WO1999048608A3 - Multi-site reactor system with dynamic, independent control of individual reaction sites - Google Patents

Multi-site reactor system with dynamic, independent control of individual reaction sites Download PDF

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Publication number
WO1999048608A3
WO1999048608A3 PCT/US1999/006628 US9906628W WO9948608A3 WO 1999048608 A3 WO1999048608 A3 WO 1999048608A3 US 9906628 W US9906628 W US 9906628W WO 9948608 A3 WO9948608 A3 WO 9948608A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction
heat
reactor system
site
dynamic
Prior art date
Application number
PCT/US1999/006628
Other languages
French (fr)
Other versions
WO1999048608A2 (en
Inventor
Steven J Young
Gregory T A Kovacs
M Allen Northrup
Kurt E Petersen
William A Mcmillan
Konstantin Othmer
Lee A Christel
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid filed Critical Cepheid
Priority to CA002324281A priority Critical patent/CA2324281A1/en
Priority to JP2000537649A priority patent/JP2002507815A/en
Priority to AU32065/99A priority patent/AU743740B2/en
Priority to EP99914164A priority patent/EP1066551A2/en
Publication of WO1999048608A2 publication Critical patent/WO1999048608A2/en
Publication of WO1999048608A3 publication Critical patent/WO1999048608A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
    • G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
    • G05B13/0205—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric not using a model or a simulator of the controlled system
    • G05B13/021—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric not using a model or a simulator of the controlled system in which a variable is automatically adjusted to optimise the performance
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/1906—Control of temperature characterised by the use of electric means using an analogue comparing device
    • G05D23/1913—Control of temperature characterised by the use of electric means using an analogue comparing device delivering a series of pulses

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Automation & Control Theory (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Software Systems (AREA)
  • Clinical Laboratory Science (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Control Of Temperature (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A multi-site reactor system (60) provides dynamic, independent, computer-implemented control of each reaction site, permitting different thermal profiles to be performed on samples at different reaction sites simultaneously. The system includes reaction vessels (2) for holding reaction mixtures and heat-exchanging modules (37) for receiving the vessels. The system also includes a controller (64) for independently controlling each heat-exchanging module (37) to heat and/or cool the reaction mixture contained therein. The controller (64) includes an adaptive control program for dynamically adjusting the duration or intensity of power pulses provided to each heating element and for dynamically adjusting the duration of fan operation to attain target temperatures quickly and accurately without overshooting or undershooting the target.
PCT/US1999/006628 1998-03-23 1999-03-23 Multi-site reactor system with dynamic, independent control of individual reaction sites WO1999048608A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002324281A CA2324281A1 (en) 1998-03-23 1999-03-23 Multi-site reactor system with dynamic, independent control of individual reaction sites
JP2000537649A JP2002507815A (en) 1998-03-23 1999-03-23 Multi-site reactor system with dynamic and independent control of individual reaction sites
AU32065/99A AU743740B2 (en) 1998-03-23 1999-03-23 Multi-site reactor system with dynamic, independent control of individual reaction sites
EP99914164A EP1066551A2 (en) 1998-03-23 1999-03-23 Multi-site reactor system with dynamic, independent control of individual reaction sites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4642098A 1998-03-23 1998-03-23
US09/046,420 1998-03-23

Publications (2)

Publication Number Publication Date
WO1999048608A2 WO1999048608A2 (en) 1999-09-30
WO1999048608A3 true WO1999048608A3 (en) 1999-12-09

Family

ID=21943355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006628 WO1999048608A2 (en) 1998-03-23 1999-03-23 Multi-site reactor system with dynamic, independent control of individual reaction sites

Country Status (5)

Country Link
EP (1) EP1066551A2 (en)
JP (1) JP2002507815A (en)
AU (1) AU743740B2 (en)
CA (1) CA2324281A1 (en)
WO (1) WO1999048608A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8739554B2 (en) 2007-11-13 2014-06-03 Roche Molecular Systems, Inc. Thermal block unit

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660228B1 (en) * 1998-03-02 2003-12-09 Cepheid Apparatus for performing heat-exchanging, chemical reactions
GB9915953D0 (en) * 1999-07-07 1999-09-08 Stem Corp Limited Improvements relating to multi-station reaction apparatus
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6403037B1 (en) 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
US6783934B1 (en) * 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
FR2829338B1 (en) * 2001-09-03 2003-10-31 Schneider Automation AUTOMATION EQUIPMENT EQUIPPED WITH A USB TYPE LINK
GB2399776A (en) * 2003-03-24 2004-09-29 Pa Knowledge Ltd Cyclical heating and cooling device and associated methods
CA2523040C (en) * 2003-05-23 2012-01-17 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media
GB2404098A (en) * 2003-07-14 2005-01-19 Reckitt Benckiser Controller for heater of a chemical vaporiser
WO2008146754A1 (en) * 2007-05-23 2008-12-04 Trust Co., Ltd. Container for liquid reaction mixture, reaction-promoting device using the same and method therefor
IES20080671A2 (en) * 2007-08-17 2009-03-18 James Walsh A cuvette assembly, and a method for producing a curvette
EP2108451A1 (en) * 2008-04-11 2009-10-14 Eppendorf AG Device for causing reactions in samples
EP2752668A3 (en) * 2010-07-23 2014-10-15 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
JP6717195B2 (en) * 2014-09-26 2020-07-01 東洋紡株式会社 Reaction promoting device and nucleic acid testing device
CN112934142B (en) * 2021-02-01 2023-06-06 山东大学 Homogeneous tubular reactor temperature control method and system based on back-stepping method
CN115145329B (en) * 2021-07-16 2023-11-28 武汉帝尔激光科技股份有限公司 Temperature control system and temperature control method for battery piece laser processing
CA3232733A1 (en) 2021-09-23 2023-03-30 Pranav Patel Methods and systems for sample analysis

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5088098A (en) * 1990-10-16 1992-02-11 General Instrument Corporation Thermoelectric cooler control circuit
US5180896A (en) * 1990-10-11 1993-01-19 University Of Florida System and method for in-line heating of medical fluid
US5207987A (en) * 1990-05-21 1993-05-04 Pb Diagnostic Systems Inc. Temperature controlled chamber for diagnostic analyzer
FR2683644A1 (en) * 1991-11-11 1993-05-14 Vaillant Sarl Process and device for the use of a regulator device
EP0545736A2 (en) * 1991-12-05 1993-06-09 Derek Henry Potter Method and apparatus for temperature control of multiple samples
US5241651A (en) * 1988-07-28 1993-08-31 Omron Corporation Operating method and adjusting device in fuzzy control apparatus
US5371665A (en) * 1994-03-14 1994-12-06 Quisenberry; Tony M. Power control circuit for improved power application and temperature control of thermoelectric coolers and method for controlling thereof
US5415346A (en) * 1994-01-28 1995-05-16 American Standard Inc. Apparatus and method for reducing overshoot in response to the setpoint change of an air conditioning system
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5687077A (en) * 1991-07-31 1997-11-11 Universal Dynamics Limited Method and apparatus for adaptive control
US5703342A (en) * 1993-06-14 1997-12-30 Bodenseewerk Perkin-Elmer Gmbh Temperature control method using empirically determined characteristics
WO1998038487A2 (en) * 1997-02-28 1998-09-03 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
WO1998043740A2 (en) * 1997-03-28 1998-10-08 The Perkin-Elmer Corporation Improvements in thermal cycler for pcr

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5241651A (en) * 1988-07-28 1993-08-31 Omron Corporation Operating method and adjusting device in fuzzy control apparatus
US5207987A (en) * 1990-05-21 1993-05-04 Pb Diagnostic Systems Inc. Temperature controlled chamber for diagnostic analyzer
US5180896A (en) * 1990-10-11 1993-01-19 University Of Florida System and method for in-line heating of medical fluid
US5088098A (en) * 1990-10-16 1992-02-11 General Instrument Corporation Thermoelectric cooler control circuit
US5687077A (en) * 1991-07-31 1997-11-11 Universal Dynamics Limited Method and apparatus for adaptive control
FR2683644A1 (en) * 1991-11-11 1993-05-14 Vaillant Sarl Process and device for the use of a regulator device
EP0545736A2 (en) * 1991-12-05 1993-06-09 Derek Henry Potter Method and apparatus for temperature control of multiple samples
US5703342A (en) * 1993-06-14 1997-12-30 Bodenseewerk Perkin-Elmer Gmbh Temperature control method using empirically determined characteristics
US5415346A (en) * 1994-01-28 1995-05-16 American Standard Inc. Apparatus and method for reducing overshoot in response to the setpoint change of an air conditioning system
US5371665A (en) * 1994-03-14 1994-12-06 Quisenberry; Tony M. Power control circuit for improved power application and temperature control of thermoelectric coolers and method for controlling thereof
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
WO1998038487A2 (en) * 1997-02-28 1998-09-03 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
WO1998043740A2 (en) * 1997-03-28 1998-10-08 The Perkin-Elmer Corporation Improvements in thermal cycler for pcr

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8739554B2 (en) 2007-11-13 2014-06-03 Roche Molecular Systems, Inc. Thermal block unit

Also Published As

Publication number Publication date
WO1999048608A2 (en) 1999-09-30
CA2324281A1 (en) 1999-09-30
EP1066551A2 (en) 2001-01-10
AU3206599A (en) 1999-10-18
AU743740B2 (en) 2002-02-07
JP2002507815A (en) 2002-03-12

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