WO1999045105A3 - Highly crystalline urokinase - Google Patents

Highly crystalline urokinase Download PDF

Info

Publication number
WO1999045105A3
WO1999045105A3 PCT/US1999/004992 US9904992W WO9945105A3 WO 1999045105 A3 WO1999045105 A3 WO 1999045105A3 US 9904992 W US9904992 W US 9904992W WO 9945105 A3 WO9945105 A3 WO 9945105A3
Authority
WO
WIPO (PCT)
Prior art keywords
urokinase
highly crystalline
modified urokinase
modified
polynucleotides
Prior art date
Application number
PCT/US1999/004992
Other languages
French (fr)
Other versions
WO1999045105A2 (en
Inventor
Jieyi Wang
Vicki L Nienaber
Jack Henkin
Richard A Smith
Karl A Walter
Jean M Severin
Rohinton Edalji
Robert W Johnson Jr
Thomas Holzman
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to EP99909895A priority Critical patent/EP1060255A2/en
Priority to JP2000534637A priority patent/JP2003521222A/en
Priority to CA002322622A priority patent/CA2322622A1/en
Priority claimed from US09/264,468 external-priority patent/US20020106775A1/en
Publication of WO1999045105A2 publication Critical patent/WO1999045105A2/en
Publication of WO1999045105A3 publication Critical patent/WO1999045105A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Abstract

The present disclosure describes a biologically active modified urokinase and high resolution crystalline forms of modified urokinase. Polynucleotides which encode modified urokinase and methods for making modified urokinase are also disclosed.
PCT/US1999/004992 1998-03-06 1999-03-05 Highly crystalline urokinase WO1999045105A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99909895A EP1060255A2 (en) 1998-03-06 1999-03-05 Highly crystalline urokinase
JP2000534637A JP2003521222A (en) 1998-03-06 1999-03-05 Highly crystalline urokinase
CA002322622A CA2322622A1 (en) 1998-03-06 1999-03-05 Highly crystalline urokinase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3636198A 1998-03-06 1998-03-06
US09/036,361 1998-03-06
US09/264,468 US20020106775A1 (en) 1999-03-05 1999-03-05 Highly crystalline urokinase
US09/264,468 1999-03-05

Publications (2)

Publication Number Publication Date
WO1999045105A2 WO1999045105A2 (en) 1999-09-10
WO1999045105A3 true WO1999045105A3 (en) 2000-03-09

Family

ID=26713110

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004992 WO1999045105A2 (en) 1998-03-06 1999-03-05 Highly crystalline urokinase

Country Status (4)

Country Link
EP (1) EP1060255A2 (en)
JP (1) JP2003521222A (en)
CA (1) CA2322622A1 (en)
WO (1) WO1999045105A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338409A1 (en) * 1988-04-18 1989-10-25 PHARMACIA S.p.A. Low molecular weight derivatives of prourokinase and pharmaceutical compositions containing the same
EP0496327A1 (en) * 1991-01-22 1992-07-29 Grünenthal GmbH Polypeptides with prourokinase activity, plasmids coding therefor and process for their preparation and use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338409A1 (en) * 1988-04-18 1989-10-25 PHARMACIA S.p.A. Low molecular weight derivatives of prourokinase and pharmaceutical compositions containing the same
EP0496327A1 (en) * 1991-01-22 1992-07-29 Grünenthal GmbH Polypeptides with prourokinase activity, plasmids coding therefor and process for their preparation and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIJNEN, H.R. ET AL.: "Biochemical properties of recombinant single-chain urokinase-type plasminogen activator mutants with deletion of Asn2 through Phe157 and/or substitution of Cys279 with Ala", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 205, no. 2, 15 April 1992 (1992-04-15), pages 701 - 709, XP002126807 *
SPRAGGON, G. ET AL.: "The crystal structure of the catalytic domain of human urokinase-type plasminogen activator", STRUCTURE, vol. 3, no. 7, 15 July 1995 (1995-07-15), pages 681 - 691, XP002126808 *

Also Published As

Publication number Publication date
CA2322622A1 (en) 1999-09-10
WO1999045105A2 (en) 1999-09-10
EP1060255A2 (en) 2000-12-20
JP2003521222A (en) 2003-07-15

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