WO1999057273A3 - Sequences de codage antiproteinase-3 cytoplasmique en therapie genique - Google Patents

Sequences de codage antiproteinase-3 cytoplasmique en therapie genique Download PDF

Info

Publication number
WO1999057273A3
WO1999057273A3 PCT/US1999/008949 US9908949W WO9957273A3 WO 1999057273 A3 WO1999057273 A3 WO 1999057273A3 US 9908949 W US9908949 W US 9908949W WO 9957273 A3 WO9957273 A3 WO 9957273A3
Authority
WO
WIPO (PCT)
Prior art keywords
coding sequence
gene therapy
cytoplasmic antiproteinase
antiproteinase
cytoplasmic
Prior art date
Application number
PCT/US1999/008949
Other languages
English (en)
Other versions
WO1999057273A2 (fr
Inventor
Cindy A Sprecher
Donald C Foster
Stephen R Jaspers
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU38667/99A priority Critical patent/AU3866799A/en
Publication of WO1999057273A2 publication Critical patent/WO1999057273A2/fr
Publication of WO1999057273A3 publication Critical patent/WO1999057273A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des acides nucléiques antiprotéinase cytoplasmique ainsi que des protéines inhibitrices de sérine et cystéine protéase codées par lesdits acides nucléiques, utiles dans la purification des protéines et le traitement des maladies inflammatoires et des maladies faisant intervenir l'apoptose.
PCT/US1999/008949 1998-05-04 1999-04-27 Sequences de codage antiproteinase-3 cytoplasmique en therapie genique WO1999057273A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38667/99A AU3866799A (en) 1998-05-04 1999-04-27 Cytoplasmic antiproteinase-3 coding sequence in gene therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7227598A 1998-05-04 1998-05-04
US09/072,275 1998-05-04

Publications (2)

Publication Number Publication Date
WO1999057273A2 WO1999057273A2 (fr) 1999-11-11
WO1999057273A3 true WO1999057273A3 (fr) 2000-01-20

Family

ID=22106607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008949 WO1999057273A2 (fr) 1998-05-04 1999-04-27 Sequences de codage antiproteinase-3 cytoplasmique en therapie genique

Country Status (2)

Country Link
AU (1) AU3866799A (fr)
WO (1) WO1999057273A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005067958A2 (fr) * 2003-02-19 2005-07-28 University Of Chicago Procedes et compositions pour inhiber des cathepsines
GB201804514D0 (en) * 2018-03-21 2018-05-02 Ucl Business Plc Treatment of pyroptosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612194A (en) * 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5710026A (en) * 1995-02-08 1998-01-20 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and cytoplasmic antiproteinase-3 and coding sequences
WO1998011129A1 (fr) * 1996-09-12 1998-03-19 Idun Pharmaceuticals, Incorporated DIPEPTIDES DE (N-SUBSTITUE)-2-INDOLYLE A MODIFICATION C-TERMINALE UTILISES EN TANT QU'INHIBITEURS DE LA FAMILLE ICE/ced-3 DE CYSTEINE PROTEASES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612194A (en) * 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5710026A (en) * 1995-02-08 1998-01-20 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and cytoplasmic antiproteinase-3 and coding sequences
WO1998011129A1 (fr) * 1996-09-12 1998-03-19 Idun Pharmaceuticals, Incorporated DIPEPTIDES DE (N-SUBSTITUE)-2-INDOLYLE A MODIFICATION C-TERMINALE UTILISES EN TANT QU'INHIBITEURS DE LA FAMILLE ICE/ced-3 DE CYSTEINE PROTEASES

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GAGLIARDINI V ET AL: "Prevention of vertebrate neuronal death by the crmA gene", SCIENCE, vol. 263, 11 February 1994 (1994-02-11), pages 826 - 828, XP002122713 *
NICHOLSON DW ET AL: "Caspases: killer proteases", TIBS, vol. 22, August 1997 (1997-08-01), pages 299 - 306, XP002122715 *
ROUQUET N ET AL: "ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis.", CURRENT BIOLOGY, (1996 SEP 1) 6 (9) 1192-5., XP002122714 *

Also Published As

Publication number Publication date
WO1999057273A2 (fr) 1999-11-11
AU3866799A (en) 1999-11-23

Similar Documents

Publication Publication Date Title
WO1996024650A3 (fr) L'antiproteinase-2 cytoplasmique et l'antiproteinase-3 cytoplasmique et leurs sequences de codage
WO2003000840A3 (fr) Nitrilases
WO2002083921A8 (fr) Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers
WO2003023008A8 (fr) Polypeptides therapeutiques, acides nucleiques les codant, et modalites d'emploi correspondantes
FI964174A0 (fi) Menetelmät tehokkaisen yhdistelmä-DNA-seriiniproteaasi-inhibiittoreiden tuottamiseksi ja näiden inhibiittorien käyttöjä
AU2001236638A1 (en) Evi27 gene sequences and protein encoded thereby
WO2000053776A3 (fr) Nouveaux genes humains du type kallikreine
AU2002357004A1 (en) Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
AU2002214542A1 (en) Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
AU2003259246A1 (en) Methods for the use of neurotoxin in the treatment of urologic disorders
EP1244780A4 (fr) Adn codant la serine protease t humaine
WO1999057273A3 (fr) Sequences de codage antiproteinase-3 cytoplasmique en therapie genique
AU2003217956A1 (en) Therapeutic polypeptides, nucleic acids encoding same and methods of use
WO2003040330A8 (fr) Polypeptides therapeutiques, acides nucleiques les codant et procedes d'utilisation correspondant
AU2001288363A1 (en) Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
AU2002258630A1 (en) Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
EP1045914B8 (fr) Svph1-8 proteinase humaine specifique aux testicules
AU2003298570A1 (en) Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
EP1383871A4 (fr) Proteines enzymatiques humaines isolees, molecules d'acides nucleiques codant pour ces proteines, et leurs utilisations
AU2002303137A1 (en) Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
AU2002365216A1 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2003060149A9 (fr) Polypeptides therapeutiques, acides nucleiques codant ces polypeptides et procedes d'utilisation
AU2003304034A1 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1385991A4 (fr) Proteines enzymatiques humaines isolees, molecules d'acide nucleique codant lesdites proteines et utilisations associees
AU2001282640A1 (en) Protein of phenoloxidase system and gene coding the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase