WO1999056698A3 - Treatment of celiac disease - Google Patents
Treatment of celiac disease Download PDFInfo
- Publication number
- WO1999056698A3 WO1999056698A3 PCT/DK1999/000255 DK9900255W WO9956698A3 WO 1999056698 A3 WO1999056698 A3 WO 1999056698A3 DK 9900255 W DK9900255 W DK 9900255W WO 9956698 A3 WO9956698 A3 WO 9956698A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- interfering
- deamidation
- celiac disease
- glutamine residue
- gliadin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU35961/99A AU3596199A (en) | 1998-05-06 | 1999-05-06 | Treatment of celiac disease |
EP99917810A EP1075267A2 (en) | 1998-05-06 | 1999-05-06 | Treatment of celiac disease |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0621/98 | 1998-05-06 | ||
DK62198 | 1998-05-06 | ||
US9154598P | 1998-07-01 | 1998-07-01 | |
US60/091,545 | 1998-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999056698A2 WO1999056698A2 (en) | 1999-11-11 |
WO1999056698A3 true WO1999056698A3 (en) | 1999-12-29 |
Family
ID=26064330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK1999/000255 WO1999056698A2 (en) | 1998-05-06 | 1999-05-06 | Treatment of celiac disease |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1075267A2 (en) |
AU (1) | AU3596199A (en) |
WO (1) | WO1999056698A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6348495B1 (en) | 1996-06-06 | 2002-02-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Method for treating celiac disease |
TWI289557B (en) | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
PT1191025E (en) | 1999-06-30 | 2005-09-30 | Takeda Pharmaceutical | LANSOPRAZOL CRYSTALS |
DK1572127T4 (en) | 2002-02-14 | 2014-11-24 | Univ Leland Stanford Junior | Enzyme processing of foods for celiac disease |
US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
CA2771725C (en) | 2002-10-16 | 2015-08-18 | Takeda Pharmaceutical Company Limited | Solid preparation comprising a non-toxic base and a proton pump inhibitor |
CA2502700C (en) * | 2002-11-20 | 2017-01-17 | Chaitan Khosla | Diagnostic method for celiac sprue |
US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
ITMI20062080A1 (en) * | 2006-10-30 | 2008-04-30 | Consiglio Nazionale Ricerche | TREATMENT OF CEREAL FLOURS FOR FOOD CONSUMPTION BY CELIAC PATIENTS |
AU2008229448B2 (en) | 2007-03-16 | 2013-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Combination enzyme therapy for digestion of dietary gluten |
EA017064B1 (en) | 2008-03-10 | 2012-09-28 | Такеда Фармасьютикал Компани Лимитед | Crystal of benzimidazole compound |
JP5937106B2 (en) * | 2011-01-20 | 2016-06-22 | サイレックス ラボラトリーズ,エルエルシー | Method and apparatus for detecting gluten sensitivity and differentiating gluten sensitivity from celiac disease |
WO2012108827A1 (en) * | 2011-02-08 | 2012-08-16 | Phadia Ab | Wheat antigens and peptides for diagnosis of wheat induced hypersensitivity |
ITSR20130002A1 (en) | 2013-10-08 | 2015-04-08 | Danilo Ciciulla | NEW INDUSTRIAL PROCESS OF PROCESSING FOR THE PRODUCTION OF FARINACEOUS FOODS, INTENDED FOR SUBJECTS WITH CELIAC DISEASE CLINICALLY MANIFESTED, BASED ON COMMON FLOURS. |
WO2017089961A1 (en) * | 2015-11-24 | 2017-06-01 | Universidade De Trás-Os-Montes E Alto Douro | Process for preparing cereal flours enriched with l-theanine and corresponding products |
CN105434459A (en) * | 2015-12-25 | 2016-03-30 | 南阳医学高等专科学校 | Formula of western medicine for treating ulcer and preparation process for western medicine |
IT201800010305A1 (en) | 2018-11-13 | 2020-05-13 | Danilo Ciciulla | PROCEDURE FOR THE PREPARATION OF WHEAT-BASED FOODS INTENDED FOR CELIACS OR SUBJECTS WITH GLUTEN SENSITIVITY |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4338334A (en) * | 1977-12-29 | 1982-07-06 | Merck & Co., Inc. | 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases |
EP0278174A2 (en) * | 1986-12-24 | 1988-08-17 | Glaxo Group Limited | Use of fluticasone propionate in the preparation of a pharmaceutical composition for the treatment of bowel diseases |
DD262999A1 (en) * | 1987-07-27 | 1988-12-21 | Adw Ddr | METHOD FOR PRODUCING A DIETETIC FOR ZOELIAKIE AND SPRUCE BARRIER |
SU1581315A1 (en) * | 1987-12-07 | 1990-07-30 | Пятигорский научно-исследовательский институт курортологии и физиотерапии | Method of treating celiac disease of children |
EP0444829A2 (en) * | 1990-02-27 | 1991-09-04 | FISONS plc | Immunosuppressive compounds |
WO1992018524A1 (en) * | 1991-04-17 | 1992-10-29 | Prodotti Chimici E Alimentari S.P.A. | N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them |
WO1998003872A2 (en) * | 1996-07-18 | 1998-01-29 | Detlef Schuppan | Immunological process for detecting antibodies directed towards tissue transglutaminase (ttg), use of ttg for diagnostic purposes and therapy control, and oral pharmaceutical agent containing ttg |
-
1999
- 1999-05-06 AU AU35961/99A patent/AU3596199A/en not_active Abandoned
- 1999-05-06 EP EP99917810A patent/EP1075267A2/en not_active Withdrawn
- 1999-05-06 WO PCT/DK1999/000255 patent/WO1999056698A2/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4338334A (en) * | 1977-12-29 | 1982-07-06 | Merck & Co., Inc. | 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases |
EP0278174A2 (en) * | 1986-12-24 | 1988-08-17 | Glaxo Group Limited | Use of fluticasone propionate in the preparation of a pharmaceutical composition for the treatment of bowel diseases |
DD262999A1 (en) * | 1987-07-27 | 1988-12-21 | Adw Ddr | METHOD FOR PRODUCING A DIETETIC FOR ZOELIAKIE AND SPRUCE BARRIER |
SU1581315A1 (en) * | 1987-12-07 | 1990-07-30 | Пятигорский научно-исследовательский институт курортологии и физиотерапии | Method of treating celiac disease of children |
EP0444829A2 (en) * | 1990-02-27 | 1991-09-04 | FISONS plc | Immunosuppressive compounds |
WO1992018524A1 (en) * | 1991-04-17 | 1992-10-29 | Prodotti Chimici E Alimentari S.P.A. | N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them |
WO1998003872A2 (en) * | 1996-07-18 | 1998-01-29 | Detlef Schuppan | Immunological process for detecting antibodies directed towards tissue transglutaminase (ttg), use of ttg for diagnostic purposes and therapy control, and oral pharmaceutical agent containing ttg |
Non-Patent Citations (14)
Title |
---|
BRUCE, S. E. ET AL: "Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and celiac disease", CLIN. SCI. (1985), 68(5), 573-9 CODEN: CSCIAE;ISSN: 0143-5221, XP002085949 * |
DATABASE WPI Section Ch Week 199113, Derwent World Patents Index; Class B06, AN 1991-092939, XP002118955 * |
DE MAGALHAES A.F.N. ET AL: "[The use of antibiotics in digestive tract diseases]. USO DE ANTIBIOTICOS EM DOENCAS DO APARELHO DIGESTIVO.", REVISTA BRASILEIRA DE CLINICA E TERAPEUTICA, (1979) 8/11 (505-516). CODEN: RBCTAP, XP002118952 * |
FREEMAN H.J.: "Ranitidine -associated interstitial nephritis in a patient with celiac sprue.", CAN. J. GASTROENTEROL., (1988) 2/1 (35-36). ISSN: 0835-7900 CODEN: CJGAEJ, Canada, XP002085955 * |
FRIIS S U: "COELIAC DISEASE. PATHOGENESIS AND CLINICAL ASPECTS", APMIS, vol. 104, no. SUPPL. 61, 1 January 1996 (1996-01-01), pages 5 - 48, XP000605982, ISSN: 0903-4641 * |
GRAHAM D Y ET AL: "Mechanism of increase in steatorrhea with calcium and magnesium in exocrine pancreatic insufficiency: an animal model.", GASTROENTEROLOGY, (1982 SEP) 83 (3) 638-44. JOURNAL CODE: FH3. ISSN: 0016-5085., United States, XP002085956 * |
GRAHAM D Y: "Pancreatic enzyme replacement: the effect of antacids or cimetidine.", DIGESTIVE DISEASES AND SCIENCES, (1982 JUN) 27 (6) 485-90. JOURNAL CODE: EAD. ISSN: 0163-2116., United States, XP002085957 * |
JOURET A. ET AL: "[Digestive pathologies and intraepithelial lymphocytes]. PATHOLOGIE DIGESTIVE ET LYMPHOCYTES INTRA-EPITHELIAUX.", ACTA ENDOSCOPICA, (1995) 25/5 SUPPL. (563-569). ISSN: 0240-642X CODEN: AENDD5, France, XP002085954 * |
KASPER H ET AL: "[Therapy of diseases of the small intestine]. Die Therapie von Dunndarmerkrankungen.", MEDIZINISCHE WELT, (1969 DEC 20) 51 2777-9. JOURNAL CODE: MIM. ISSN: 0025-8512., GERMANY, WEST: Germany, Federal Republic of, XP002085953 * |
MEHTA D.I. ET AL: "Chronic diarrhea: Causes, presentation, and management.", INDIAN JOURNAL OF PEDIATRICS, (1996) 63/4 (459-471). ISSN: 0019-5456 CODEN: IJPEA2, India, XP002085951 * |
MOLBERG, OYBIND ET AL: "Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease", NAT. MED. (N. Y.) (1998), 4(6), 713-717 CODEN: NAMEFI;ISSN: 1078-8956, XP002085952 * |
SOLLID L M ET AL: "Autoantibodies in coeliac disease: tissue transglutaminase --guilt by association?.", GUT, (1997 DEC) 41 (6) 851-2., XP002118953 * |
UHLIG, H. ET AL: "Role of tissue transglutaminase in gliadin binding to reticular extracellular matrix and relation to coeliac disease autoantibodies", AUTOIMMUNITY (1998), 28(4), 185-195, XP002118954 * |
UNSWORTH J ET AL: "Flat small intestinal mucosa and autoantibodies against the gut epithelium.", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1982) 1 (4) 503-13. JOURNAL CODE: JL6. ISSN: 0277-2116., United States, XP002085950 * |
Also Published As
Publication number | Publication date |
---|---|
AU3596199A (en) | 1999-11-23 |
WO1999056698A2 (en) | 1999-11-11 |
EP1075267A2 (en) | 2001-02-14 |
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