WO1999047517A8 - Novel heterocyclic compounds - Google Patents

Novel heterocyclic compounds

Info

Publication number
WO1999047517A8
WO1999047517A8 PCT/DK1999/000135 DK9900135W WO9947517A8 WO 1999047517 A8 WO1999047517 A8 WO 1999047517A8 DK 9900135 W DK9900135 W DK 9900135W WO 9947517 A8 WO9947517 A8 WO 9947517A8
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
heterocyclic compounds
novel heterocyclic
treatment
novel
Prior art date
Application number
PCT/DK1999/000135
Other languages
French (fr)
Other versions
WO1999047517A1 (en
Inventor
Rolf Hohlweg
Tine Krogh Joergensen
Knud Erik Andersen
Uffe Bang Olsen
Zdenek Polivka
Karel Sindelar
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to EP99908771A priority Critical patent/EP1071679A1/en
Priority to JP2000536712A priority patent/JP2002506863A/en
Priority to AU28259/99A priority patent/AU2825999A/en
Publication of WO1999047517A1 publication Critical patent/WO1999047517A1/en
Publication of WO1999047517A8 publication Critical patent/WO1999047517A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to novel N-substituted azaheterocyclic compounds of general formula (I) wherein X, Y, R1, R2, Z and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
PCT/DK1999/000135 1998-03-17 1999-03-16 Novel heterocyclic compounds WO1999047517A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99908771A EP1071679A1 (en) 1998-03-17 1999-03-16 Novel heterocyclic compounds
JP2000536712A JP2002506863A (en) 1998-03-17 1999-03-16 New heterocyclic compounds
AU28259/99A AU2825999A (en) 1998-03-17 1999-03-16 Novel heterocyclic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK0366/98 1998-03-17
DK36698 1998-03-17

Publications (2)

Publication Number Publication Date
WO1999047517A1 WO1999047517A1 (en) 1999-09-23
WO1999047517A8 true WO1999047517A8 (en) 1999-11-25

Family

ID=8092704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000135 WO1999047517A1 (en) 1998-03-17 1999-03-16 Novel heterocyclic compounds

Country Status (4)

Country Link
EP (1) EP1071679A1 (en)
JP (1) JP2002506863A (en)
AU (1) AU2825999A (en)
WO (1) WO1999047517A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19952147A1 (en) * 1999-10-29 2001-05-03 Boehringer Ingelheim Pharma New cyclopropanes, pharmaceutical compositions containing these compounds and process for their preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH379507A (en) * 1962-02-01 1964-07-15 Cilag Chemie Aktiengesellschaf Process for the preparation of new 10- (1'-hydroxyalkyl-pyrrolidyl- (3 ') -methyl) -phenothiazines
GB1043158A (en) * 1962-06-07 1966-09-21 Sandoz Ag Improvements in or relating to piperidylalkidene-5h-dibenzo(a,d)cycloheptenes
US4017621A (en) * 1974-12-09 1977-04-12 Sumitomo Chemical Company, Limited 2-Morpholinyl tricyclic dibenzazepine compounds
FI753701A (en) * 1975-01-06 1976-07-07 Sumitomo Chemical Co
WO1996031500A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S Novel heterocyclic compounds
US5698551A (en) * 1995-04-07 1997-12-16 Novo Nordisk A/S Heterocyclic compounds
UA54385C2 (en) * 1995-04-07 2003-03-17 Ново Нордіск А/С N-substituted azaheterocyclic carboxylic acids and etHers thereof, a method for THEIR PREPARATION, a pharmaceutical composition and a method for treatment

Also Published As

Publication number Publication date
AU2825999A (en) 1999-10-11
WO1999047517A1 (en) 1999-09-23
JP2002506863A (en) 2002-03-05
EP1071679A1 (en) 2001-01-31

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