WO1999057273A3 - Sequences de codage antiproteinase-3 cytoplasmique en therapie genique - Google Patents

Sequences de codage antiproteinase-3 cytoplasmique en therapie genique Download PDF

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Publication number
WO1999057273A3
WO1999057273A3 PCT/US1999/008949 US9908949W WO9957273A3 WO 1999057273 A3 WO1999057273 A3 WO 1999057273A3 US 9908949 W US9908949 W US 9908949W WO 9957273 A3 WO9957273 A3 WO 9957273A3
Authority
WO
WIPO (PCT)
Prior art keywords
coding sequence
gene therapy
cytoplasmic antiproteinase
antiproteinase
cytoplasmic
Prior art date
Application number
PCT/US1999/008949
Other languages
English (en)
Other versions
WO1999057273A2 (fr
Inventor
Cindy A Sprecher
Donald C Foster
Stephen R Jaspers
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU38667/99A priority Critical patent/AU3866799A/en
Publication of WO1999057273A2 publication Critical patent/WO1999057273A2/fr
Publication of WO1999057273A3 publication Critical patent/WO1999057273A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des acides nucléiques antiprotéinase cytoplasmique ainsi que des protéines inhibitrices de sérine et cystéine protéase codées par lesdits acides nucléiques, utiles dans la purification des protéines et le traitement des maladies inflammatoires et des maladies faisant intervenir l'apoptose.
PCT/US1999/008949 1998-05-04 1999-04-27 Sequences de codage antiproteinase-3 cytoplasmique en therapie genique WO1999057273A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38667/99A AU3866799A (en) 1998-05-04 1999-04-27 Cytoplasmic antiproteinase-3 coding sequence in gene therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7227598A 1998-05-04 1998-05-04
US09/072,275 1998-05-04

Publications (2)

Publication Number Publication Date
WO1999057273A2 WO1999057273A2 (fr) 1999-11-11
WO1999057273A3 true WO1999057273A3 (fr) 2000-01-20

Family

ID=22106607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008949 WO1999057273A2 (fr) 1998-05-04 1999-04-27 Sequences de codage antiproteinase-3 cytoplasmique en therapie genique

Country Status (2)

Country Link
AU (1) AU3866799A (fr)
WO (1) WO1999057273A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2514395A1 (fr) * 2003-02-19 2005-07-28 University Of Chicago Procedes et compositions pour inhiber des cathepsines
GB201804514D0 (en) 2018-03-21 2018-05-02 Ucl Business Plc Treatment of pyroptosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612194A (en) * 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5710026A (en) * 1995-02-08 1998-01-20 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and cytoplasmic antiproteinase-3 and coding sequences
WO1998011129A1 (fr) * 1996-09-12 1998-03-19 Idun Pharmaceuticals, Incorporated DIPEPTIDES DE (N-SUBSTITUE)-2-INDOLYLE A MODIFICATION C-TERMINALE UTILISES EN TANT QU'INHIBITEURS DE LA FAMILLE ICE/ced-3 DE CYSTEINE PROTEASES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612194A (en) * 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5710026A (en) * 1995-02-08 1998-01-20 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and cytoplasmic antiproteinase-3 and coding sequences
WO1998011129A1 (fr) * 1996-09-12 1998-03-19 Idun Pharmaceuticals, Incorporated DIPEPTIDES DE (N-SUBSTITUE)-2-INDOLYLE A MODIFICATION C-TERMINALE UTILISES EN TANT QU'INHIBITEURS DE LA FAMILLE ICE/ced-3 DE CYSTEINE PROTEASES

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GAGLIARDINI V ET AL: "Prevention of vertebrate neuronal death by the crmA gene", SCIENCE, vol. 263, 11 February 1994 (1994-02-11), pages 826 - 828, XP002122713 *
NICHOLSON DW ET AL: "Caspases: killer proteases", TIBS, vol. 22, August 1997 (1997-08-01), pages 299 - 306, XP002122715 *
ROUQUET N ET AL: "ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis.", CURRENT BIOLOGY, (1996 SEP 1) 6 (9) 1192-5., XP002122714 *

Also Published As

Publication number Publication date
AU3866799A (en) 1999-11-23
WO1999057273A2 (fr) 1999-11-11

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