WO1999045116A3 - Human homolog of a nuclear migration gene and its use - Google Patents

Human homolog of a nuclear migration gene and its use Download PDF

Info

Publication number
WO1999045116A3
WO1999045116A3 PCT/US1999/004996 US9904996W WO9945116A3 WO 1999045116 A3 WO1999045116 A3 WO 1999045116A3 US 9904996 W US9904996 W US 9904996W WO 9945116 A3 WO9945116 A3 WO 9945116A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
human homolog
nuclear migration
cell growth
migration gene
Prior art date
Application number
PCT/US1999/004996
Other languages
French (fr)
Other versions
WO1999045116A9 (en
WO1999045116A2 (en
Inventor
Barbara A Miller
Stephen A Osmani
Original Assignee
Penn State Res Found
Barbara A Miller
Stephen A Osmani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Res Found, Barbara A Miller, Stephen A Osmani filed Critical Penn State Res Found
Priority to AU30713/99A priority Critical patent/AU3071399A/en
Publication of WO1999045116A2 publication Critical patent/WO1999045116A2/en
Publication of WO1999045116A3 publication Critical patent/WO1999045116A3/en
Publication of WO1999045116A9 publication Critical patent/WO1999045116A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A human homolog to a nuclear migration in Aspergillus gene has been cloned and sequenced. Expression of the gene is correlated with uncontrolled cell growth. Methods and compositions for the diagnosis and treatment of uncontrolled cell growth in humans employ antisense molecules to the gene and RNA, and antibodies to the protein expression product.
PCT/US1999/004996 1998-03-05 1999-03-05 Human homolog of a nuclear migration gene and its use WO1999045116A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30713/99A AU3071399A (en) 1998-03-05 1999-03-05 Human homolog of a nuclear migration and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7688598P 1998-03-05 1998-03-05
US60/076,885 1998-03-05

Publications (3)

Publication Number Publication Date
WO1999045116A2 WO1999045116A2 (en) 1999-09-10
WO1999045116A3 true WO1999045116A3 (en) 2000-02-10
WO1999045116A9 WO1999045116A9 (en) 2000-07-27

Family

ID=22134770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004996 WO1999045116A2 (en) 1998-03-05 1999-03-05 Human homolog of a nuclear migration gene and its use

Country Status (2)

Country Link
AU (1) AU3071399A (en)
WO (1) WO1999045116A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1774043A4 (en) * 2004-05-28 2009-09-02 Dana Farber Cancer Inst Inc Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
CN100432102C (en) * 2004-09-30 2008-11-12 百瑞全球有限公司 Blood platelet reinforcing protein and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033911A1 (en) * 1997-01-31 1998-08-06 Incyte Pharmaceuticals, Inc. Human signal transduction protein regulating the nuclear movement

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033911A1 (en) * 1997-01-31 1998-08-06 Incyte Pharmaceuticals, Inc. Human signal transduction protein regulating the nuclear movement

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHIU Y.-H. ET AL.: "Extragenic Suppressors of nudC3, a Mutation That Blocks Nuclear Migration in Aspergillus nidulans", GENETICS, vol. 141, no. 2, October 1995 (1995-10-01), pages 453 - 464, XP002122521 *
GOCKE C.D.: "EXPRESSION AND LOCATION OF HNUDC, A CELL GROWTH-RELATED PROTEIN, IN HUMAN TISSUE", LABORATORY INVESTIGATION, vol. 79, no. 1, January 1999 (1999-01-01), pages 175A, XP002122519 *
HILLIER L. ET AL.: "The WashU-Merck EST Project; 592753 3' similar to TR:G619907 G619907 C15 MRNA", EMBL DATABASE ENTRY HSAA60698; ACCESSION NUMBER AA160698, 19 January 1997 (1997-01-19), XP002124443 *
MILLER B.A. ET AL.: "A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis", EXPERIMENTAL HEMATOLOGY, vol. 27, no. 4, April 1999 (1999-04-01), pages 742 - 750, XP002122520 *
MORRIS N. R. ET AL.: "Nuclear migration, nucleokinesis and lissencephaly", TRENDS IN CELL BIOLOGY, vol. 8, December 1998 (1998-12-01), pages 467 - 470, XP002122522 *
MORRIS S.M. ET AL.: "Expression of RNUDC, a Potential Nuclear Movement Protein, in Mammalian Cells: Localization to the Golgi Apparatus", EXPERIMENTAL CELL RESEARCH, vol. 238, no. 1, January 1998 (1998-01-01), pages 23 - 32, XP002122518 *

Also Published As

Publication number Publication date
WO1999045116A9 (en) 2000-07-27
AU3071399A (en) 1999-09-20
WO1999045116A2 (en) 1999-09-10

Similar Documents

Publication Publication Date Title
IE870201L (en) "a method for the expression of genes in plants, parts of¹plants, and plant cell cultures, and dna fragments,¹plasmids, and transformed microorganisms to be used when¹carrying out the method, as well as the use thereof for the¹expression of genes in plants parts of plants, and plant¹cell cultures"
AP2000001762A0 (en) Method of delivering genes to antigen presenting cells of the skin
CA2149329A1 (en) Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
TW376320B (en) Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
EP0400958A3 (en) Live vaccines
AU6649996A (en) Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
HU883981D0 (en) Process for the production of medical preparations with antiviral or antibacterial effect
MX9801264A (en) Control of cd44 gene expression for therapeutic use.
JPS6463505A (en) Cosmetics
WO1999015643A3 (en) ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS TARGETED TO ANGIOTENSI N CONVERTING ENZYME mRNA AND METHODS OF USE
EP1189918A4 (en) Antisense modulation of integrin beta 3 expression
WO2002064088A3 (en) Pharmaceutical composition for the treatment of alopecia
HUP9900654A3 (en) Preparations stimulating nail growth, process for their preparation and use of them
CA2083377A1 (en) Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna
EP0209543A4 (en) Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use.
AU1502695A (en) Double stranded RNA correction of abherrant metabolic pathways associated with uncontrolled tumor cell and virus growth cycles
BR9811014A (en) "concentrated gene regulatory region specifically for early seed"
WO1999045116A3 (en) Human homolog of a nuclear migration gene and its use
WO2003000222A3 (en) Cosmetic preparation with anti-wrinkle action
WO2000079267A3 (en) Use of hte ubiquitin specific protease usp25 in the treatment, prophylaxis and diagnosis of cancer
SG74579A1 (en) Enzyme with leudh activity, nucleotide sequence coding therefor and process for the preparation of the enzyme
AU6125496A (en) Human growth factors, nucleotide sequence encoding growth factors, and methods of use thereof
MD1119G2 (en) Method for female genitals inflammatory diseases treatment
WO2001042448A3 (en) Artificial promoters for protein expression in plants
Näthke et al. Glucosylated plasma protein injection does not produce glomerular basement membrane thickening

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C2

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

COP Corrected version of pamphlet

Free format text: PAGES 1/12-12/12, DRAWINGS, REPLACED BY NEW PAGES 1/12-12/12; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWE Wipo information: entry into national phase

Ref document number: 09623568

Country of ref document: US

122 Ep: pct application non-entry in european phase