WO1999055901A3 - Screening assay for identifying human purinoreceptor ligands - Google Patents

Screening assay for identifying human purinoreceptor ligands Download PDF

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Publication number
WO1999055901A3
WO1999055901A3 PCT/US1999/008923 US9908923W WO9955901A3 WO 1999055901 A3 WO1999055901 A3 WO 1999055901A3 US 9908923 W US9908923 W US 9908923W WO 9955901 A3 WO9955901 A3 WO 9955901A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
screening assay
purinoreceptor
identifying human
purinoreceptors
Prior art date
Application number
PCT/US1999/008923
Other languages
French (fr)
Other versions
WO1999055901A2 (en
Inventor
Tim Vanbiesen
Michael F Jarvis
Kevin J Lynch
Randy E Metzger
Edward C Burgard
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO1999055901A2 publication Critical patent/WO1999055901A2/en
Publication of WO1999055901A3 publication Critical patent/WO1999055901A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

A method of screening candidate compounds for their ability to modulate expression of human purinoreceptors is provided. The method relates to the use of stably transfected cell lines that express human or other mammalian purinoreceptors to identify purinoreceptor ligands, and to determine the amount of a receptor agonist or antagonist in a test sample.
PCT/US1999/008923 1998-04-30 1999-04-23 Screening assay for identifying human purinoreceptor ligands WO1999055901A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8357998P 1998-04-30 1998-04-30
US60/083,579 1998-04-30

Publications (2)

Publication Number Publication Date
WO1999055901A2 WO1999055901A2 (en) 1999-11-04
WO1999055901A3 true WO1999055901A3 (en) 2000-04-20

Family

ID=22179257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008923 WO1999055901A2 (en) 1998-04-30 1999-04-23 Screening assay for identifying human purinoreceptor ligands

Country Status (1)

Country Link
WO (1) WO1999055901A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL153747A0 (en) * 2000-07-07 2003-07-06 Univ North Carolina A method and system for assaying p2y receptors
US7056889B2 (en) * 2002-12-16 2006-06-06 Kimberly-Clark, Worldwide, Inc. Compounds that bind P2Y2 or P2Y1 receptors
DK1469072T3 (en) 2003-04-17 2008-01-07 Affectis Pharmaceuticals Ag Agent and method for diagnosing and treating affective disorders
WO2005101003A1 (en) * 2004-04-13 2005-10-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with purinoceptor 4 type y (p2y4)
ES2365790T3 (en) * 2004-12-13 2011-10-11 Centre National De La Recherche Scientifique - Cnrs PROCEDURE FOR THE IDENTIFICATION OF THE MODULATORS OF THE ACTIVITY OF THE RECEIVERS OF ION CHANNELS.
EP1959968A2 (en) * 2005-12-06 2008-08-27 P2-Science APS Modulation of the p2y2 receptor pathway
JP2010530427A (en) 2007-06-21 2010-09-09 シェーリング コーポレイション Polycyclic guanine derivatives and methods of use thereof
JP2022545558A (en) * 2019-08-26 2022-10-27 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Compositions and uses for engineered therapeutic microbes and related receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010538A1 (en) * 1993-10-15 1995-04-20 The University Of North Carolina At Chapel Hill Dna encoding the human p2u receptor and null cells expressing p2u receptors
WO1995033048A2 (en) * 1994-05-27 1995-12-07 Glaxo Group Limited P2x receptors (purinoceptor family)
WO1997041222A1 (en) * 1996-04-30 1997-11-06 Smithkline Beecham P.L.C. HUMAN P2x4 RECEPTOR SPLICE-VARIANTS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010538A1 (en) * 1993-10-15 1995-04-20 The University Of North Carolina At Chapel Hill Dna encoding the human p2u receptor and null cells expressing p2u receptors
WO1995033048A2 (en) * 1994-05-27 1995-12-07 Glaxo Group Limited P2x receptors (purinoceptor family)
WO1997041222A1 (en) * 1996-04-30 1997-11-06 Smithkline Beecham P.L.C. HUMAN P2x4 RECEPTOR SPLICE-VARIANTS

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GARCIA-GUZMAN M ET AL: "CHARACTERIZATION OF RECOMBINANT HUMAN P2X4 RECEPTOR REVEALS PHARMACOLOGICAL DIFFERENCES TO THE RAT HOMOLOGUE", MOLECULAR PHARMACOLOGY, vol. 51, 1 January 1997 (1997-01-01), pages 109 - 118, XP002059398, ISSN: 0026-895X *
LUSTIG K D ET AL: "EXPRESSION CLONING OF AN ATP RECEPTOR FROM MOUSE NEUROBLASTOMA CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, no. 11, 1 June 1993 (1993-06-01), pages 5113 - 5117, XP000609154, ISSN: 0027-8424 *
PARR C E ET AL: "CLONING AND EXPRESSION OF A HUMAN P2U NUCLEOTIDE RECEPTOR, A TARGETFOR CYSTIC FIBROSIS PHARMACOTHERAPY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 91, pages 3275-3279, XP000611412, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO1999055901A2 (en) 1999-11-04

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