WO1999051253A3 - Immune response modulation - Google Patents

Immune response modulation Download PDF

Info

Publication number
WO1999051253A3
WO1999051253A3 PCT/GB1999/000825 GB9900825W WO9951253A3 WO 1999051253 A3 WO1999051253 A3 WO 1999051253A3 GB 9900825 W GB9900825 W GB 9900825W WO 9951253 A3 WO9951253 A3 WO 9951253A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune response
response modulation
modulation
leptin
patient
Prior art date
Application number
PCT/GB1999/000825
Other languages
French (fr)
Other versions
WO1999051253A2 (en
Inventor
Graham Lord
Giuseppe Matarese
Jane Howard
Robert Lechler
Stephen Robert Bloom
Original Assignee
Imp College Innovations Ltd
Graham Lord
Giuseppe Matarese
Jane Howard
Robert Lechler
Stephen Robert Bloom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imp College Innovations Ltd, Graham Lord, Giuseppe Matarese, Jane Howard, Robert Lechler, Stephen Robert Bloom filed Critical Imp College Innovations Ltd
Priority to AU29455/99A priority Critical patent/AU2945599A/en
Publication of WO1999051253A2 publication Critical patent/WO1999051253A2/en
Publication of WO1999051253A3 publication Critical patent/WO1999051253A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons

Abstract

A method of modulating an immune response in a patient in need of such modulation, the method comprising administering to the patient an effective amount of leptin or a functional derivative thereof, or an effective amount of an antagonist or of an agonist of leptin.
PCT/GB1999/000825 1998-04-02 1999-03-17 Immune response modulation WO1999051253A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29455/99A AU2945599A (en) 1998-04-02 1999-03-17 Immune response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9807062.6 1998-04-02
GB9807062A GB9807062D0 (en) 1998-04-02 1998-04-02 Immune response

Publications (2)

Publication Number Publication Date
WO1999051253A2 WO1999051253A2 (en) 1999-10-14
WO1999051253A3 true WO1999051253A3 (en) 1999-11-18

Family

ID=10829725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/000825 WO1999051253A2 (en) 1998-04-02 1999-03-17 Immune response modulation

Country Status (3)

Country Link
AU (1) AU2945599A (en)
GB (1) GB9807062D0 (en)
WO (1) WO1999051253A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002321557B2 (en) * 2001-08-29 2006-03-30 The University Of Buckingham Use of leptin for infant with low birth weight for prevention of obesity
US8716220B2 (en) 2005-09-07 2014-05-06 Nikolaos Tezapsidis Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
US8227408B2 (en) 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
EP2326339A4 (en) 2008-05-21 2012-06-20 Neurotez Inc Methods for treating progressive cognitive disorders related to neurofibrillary tangles

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
G.M. LORD ET AL.: "LEPTIN MODULATES THE T-CELL IMMUNE RESPONSE AND REVERSES STARVATION-INDUCED IMMUNOSUPPRESSION.", NATURE, vol. 394, 27 August 1998 (1998-08-27), LONDON GB, pages 897 - 901, XP002115540 *
R.S. AHIMA ET AL.: "ROLE OF LEPTIN IN THE NEUROENDOCRINE RESPONSE TO FASTING.", NATURE, vol. 382, 18 July 1996 (1996-07-18), LONDON GB, pages 250 - 252, XP002115539 *
S. LOFFREDA ET AL.: "LEPTIN REGULATES PROINFLAMMATORY IMMUNE RESPONSES.", FASEB JOURNAL FOR EXPERIMENTAL BIOLOGY, vol. 12, no. 1, January 1998 (1998-01-01), BETHESDA, MD US, pages 57 - 65, XP002115538 *

Also Published As

Publication number Publication date
WO1999051253A2 (en) 1999-10-14
GB9807062D0 (en) 1998-06-03
AU2945599A (en) 1999-10-25

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