WO1999048507A3 - Steroidal saponins for treating alzheimer's disease - Google Patents
Steroidal saponins for treating alzheimer's disease Download PDFInfo
- Publication number
- WO1999048507A3 WO1999048507A3 PCT/GB1999/000951 GB9900951W WO9948507A3 WO 1999048507 A3 WO1999048507 A3 WO 1999048507A3 GB 9900951 W GB9900951 W GB 9900951W WO 9948507 A3 WO9948507 A3 WO 9948507A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- disease
- treating alzheimer
- steroidal saponins
- saponins
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/944—Acetylcholine
Abstract
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU31574/99A AU748138B2 (en) | 1998-03-26 | 1999-03-26 | Steroidal sapogenins and their derivatives for treating alzheimers disease |
JP2000537555A JP3768100B2 (en) | 1998-03-26 | 1999-03-26 | Steroid sapogenins and their derivatives for the treatment of Alzheimer's disease |
BR9909109-7A BR9909109A (en) | 1998-03-26 | 1999-03-26 | Uses of one or more among smilagenin, pleasedigenin, an astragaloside, tigogenin, ruscogenin, hecogenin, diogenin, smilagenin, anzurogenin d or an astragaloside and an extract from a plant of the genus smilax, asparagus, anemarrhena, yucca, yucca or yucca. for the treatment of a condition distinguished by a deficiency in the function or the number of membrane-bound postsynaptic receptors, pharmaceutical composition, and, processes to enhance cognitive function in a human or non-human animal and in a patient suffering from an age-related cognitive impairment, and to treat a condition distinguished by a deficiency in function or the number of membrane-bound receptors in a tissue, organ, cell type or organelle |
EP99913453A EP1066042B1 (en) | 1998-03-26 | 1999-03-26 | Steroidal saponins for treating alzheimer's disease |
HU0101693A HUP0101693A3 (en) | 1998-03-26 | 1999-03-26 | Use of steroidal sapogenins and their derivatives for producing pharmaceutical compositions for the treatment of alzheimeirs disease |
CA002325633A CA2325633C (en) | 1998-03-26 | 1999-03-26 | Steroidal sapogenins and their derivatives for treating alzheimer's disease |
NZ507355A NZ507355A (en) | 1998-03-26 | 1999-03-26 | Membrane-bound receptors and their function; cognitive disfunction; treatments therefor; and compositions for use in such treatments |
IL13866399A IL138663A0 (en) | 1998-03-26 | 1999-03-26 | Steroidal sapogenins and their derivatives for treating alzheimer's disease |
DE69933016T DE69933016T2 (en) | 1998-03-26 | 1999-03-26 | STEROIDAL SAPONINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
PL99343423A PL195897B1 (en) | 1998-03-26 | 1999-03-26 | Membrane-bound receptors and their function; cognitive disfunction; treatments therefor; and compositions for use in such treatments |
PL380866A PL207723B1 (en) | 1998-03-26 | 1999-03-26 | Steroid sapogenins and their derivatives intended for treating Alzheimer disease |
IL138663A IL138663A (en) | 1998-03-26 | 2000-09-24 | Steroidal sapogenins and their derivatives for treating alzheimer's disease |
IS5637A IS5637A (en) | 1998-03-26 | 2000-09-25 | Steroid sapogenins and their derivatives for the treatment of Alzheimer's disease |
HR20000638A HRP20000638A2 (en) | 1998-03-26 | 2000-09-26 | Steroidal sapogenins and their derivatives for treating alzheimer's disease |
NO20004804A NO20004804L (en) | 1998-03-26 | 2000-09-26 | Steroid sapogenes and their derivatives for the treatment of Alzheimer's disease |
HK01104373A HK1033903A1 (en) | 1998-03-26 | 2001-06-22 | Steroidal saponins for treating alzheimer's disease |
US10/077,493 US6812213B2 (en) | 1998-03-26 | 2002-02-15 | Steroidal sapogenins and their derivatives for treating alzheimer's disease |
US10/109,095 US7138427B2 (en) | 1999-03-26 | 2002-03-28 | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
US11/346,046 US20060165757A1 (en) | 1999-03-26 | 2006-02-02 | 5-hydroxysapogenin derivatives with anti-dementia activity |
IL174991A IL174991A0 (en) | 1998-03-26 | 2006-04-11 | Steroidal sapogenins and their derivatives for treating alzheimer's disease |
US11/502,784 US7507720B2 (en) | 1998-03-26 | 2006-08-11 | 5-Beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
CY20061101448T CY1105653T1 (en) | 1998-03-26 | 2006-10-10 | Steroidal saponins for the treatment of ALZHEIMER'S DISEASE |
US11/894,105 US20080020021A1 (en) | 1999-03-26 | 2007-08-20 | 5-Hydroxysapogenin derivatives with anti-dementia activity |
NO20083993A NO20083993L (en) | 1998-03-26 | 2008-09-19 | Use of sarsasapogenin and smilagenin in the preparation of medications |
NO20085251A NO20085251L (en) | 1998-03-26 | 2008-12-16 | Steroid sapogenes and their derivatives for the treatment of Alzheimer's disease |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9806513.9 | 1998-03-26 | ||
GBGB9806513.9A GB9806513D0 (en) | 1998-03-26 | 1998-03-26 | Membrane-bound receptors |
GB9905275.5 | 1999-03-08 | ||
GBGB9905275.5A GB9905275D0 (en) | 1999-03-08 | 1999-03-08 | Treatment of conditions associated with membrane-bound receptors and their function |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09647110 A-371-Of-International | 1999-03-26 | ||
PCT/GB2000/003737 Continuation-In-Part WO2001023406A1 (en) | 1998-03-26 | 2000-09-29 | 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
PCT/GB2000/003750 Continuation-In-Part WO2001023408A1 (en) | 1999-03-26 | 2000-09-29 | 5-hydroxysapogenin derivatives with anti-dementia activity |
US10/108,737 Continuation US20030100542A1 (en) | 1999-03-26 | 2002-03-28 | 5-hydroxysapogenin derivatives with anti-dementia activity |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999048507A2 WO1999048507A2 (en) | 1999-09-30 |
WO1999048507A3 true WO1999048507A3 (en) | 1999-11-25 |
Family
ID=26313369
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/000951 WO1999048507A2 (en) | 1998-03-26 | 1999-03-26 | Steroidal saponins for treating alzheimer's disease |
PCT/GB1999/000960 WO1999048482A2 (en) | 1998-03-26 | 1999-03-26 | Smilagenin and anzurogenin-d for the treatment of alzheimer's disease |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/000960 WO1999048482A2 (en) | 1998-03-26 | 1999-03-26 | Smilagenin and anzurogenin-d for the treatment of alzheimer's disease |
Country Status (28)
Country | Link |
---|---|
US (2) | US6812213B2 (en) |
EP (3) | EP1719512B1 (en) |
JP (4) | JP3768100B2 (en) |
KR (6) | KR20090009997A (en) |
CN (3) | CN1198622C (en) |
AT (3) | ATE337788T1 (en) |
AU (2) | AU3158199A (en) |
BR (2) | BR9909110A (en) |
CA (2) | CA2325634A1 (en) |
CY (1) | CY1105653T1 (en) |
DE (3) | DE69929177T2 (en) |
DK (2) | DK1719512T3 (en) |
ES (2) | ES2272060T3 (en) |
GB (1) | GB2335599B (en) |
HK (3) | HK1033742A1 (en) |
HR (2) | HRP20000637A2 (en) |
HU (2) | HUP0101693A3 (en) |
ID (2) | ID26781A (en) |
IL (4) | IL138663A0 (en) |
IS (2) | IS5637A (en) |
MX (1) | MXPA00009437A (en) |
NO (4) | NO20004803L (en) |
NZ (1) | NZ507355A (en) |
PL (3) | PL195897B1 (en) |
PT (1) | PT1066042E (en) |
RU (1) | RU2297228C2 (en) |
TR (2) | TR200002773T2 (en) |
WO (2) | WO1999048507A2 (en) |
Families Citing this family (42)
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US6277978B1 (en) | 1995-12-22 | 2001-08-21 | University Of Utah Research Foundation | KVLQT1—a long QT syndrome gene |
GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
AU781810B2 (en) * | 1998-03-26 | 2005-06-16 | Phytopharm Plc. | Steroidal sapogenins and their derivatives for treating Alzheimer's disease |
US20030118673A1 (en) * | 1998-03-26 | 2003-06-26 | Zongqin Xia | Smilagenin and anzurogenin-D for the treatment of alzheimer's disease |
DE69929177T2 (en) * | 1998-03-26 | 2006-08-24 | Phytopharm Plc, Godmanchester | SMILAGENINE AND ANZUROGENIN-D FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
GB2347676A (en) * | 1999-03-08 | 2000-09-13 | Phytopharm Plc | Screening method |
US20010024664A1 (en) * | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
PT1490071E (en) * | 2002-03-27 | 2009-05-25 | Phytopharm Plc | Therapeutic uses of sapogenins |
ATE424211T1 (en) * | 2002-03-27 | 2009-03-15 | Phytopharm Plc | THERAPEUTIC USE OF SAPOGENINS |
CA2477787C (en) * | 2002-03-27 | 2011-12-20 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
CN102727501A (en) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | Uses of sapogenins and their derivatives |
KR101092150B1 (en) * | 2002-10-28 | 2011-12-12 | 파이토팜 피엘씨 | -3- stereospecific reduction of sapogen-3-ones |
GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
GB0409567D0 (en) * | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
JP2008516972A (en) * | 2004-10-14 | 2008-05-22 | ジョージタウン ユニバーシティー | Pharmaceutical composition of spirostenol having neuroprotective action |
GB0424528D0 (en) | 2004-11-05 | 2004-12-08 | Phytopharm Plc | Chemical compounds |
GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
GB0513888D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
KR100779179B1 (en) * | 2006-05-19 | 2007-11-28 | 충북대학교 산학협력단 | Agent for neuroprotection or for prophylaxis or treatment of neurodegenerative disorders containing methanol extract of Smilacis chinae rhizome |
JP2009256243A (en) * | 2008-04-17 | 2009-11-05 | Noevir Co Ltd | Humectant, antiaging agent, antioxidant, skin care preparation and functional oral composition |
WO2009153800A1 (en) | 2008-06-17 | 2009-12-23 | Pawan Kumar Goel | A novel process for extraction of furostanolic saponins from fenugreek seeds |
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CN105168785A (en) * | 2015-10-08 | 2015-12-23 | 湖北民族学院 | Traditional Chinese medicine preparation for treating AD (Alzheimer's disease) and preparation method |
EP3572085A1 (en) * | 2018-05-25 | 2019-11-27 | Neuro-Sys | Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound |
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KR102028730B1 (en) | 2019-05-22 | 2019-10-04 | (주)클래시스 | Method for preparing anemarrhena asphodeloides extract using focused ultrasonic treatment, and anemarrhena asphodeloides extract obtained therefrom |
CN110859849A (en) * | 2019-12-11 | 2020-03-06 | 大连医科大学 | Application of dioscin in preparation of Parkinson disease protection medicine |
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WO1999016786A1 (en) * | 1997-09-26 | 1999-04-08 | Institute Of Radiation Medicine, Academy Of Military Medical Sciences Of The Pla | The use of steroid saponin compounds to prevent senility, and novel steroid saponin compounds |
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