfer adapter 90. The other inlet/outlet 40 comprises, according to one embodiment of the invention, a coupling with an outer thread, preferably the male part of a so-called Luer®-lock. Further, according to the present invention, said inlet/outlet 40 comprising the coupling preferably comprises a valve 50 which, under mechanical influence, allows the transport of fluid in or out of the bag 10 for infusion. One example of such valve is an elastic plug 80, arranged in narrowing of the inlet/outlet 40, reachable with the tip of a syringe 100 when said syringe is locked to the threaded coupling. The tip of the syringe 100 compresses the elastic plug 80 and thereby the inlet/outlet 40 is held open.
As stated above, it is an important characteristic of the present invention is that these two inlets/outlets 20, 40 are at a suitable distance from each other. Preferably they are placed at least 40 millimetres from the liquid filled part of the bag 10 for infusion. Further the centreline of each two inlets/outlets 20, 40 run parallel at the distance of at least 35 mm.

Claims

Claims
1. Bag (10) for infusion having two inlets/outlets (20, 40) for the addition and/or withdrawal of liquid, characterized in that a first inlet/outlet (20) comprises a membrane (30) and a second inlet/outlet (40) comprises a mechanic valve (50), said valve (50) opening when a syringe (100) is inserted and closing when said syringe (100) is removed, said membrane (30) having a removable seal (60), adapted to be combined with both a needle and an infusion apparatus, and said membrane being enclosed in a casing (70), adapted to fit in a transfer adapter (90).
2. Bag (10) for infusion according to claim 1, characterized in that said first and second inlet/outlet (20, 40) extend at least 40 mm from the liquid filled part of the bag
(10) for infusion.
3. Bag (10) for infusion according to claim 1, characterized in that the centre lines of said first and second inlet/outlet (20, 40) run parallel at the distance of at least 35 mm.
4. Bag (10) for infusion according to any one of claim 1-3, characterized in that said bag is a bag manufactured of any one of the polymer materials PA, PP and PE or a mixture thereof, and having a volume less than or equal to 100 ml.
PCT/SE1999/000772 1998-05-15 1999-05-07 Improved bag for infusions WO1999059522A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19990927040 EP1077667A1 (en) 1998-05-15 1999-05-07 Improved bag for infusions
AU44034/99A AU4403499A (en) 1998-05-15 1999-05-07 Improved bag for infusions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801720A SE9801720D0 (en) 1998-05-15 1998-05-15 Improved bag for infusions
SE9801720-5 1998-05-15

Publications (1)

Publication Number Publication Date
WO1999059522A1 true WO1999059522A1 (en) 1999-11-25

Family

ID=20411335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1999/000772 WO1999059522A1 (en) 1998-05-15 1999-05-07 Improved bag for infusions

Country Status (4)

Country Link
EP (1) EP1077667A1 (en)
AU (1) AU4403499A (en)
SE (1) SE9801720D0 (en)
WO (1) WO1999059522A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1161960A2 (en) * 2000-06-09 2001-12-12 Sidam di Azzolini Graziano E C. S.a.s. Single-use preassembled medical device for administering at least two drugs in preset proportions to patients
WO2012040799A1 (en) * 2010-09-29 2012-04-05 Norival Ceatano Spike-type connector for a medicament reconstitution bag, and safety device for a bottle containing a medicament to be reconstituted
ITMI20120643A1 (en) * 2012-04-18 2013-10-19 Frattini Paolo Giuseppe Gobbi BAG FOR LIQUID SOLUTIONS THAT CAN BE MIXED WITH ACTIVE SUBSTANCES AVAILABLE IN SEPARATE SHAPE, IN POWDER OR GEL IN PARTICULAR, FOR THE FORMATION OF MEDICINAL OR LIQUID NUTRITIONAL SUBSTANCES ADMINISTABLE TO PATIENTS FOR INTERNAL INSTILLATION.
CN103800199A (en) * 2014-03-06 2014-05-21 容家杨 Infusion bag with brown frosted surface
EP3200744A4 (en) * 2014-09-30 2017-11-15 Sirtex Medical Limited A transferring device for transferring a toxic substance

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE123973C (en) *
DE3244151A1 (en) * 1982-11-29 1984-05-30 Fresenius AG, 6380 Bad Homburg Medical storage bag
US5053012A (en) * 1989-09-29 1991-10-01 Harmac Medical Products, Inc. Disposable pressure cuff having flow-through pressure gauge

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE123973C (en) *
DE3244151A1 (en) * 1982-11-29 1984-05-30 Fresenius AG, 6380 Bad Homburg Medical storage bag
US5053012A (en) * 1989-09-29 1991-10-01 Harmac Medical Products, Inc. Disposable pressure cuff having flow-through pressure gauge

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1161960A2 (en) * 2000-06-09 2001-12-12 Sidam di Azzolini Graziano E C. S.a.s. Single-use preassembled medical device for administering at least two drugs in preset proportions to patients
EP1161960A3 (en) * 2000-06-09 2002-09-11 Sidam di Azzolini Graziano E C. S.a.s. Single-use preassembled medical device for administering at least two drugs in preset proportions to patients
US6712786B2 (en) 2000-06-09 2004-03-30 Sidam Di Azzolini Graziano E C. S.A.S. Single-use preassembled medical device for administering at least two drugs in preset proportions to patients
WO2012040799A1 (en) * 2010-09-29 2012-04-05 Norival Ceatano Spike-type connector for a medicament reconstitution bag, and safety device for a bottle containing a medicament to be reconstituted
US9833381B2 (en) 2010-09-29 2017-12-05 Norival Caetano Spike-type connector for a medicament reconstitution bag, and safety device for a bottle containing a medicament to be reconstituted
ITMI20120643A1 (en) * 2012-04-18 2013-10-19 Frattini Paolo Giuseppe Gobbi BAG FOR LIQUID SOLUTIONS THAT CAN BE MIXED WITH ACTIVE SUBSTANCES AVAILABLE IN SEPARATE SHAPE, IN POWDER OR GEL IN PARTICULAR, FOR THE FORMATION OF MEDICINAL OR LIQUID NUTRITIONAL SUBSTANCES ADMINISTABLE TO PATIENTS FOR INTERNAL INSTILLATION.
US8894609B2 (en) 2012-04-18 2014-11-25 Ditta Paola Giuseppe Gobbi Frattini Bag for mixable liquid solutions
CN103800199A (en) * 2014-03-06 2014-05-21 容家杨 Infusion bag with brown frosted surface
EP3200744A4 (en) * 2014-09-30 2017-11-15 Sirtex Medical Limited A transferring device for transferring a toxic substance

Also Published As

Publication number Publication date
SE9801720D0 (en) 1998-05-15
AU4403499A (en) 1999-12-06
EP1077667A1 (en) 2001-02-28

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