WO1999044598A3 - Methods for inhibiting βcell apoptosis - Google Patents
Methods for inhibiting βcell apoptosis Download PDFInfo
- Publication number
- WO1999044598A3 WO1999044598A3 PCT/US1999/004730 US9904730W WO9944598A3 WO 1999044598 A3 WO1999044598 A3 WO 1999044598A3 US 9904730 W US9904730 W US 9904730W WO 9944598 A3 WO9944598 A3 WO 9944598A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- βcell
- apoptosis
- inhibiting
- cell destruction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU28931/99A AU2893199A (en) | 1998-03-03 | 1999-03-03 | Fatty acid-induced beta-cell apoptosis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7681898P | 1998-03-03 | 1998-03-03 | |
US60/076,818 | 1998-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999044598A2 WO1999044598A2 (en) | 1999-09-10 |
WO1999044598A3 true WO1999044598A3 (en) | 1999-11-04 |
Family
ID=22134367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/004730 WO1999044598A2 (en) | 1998-03-03 | 1999-03-03 | Methods for inhibiting βcell apoptosis |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2893199A (en) |
WO (1) | WO1999044598A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19921537A1 (en) * | 1999-05-11 | 2000-11-23 | Dieter Hoersch | Treating carbohydrate metabolism disorders, especially diabetes, comprises activating insulin-secreting b-cells using glucagon-related peptide, glucose-dependent insulinotropic polypeptide, exendin-4 or related drugs |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997002004A2 (en) * | 1995-06-30 | 1997-01-23 | Eli Lilly And Company | Methods for treating diabetes |
WO1997010819A1 (en) * | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Treating niddm with rxr agonists |
WO1997023204A1 (en) * | 1995-12-22 | 1997-07-03 | Smithkline Beecham Plc | Nitric oxide (no) synthase inhibitor to treat or prevent type ii diabetes |
WO1998002159A1 (en) * | 1996-07-12 | 1998-01-22 | Smithkline Beecham Plc | Novel treatment of leptine resistance |
EP0849276A1 (en) * | 1996-12-20 | 1998-06-24 | Eli Lilly And Company | Anti-obesity proteins |
-
1999
- 1999-03-03 WO PCT/US1999/004730 patent/WO1999044598A2/en active Application Filing
- 1999-03-03 AU AU28931/99A patent/AU2893199A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997002004A2 (en) * | 1995-06-30 | 1997-01-23 | Eli Lilly And Company | Methods for treating diabetes |
WO1997010819A1 (en) * | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Treating niddm with rxr agonists |
WO1997023204A1 (en) * | 1995-12-22 | 1997-07-03 | Smithkline Beecham Plc | Nitric oxide (no) synthase inhibitor to treat or prevent type ii diabetes |
WO1998002159A1 (en) * | 1996-07-12 | 1998-01-22 | Smithkline Beecham Plc | Novel treatment of leptine resistance |
EP0849276A1 (en) * | 1996-12-20 | 1998-06-24 | Eli Lilly And Company | Anti-obesity proteins |
Non-Patent Citations (9)
Title |
---|
FORMAN B M ET AL: "HYPOLIPIDEMIC DRUGS, POLYUNSATURATED FATTY ACIDS, AND EICOSANOIDS ARE LIGANDS FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA AND DELTA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, no. 9, 29 April 1997 (1997-04-29), pages 4312 - 4317, XP000677599, ISSN: 0027-8424 * |
MERRILL A.H. JR. ET AL: "Sphingolipids - The enigmatic lipid class: Biochemistry, physiology and pathophysiology.", TOXICOLOGY AND APPLIED PHARMACOLOGY, (1997) 142/1 (208-225)., XP002114145 * |
MURPHY, JOHN E. ET AL: "Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin", PROC. NATL. ACAD. SCI. U. S. A. (1997), 94(25), 13921-13926, XP002114143 * |
SHIMABUKURO M ET AL: "Fatty Acid-Induced Beta Cell Apoptosis: A Link Between Obesity and Diabetes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, no. 95, March 1998 (1998-03-01), pages 2498 - 2502 2502, XP002099922, ISSN: 0027-8424 * |
SHIMABUKURO, MICHIO ET AL: "Direct antidiabetic effect of leptin through triglyceride depletion of tissues", PROC. NATL. ACAD. SCI. U. S. A. (1997), 94(9), 4637-4641, XP002114142 * |
SHIMABUKURO, MICHIO ET AL: "Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1.beta. cytotoxicity", J. CLIN. INVEST. (1997), 100(7), 1750-1754, XP002114141 * |
SHIMABUKURO, MICHIO ET AL: "Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression", J. BIOL. CHEM. (1998), 273(49), 32487-32490, XP002114147 * |
SHIMABUKURO, MICHIO ET AL: "Role in nitric oxide in obesity -induced.beta. cell disease", J. CLIN. INVEST. (1997), 100(2), 290-295, XP002114144 * |
UNGER R.H.: "How obesity causes diabetes in Zucker diabetic fatty rats.", TRENDS IN ENDOCRINOLOGY AND METABOLISM, (1997) 8/7 (276-282)., XP002114146 * |
Also Published As
Publication number | Publication date |
---|---|
AU2893199A (en) | 1999-09-20 |
WO1999044598A2 (en) | 1999-09-10 |
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