WO1999050284A3 - Nucleic acid molecules which code proteins influencing bone development - Google Patents

Nucleic acid molecules which code proteins influencing bone development Download PDF

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Publication number
WO1999050284A3
WO1999050284A3 PCT/EP1999/002055 EP9902055W WO9950284A3 WO 1999050284 A3 WO1999050284 A3 WO 1999050284A3 EP 9902055 W EP9902055 W EP 9902055W WO 9950284 A3 WO9950284 A3 WO 9950284A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
bone development
influencing bone
code proteins
Prior art date
Application number
PCT/EP1999/002055
Other languages
German (de)
French (fr)
Other versions
WO1999050284A2 (en
Inventor
Andre Rosenthal
Andreas Rump
Jochen Hess
Thomas Aigner
Thomas Wirth
Original Assignee
Andre Rosenthal
Andreas Rump
Jochen Hess
Thomas Aigner
Thomas Wirth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andre Rosenthal, Andreas Rump, Jochen Hess, Thomas Aigner, Thomas Wirth filed Critical Andre Rosenthal
Priority to AU31476/99A priority Critical patent/AU3147699A/en
Priority to EP99913304A priority patent/EP1066318A1/en
Publication of WO1999050284A2 publication Critical patent/WO1999050284A2/en
Publication of WO1999050284A3 publication Critical patent/WO1999050284A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The invention relates to nucleic acid molecules which code proteins influencing bone development in mammals, and to the corresponding coded proteins, antibodies and pharmaceutical and diagnostic compositions. The invention also relates to transgenic animals which express said proteins and to animals in which the corresponding gene is inactivated and which have an extension of the bone.
PCT/EP1999/002055 1998-03-27 1999-03-26 Nucleic acid molecules which code proteins influencing bone development WO1999050284A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU31476/99A AU3147699A (en) 1998-03-27 1999-03-26 Nucleic acid molecules which code proteins influencing bone development
EP99913304A EP1066318A1 (en) 1998-03-27 1999-03-26 Nucleic acid molecules which code proteins influencing bone development

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813799 1998-03-27
DE19813799.0 1998-03-27

Publications (2)

Publication Number Publication Date
WO1999050284A2 WO1999050284A2 (en) 1999-10-07
WO1999050284A3 true WO1999050284A3 (en) 2001-04-12

Family

ID=7862700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002055 WO1999050284A2 (en) 1998-03-27 1999-03-26 Nucleic acid molecules which code proteins influencing bone development

Country Status (3)

Country Link
EP (1) EP1066318A1 (en)
AU (1) AU3147699A (en)
WO (1) WO1999050284A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1300418A1 (en) 2001-10-04 2003-04-09 Erasmus Universiteit Rotterdam Gene regulation by oligopeptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039767A1 (en) * 1996-04-19 1997-10-30 Zymogenetics, Inc. Methods for inducing bone formation
WO1998001468A1 (en) * 1996-07-05 1998-01-15 University Of Rochester Chondrocyte proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039767A1 (en) * 1996-04-19 1997-10-30 Zymogenetics, Inc. Methods for inducing bone formation
WO1998001468A1 (en) * 1996-07-05 1998-01-15 University Of Rochester Chondrocyte proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AMLING M. ET AL.: "Bcl-2 lies downstream of parathyroid hormone-related peptide in a signalling pathway that regulates chondrocyte maturation during skeletal development", JOURNAL OF CELL BIOLOGY, vol. 136, no. 1, 13 January 1997 (1997-01-13), pages 205 - 213, XP002118856 *
RUMP A. ET AL.: "Identification and characterization of LOBO, a gene responsible for the generation of extraordinary long bones in transgenic mice", JOURNAL OF MOLECULAR MEDICINE, vol. 76, no. 6, May 1998 (1998-05-01), pages pB37, XP002118855 *

Also Published As

Publication number Publication date
EP1066318A1 (en) 2001-01-10
WO1999050284A2 (en) 1999-10-07
AU3147699A (en) 1999-10-18

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