WO1999047156A3 - Compositions for modulating cell differentiation comprising a lipid and a morphogen - Google Patents

Compositions for modulating cell differentiation comprising a lipid and a morphogen Download PDF

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Publication number
WO1999047156A3
WO1999047156A3 PCT/US1999/005533 US9905533W WO9947156A3 WO 1999047156 A3 WO1999047156 A3 WO 1999047156A3 US 9905533 W US9905533 W US 9905533W WO 9947156 A3 WO9947156 A3 WO 9947156A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
morphogen
lipid
cell differentiation
modulating cell
Prior art date
Application number
PCT/US1999/005533
Other languages
French (fr)
Other versions
WO1999047156A2 (en
Inventor
David C Rueger
Original Assignee
Creative Biomolecules Inc
David C Rueger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Biomolecules Inc, David C Rueger filed Critical Creative Biomolecules Inc
Priority to EP99913875A priority Critical patent/EP1064016A2/en
Priority to CA002323078A priority patent/CA2323078A1/en
Priority to JP2000536395A priority patent/JP2002506623A/en
Priority to AU31855/99A priority patent/AU3185599A/en
Publication of WO1999047156A2 publication Critical patent/WO1999047156A2/en
Publication of WO1999047156A3 publication Critical patent/WO1999047156A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor

Abstract

Disclosed are compositions and methods for modulating the differentiation state of cells.
PCT/US1999/005533 1998-03-14 1999-03-12 Compositions for modulating cell differentiation comprising a lipid and a morphogen WO1999047156A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99913875A EP1064016A2 (en) 1998-03-14 1999-03-12 Compositions for modulating cell differentiation comprising a lipid and a morphogen
CA002323078A CA2323078A1 (en) 1998-03-14 1999-03-12 Compositions for modulating cell differentiation comprising a lipid and a morphogen
JP2000536395A JP2002506623A (en) 1998-03-14 1999-03-12 Composition for regulating cell differentiation, comprising lipid and morphogen
AU31855/99A AU3185599A (en) 1998-03-14 1999-03-12 Compositions for modulating cell differentiation comprising a lipid and a morphogen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7802798P 1998-03-14 1998-03-14
US60/078,027 1998-03-14

Publications (2)

Publication Number Publication Date
WO1999047156A2 WO1999047156A2 (en) 1999-09-23
WO1999047156A3 true WO1999047156A3 (en) 1999-12-29

Family

ID=22141466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005533 WO1999047156A2 (en) 1998-03-14 1999-03-12 Compositions for modulating cell differentiation comprising a lipid and a morphogen

Country Status (5)

Country Link
EP (1) EP1064016A2 (en)
JP (1) JP2002506623A (en)
AU (1) AU3185599A (en)
CA (1) CA2323078A1 (en)
WO (1) WO1999047156A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003018984A (en) * 2001-07-06 2003-01-21 Mitsubishi Chemicals Corp Method for producing cell having multiple differentiation potency

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514720A2 (en) * 1991-05-03 1992-11-25 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
WO1994006447A2 (en) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. 60a protein-induced morphogenesis
WO1997040137A1 (en) * 1996-04-19 1997-10-30 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
WO1998033515A1 (en) * 1997-02-05 1998-08-06 Case Western Reserve University STIMULATORY EFFECTS OF bFGF AND BMP-2 ON OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514720A2 (en) * 1991-05-03 1992-11-25 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
WO1994006447A2 (en) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. 60a protein-induced morphogenesis
WO1997040137A1 (en) * 1996-04-19 1997-10-30 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
WO1998033515A1 (en) * 1997-02-05 1998-08-06 Case Western Reserve University STIMULATORY EFFECTS OF bFGF AND BMP-2 ON OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RICKARD D ET AL: "Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2.", DEVELOPMENTAL BIOLOGY, vol. 161, January 1994 (1994-01-01), pages 218 - 28, XP002911873 *
SCOTT D ET AL: "Differential effects and glucocorticoid potentiation of bone morphogenic protein action during rat osteoblast differentiation in vitro.", ENDOCRINOLOGY, vol. 137, no. 8, 1 August 1996 (1996-08-01), pages 3401 - 7, XP002083265 *
ZOHAR R ET AL: "Flow cytometric analysis of recombinant human osteogenic protein - 1 ( BMP - 7 ) responsive subpopulations from fetal rat calvaria based on intracellular osteopontin content.", MATRIX BIOLOGY, vol. 16, no. 6, January 1998 (1998-01-01), pages 295 - 306, XP002118378 *

Also Published As

Publication number Publication date
JP2002506623A (en) 2002-03-05
AU3185599A (en) 1999-10-11
EP1064016A2 (en) 2001-01-03
CA2323078A1 (en) 1999-09-23
WO1999047156A2 (en) 1999-09-23

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