WO1999056126A3 - Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof - Google Patents

Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof Download PDF

Info

Publication number
WO1999056126A3
WO1999056126A3 PCT/DE1999/001228 DE9901228W WO9956126A3 WO 1999056126 A3 WO1999056126 A3 WO 1999056126A3 DE 9901228 W DE9901228 W DE 9901228W WO 9956126 A3 WO9956126 A3 WO 9956126A3
Authority
WO
WIPO (PCT)
Prior art keywords
utilization
production
immuno
activated
adsorption matrix
Prior art date
Application number
PCT/DE1999/001228
Other languages
German (de)
French (fr)
Other versions
WO1999056126A2 (en
Inventor
Wolfgang Roenspeck
Frank Gebauer
Original Assignee
Affina Immuntechnik Gmbh
Wolfgang Roenspeck
Frank Gebauer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affina Immuntechnik Gmbh, Wolfgang Roenspeck, Frank Gebauer filed Critical Affina Immuntechnik Gmbh
Priority to AU46000/99A priority Critical patent/AU4600099A/en
Publication of WO1999056126A2 publication Critical patent/WO1999056126A2/en
Publication of WO1999056126A3 publication Critical patent/WO1999056126A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Abstract

The invention relates to a novel immuno-adsorption matrix, a method for the production thereof, and the utilization thereof for therapeutic, diagnostic, preparative, analytic and medicine technological purposes. By coupling to a supporting material, antigen binding structures are derivatized and/or activated while protecting the antigen binding site with functional groups which are suited for coupling to a chemically activated matrix or which represent an activated group themselves.
PCT/DE1999/001228 1998-04-27 1999-04-24 Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof WO1999056126A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46000/99A AU4600099A (en) 1998-04-27 1999-04-24 Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19818790.4 1998-04-27
DE1998118790 DE19818790A1 (en) 1998-04-27 1998-04-27 Preparation of an immuno-adsorption matrix, useful for diagnostic and therapeutic purposes

Publications (2)

Publication Number Publication Date
WO1999056126A2 WO1999056126A2 (en) 1999-11-04
WO1999056126A3 true WO1999056126A3 (en) 2000-01-13

Family

ID=7865940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001228 WO1999056126A2 (en) 1998-04-27 1999-04-24 Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof

Country Status (3)

Country Link
AU (1) AU4600099A (en)
DE (1) DE19818790A1 (en)
WO (1) WO1999056126A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042507A1 (en) * 2004-10-20 2006-04-27 Adexter Technology Limited Immunoadsorber for treating inflammations
EP1832600A1 (en) 2006-03-09 2007-09-12 Max-Delbrück-Centrum Für Molekulare Medizin Peptides against autoantibodies associated with glaucoma and use of these peptides
DE102007004909A1 (en) 2007-01-26 2008-07-31 Ga Generic Assays Gmbh Use of pancreatic zymogen granule polypeptide GP2 as a medicament, especially for treating autoimmune diseases by plasmapheresis
EP1950222A1 (en) 2007-01-26 2008-07-30 GA Generic Assays GmbH Method for proving antibodies in body fluids via an immune reaction with glycoprotein 2 (GP2) from zymogen granula of the pancreas for a differential diagnosis of inflammable intestinal illnesses and chronic pancreatitis
EP2199305A1 (en) 2008-12-18 2010-06-23 Max-Delbrück-Centrum Peptides against autoantibodies associated with CRPS and use of these peptides
EP2742065B1 (en) 2011-08-12 2017-08-02 E.R.D.E.-aak-Diagnostik Gmbh Agonistic autoantibodies to the alpha1-adrenergic receptor and the beta2-adrenergic receptor in alzheimer's and vascular dementia
EP2913675B1 (en) 2014-02-28 2020-02-12 GA Generic Assays GmbH GP2 isoforms and their use in autoantibody capture
EP3209697A4 (en) 2014-10-23 2018-05-30 La Trobe University Fn14-binding proteins and uses thereof
SG10202111844VA (en) 2015-01-09 2021-12-30 Adalta Ltd Cxcr4 binding molecules
EP3299818B1 (en) 2016-09-26 2019-12-04 GA Generic Assays GmbH Method for the diagnosis of acute pancreatitis (ap) by detection of glycoprotein 2 isoform alpha (gp2a)
WO2019015814A1 (en) 2017-07-20 2019-01-24 Ga Generic Assays Gmbh Chitinase-3-like protein 1 (chi3l1) as an autoantigen in autoimmune disorders of the digestive system
JP2022540913A (en) 2019-07-16 2022-09-20 ドイチェス ツェントラム フューア ノイロデジェネラティヴ エアクランクンゲン エー． ファウ．（ディーゼットエヌイー） NMDA Receptor Constructs for Detection and Isolation of NMDAR Autoantibodies
EP3872492A1 (en) 2020-02-28 2021-09-01 Seramun Diagnostica GmbH Identifying borna disease virus (bodv) infection through detection of antibodies against the bodv glycoprotein
EP4157867A1 (en) 2020-05-29 2023-04-05 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Human recombinant monoclonal antibody against sars-cov-2 spike glycoprotein
WO2022195096A1 (en) 2021-03-19 2022-09-22 Charité - Universitätsmedizin Berlin Peptide and method for direct analysis of sars-cov-2 immune responses
EP4183409A1 (en) 2021-11-17 2023-05-24 Charité - Universitätsmedizin Berlin Vaccine with improved immunogenicity against mutant coronaviruses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653669A1 (en) * 1996-12-13 1998-06-18 Affina Immuntechnik Gmbh Immuno-adsorbent for removing immunoglobulin(s) from biological fluids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653669A1 (en) * 1996-12-13 1998-06-18 Affina Immuntechnik Gmbh Immuno-adsorbent for removing immunoglobulin(s) from biological fluids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 115, no. 21, 25 November 1991, Columbus, Ohio, US; abstract no. 223755, XP002121981 *
L.I. SURVILO ET AL.: "Production of immunoaffinity sorbent with biospecific protected antigen - binding centers and its use for separation of human thyrotropin", VESTSI AKAD. NAVUK BSSR, SER. KHIM. NAVUK, vol. 4, 1991, Minsk USSR, pages 79 - 83 *

Also Published As

Publication number Publication date
AU4600099A (en) 1999-11-16
DE19818790A1 (en) 1999-10-28
WO1999056126A2 (en) 1999-11-04

Similar Documents

Publication Publication Date Title
WO1999056126A3 (en) Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof
WO2001045678A3 (en) Medicament, a method for its production and the use thereof
EP1022283A4 (en) Novel lignin derivative, moldings produced by using the derivative, and process for the preparation thereof
EP0681862A3 (en) Composite membrane and process for the production thereof.
ZA200202521B (en) 2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preprations containing said compounds.
MY116595A (en) Polycarboxylic based cross-linked copolymers
DE69021341T2 (en) CURING AGENT, METHOD FOR THE PRODUCTION THEREOF AND THE CURABLE COMPOSITION THEREFORE.
HUP9900375A3 (en) Transdermal matrix system, its use and process for producing the same
DE69526022D1 (en) Elastic, tied-up composite material
ZA975959B (en) Method for the production of a therapeutic DNA.
WO1997020045A3 (en) P2u2 purinergic receptor
WO1999054315A3 (en) Triazolones with a neuroprotective action
TR199600421A2 (en) Florphenyl substituted alkenyl carbon acid-guanidide, the method for their manufacture, their use as a drug or diagnostic agent, and medicaments containing them.
EP0627451A3 (en) Moisture curable, plasticized polyurethane adhesives.
NO953200D0 (en) Therapeutic plant material, as well as its preparation
ZA974665B (en) Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them.
WO2003106655A3 (en) Fibrous protein-immobilization systems
DE59000136D1 (en) REINFORCEMENT CONNECTION AND BRACKET FOR REINFORCEMENT CONNECTION.
PL344309A1 (en) Novel antiestrogens, a method for the production thereof, and their pharmaceutical application
AU6043490A (en) Toughened, high temperature resin matrix system
ZA976735B (en) Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them.
AU7008094A (en) Production of toxin binding biopolymers, use thereof
ID17348A (en) 1-NAFTOILGUANIDIN SUBSTITUTED, THE PROCESS FOR MAKING IT, USING IT AS A DRUG OR DIAGNOSTIC, AND THE DRUGS CONTAINING IT
FI19992506A (en) Strain the crosslinking process
WO1999031229A3 (en) Peptides and nucleic acids derived from eisenia foetida and the use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: KR

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA